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特任助教 Ikramy Abdelraheem Khalil Ibraheem 生年月日：１９７４年１２月７日 E-mail：ibraheem☆pharm.hokudai.ac.jp （☆は＠です） |
学歴
Bachelor of Pharmaceutical Sciences
Faculty of Pharmacy - Assiut University, Assiut, Egypt (June, 1997). Grade: Excellent with Degree of Honor.
Master of Pharmaceutical Sciences
Graduate School of Pharmaceutical Sciences - Hokkaido University, Sapporo, Hokkaido, Japan (March, 2003).
Doctor of Philosophy - Pharmaceutical Sciences
Graduate School of Pharmaceutical Sciences - Hokkaido University, Sapporo, Hokkaido, Japan (March, 2006).
研究歴
Demonstrator of Pharmaceutics
Pharmaceutics Department - Faculty of Pharmacy - Assiut University, Assiut, Egypt (September 1997-June 2006).
Lecturer of Pharmaceutics
Pharmaceutics Department - Faculty of Pharmacy - Assiut University, Assiut, Egypt (June 2006-May2014).
JSPS Research Fellow
Laboratory of Molecular Design of Pharmaceutics - Graduate School of Pharmaceutical Sciences - Hokkaido University, Sapporo, Hokkaido, Japan (September 2007 – September 2009).
Assistant Professor of Pharmaceutics
Pharmaceutics and Pharmaceutical Technology Department – Faculty of Pharmacy – Taibah University, Almadinah Almonawwarah, KSA (October 2012 – May 2014).
Associate Professor of Pharmaceutics
Pharmaceutics Department - Faculty of Pharmacy – Assiut University, Assiut, Egypt (May 2014 - current).
Specially Appointed Assistant Professor
Laboratory of Innovative Nanomedicine - Graduate School of Pharmaceutical Sciences - Hokkaido University, Sapporo – Hokkaido – Japan (September 2016 – current).
賞罰
A scholarship from Egyptian government for postgraduate studies in Japan (October 2000 to April 2006).
A post-doctor research fellow from the Japan Society for the Promotion of Science (JSPS) (September 2007 to September 2009).
Second Best Poster for young researchers - The 9th Liposome Research Days (LRD) 2004 – Taiwan – May, 2004.
Nagai Konishi Student Award – Nagai Foundation – Tokyo – Japan – September, 2005.
所属学会
Egyptian Pharmacists General Syndicate、Egyptian Pharmaceutical Society (EPS)
信条
Seek knowledge from the cradle to the grave.
好きなもの
特任助教：Ikramy Abdelraheem Khalil Ibraheem
原著論文
| 1. | Abd Elwakil MM, Khalil IA, Elewa YE, Kusumoto K, Sato Y, Shobaki N, Kon Y, Harashima H. Lung‐Endothelium‐Targeted Nanoparticles Based on a pH‐Sensitive Lipid and the GALA Peptide Enable Robust Gene Silencing and the Regression of Metastatic Lung Cancer. Advanced Functional Materials, Volume29, Issue18, May 2, 2019, 1807677. https://doi.org/10.1002/adfm.201807677 |
| 2. | Santiwarangkool S, Akita H, Khalil IA, Abd Elwakil MM, Sato Y, Kusumoto K, Harashima H. A study of the endocytosis mechanism and transendothelial activity of lung-targeted GALA-modified liposomes. J Control Release. 2019 Jun 8;307:55-63. doi: 10.1016/j.jconrel.2019.06.009. [Epub ahead of print] |
| 3. | Ikramy A. Khalil, Seigo Kimura, Yusuke Sato, & Hideyoshi Harashima. “Synergism between a cell penetrating peptide and a pH-sensitive cationic lipid in efficient gene delivery based on double-coated nanoparticles”. Journal of Controlled Release, 275:107-16 (2018). [PMID: 29452131]. |
| 4. | Ikramy A. Khalil & Hideyoshi Harashima. An efficient PEGylated gene delivery system with improved targeting: Synergism between octaarginine and a fusogenic peptide. International Journal of Pharmaceutics, 538(1-2):179-187 (2018). [PMID: 29341911]. |
| 5. | Hayashi Y, Mizuno R, Ikramy KA, Akita H, & Harashima H. “Pretreatment of hepatocyte growth factor gene transfer mediated by octaarginine peptide-modified nanoparticles ameliorates LPS/D-galactosamine-induced hepatitis”. Nucleic Acid Ther, 22(5):360-3 (2012). [PMID: 22963044]. |
| 6. | Khalil IA, Hayashi Y, Mizuno R, & Harashima H. “Octaarginine- and pH sensitive fusogenic peptide-modified nanoparticles for liver gene delivery”. Journal of Controlled Release, 156(3):374-80 (2011). [PMID: 21864599]. |
| 7. | Hayashi Y, Yamauchi J, Khalil IA, Kajimoto K, Akita H, & Harashima H. “Cell penetrating peptide-mediated systemic siRNA delivery to the liver”. International Journal of Pharmaceutics, 419(1-2): 308-13 (2011). [PMID: 21827843]. |
| 8. | El-Sayed A, Masuda T, Khalil IA, Akita H, & Harashima H. “Enhanced gene expression by a novel stearylated INF7 peptide derivative through fusion independent endosomal escape”. Journal of Controlled Release, 138(2):160-167 (2009). [PMID: 19465073]. |
