{"id":14,"date":"2019-05-21T16:53:17","date_gmt":"2019-05-21T07:53:17","guid":{"rendered":"https:\/\/www.pharm.hokudai.ac.jp\/nano\/?page_id=14"},"modified":"2024-11-29T14:40:49","modified_gmt":"2024-11-29T05:40:49","slug":"pharmacy","status":"publish","type":"page","link":"https:\/\/www.pharm.hokudai.ac.jp\/nano\/pharmacy","title":{"rendered":"\u85ac\u5b66\u7814\u7a76\u9662 \u7814\u7a76\u5185\u5bb9"},"content":{"rendered":"<h3 style=\"text-align: center;\">\u30ca\u30ceDDS\u306b\u57fa\u3065\u304f\u500b\u5225\u5316\u30ca\u30ce\u533b\u7642<\/h3>\n<div class=\"area\">\n<ol>\n<li><a href=\"#001\">\u72ec\u81ea\u306e\u30a4\u30aa\u30f3\u5316\u8102\u8cea\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\u3092\u57fa\u76e4\u3068\u3057\u305f\u9ad8\u5206\u5b50\u9001\u9054<\/a><\/li>\n<li><a href=\"#002\">\u30ca\u30ceDDS\u3092\u57fa\u76e4\u3068\u3057\u305f\u304c\u3093\u514d\u75ab\u6cbb\u7642: \u30ca\u30ce\u304c\u3093\u514d\u75ab\u6cbb\u7642<\/a><\/li>\n<li><a href=\"#003\">\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a19\u7684\u578bDDS\u3092\u57fa\u76e4\u3068\u3059\u308b\u30aa\u30eb\u30ac\u30cd\u30e9\u6cbb\u7642<\/a><\/li>\n<\/ol>\n<\/div>\n<p>\u672c\u53d6\u7d44\u306f2009\u5e74\u5ea6\u3088\u308a\u958b\u59cb\u3057\u305f\u6700\u5148\u7aef\u7570\u5206\u91ce\u878d\u5408\u7814\u7a76\u300c\u8840\u7ba1\u3092\u6a19\u7684\u3068\u3059\u308b\u9769\u65b0\u7684\u533b\u85ac\u5206\u5b50\u9001\u9054\u6cd5\u306e\u57fa\u76e4\u6280\u8853\u306e\u78ba\u7acb\u300d\u306b\u59cb\u307e\u308a\u3001\u85ac\u5b66\u7814\u7a76\u9662\u306b\u672a\u6765\u5275\u5264\u5b66\u7814\u7a76\u5ba4\u3092\u5275\u8a2d\u3057\u3001\u8840\u7ba1\u3092\u6a19\u7684\u3068\u3059\u308b\u9769\u65b0\u7684\u533b\u85ac\u5206\u5b50\u9001\u9054\u6cd5\u306e\u78ba\u7acb\u3092\u9032\u3081\u3066\u304d\u305f\u30022014\u5e74\u5ea6\u304b\u3089\u300c\u8840\u7ba1\u3092\u6a19\u7684\u3068\u3059\u308b\u30ca\u30ce\u533b\u7642\u306e\u5b9f\u7528\u5316\u300d\u306b\u7d99\u7d9a\u3057\u3066\u3044\u308b\u30022019\u5e74\u5ea6\u3088\u308a\u300c\u8840\u7ba1\u3092\u6a19\u7684\u3068\u3059\u308b\u30ca\u30ce\u533b\u7642\u306e\u5b9f\u88c5\uff5ePersonalized Nanomedicine\u306e\u5317\u5927\u30d6\u30e9\u30f3\u30c9\u5316\uff5e\u300d\u3068\u3057\u3066\u3001\u85ac\u5b66\u7814\u7a76\u9662\u306e\u672a\u6765\u5275\u5264\u5b66\u3001\u6b6f\u5b66\u7814\u7a76\u9662\u306e\u8840\u7ba1\u751f\u7269\u5b66\u3001\u5de5\u5b66\u7814\u7a76\u9662\u306e\u751f\u7269\u8a08\u6e2c\u79d1\u5b66\u306e\uff13\u30b0\u30eb\u30fc\u30d7\u3067\u30b3\u30a2\u3092\u5f62\u6210\u3057\u3001\u5b9f\u7528\u5316\u3078\u5411\u3051\u305f\u7814\u7a76\u3092\u958b\u59cb\u3057\u305f\u3002\u672a\u6765\u5275\u5264\u5b66\u7814\u7a76\u5ba4\u306f\u3001\u85ac\u5264\u5206\u5b50\u8a2d\u8a08\u5b66\u7814\u7a76\u5ba4\u3068\u5bc6\u63a5\u306a\u9023\u643a\u306e\u3082\u3068\u306b\u3001\u8840\u7ba1\u3092\u6a19\u7684\u3068\u3059\u308b\u500b\u5225\u5316\u30ca\u30ce\u533b\u7642\u306e\u5b9f\u7528\u5316\u3092\u9032\u3081\u308b\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u672c\u4e8b\u696d\u304b\u3089\u3001KPI (Key Performance Indicator)\u3092\u5c0e\u5165\u3059\u308b\u3053\u3068\u306b\u306a\u3063\u305f\u3002KPI\u306f\u3001<\/p>\n<ul>\n<li>Top10%\u88ab\u5f15\u7528\u8ad6\u6587\u306e\u5272\u540835\uff05<\/li>\n<li>\u5927\u578b\u5171\u540c\u7814\u7a76\uff08\u5e74\u9593500\u4e07\u5186\u4ee5\u4e0a\uff092\u4ef6<\/li>\n<li>\u7523\u696d\u5275\u51fa\u8b1b\u5ea71\u4ef6<\/li>\n<\/ul>\n<p>\u306e\u3088\u3046\u306b\u8a2d\u5b9a\u3057\u305f\u3002\u3044\u305a\u308c\u3082\u9ad8\u3044\u76ee\u6a19\u3067\u3042\u3063\u305f\u304c\u3001\u81ea\u3089\u3092\u9f13\u821e\u3059\u308b\u305f\u3081\u306e\u76ee\u6a19\u8a2d\u5b9a\u3068\u6349\u3048\u3001\u6a0b\u7530\u5148\u751f\u3068\u6e21\u6176\u6b21\u5148\u751f\u306e\u5408\u610f\u3092\u5f97\u3066\u3001\u5168\u54e1\u3067\u5171\u6709\u3057\u305f\u3002\u5168\u54e1\u304c\u771f\u5263\u306b\u53d6\u308a\u7d44\u3081\u308b\u3088\u3046\u306a\u30b7\u30b9\u30c6\u30e0\u304c\u5fc5\u8981\u3068\u306a\u308a\u3001\u7814\u7a76\u6210\u679c\u3092\u5b9a\u91cf\u7684\u306b\u8a55\u4fa1\u3057\u3066\u3001\u6b21\u5e74\u5ea6\u306e\u7814\u7a76\u8cbb\u914d\u5206\u3078\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u3059\u308b\u3053\u3068\u306b\u3057\u305f\u3002KPI\u306e\u76ee\u6a19\u9054\u6210\u3068\u7814\u7a76\u8cbb\u914d\u5206\u3092\u30ea\u30f3\u30af\u3059\u308b\u3053\u3068\u3067\u3001\u53c2\u52a0\u8005\u5168\u54e1\u306b\u3068\u3063\u3066KPI\u304c\u81ea\u8eab\u306e\u76ee\u6a19\u306b\u306a\u3063\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>KPI-1:\u3000Citation\u3092\u5982\u4f55\u306b\u3057\u3066\u5411\u4e0a\u3055\u305b\u308b\u304b\u3001\u8a66\u884c\u932f\u8aa4\u304c\u7d9a\u3044\u305f\u3002\u5f53\u521d\u306f\u3001citation\u306e\u7d50\u679c\u3092\u305f\u3060\u773a\u3081\u3066\u3044\u308b\u3060\u3051\u3067\u3042\u3063\u305f\u304c\u3001Top10%\u88ab\u5f15\u7528\u7387\u306e\u5272\u540835\uff05\u3