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学部担当授業科目

  生理学,生物化学実習 III,先端生物科学実験法 I,II

研究業績

23. Mueller N, Sassa T, Morales-Gonzalez S, Schneider J, Salchow DJ, Seelow D, Knierim E, Stenzel W, Kihara A, Schuelke M. (2018)
De novo mutation in ELOVL1 causes ichthyosis, acanthosis nigricans, hypomyelination, spastic paraplegia, high frequency deafness, and optic atrophy. J Med Genet, in press.

22. Kanetake T, Sassa T, Nojiri K, Sawai M, Hattori S, Miyakawa T, Kitamura T, Kihara A. (2018) Neural symptoms in a gene knockout mouse model of Sjögren-Larsson syndrome are associated with a decrease in 2-hydroxygalactosylceramide. FASEB J, in press.

21. Sassa T, Tadaki M, Kiyonari H, Kihara A. (2018)
Very long-chain tear film lipids produced by fatty acid elongase ELOVL1 prevent dry eye disease in mice. FASEB J, 32, 2966-2978.
(プレスリリース:北大AMED

20. Honda Y, Kitamura T, Naganuma T, Abe T, Ohno Y, Sassa T, Kihara A. (2017)
Decreased skin barrier lipid acylceramide and differentiation-dependent gene expression in ichthyosis gene Nipal4 knockout mice. J Invest Dermatol, 138, 741-749.

19. Sawai M, Uchida Y, Ohno Y, Miyamoto M, Nishioka C, Itohara S, Sassa T, Kihara A. (2017) The 3-hydroxyacyl-CoA dehydratases HACD1 and HACD2 exhibit functional redundancy and are active in a wide range of fatty acid elongation pathways. J Biol Chem, 292, 15538-15551.

18. Naganuma T, Takagi S, Kanetake T, Kitamura T, Hattori S, Miyakawa T, Sassa T, Kihara A. (2016)
Disruption of the Sjögren-Larsson syndrome gene Aldh3a2 in mice increases keratinocyte growth and retards skin barrier recovery.
J Biol Chem, 291, 11676-11688.

17. Sassa T, Hirayama T, Kihara A. (2016)
Enzyme activities of the ceramide synthases CERS2-6 are regulated by phosphorylation in the C-terminal region.
J Biol Chem, 291, 7477-7487.

16. Sassa T, Kihara A (2014)
Metabolism of very long-chain fatty acids: genes and pathophysiology.
Biomol Ther, 22, 83-92. Review

15. Sassa T, Wakashima T, Ohno Y, Kihara A (2014)
Lorenzo's oil inhibits ELOVL1 and lowers the level of sphingomyelin with a saturated very long-chain fatty acid.
J Lipid Res
, 55, 524-530.
ASBMB のブログ「WILD TYPES」で紹介

14. Abe K, Ohno Y, Sassa T, Taguchi R, Caliskan M, Ober C, Kihara A (2013)
Mutation for non-syndromic mental retardation in the trans-2-enoyl-CoA reductase TER gene involved in fatty acid elongation impairs the enzyme activity and stability leading to change in sphingolipid profile.
J Biol Chem
, 288, 36741-36749.

13. Mizutani Y, Sun H, Ohno Y, Sassa T, Wakashima T, Obara M, Yuyama K, Kihara A, Igarashi Y (2013)
Cooperative synthesis of ultra long-chain fatty acid and ceramide during keratinocyte differentiation.
PLoS One
, 8, e67317.

12. Sassa T, Ohno Y, Suzuki S, Nomura T, Nishioka C, Kashiwagi T, Hirayama T, Akiyama M, Taguchi R, Shimizu H, Itohara S, Kihara A (2013)
Impaired epidermal permeability barrier in mice lacking the Elovl1 gene responsible for very long-chain fatty acid production.
Mol. Cell Biol., 33, 2787-2796.

11. Sassa T, Suto S, Okayasu Y, Kihara A (2012)
A shift in sphingolipid composition from C24 to C16 increases susceptibility to apoptosis in HeLa cells.
Biochim. Biophys. Acta, 1821, 1031-1037.

10. Naganuma T.,Sato Y., Sassa T., Ohno Y., Kihara A. (2011)
Biochemical characterization of the very long-chain fatty acid elongase ELOVL7.
FEBS Lett., 585, 3337-3341.

9. Agetsuma M, Aizawa H, Aoki T, Nakayama R, Takahoko M, Goto M, Sassa T, Amo R, Shiraki T, Kawakami K, Hosoya T, Higashijima S, Okamoto H. (2010)
The habenula is crucial for experience-dependent modification of fear responses in zebrafish.
Nature Neuroscience, 13, 1354-1356.

8. Ohno, Y., Suto, S., Yamanaka, M., Mizutani, Y., Mitsutake, S., Igarashi, Y., Sassa, T., Kihara, A. (2010)
ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis.
Proc. Natl. Acad. Sci. USA, 107, 18439-18444.

7. Gomi, H, Sassa, T, Thompson, RF, Itohara, S. (2010)
Involvement of cyclin-dependent kinase-like 2 in cognitive function required for contextual and spatial learning in mice.
Frontiers in Behavioral Neuroscience, 4, 17.

6. Guerrier, S, Coutinho-Budd, J, Sassa, T, Gresset, A, Jordan, NV, Chen, K, Jin, WL, Frost, A, Polleux F. (2009)
srGAP2 regulates neuronal migration and morphogenesis through the ability of its F-BAR domain to induce filopodial-like membrane protrusions.
Cell, 138, 990-1004.

5. Powell A., Sassa T., Wu Y.Q., Tessier-Lavigne M. and Polleux F. (2008)
Topography of Thalamic Projections Requires Attractive and Repulsive Functions of Netrin-1 in the Ventral Telencephalon.
PLoS Biol. 6(5): e116.

4. Sassa T, Aizawa H, Okamoto H. (2007)
Visualization of two distinct classes of neurons by gad2 and zic1 promoter/enhancer elements in the dorsal hindbrain of developing zebrafish reveals neuronal connectivity related to the auditory and lateral line system.
Dev Dyn. 236: 706-718.

3. Sassa T, Gomi H, Itohara S. (2004)
Postnatal expression of Cdkl2 in mouse brain revealed by LacZ inserted into the Cdkl2 locus.
Cell Tissue Res. 315: 147-156.

2. Yokoyama T, Kimura KM, Ushiki Y, Yamada S, Morooka A, Nakashiba T, Sassa T, Itohara S. (2001)
In Vivo Conversion of Cellular Prion Protein to Pathogenic Isoforms, as Monitored by Conformation-specific Antibodies.
J. Biol. Chem. 276: 11265-11271.

1. Sassa T, Gomi H, Sun W, Ikeda T, Thompson RF, Itohara S (2000)
Identification of Variants and Dual Promoters of Murine Serine/Threonine Kinase KKIAMRE.
J. Neurochem. 74: 1809-1819.

 

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〒060-0812
札幌市北区北12条西6丁目
北海道大学大学院薬学研究院
生化学研究室
木原 章雄
Tel : 011-706-3754
Fax : 011-706-4900
Email : kihara@pharm.hokudai.ac.jp