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北海道大学大学院薬学研究院に、株式会社なの花北海道及び株式会社ニナファームジャポンの寄附講座「ナノ医薬品創剤学分野」が開設
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Hibino M, Filosi T, Carrion LL, Porcu E, Malhota A, Lüdtke-Buzug K, Ibrahim SM, Yamada Y, Hirose M, An efficient approach to modulate mitochondrial function in murine primary macrophages by mitochondria-targeting nanocapsule, MITO-Porter. Biomedicine & Pharmacotherapy 186: 118019 (2025)
DOI: 10.1016/j.biopha.2025.118019 -
Norota K, Ishizuka S, Hirose M, Sato Y, Maeki M, Tokeshi M, Ibrahim SM, Harashima H, Yamada Y, Lipid nanoparticle delivery of the CRISPR/Cas9 system directly into the mitochondria of cells carrying m.7778G>T mutation in mtDNA (mt-Atp8). Scientific Report 15: 18717 (2025)
DOI: 10.1038/s41598-025-03671-8 -
Sato I, Sasaki D, Abe J, Yamanouchi K, Takeda A, Yamada YMitochondrial coenzyme Q10 delivery improves energy production in rat cardiac myoblasts and Duchenne muscular dystrophy model rat cardiomyocytes.
Biol. Pharm. Bull. 48, 1533 (2025)
DOI: 10.1248/bpb.b25-00327 -
Hibino M, Muramatsu Y, Harashima H, Yamada Y, Mitochondria-targeted coenzyme Q10 nanocarriers evaluated by particle size and lipid composition alleviate early acetaminophen-induced liver injury.
J Control Release 392, 114682 (2026)
DOI: 10.1016/j.jconrel.2026.114682