068\u3044\u3046\u76ee\u6a19\u3092\u9054\u6210\u3059\u308b\u305f\u3081\u306b\u306f\u7a4d\u6975\u7684\u306b\u4f55\u304b\u3059\u308b\u5fc5\u8981\u304c\u3042\u3063\u305f\u3002\u8a66\u884c\u932f\u8aa4\u306e\u672b\u306b\u3001self-citation\u306f\u78ba\u5b9f\u306b\u6570\u3092\u5897\u3084\u3059\u306e\u3067\u3001\u65b0\u305f\u306b\u539f\u8457\u8ad6\u6587\u3092\u66f8\u304f\u6642\u3001\u3067\u304d\u308b\u3060\u3051self-citation\u3059\u308b\u3088\u3046\u306b\u52d9\u3081\u305f\u3002\u7dcf\u8aac\u4f9d\u983c\u306f\u304b\u306a\u308a\u306e\u983b\u5ea6\u3067\u6765\u3066\u3044\u305f\u306e\u3067\u3001\u7a4d\u6975\u7684\u306bself-citation\u3057\u3066\u307f\u308b\u3068\u3001\u7fcc\u5e74\u306bTop10%\u88ab\u5f15\u7528\u8ad6\u6587\u306e\u6570\u304c\u4e0a\u6607\u3057\u305f\u3002\u305f\u3060\u3057\u3001self-citation\u306e\u52b9\u679c\u304c\u8868\u308c\u308b\u306e\u306f\u6700\u521d\u306e1\uff5e2\u5e74\u3060\u3051\u3067\u30013\u5e74\u4ee5\u964d\u306f\u4ed6\u8005\u304b\u3089\u306e\u5f15\u7528\u304c\u652f\u914d\u7684\u3067\u3042\u3063\u305f\u3002\u7d50\u679c\u306f\u30012019\u5e74\u304b\u30892023\u5e74\u306e5\u5e74\u9593\u3067\u3001\u8ad6\u6587\u7dcf\u657099\u5831\u3001Top10%\u88ab\u5f15\u7528\u8ad6\u658740\u5831\u3001\u5272\u5408\u306f40.4\uff05\u3067\u3042\u3063\u305f\u3002\u6b6f\u5b66\u3068\u5de5\u5b66\u3092\u542b\u3081\u305f\u5168\u4f53\u306e\u5e73\u5747\u5024\u306f38.5\uff05\u3067\u3001\u76ee\u6a19\u306e35\uff05\u3092\u8d85\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>KPI-2:\u30002018\u5e74\u5f53\u6642\u3001\u5e74\u9593500\u4e07\u5186\u4ee5\u4e0a\u306e\u5927\u578b\u5171\u540c\u7814\u7a76\u3092\u7372\u5f97\u3059\u308b\u3053\u3068\u306f\u975e\u5e38\u306b\u96e3\u3057\u304f\u3001\u5b9f\u4f8b\u3082\u4e4f\u3057\u3044\u72b6\u6cc1\u3067\u3042\u3063\u305f\u3002\u5168\u304f\u81ea\u4fe1\u304c\u7121\u304b\u3063\u305f\u306e\u3067\u3001\u76ee\u6a19\u50242\u4ef6\u3068\u8a2d\u5b9a\u3057\u305f\u3002\u5b9f\u969b\u306b\u59cb\u307e\u308b\u3068\u30012019\u5e743\u4ef6\u30012020\u5e746\u4ef6\u30012021\u5e744\u4ef6\u30012022\u5e744\u4ef6\u30012023\u5e746\u4ef6\u3001\u306e\u307923\u4ef6\u306e\u5927\u578b\u5171\u540c\u7814\u7a76\u304c\u8d70\u3063\u305f\u30022018\u5e74\u306e\u30aa\u30f3\u30d1\u30c3\u30c8\u30ed<sup>\u00ae<\/sup>\u306eFDA\u306b\u3088\u308b\u627f\u8a8d\u306f\u3001\u30ca\u30ce\u533b\u85ac\u54c1\u306e\u5b9f\u7528\u5316\u306b\u304a\u3044\u3066\u5909\u66f2\u70b9\u3068\u306a\u308a\u3001\u4f01\u696d\u304b\u3089\u306e\u5171\u540c\u7814\u7a76\u8cbb\u306f\u5927\u578b\u5316\u3057\u305f\u3002\u6211\u3005\u81ea\u8eab\u3082\u4f01\u696d\u9023\u643a\u3092\u884c\u3046\u3068\u304d\u3001500\u4e07\u5186\u3092\u4e00\u3064\u306e\u57fa\u6e96\u3068\u3057\u3066\u8003\u3048\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u3002\u52ff\u8ad6\u3001200\uff5e300\u4e07\u5186\u306e\u5171\u540c\u7814\u7a76\u3082\u53d7\u3051\u5165\u308c\u3066\u3044\u305f\u304c\u3001500\u4e07\u5186\u4ee5\u4e0a\u30011000\u4e07\u5186\u8d8a\u3048\u3092\u76ee\u6307\u3059\u3088\u3046\u306b\u3057\u305f\u3002\u5927\u578b\u5171\u540c\u7814\u7a76\u8cbb\u306e5\u5e74\u9593\u306e\u7dcf\u984d\u306f\u300118\u4ef6\u30673\u51043,172\u4e07\u5186\u3001\u4e00\u4ef6\u5f53\u305f\u308a\u5e73\u57471,842\u4e07\u5186\u3067\u3042\u3063\u305f\uff08\u4e8b\u696d\u5168\u4f53\u3067\u306f23\u4ef6\u30674\u51041,048\u4e07\u5186\u3001\u4e00\u4ef6\u5f53\u305f\u308a\u5e73\u57471,784\u4e07\u5186\uff09\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>KPI-3\uff1a\u3000\u7523\u696d\u5275\u51fa\u5206\u91ce\u306e\u5275\u51fa\u306f\u6700\u5927\u306e\u58c1\u3067\u3042\u3063\u305f\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u672c\u4e8b\u696d\u306f\u793e\u4f1a\u5b9f\u88c5\u304c\u7a76\u6975\u306e\u76ee\u6a19\u3067\u3042\u308a\u3001\u307e\u305f\u3001\u5927\u5b66\u5074\u304b\u3089\u306e\u8981\u8acb\u3082\u611f\u3058\u3066\u3044\u305f\u306e\u3067\u30011\u4ef6\u3092\u76ee\u6a19\u3068\u3057\u3066\u63b2\u3052\u305f\uff082018\u5e74\uff09\u3002\uff17SEAS PROJECT\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6cbb\u7642\u306e\u5b9f\u73fe\u3092\u76ee\u6307\u3059\u30c1\u30fc\u30e0\u3067\u3001\u3044\u3064\u9803\u304b\u3089\u304b\u3001\u6211\u3005\u3082\u9023\u643a\u3057\u3066\u3044\u305f\u30022018\u5e74\u306b\u83c5\u6cbc\u6b63\u53f8\u6c0f\u304c\u30eb\u30ab\u30b5\u30a4\u30a8\u30f3\u30b9\u793e\u3092\u8a2d\u7acb\u3057\u3001\u5c71\u7530\u52c7\u78e8\u51c6\u6559\u6388\u3068\u539f\u5cf6\u79c0\u5409\u6559\u6388\u306f\u79d1\u5b66\u9867\u554f\u3068\u3057\u3066\u5354\u529b\u3057\u3066\u304d\u305f\u3002\u3053\u308c\u304c\u5e78\u904b\u3092\u62db\u304d\u30012020\u5e74\u3088\u308a\u30eb\u30ab\u30b5\u30a4\u30a8\u30f3\u30b9\u793e\u304c\u85ac\u5b66\u7814\u7a76\u9662\u306b\u7523\u696d\u5275\u51fa\u5206\u91ce\u3068\u3057\u3066\u300c\u30d0\u30a4\u30aaDDS\u5b9f\u7528\u5316\u5206\u91ce\u300d\u3092\u8a2d\u7f6e\u3059\u308b\u3053\u3068\u3068\u306a\u308a\u3001\u5c71\u7530\u52c7\u