{"id":4723,"date":"2025-06-30T15:41:37","date_gmt":"2025-06-30T06:41:37","guid":{"rendered":"https:\/\/www.pharm.hokudai.ac.jp\/inps\/?p=4723"},"modified":"2025-09-16T12:34:59","modified_gmt":"2025-09-16T03:34:59","slug":"%e3%80%8c%e3%83%8a%e3%83%8e%e3%82%ab%e3%83%97%e3%82%bb%e3%83%ab%e3%82%92%e7%94%a8%e3%81%84%e3%81%9f%e3%83%9f%e3%83%88%e3%82%b3%e3%83%b3%e3%83%89%e3%83%aa%e3%82%a2%e3%82%b2%e3%83%8e%e3%83%a0%e7%b7%a8","status":"publish","type":"post","link":"https:\/\/www.pharm.hokudai.ac.jp\/inps\/4723\/","title":{"rendered":"\u300c\u30ca\u30ce\u30ab\u30d7\u30bb\u30eb\u3092\u7528\u3044\u305f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30b2\u30ce\u30e0\u7de8\u96c6\u300d\u306b\u95a2\u3059\u308b\u8ad6\u6587\u304c\u00a0Sci.\u00a0Rep.\u00a0\u306b\u63b2\u8f09\u00a0\uff08\u30ea\u30e5\u30fc\u30d9\u30c3\u30af\u5927\u5b66\uff08\u30c9\u30a4\u30c4\uff09\u3068\u306e\u5171\u540c\u7814\u7a76\uff09\u00a0(\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\uff1a\u5317\u5927\u3001JST)"},"content":{"rendered":"\n<p>Our paper entitled \u201cLipid nanoparticle delivery of the CRISPR\/Cas9 system directly into the mitochondria of cells carrying m.7778G&gt;T mutation in mtDNA (mt-Atp8)\u201d.<\/p>\n\n\n\n<p>\u5317\u6d77\u9053\u5927\u5b66\u30fb\u5927\u5b66\u9662\u85ac\u5b66\u7814\u7a76\u9662\u3068\u30c9\u30a4\u30c4\u30fb\u30ea\u30e5\u30fc\u30d9\u30c3\u30af\u5927\u5b66\u3068\u306e\u5171\u540c\u7814\u7a76\u8ad6\u6587\u300c\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\uff08mt-Atp8\uff09\u306bm.7778G&gt;T\u5909\u7570\u3092\u6709\u3059\u308b\u7d30\u80de\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3078CRISPR\/Cas9\u30b7\u30b9\u30c6\u30e0\u3092\u76f4\u63a5\u9001\u9054\u3059\u308b\u9769\u65b0\u7684\u306a\u8102\u8cea\u30ca\u30ce\u30ab\u30d7\u30bb\u30eb\u300d\u304c<a href=\"https:\/\/doi.org\/10.1038\/s41598-025-03671-8\">\u201dScientific Reports<\/a>\u201d\u306b\u30a2\u30af\u30bb\u30d7\u30c8\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u3061\u3089\u306e\u7814\u7a76\u3010\u30ca\u30ce\u30ab\u30d7\u30bb\u30eb\u3067\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u30b2\u30ce\u30e0\u7de8\u96c6\u306b\u6210\u529f\u3011\u3092<a href=\"https:\/\/www.hokudai.ac.jp\/news\/2025\/06\/post-1929.html\">\u5317\u6d77\u9053\u5927\u5b66<\/a>\u304a\u3088\u3073<a href=\"https:\/\/www.jst.go.jp\/pr\/announce\/20250619\/index.html\">JST<\/a>\u306e\u30db\u30fc\u30e0\u30da\u30fc\u30b8\u3067PRESS RELEASE\u8a18\u4e8b\u3068\u3057\u3066\u7d39\u4ecb\u3057\u3066\u9802\u304d\u307e\u3057\u305f\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our paper entitled \u201cLipid nanoparticle delivery of the CRISPR\/Cas9 system directly into the mitochondria of ce [&hellip;]<\/p>\n","protected":false},"author":10,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[152,153],"tags":[],"class_list":["post-4723","post","type-post","status-publish","format-standard","hentry","category-topics","category-pressrelease"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.pharm.hokudai.ac.jp\/inps\/wp-json\/wp\/v2\/posts\/4723","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharm.hokudai.ac.jp\/inps\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pharm.hokudai.ac.jp\/inps\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharm.hokudai.ac.jp\/inps\/wp-json\/wp\/v2\/users\/10"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharm.hokudai.ac.jp\/inps\/wp-json\/wp\/v2\/comments?post=4723"}],"version-history":[{"count":1,"href":"https:\/\/www.pharm.hokudai.ac.jp\/inps\/wp-json\/wp\/v2\/posts\/4723\/revisions"}],"predecessor-version":[{"id":4724,"href":"https:\/\/www.pharm.hokudai.ac.jp\/inps\/wp-json\/wp\/v2\/posts\/4723\/revisions\/4724"}],"wp:attachment":[{"href":"https:\/\/www.pharm.hokudai.ac.jp\/inps\/wp-json\/wp\/v2\/media?parent=4723"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pharm.hokudai.ac.jp\/inps\/wp-json\/wp\/v2\/categories?post=4723"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pharm.hokudai.ac.jp\/inps\/wp-json\/wp\/v2\/tags?post=4723"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}