| 9. | Higashi T, Khalil IA, Maiti KK, Lee WS, Akita H, Harashima H, & Chung SK. “Novel lipidated sorbitol-based molecular transporters for non-viral gene delivery”. Journal of Controlled Release, 136(2):140-147 (2009). [PMID: 19331845]. |
| 10. | Akita H, Kudo A, Minoura A, Yamaguti M, Khalil IA, Moriguchi R, Masuda T, Danev R, Nagayama K, Kogure K, & Harashima, H. “Multi-layered nanoparticles for penetrating the endosome and nuclear membrane via a step-wise membrane fusion process”. Biomaterials, 30(15):2940-2949 (2009). [PMID: 19261326]. |
| 11. | El-Sayed A, Khalil IA, Kogure K, Futaki S, & Harashima H. “Octaarginine- and octalysine-modified nanoparticles have different modes of endosomal escape”. J Biol Chem, 283(34):23450-61 (2008). [PMID: 18550548]. |
| 12. | Khalil IA, Kogure K, Futaki S, Hama S, Akita H, Ueno M, Kishida H, Kudoh M, Mishina Y, Kataoka K, Yamada M, & Harashima H. “Octaarginine-modified multifunctional envelope-type nanoparticles for gene delivery”. Gene Ther, 14(8):682-9 (2007). [PMID: 17268535]. |
| 13. | Yang T, Hussain A, Bai S, Khalil IA, Harashima H, and Ahsan F. “Positively charged polyethylenimines enhance nasal absorption of the negatively charged drug, low molecular weight heparin”. Journal of Controlled Release, 115(3):289-297 (2006). [PMID: 17023085]. |
| 14. | Iwasa A, Akita H, Khalil IA, Kogure K, Futaki S, & Harashima H. “Cellular uptake and subsequent intracellular trafficking of R8-liposomes introduced at low temperature”. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1758(6):713-720 (2006). [PMID: 16780792]. |
| 15. | Khalil IA, Kogure K, Futaki S, & Harashima H. “High density of octaarginine stimulates macropinocytosis leading to efficient intracellular trafficking for gene expression”. J Biol Chem 281(6):3544-3551 (2006). [PMID: 16326716]. |
| 16. | Mudhakir D, Akita H, Khalil IA, Futaki S, & Harashima H. “Pharmacokinetic analysis of the tissue distribution of octaarginine modified liposomes in mice”. Drug Metab Pharmacokinet, 20(4):275-81 (2005). [PMID: 16141607]. |
| 17. | Khalil IA, Futaki S, Niwa M, Baba Y, Kaji N, Kamiya H, & Harashima H. “Mechanism of improved gene transfer by the N-terminal stearylation of octaarginine: enhanced cellular association by hydrophobic core formation”. Gene Ther, 11(7):636-44 (2004). [PubMed ID: 14973542]. |
| 18. | Akita H, Ito R, Khalil IA, Futaki S, & Harashima H. “Quantitative three-dimensional analysis of the intracellular trafficking of plasmid DNA transfected by a nonviral gene delivery system using confocal laser scanning microscopy”. Mol Ther, 9(3):443-51 (2004). [PubMed ID: 15006612]. |
Page Up総説
英文総説| 1. | Khalil IA, Yamada Y, Harashima H. Optimization of siRNA delivery to target sites: issues and future directions. Expert Opinion on Drug Delivery, Volume 15, 2018 - Issue 11, Pages 1053-1065, https://doi.org/10.1080/17425247.2018.1520836 |
| 2. | Nakamura T, Yamada Y, Sato Y, Khalil IA, Harashima H. Innovative nanotechnologies for enhancing nucleic acids/gene therapy: Controlling intracellular trafficking to targeted biodistribution. Biomaterials. 2019 Jul 4;218:119329. doi: 10.1016/j.biomaterials.2019.119329. [Epub ahead of print] |
| 3. | Khalil IA, Kogure K, Akita H, & Harashima H. “Uptake pathways and subsequent intracellular trafficking in nonviral gene delivery”. Pharmacol Rev, 58(1): 32-45 (2006). [PMID: 16507881] |
| 4. | Khalil IA, Kogure K, Futaki S, & Harashima H. “Octaarginine-modified liposomes: Enhanced cellular uptake and controlled intracellular trafficking”. International Journal of Pharmaceutics, 354(1-2):39-48 (2008). [PMID: 18242018] |
和文総説
教育
学部担当授業科目：
先端生物科学実験法 II、薬剤学実習
その他
| 1. | Akita H, Khalil IA, Kogure K. & Harashima H. “Pharmacokinetic considerations in nonviral gene delivery”. In: Non-viral gene delivery: Gene Design and Delivery, Springer-Verlag, Tokyo 2005. Pages: 135-154. [http://link.springer.com/chapter/10.1007%2F4-431-27879-6_11#page-1] |
| 2. | Khalil IA, Yamada Y, Akita H, & Harashima H. "Uptake Pathways Dependent Intracellular Trafficking of DNA Carrying Nanodelivery System”. In: Organelle-Specific Pharmaceutical Nanotechnology, Editors: Volkmar Weissig and Gerard G.M. D'Souza. Wiley A John Wiley&Sons, Inc., Publication (2010) Pages: 475-506. [http://eu.wiley.com/WileyCDA/WileyTitle/productCd-0470631651.html] |
| 3. | Akita H, Hatakeyama H, Khalil IA, Yamada Y. & Harashima H. "Delivery of Nucleic Acids and Gene Delivery". In: P. Ducheyne, K.E. Healy, D.W. Hutmacher, D.W. Grainger, C.J. Kirkpatrick (eds.) Comprehensive Biomaterials, vol. 4, pp. 411-444 Elsevier (2011) [http://www.sciencedirect.com/science/article/pii/B9780080552941001501]. |