78e8\u51c6\u6559\u6388\uff08\u73fe\u3001\u6559\u6388\uff09\u304c\u7814\u7a76\u4ee3\u8868\u8005\u3068\u3057\u3066\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u9001\u9054\u30fb\u6cbb\u7642\u306e\u5b9f\u7528\u5316\u3092\u52a0\u901f\u3057\u305f\u3002\u30eb\u30ab\u30b5\u30a4\u30a8\u30f3\u30b9\u793e\u306f\u83c5\u6cbc\u6c0f\u3092\u4e2d\u5fc3\u306b\u30d7\u30ed\u96c6\u56e3\u3092\u5f62\u6210\u3057\u3001\u30d9\u30f3\u30c1\u30e3\u30fc\u30ad\u30e3\u30d4\u30bf\u30eb\u304b\u3089\u30b7\u30ea\u30fc\u30baA\uff0810.3\u5104\u5186\uff09\u3001\u30b7\u30ea\u30fc\u30baB\uff0838.6\u5104\u5186\uff09\u3092\u7372\u5f97\u3059\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u305f\u30022024\u5e74\u5ea6\u304b\u3089\u306f\u3001\u65b0\u305f\u306b\u300c\u7d30\u80de\u30fb\u30aa\u30eb\u30ac\u30cd\u30e9\u88fd\u5264\u5b66\u5206\u91ce\u300d\u304c\u5275\u8a2d\u3055\u308c\u3001\u539f\u5cf6\u79c0\u5409\u5353\u8d8a\u6559\u6388\u304c\u7814\u7a76\u4ee3\u8868\u8005\u3092\u517c\u52d9\u3057\u3066\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u9001\u9054\u30fb\u6cbb\u7642\u306e\u5b9f\u7528\u5316\u3092\u7d99\u7d9a\u3057\u3066\u3044\u308b\u3002<\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<h4>\uff11\uff0e\u72ec\u81ea\u306e\u30a4\u30aa\u30f3\u5316\u8102\u8cea\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\u3092\u57fa\u76e4\u3068\u3057\u305f\u9ad8\u5206\u5b50\u9001\u9054<\/h4>\n<p id=\"001\">\u30102019\u5e74\u5ea6\uff5e2023\u5e74\u5ea6\u306e\u6210\u679c\u3011<\/p>\n<p>\u4f50\u85e4\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001siRNA\u3001mRNA\u7b49\u306e\u6838\u9178\u3084\u30b2\u30ce\u30e0\u7de8\u96c6\u56e0\u5b50\u306e\u9001\u9054\u52b9\u7387\u304a\u3088\u3073\u6a19\u7684\u591a\u69d8\u6027\u3092\u6700\u5927\u5316\u3055\u305b\u308b\u305f\u3081\u306e\u30a4\u30aa\u30f3\u5316\u8102\u8cea\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\u306e\u958b\u767a\u3068\u672c\u6280\u8853\u3092\u57fa\u76e4\u3068\u3057\u305f\u88fd\u5264\u958b\u767a\u3092\u9032\u3081\u305f\u3002<\/p>\n<p>\u65e2\u306b\u7269\u8cea\u7279\u8a31\u3068\u3057\u3066\u51fa\u9858\u6e08\u307f\u3067\u3042\u3063\u305f\u30a4\u30aa\u30f3\u5316\u8102\u8ceaYSK12\u3092\u57fa\u76e4\u3068\u3057\u3066\u89aa\u6c34\u6027\u982d\u90e8\u304a\u3088\u3073\u758e\u6c34\u6027\u8db3\u5834\u69cb\u9020\u306e\u7d44\u307f\u5408\u308f\u305b\u306b\u3088\u308a\u591a\u69d8\u306a\u5316\u5b66\u69cb\u9020\u3092\u6709\u3059\u308b\u4f53\u7cfb\u7684\u306a\u30a4\u30aa\u30f3\u5316\u8102\u8cea\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\u3092\u69cb\u7bc9\u3057\u305f\u3002\u305d\u306e\u4e2d\u306eCL4H6\u306f\u521d\u3081\u306b\u305d\u306e\u512a\u308c\u305f\u6027\u80fd\u304c\u898b\u3044\u3060\u3055\u308c\u305f\u30a4\u30aa\u30f3\u5316\u8102\u8cea\u3067\u3042\u308a\u3001\u4e16\u754c\u30c8\u30c3\u30d7\u30af\u30e9\u30b9\u306e\u52b9\u7387\u3067\u809d\u81d3\u3078siRNA\u3092\u5c0e\u5165\u3067\u304d\u308b\u3068\u3068\u3082\u306b\u512a\u308c\u305f\u751f\u5206\u89e3\u6027\u306b\u3088\u308b\u9ad8\u3044\u5b89\u5168\u6027\u304c\u793a\u3055\u308c\u305f\uff08Sato Y et al., <em>J Control Release<\/em> 295: 140-152, 2019\uff09\u3002CL4H6\u306f\u809d\u3078\u306emRNA\uff08Hashiba A et al., <em>J Control Release<\/em> 327: 467-476, 2020\uff09\u304a\u3088\u3073\u30b2\u30ce\u30e0\u7de8\u96c6\u56e0\u5b50CRISPR\/Cas9 ribonucleoprotein\uff08RNP\uff09\u9001\u9054\uff08Onuma H et al., <em>J Control Release<\/em> 255: 406-416, 2023\uff09\u3078\u306e\u5fdc\u7528\u306b\u6210\u529f\u3059\u308b\u3068\u3068\u3082\u306b\u3001\u88fd\u5264\u51e6\u65b9\u306e\u6700\u9069\u5316\u306b\u3088\u308a\u816b\u760d\u95a2\u9023\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3078\u306esiRNA\u9001\u9054\u306b\u3088\u308b\u7d30\u80de\u6975\u6027\u5909\u5316\u8a98\u5c0e\u3068\u304c\u3093\u6cbb\u7642\u3078\u306e\u5fdc\u7528\uff08Shobaki N et al., <em>J Control Release<\/em> 325: 235-248, 2020\uff09\u3084\u813e\u81d3\u6a39\u72b6\u7d30\u80de\u3078\u306emRNA\u9001\u9054\u306b\u3088\u308bmRNA\u304c\u3093\u30ef\u30af\u30c1\u30f3\u3078\u306e\u5fdc\u7528\uff08Okuda K et al., <em>J Control Release<\/em> 348: 648-659, 2022\uff09\u3001\u3055\u3089\u306b\u306f\u8840\u5c0f\u677f\u3078\u306emRNA\u9001\u9054\uff08Leung J et al., <em>Sci Adv<\/em> 9: eadi0508, 2023\uff09\u7b49\u3001\u591a\u5c90\u306b\u4e98\u308b\u6210\u679c\u3092\u3082\u305f\u3089\u3057\u305f\u3002JSR\u682a\u5f0f\u4f1a\u793e\u3068\u9023\u643a\u3059\u308b\u3053\u3068\u3067CL4H6\u306e\u88fd\u9020\u6280\u8853\u306e\u958b\u767a\u306b\u6210\u529f\u3057\u3001\u540c\u793e\u3088\u308a\u8a66\u9a13\u7814\u7a76\u7528\u306b\u88fd\u9020\u8ca9\u58f2\u3055\u308c\u3066\u3044\u308b\u3002\u307e\u305f\u3001\u9178\u4e56\u96e2\u5b9a\u6570\u304c\u6bd4\u8f03\u7684\u9ad8\u3044\u30a4\u30aa\u30f3\u5316\u8102\u8ceaCL15A6\u3084CL15H6\u306f\u809d\u7dda\u7dad\u75c7\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b\u6d3b\u6027\u5316\u809d\u661f\u7d30\u80de\u3078\u306e\u512a\u308c\u305fsiRNA\u304a\u3088\u3073mRNA\u5c0e\u5165\u3092\u5b9f\u73fe\u3057\u3001\u96e3\u6cbb\u6027\u306e\u809d\u7dda\u7dad\u6027\u75be\u60a3\u6cbb\u7642\u3078\u306e\u53ef\u80fd\u6027\u3092\u958b\u3044\u305f\uff08Younis MA et al., <em>J Control Release<\/em> 353: 685-698, 2023, Younis MA et al., <em>J Control Release<\/em> 361: 592-603, 2023\uff09\u3002\u3055\u3089\u306b\u3001\u5f8c\u8ff0\u306e\u4e2d\u6751\u30b0\u30eb\u30fc\u30d7\u3068\u306e\u9023\u643a\u306b\u3088\u308a\u3001\u9178\u4e56\u96e2\u5b9a\u6570\u304c\u6700\u3082\u9ad8\u3044\u30a4\u30aa\u30f3\u5316\u8102\u8ceaCL1H6\u306f\u30d2\u30c8NK\u7d30\u80de\u306b\u5bfe\u3059\u308b\u4e16\u754c\u30c8\u30c3\u30d7\u30af\u30e9\u30b9\u306e\u52b9\u7387\u306esiRNA\u304a\u3088\u3073mRNA\u5c0e\u5165\u3092\u5b9f\u73fe\u3057\u305f\u3002\u3053\u306e\u3088\u3046\u306b\u3001\u7279\u6027\u306e\u7570\u306a\u308b\u8102\u8cea\u306e\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\u5316\u306b\u3088\u308a\u591a\u69d8\u306a\u7528\u9014\u306b\u305d\u308c\u305e\u308c\u6700\u9069\u306a\u8102\u8cea\u306e\u63d0\u4f9b\u304c\u53ef\u80fd\u3068\u306a\u3063\u305f\u3002\u307e\u305f\u3001\u672c\u8102\u8cea\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\u3092\u57fa\u76e4\u3068\u3057\u3066\u8a73\u7d30\u306a\u69cb\u9020-\u7269\u6027-\u6d3b\u6027\u76f8\u95a2\u7814\u7a76\u3082\u9032\u3081\u3001\u758e\u6c34\u6027\u8db3\u5834\u69cb\u9020\u306e\u5206\u5c90\u69cb\u9020\u304cLNP\u69cb\u9020\u5b89\u5b9a\u6027\u3084\u819c\u878d\u5408\u6d3b\u6027\u3092\u6700\u5927\u5316\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\uff08Hashiba H et al., <em>Small Sci<\/em> 3: 2200071, 2023\uff09\u3084RNP\u9001\u9054\u3078\u306e\u5fdc\u7528\u306b\u3088\u308b\u809d\u81d3\u3067\u306e98%\u3092\u8d85\u3048\u308b\u975e\u5e38\u306b\u512a\u308c\u305f\u907a\u4f1d\u5b50\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u306e\u5b9f\u73fe\uff08Onuma H et al., <em>iScience<\/em> 27: 110928, 2024\uff09\u3001\u5206\u5c90\u8db3\u5834\u9396\u9577\u306b\u3088\u308b\u81d3\u5668\u9078\u629e\u7684mRNA\u9001\u9054\uff08Hashiba H et al., <em>Nano Lett<\/em> 24: 12758-12767, 2024\uff09\u306b\u52a0\u3048\u3001\u89aa\u6c34\u6027\u982d\u90e8\u69cb\u9020\u6539\u5909\u306b\u3088\u308bmRNA-LNP\u88fd\u5264\u306e\u71b1\u5b89\u5b9a\u6027\u306e\u5927\u5e45\u306a\u5411\u4e0a\u6280\u8853\u306e\u63d0\u6848\uff08Hashiba H et al., <em>Commun Biol<\/em> 7: 556, 2024\uff09\u7b49\u306b\u6210\u529f\u3057\u3066\u3044\u308b\u3002<\/p>\n<p>\u3053\u308c\u3089\u306e\u6210\u679c\u306b\u3088\u308a2023\u5e74\u306eField-Weighted Citation Impact\uff08FWCI\uff09\u306f3.98\u306b\u9054\u3057\u300110% Top Citation Percentile\u306f56.6%\uff0830\u5831\uff09\u3092\u8a18\u9332\u3057\uff08Elseveir\u793eSciVal\u3088\u308a\uff09\u3001\u5f53\u8a72\u5206\u91ce\u306b\u304a\u3044\u3066\u9ad8\u3044\u8a55\u4fa1\u3092\u53d7\u3051\u3066\u3044\u308b\u3002\u307e\u305f\u300120\u3092\u8d85\u3048\u308b\u7279\u8a31\u3092\u51fa\u9858\u3057\u30013\u4ef6\u306e\u5927\u578b\u7814\u7a76\u3092\u542b\u308130\u793e\u4ee5\u4e0a\u306e\u56fd\u5185\u5916\u4f01\u696d\u3068\u9023\u643a\u3057\u3066\u5275\u85ac\u3092\u76ee\u6307\u3057\u305f\u7523\u5b66\u9023\u643a\u3092\u63a8\u9032\u3057\u3066\u3044\u308b\u3002\u307e\u305f\u3001\u30a2\u30ab\u30c7\u30df\u30a2\u9593\u9023\u643a\u306b\u3088\u308aAMED\u4e8b\u696d\u306b\u304a\u3044\u3066\u96e3\u6cbb\u6027\u75be\u60a3\u6cbb\u7642\u3078\u306e\u5fdc\u7528\u3092\u7cbe\u529b\u7684\u306b\u9032\u3081\u3001\u6280\u8853\u306e\u793e\u4f1a\u5b9f\u88c5\u3092\u76ee\u6307\u3057\u3066\u3044\u308b\u3002\u73fe\u5728\u306f\u30ca\u30ce\u7c92\u5b50-\u751f\u4f53\u9593\u76f8\u4e92\u4f5c\u7528\u306b\u7740\u773c\u3057\u305f\u809d\u81d3\u5916\u7d44\u7e54\u3078\u306e\u85ac\u7269\u9001\u9054\u6280\u8853\u306e\u958b\u767a\u3092\u4e2d\u5fc3\u306b\u7814\u7a76\u3092\u63a8\u9032\u3057\u3066\u3044\u308b\u3002<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-692\" src=\"https:\/\/www.pharm.hokudai.ac.jp\/nano\/wp-content\/uploads\/2024\/11\/9d74378f7c0682c78e595226711e757a.png\" alt=\"\" width=\"858\" height=\"513\" \/><\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<h4>\uff12\uff0e\u30ca\u30ceDDS\u3092\u57fa\u76e4\u3068\u3057\u305f\u304c\u3093\u514d\u75ab\u6cbb\u7642: \u30ca\u30ce\u304c\u3093\u514d\u75ab\u6cbb\u7642<\/h4>\n<p id=\"001\">\u30102019\u5e74\u5ea6\uff5e2023\u5e74\u5ea6\u306e\u6210\u679c\u3011<\/p>\n<p>\u4e2d\u6751\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001\u304c\u3093\u514d\u75ab\u5fdc\u7b54\u3092\u6700\u5927\u5316\u3059\u308b\u305f\u3081\u306e\u30ca\u30ceDDS\u958b\u767a\u3068\u65b0\u3057\u3044\u30ca\u30ce\u304c\u3093\u514d\u75ab\u7642\u6cd5\u306b\u8ca2\u732e\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u3092\u9032\u3081\u305f\u3002<\/p>\n<p>\u307e\u305a\u3001\u6211\u3005\u306f\u30de\u30a4\u30af\u30ed\u6d41\u8def\u30c7\u30d0\u30a4\u30b9\u3092\u7528\u3044\u3066\u7c92\u5b50\u30b5\u30a4\u30ba\u3068\u96fb\u8377\u304c\u7570\u306a\u308bLNP\u3092\u8abf\u88fd\u3057\u3001\u514d\u75ab\u7d30\u80de\u306e\u6d3b\u6027\u5316\u306e\u5834\u3067\u3042\u308b\u30ea\u30f3\u30d1\u7bc0\u9001\u9054\u306b\u9069\u3057\u305fLNP\u7279\u6027\u3092\u4e16\u754c\u306b\u5148\u99c6\u3051\u3066\u5831\u544a\u3057\u305f\uff08Nakamura T*, et al., <em>Mol Pharm<\/em> 17: 944-953, 2020\uff09\u3002\u3053\u306e\u6210\u679c\u306f\u3001\u85ac\u5264\u5b66\u9818\u57df\u306eTop1%\u5f15\u7528\u8ad6\u6587\u3068\u3057\u3066\u9ad8\u304f\u8a55\u4fa1\u3055\u308c\u3066\u3044\u308b\u3002\u307e\u305f\u3001\u4e2d\u6751\u306fDDS\u5206\u91ce\u3067\u6a29\u5a01\u3042\u308b\u7dcf\u8aac\u96d1\u8a8c<em>Advanced Drug Delivery Reviews<\/em>\u306eguest editor\u306b\u9078\u51fa\u3055\u308c\u3001\u30ea\u30f3\u30d1\u7bc0\u9001\u9054\u306e\u7279\u96c6\u8a18\u4e8b\u3092\u7de8\u96c6\u3057\u305f\uff08Nakamura T*, et al., <em>Adv Drug Deliv Rev<\/em> 167: 78-88, 2020 Top10%\u5f15\u7528\u8ad6\u6587\uff09\u3002\u4e26\u884c\u3057\u3066\u3001\u816b\u760d\u5185\u306e\u514d\u75ab\u72b6\u614b\u3092\u7c21\u4fbf\u306b\u628a\u63e1\u3057\u3001\u30ca\u30ceDDS\u8a2d\u8a08\u3078\u3068\u9084\u5143\u3059\u308b\u305f\u3081\u306e\u72ec\u81ea\u306e\u907a\u4f1d\u5b50\u30d1\u30cd\u30eb\u3092\u958b\u767a\u3059\u308b\u3053\u3068\u3067\u30ca\u30ce\u304c\u3093\u514d\u75ab\u7642\u6cd5\u306e\u958b\u767a\u3092\u52a0\u901f\u3055\u305b\u305f\uff08Nakamura T*, et al., <em>J Control Release<\/em> 345: 200-213, 2022 Top10%\u5f15\u7528\u8ad6\u6587\uff09\u3002<\/p>\n<p>\u514d\u75ab\u4e0d\u5fdc\u7b54\u306b\u3088\u308b\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\u8010\u6027\u304c\u3093\u306b\u5bfe\u3057\u3001\u6211\u3005\u304c\u958b\u767a\u3057\u305fstimulator of interferon genes\uff08STING\uff09\u7d4c\u8def\u3092\u6d3b\u6027\u5316\u3059\u308b\u30a2\u30b8\u30e5\u30d0\u30f3\u30c8\u642d\u8f09\u3057\u305fLNP\uff08STING-LNP\uff09\u3092\u4f75\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u76f8\u4e57\u7684\u306b\u6297\u816b\u760d\u6d3b\u6027\u304c\u5897\u52a0\u3057\u3001\u8010\u6027\u304c\u3093\u306b\u5bfe\u3059\u308b\u6709\u52b9\u6027\u304c\u8a8d\u3081\u3089\u308c\u305f\u3002\u3055\u3089\u306b\u3001STING\u7d4c\u8def\u3092\u4ecb\u3057\u305fnatural killer\uff08NK\uff09\u7d30\u80de\u306e\u6d3b\u6027\u5316\u304c\u816b\u760d\u5185\u306e\u514d\u75ab\u72b6\u614b\u3092\u6539\u5584\u3057\u3001\u8010\u6027\u3092\u514b\u670d\u3059\u308b\u3068\u3044\u3046\u30e1\u30ab\u30cb\u30ba\u30e0\u3082\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u305f\uff08Nakamura T*, et al., <em>J Immunother Cancer<\/em> 9: 2002852, 2021\uff09\u3002\u672c\u8ad6\u6587\u306f\u3001\u816b\u760d\u5b66\u9818\u57df\u306eTop1%\u8ad6\u6587\u3068\u3057\u3066\u9ad8\u304f\u8a55\u4fa1\u3055\u308c\u3066\u3044\u308b\u3002\u307e\u305f\u3001\u56fd\u5185\u88fd\u85ac\u4f01\u696d\u3068\u5171\u540c\u7814\u7a76\u3078\u3068\u767a\u5c55\u3057\u3001STING-LNP\u306e\u7279\u6027\u304c\u3069\u306e\u3088\u3046\u306b\u304c\u3093\u514d\u75ab\u5fdc\u7b54\u306b\u5f71\u97ff\u3092\u8abf\u3079\u308b\u5b9f\u7528\u5316\u7814\u7a76\u3092\u9032\u3081\u305f\uff08\u6210\u679c: Endo R, et al., <em>J Control Release<\/em> 372: 609-618, 2024\uff09\u3002\u3055\u3089\u306b\u3001\u975e\u5e38\u306b\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001STING-LNP\u3068\u816b\u760d\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u30ce\u30c3\u30af\u30c0\u30a6\u30f3\u3092\u4f75\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u6025\u901f\u306a\u816b\u760d\u8840\u7ba1\u7834\u58ca\u3092\u8a98\u5c0e\u3057\u3001\u975e\u5e38\u306b\u5f37\u529b\u306a\u6297\u816b\u760d\u6d3b\u6027\u3092\u793a\u3059\u3053\u3068\u3092\u767a\u898b\u3057\u305f\u3002\u65b0\u898f\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3088\u308b\u816b\u760d\u8840\u7ba1\u7834\u58ca\u3067\u3042\u308a\u3001\u30d2\u30c8\u816b\u760d\u306b\u5bfe\u3057\u3066\u3082\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u304b\u3089\u3001\u5275\u85ac\u30b7\u30fc\u30ba\u5316\u3092\u76ee\u6307\u3057\u305f\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u308b\u3002<\/p>\n<p>\u4e0a\u8ff0\u306e\u6210\u679c\u3088\u308a\u3001\u304c\u3093\u514d\u75ab\u7642\u6cd5\u306b\u304a\u3051\u308bNK\u7d30\u80de\u306e\u6709\u7528\u6027\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3053\u3068\u304b\u3089NK\u7d30\u80de\u3092\u76f4\u63a5\u907a\u4f1d\u5b50\u30ec\u30d9\u30eb\u3067\u6a5f\u80fd\u6539\u5909\u3059\u308b\u305f\u3081\u306eLNP\u306e\u958b\u767a\u3092\u9032\u3081\u3001\u30d2\u30c8NK\u7d30\u80de\u306b\u5bfe\u3057\u3066\u4e16\u754c\u30c8\u30c3\u30d7\u30af\u30e9\u30b9\u306e\u52b9\u7387\u3067siRNA\u3084mRNA\u3092\u5c0e\u5165\u3059\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u305f\uff08Nakamura T*, et al., <em>Int J Pharm<\/em> 609: 121140, 2021; Nakamura T*, et al., <em>Int J Pharm<\/em> 636: 122810, 2023\uff09\u3002\u3053\u306e\u6210\u679c\u3092\u3082\u3068\u306b\u3001\u6d77\u5916\u30d9\u30f3\u30c1\u30e3\u30fc\u4f01\u696d\u3068\u30d2\u30c8NK\u7d30\u80de\u3078\u306emRNA\u9001\u9054\u306b\u95a2\u3059\u308b\u5b9f\u7528\u5316\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u308b\u3002<\/p>\n<p>\u672c\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306e5\u5e74\u9593\u306e\u7279\u7b46\u3059\u3079\u304d\u6210\u679c\u3068\u3057\u3066\u3001Top1%\u5f15\u7528\u8ad6\u6587\u30923\u5831\uff08\u539f\u84572\u5831\u3001\u7dcf\u8aac1\u5831\uff09\u767a\u8868\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u305f\u3002\u307e\u305f\u5927\u578b\u4e88\u7b97\u306e\u7372\u5f97\u3078\u3082\u7e4b\u304c\u308a\u3001AMED\u5275\u85ac\u57fa\u76e4\u63a8\u9032\u7814\u7a76\u4e8b\u696d\uff08\u4ee3\u8868: \u4e2d\u6751\uff09\u306b\u63a1\u629e\u3055\u308c\u3001\u30b5\u30d6\u30bb\u30c3\u30c8\u30ec\u30d9\u30eb\u3067\u7d30\u80de\u3092\u8b58\u5225\u53ef\u80fd\u306a\u4e16\u754c\u521d\u306eactive targeting\u6280\u8853\u306e\u958b\u767a\u306b\u6210\u529f\u3057\u3066\u3044\u308b\uff08PCT\/JP2024\/036074\uff09\u3002\u3055\u3089\u306b\u3001\u79d1\u7814\u8cbb\u57fa\u76e4\u7814\u7a76\uff08A\uff09\u306e\u63a1\u629e\uff08\u4ee3\u8868: \u4e2d\u6751\uff09\u306b\u3082\u7e4b\u304c\u308a\u3001NK\u7d30\u80de\u3092\u6a19\u7684\u3068\u3057\u305f\u65b0\u3057\u3044\u30ca\u30ce\u304c\u3093\u514d\u75ab\u7642\u6cd5\u306e\u958b\u767a\u306b\u6311\u3093\u3067\u3044\u308b\u3002\u4eba\u6750\u80b2\u6210\u306e\u89b3\u70b9\u304b\u3089\u3082\u6210\u679c\u304c\u3042\u308a\u3001\u30ca\u30ce\u304c\u3093\u514d\u75ab\u7642\u6cd5\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u3092\u7387\u3044\u3066\u3044\u305f\u4e2d\u6751\u306f2024\u5e7410\u6708\u3088\u308a\u3001\u91d1\u6ca2\u5927\u5b66\u533b\u85ac\u4fdd\u5065\u7814\u7a76\u57df\u85ac\u5b66\u7cfb\u306e\u6559\u6388\u306e\u30dd\u30b8\u30b7\u30e7\u30f3\u3092\u5f97\u305f\u3002<\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-687\" src=\"https:\/\/www.pharm.hokudai.ac.jp\/nano\/wp-content\/uploads\/2024\/11\/30ed1005cb5b461fba9aa38729305853.png\" alt=\"\" width=\"853\" height=\"480\" \/><\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<h4>\uff13\uff0e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a19\u7684\u578bDDS\u3092\u57fa\u76e4\u3068\u3059\u308b\u30aa\u30eb\u30ac\u30cd\u30e9\u6cbb\u7642<\/h4>\n<p>\u30102019\u5e74\u5ea6\uff5e2023\u5e74\u5ea6\u306e\u6210\u679c\u3011<\/p>\n<p>\u5c71\u7530\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001\u591a\u5f69\u306a\u6a5f\u80fd\u3092\u6709\u3059\u308b\u30aa\u30eb\u30ac\u30cd\u30e9\u3067\u3042\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u6a19\u7684\u3068\u3057\u305fDDS (MITO-Porter)\u3092\u57fa\u76e4\u3068\u3059\u308b\u30aa\u30eb\u30ac\u30cd\u30e9\u6cbb\u7642\u306b\u53d6\u308a\u7d44\u3093\u3060\u3002\u30aa\u30eb\u30ac\u30cd\u30e9\u6a19\u7684\u578bDDS\u306e\u793e\u4f1a\u5b9f\u88c5\u3092\u7814\u7a76\u306e\u6700\u7d42\u30b4\u30fc\u30eb\u306b\u636e\u3048\u3001\u81e8\u5e8a\u533b\u30fb\u57fa\u790e\u7814\u7a76\u8005\u3068\u9023\u643a\u3057\u3001Proof of concept (POC)\u53d6\u5f97\u306b\u95a2\u3059\u308b\u81ea\u4e3b\u81e8\u5e8a\u7814\u7a76\u30fb\u5fdc\u7528\u7814\u7a76\u3092\u63a8\u9032\u3057\u3066\u304d\u305f\u3002\u671f\u9593\u4e2d\u3001\u7279\u306b\u7cbe\u529b\u7684\u306b\u53d6\u308a\u7d44\u3093\u3067\u304d\u305f\u764c\u6cbb\u7642\u3001\u7d30\u80de\u6cbb\u7642\u306b\u95a2\u3059\u308b\u7814\u7a76\u6210\u679c\u3092\u8a18\u8f09\u3059\u308b\u3002<\/p>\n<p><em>\u764c\u6cbb\u7642: <\/em>\u764c\u7d30\u80de\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u5de5\u5834\u3067\u3042\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u7834\u58ca\u3059\u308b\u6cbb\u7642\u62b5\u6297\u6027\u764c\u306b\u5bfe\u3059\u308b\u65b0\u305f\u306a\u6cbb\u7642\u6226\u7565\u306e\u691c\u8a3c\u3092\u9032\u3081\u305f\u3002\u85ac\u5264\u6027\u8010\u6027\u764c\u7d30\u80de\u3067\u3042\u308bOSRC2\u7d30\u80de\u3092\u7528\u3044\u305f\u691c\u8a0e\u3092\u884c\u3044\u3001\u6297\u764c\u5264\u642d\u8f09MITO-Porter\u3092\u6295\u4e0e\u3057\u305f\u969b\u306b\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3001\u6bba\u7d30\u80de\u52b9\u679c\u3001\u62c5\u764c\u30e2\u30c7\u30eb\u52d5\u7269\u3092\u7528\u3044\u305f\u6297\u816b\u760d\u52b9\u679c\u3082\u89b3\u5bdf\u3057\u3066\u304a\u308a\u3001\u672c\u6226\u7565\u304c\u6cbb\u7642\u62b5\u6297\u6027\u764c\u306b\u5bfe\u3059\u308b\u6709\u52b9\u306a\u6cbb\u7642\u6cd5\u306b\u306a\u308a\u5f97\u308b\u4e8b\u3092\u793a\u3057\u3066\u3044\u308b\u3002\u672c\u7814\u7a76\u306b\u5bfe\u3057\u30662022\u5e74\u306b\u7c73\u56fd\u85ac\u5264\u5e2b\u4f1a\u3088\u308aEbert Prize Award \uff08\u7c73\u56fd\u3067\u73fe\u5b58\u3059\u308b\u6700\u53e4\u306e\u85ac\u5b66\u8cde\uff09\u304c\u6388\u4e0e\u3055\u308c\u3001\u56fd\u969b\u7684\u306b\u3082\u9ad8\u3044\u8a55\u4fa1\u3092\u53d7\u3051\u305f\u3002\u764c\u7d30\u80de\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u6a19\u7684\u3068\u3057\u305f\u300c\u5149\u6cbb\u7642\u300d\u306e\u691c\u8a3c\u3082\u884c\u3063\u305f\u3002\u764c\u7d30\u80de (<em>in vitro<\/em>)\u3092\u7528\u3044\u305f\u5149\u6cbb\u7642\u306e\u5b9f\u7e3e\u3092\u6709\u3057\u3066\u304a\u308a (\u65e2\u5b58\u85ac\u306e1\/10\u306e\u6295\u4e0e\u91cf\u3067\u6709\u610f\u306a\u6cbb\u7642\u52b9\u679c)\u3001\u62c5\u764c\u30e2\u30c7\u30eb\u52d5\u7269\u3092\u7528\u3044\u305f\u764c\u5149\u6cbb\u7642\u306e\u691c\u8a3c (<em>in vivo<\/em>)\u306b\u304a\u3044\u3066\u3082\u826f\u597d\u306a\u6210\u679c\u3092\u5f97\u3066\u3044\u308b\uff08Satrialdi et al., <em>Chem. Commun.<\/em> 2020\/ Top10%\uff09\u3002\u5317\u6d77\u9053\u5927\u5b66\u75c5\u9662\u30fb\u81e8\u5e8a\u7814\u7a76\u958b\u767a\u30bb\u30f3\u30bf\u30fc\u306e\u5354\u529b\u306e\u57fa\u3001GMP\u88fd\u5264\u306e\u6e96\u5099\u30fbCRO\u3092\u6d3b\u7528\u3057\u305f\u975e\u81e8\u5e8a\u7814\u7a76\u306e\u8a08\u753b\u3092\u7acb\u6848\u4e2d\u3067\u3042\u308b\u3002\u3053\u308c\u3089\u306e\u7814\u7a76\u3092\u63a8\u9032\u3059\u308b\u305f\u3081\u306e\u7814\u7a76\u8cc7\u91d1\u8abf\u9054\u306e\u305f\u3081\u3001\u793e\u4f1a\u3078\u306e\u60c5\u5831\u767a\u4fe1\u3082\u517c\u306d\u308b\u30af\u30e9\u30a6\u30c9\u30d5\u30a1\u30f3\u30c7\u30a3\u30f3\u30b0\u6d3b\u52d5 \uff082020\u5e74\uff09\u306b\u53c2\u753b\u3057\u305f (\u5317\u6d77\u9053\u5927\u5b662\u4f8b\u76ee)\u3002\u300c\u7814\u7a76\u6d3b\u52d5\u300d\u3068\u306f\u5168\u304f\u7570\u306a\u308b\u6311\u6226\u306b\u5927\u3044\u306b\u82e6\u6226\u3057\u305f\u304c\u3001\u5f53\u521d\u76ee\u6a19\u984d\u3092\u5927\u5e45\u306b\u4e0a\u56de\u308b10,119,000\u5186\u306e\u3054\u652f\u63f4\u3092\u9802\u3044\u305f\u3002\u300c\u8cc7\u91d1\u8abf\u9054\u300d\u4ee5\u5916\u306b\u3082\u3001\u60a3\u8005\u30fb\u5bb6\u65cf\u3068\u306e\u4ea4\u6d41\u3001\u5b66\u751f\u30fb\u5e02\u6c11\u3078\u306e\u60c5\u5831\u767a\u4fe1\u304c\u5b9f\u73fe\u3067\u304d\u305f \uff08\u30a2\u30a6\u30c8\u30ea\u30fc\u30c1\u6d3b\u52d5\uff09\u3002\u672c\u7814\u7a76\u306b\u5bfe\u3057\u30662023\u5e74\u306b\u65ed\u5316\u6210\u5275\u5264\u958b\u767a\u6280\u8853\u8cde\u304c\u6388\u4e0e\u3055\u308c\u3001\u88fd\u5264\u30fb\u5275\u5264\u958b\u767a\u306e\u89b3\u70b9\u3067\u9ad8\u3044\u8a55\u4fa1\u3092\u53d7\u3051\u305f\u3002<\/p>\n<p><em>\u7d30\u80de\u6cbb\u7642: <\/em>\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u767a\u751f\u6e90\u3067\u3042\u308a\u3001\u7d30\u80de\u5185ATP\u7523\u751f\u3092\u62c5\u3046\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u6d3b\u6027\u5316\u3057\u305f\u5fc3\u7b4b\u524d\u99c6\u7d30\u80de (Cardiac progenitor cell (CPC)) (MITO cell)\u3092\u79fb\u690d\u306b\u7528\u3044\u308b\u4e8b\u3067\u3001\u8352\u5ec3\u3057\u305f\u5fc3\u4e0d\u5168\u74b0\u5883\u306b\u304a\u3044\u3066\u3082\u6709\u52b9\u306a\u5fc3\u7b4b\u5e79\u7d30\u80de\u79fb\u690d\u304c\u53ef\u80fd\u306b\u306a\u308b\u3068\u8003\u3048\u305f\u3002\u30de\u30a6\u30b9\u7531\u6765CPC\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306b\u6d3b\u6027\u5316\u5206\u5b50\u3092\u9001\u9054\u3057\u305f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6d3b\u6027\u5316CPC \uff08MITO-CPC\uff09\u306e\u69cb\u7bc9\u3057\u3001\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3\u5fc3\u7b4b\u75c7\u304a\u3088\u3073\u5fc3\u7b4b\u865a\u8840\u518d\u704c\u6d41\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u3092\u4f5c\u6210\u3057\u3001MITO cell\u3092\u7528\u3044\u305f\u7d30\u80de\u79fb\u690d\u306e\u6cbb\u7642\u52b9\u679c\u3092\u8a55\u4fa1\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u751f\u5b58\u7387\u3001\u5fc3\u6a5f\u80fd (\u5fc3\u30a8\u30b3\u30fc\u6cd5)\u3068\u3082\u306bMITO cell\u79fb\u690d\u7fa4\u306f\u5f93\u6765\u306e\u7d30\u80de\u79fb\u690d\u6cd5\u3068\u6bd4\u8f03\u3057\u3066\u6709\u52b9\u306a\u6cbb\u7642\u52b9\u679c\u3092\u8a8d\u3081\u305f \uff08Sasaki D et al., <em>Sci Rep.<\/em> 2022\/ Top10%)\u3002\u3053\u308c\u3089\u306e\u7814\u7a76\u6210\u679c\u306f\u3001\u5fc3\u75be\u60a3\u306e\u8a3a\u65ad\u30fb\u6cbb\u7642\u306e\u7d4c\u9a13\u304c\u8c4a\u5bcc\u306a\u5317\u6d77\u9053\u5927\u5b66\u75c5\u9662\u30fb\u5c0f\u5150\u5faa\u74b0\u5668\u73ed\u30fb\u533b\u5e2b\u3089\u3068\u9032\u3081\u305f\u5b9f\u7e3e\u3067\u3042\u308b\u3002MITO cell\u3092\u7528\u3044\u305f\u7d30\u80de\u6cbb\u7642\u306e\u81e8\u5e8a\u5fdc\u7528\u306b\u5411\u3051\u3001\u30d2\u30c8\u306e\u5fc3\u81d3\u304b\u3089\u5358\u96e2\u3057\u305f\u7d30\u80de\u3092\u7528\u3044\u3066\u3001\u30d2\u30c8\u7531\u6765\u306eMITO cell \uff08human MITO cell\uff09\u3092\u4f5c\u6210\u3057\u3001\u7d30\u80de\u79fb\u690d\u6cbb\u7642\u3092\u884c\u3046\u81ea\u4e3b\u81e8\u5e8a\u7814\u7a76\u3092\u5b9f\u65bd\u3057\u305f \uff08\u81e8\u5e8a\u7814\u7a76\u756a\u53f7016-0507\u3001\u5317\u6d77\u9053\u5927\u5b66\u75c5\u9662\uff09\u3002human MITO cell\u3092\u865a\u8840\u518d\u704c\u6d41\u30e2\u30c7\u30eb\u30e9\u30c3\u30c8\u306b\u6295\u4e0e\u3057\u3001\u5fc3\u6a5f\u80fd\u3001\u5fc3\u7b4b\u7dda\u7dad\u5316\u306e\u8a55\u4fa1\u304a\u3088\u3073\u5fc3\u7b4b\u30e1\u30bf\u30dc\u30ed\u30fc\u30e0\u89e3\u6790\u3092\u884c\u3044\u3001human MITO cell\u306e\u79fb\u690d\u306f\u65e2\u5b58\u306e\u7d30\u80de\u79fb\u690d\u3068\u6bd4\u8f03\u3057\u6cbb\u7642\u52b9\u679c\u304c\u5897\u5f37\u3055\u308c\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f \uff08Shiraishi M et al., <em>J. Control. Release<\/em> 2024\/ Top10%)\u3002\u672c\u7814\u7a76\u306f\u30012024\u5e74\u5ea6\u5317\u6d77\u9053\u5927\u5b66\u62e0\u70b9\/\u6a4b\u6e21\u3057\u7814\u7a76\u30d7\u30ed\u30b0\u30e9\u30e0\/\u30b7\u30fc\u30baA (AMED)\u306b\u63a1\u629e\u3055\u308c\u3066\u304a\u308a\u3001\u7814\u7a76\u3092\u3055\u3089\u306b\u52a0\u901f\u3055\u305b\u3066\u3044\u304f\u6240\u5b58\u3067\u3042\u308b\u3002<\/p>\n<p>\u672c\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306e5\u5e74\u9593\u306e\u7279\u7b46\u3059\u3079\u304d\u6210\u679c\u3068\u3057\u3066\u3001\u6211\u3005\u306eDDS\u3092\u30b3\u30a2\u6280\u8853\u3068\u3066\u8a2d\u7acb\u3055\u308c\u305f\u30eb\u30ab\u30fb\u30b5\u30a4\u30a8\u30f3\u30b9\u682a\u5f0f\u4f1a\u793e\u306e\u5354\u529b\u3092\u5f97\u3066\u30012020\u5e74\u306b\u7523\u696d\u5275\u51fa\u8b1b\u5ea7 [\u30d0\u30a4\u30aaDDS\u5b9f\u7528\u5316\u5206\u91ce] \u3092\u8a2d\u7f6e\u3057\u305f\u3053\u3068\u3067\u3042\u308b\u3002\u3053\u308c\u307e\u3067\u53d6\u308a\u7d44\u3093\u3067\u304d\u305f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a19\u7684\u578bDDS\u7814\u7a76\u306b\u52a0\u3048\u3001\u30eb\u30ab\u30fb\u30b5\u30a4\u30f3\u30a8\u30b9\u793e\u3068\u9023\u643a\u3057\u305f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5275\u5264\u7814\u7a76\u304c\u76f8\u4e92\u306b\u7814\u7a76\u3092\u767a\u5c55\u3055\u305b\u3001\u591a\u304f\u306e\u7af6\u4e89\u7684\u8cc7\u91d1 \uff08\u4ee3\u8868\u8005\uff1a JST\u30fb\u5275\u767a, \u57fa\u76e4\uff08A\uff09, \u4ed6\uff09\u3001\u4f01\u696d\u5927\u578b\u5171\u540c\u7814\u7a76 \uff088\u4ef6\uff09\u3092\u7372\u5f97\u3057\u305f (5\u5e74\u7dcf\u984d\u7d042.1\u5104\u5186)\u3002\u4eba\u6750\u80b2\u6210\u306e\u89b3\u70b9\u304b\u3089\u3082\u6210\u679c\u304c\u3042\u308a\u3001\u5c71\u7530\u306f2023\u5e744\u6708\u3088\u308a\u3001\u5317\u6d77\u9053\u5927\u5b66\u30fb\u85ac\u5b66\u90e8\u306e\u6559\u6388\u306e\u30dd\u30b8\u30b7\u30e7\u30f3\u3092\u5f97\u305f\u3002\u3055\u3089\u306b\u30015\u5e74\u9593\u306e\u672c\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u6210\u679c (\u904e\u53bb5\u5e74\u9593 Top10\uff05\u8ad6\u658711\u5831 (35.5%))\u304c\u8a55\u4fa1\u3055\u308c\u3001\u65b0\u305f\u306a\u7523\u696d\u5275\u51fa\u8b1b\u5ea7 \uff08\u7d30\u80de\u30fb\u30aa\u30eb\u30ac\u30cd\u30e9\u88fd\u5264\u5b66\u5206\u91ce\uff09\u3092\u539f\u5cf6\u6559\u6388\u3068\u5171\u306b\u8a2d\u7f6e\u3059\u308b\u306b\u81f3\u3063\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-691\" src=\"https:\/\/www.pharm.hokudai.ac.jp\/nano\/wp-content\/uploads\/2024\/11\/f4d7cd3fa4875553ebca38ca3057554b.png\" alt=\"\" width=\"611\" height=\"531\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"\u30ca\u30ceDDS\u306b\u57fa\u3065\u304f\u500b\u5225\u5316\u30ca\u30ce\u533b\u7642 \u72ec\u81ea\u306e\u30a4\u30aa\u30f3\u5316\u8102\u8cea\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\u3092\u57fa\u76e4\u3068\u3057\u305f\u9ad8\u5206\u5b50\u9001\u9054 \u30ca\u30ceDDS\u3092\u57fa\u76e4\u3068\u3057\u305f\u304c\u3093\u514d\u75ab\u6cbb\u7642: \u30ca\u30ce\u304c\u3093\u514d\u75ab\u6cbb\u7642 \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a19\u7684\u578bDDS\u3092\u57fa\u76e4\u3068\u3059\u308b\u30aa\u30eb\u30ac\u30cd\u30e9\u6cbb\u7642 \u672c\u53d6\u7d44\u306f2009\u5e74\u5ea6\u3088&#8230; <a class=\"view-article\" href=\"https:\/\/www.pharm.hokudai.ac.jp\/nano\/pharmacy\">View Article<\/a>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-pharmacy.php","meta":{"footnotes":""},"class_list":["post-14","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.pharm.hokudai.ac.jp\/nano\/wp-json\/wp\/v2\/pages\/14","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharm.hokudai.ac.jp\/nano\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pharm.hokudai.ac.jp\/nano\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharm.hokudai.ac.jp\/nano\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharm.hokudai.ac.jp\/nano\/wp-json\/wp\/v2\/comments?post=14"}],"version-history":[{"count":49,"href":"https:\/\/www.pharm.hokudai.ac.jp\/nano\/wp-json\/wp\/v2\/pages\/14\/revisions"}],"predecessor-version":[{"id":694,"href":"https:\/\/www.pharm.hokudai.ac.jp\/nano\/wp-json\/wp\/v2\/pages\/14\/revisions\/694"}],"wp:attachment":[{"href":"https:\/\/www.pharm.hokudai.ac.jp\/nano\/wp-json\/wp\/v2\/media?parent=14"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}