{"id":16,"date":"2019-05-21T16:54:09","date_gmt":"2019-05-21T07:54:09","guid":{"rendered":"https:\/\/www.pharm.hokudai.ac.jp\/nano\/?page_id=16"},"modified":"2025-01-14T18:04:20","modified_gmt":"2025-01-14T09:04:20","slug":"dentistry","status":"publish","type":"page","link":"https:\/\/www.pharm.hokudai.ac.jp\/nano\/dentistry","title":{"rendered":"\u6b6f\u5b66\u7814\u7a76\u9662 \u7814\u7a76\u5185\u5bb9"},"content":{"rendered":"<h3 style=\"text-align: center;\">\u8840\u7ba1\u5236\u5fa1\u306b\u3088\u308b\u75be\u60a3\u6cbb\u7642\u306e\u5b9f\u73fe<\/h3>\n<p>\u672c\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306f\u30012009\u5e74\u3088\u308a\u5317\u5927\u521d\u306e\u90e8\u5c40\u6a2a\u65ad\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3068\u3057\u3066\u85ac\u5b66\u7814\u7a76\u9662\u539f\u5cf6\u79c0\u5409\u5148\u751f\u30b0\u30eb\u30fc\u30d7\u3068\u306e\u9023\u643a\u306b\u3088\u308a\u958b\u59cb\u3055\u308c\u305f\u3002\u7b2c\u4e00\u671f\u300c\u8840\u7ba1\u3092\u6a19\u7684\u3068\u3059\u308b\u9769\u65b0\u7684\u533b\u85ac\u5206\u5b50\u9001\u9054\u6cd5\u306e\u57fa\u76e4\u6280\u8853\u306e\u78ba\u7acb\u300d\uff082009\u5e74\u5ea6\uff5e2013\u5e74\u5ea6\uff09\u3001\u7b2c\u4e8c\u671f\u300c\u8840\u7ba1\u3092\u6a19\u7684\u3068\u3059\u308b\u30ca\u30ce\u533b\u7642\u306e\u5b9f\u7528\u5316\u300d\uff082014\u5e74\u5ea6\uff5e2018\u5e74\u5ea6\uff09\u306b\u7d9a\u3044\u3066\u30012019\u5e744\u6708\u3088\u308a\u5de5\u5b66\u7814\u7a76\u9662\u306e\u6e21\u6176\u6b21\u5b66\u5148\u751f\u306e\u30b0\u30eb\u30fc\u30d7\u304c\u53c2\u753b\u3055\u308c\u300c\u8840\u7ba1\u3092\u6a19\u7684\u3068\u3059\u308b\u30ca\u30ce\u533b\u7642\u306e\u5b9f\u88c5\uff5ePersonalized Nanomedicine\u306e\u5317\u5927\u30d6\u30e9\u30f3\u30c9\u5316\uff5e\u300d\u304c\u59cb\u307e\u3063\u305f\u3002\u3053\u308c\u307e\u3067\u306e\u816b\u760d\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u7279\u7570\u6027\u306b\u95a2\u3059\u308b\u7814\u7a76\u304b\u3089\u3001\u708e\u75c7\u6027\u5f62\u8cea\u3092\u6a19\u7684\u3068\u3057\u305f\u514d\u75ab\u5fae\u5c0f\u74b0\u5883\u306e\u5236\u5fa1\u306b\u304a\u3051\u308b\u816b\u760d\u8840\u7ba1\u306e\u6a19\u7684\u5316\u3092\u76ee\u6307\u3059\u7814\u7a76\u304b\u3089\u3001\u304c\u3093\u95a2\u9023\u8840\u6813\u75c7\u306e\u6cbb\u7642\u6a19\u7684\u63a2\u7d22\u3001\u3055\u3089\u306b\u306f\u8840\u6813\u75c7\u304c\u7279\u5fb4\u3067\u3042\u308b\u65b0\u578b\u30b3\u30ed\u30ca\u611f\u67d3\u75c7\u91cd\u75c7\u5316\u306b\u304a\u3051\u308b\u8840\u7ba1\u75c5\u614b\u306e\u89e3\u660e\u3068\u6cbb\u7642\u85ac\u958b\u767a\u3092\u76ee\u6307\u3059\u3082\u306e\u3078\u3068\u7814\u7a76\u306e\u65b9\u5411\u6027\u304c\u5e83\u304f\u5c55\u958b\u3055\u308c\u305f\u3002<\/p>\n<p>\u3053\u306e5\u5e74\u9593\u306e\u6210\u679c\u3092\u307e\u3068\u3081\u308b\u3068\u3001Top10%\u88ab\u5f15\u7528\u8ad6\u6587\u306e\u5272\u5408\u306f\u539f\u8457\u8ad6\u6587\u306745\uff05\u3001\u5168\u8ad6\u6587\u306738\uff05\u3068\u3044\u3046\u6210\u679c\u3068\u306a\u3063\u305f\u3002\u672c\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3067\u63b2\u3052\u305fKPI\u306e\u3046\u3061\u2460Top10\uff05\u88ab\u5f15\u7528\u8ad6\u6587\u306e\u5272\u540835\uff05\u3068\u3044\u3046\u76ee\u6a19\u306e\u9054\u6210\u306b\u8ca2\u732e\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u305f\u3002\u4e00\u65b9\u3067\u2461\u5927\u578b\u5171\u540c\u7814\u7a76\uff08\u5e74\u9593500\u4e07\u5186\u4ee5\u4e0a\uff092\u4ef6\u3001\u2462\u7523\u696d\u5275\u51fa\u8b1b\u5ea71\u4ef6\u306f\u9054\u6210\u3067\u304d\u306a\u304b\u3063\u305f\u3002\u3057\u304b\u3057\u3001\u3053\u306e5\u5e74\u9593\u3067\u7279\u8a31\u51fa\u9858\u306b\u5411\u3051\u3066\u6e96\u5099\u3092\u9032\u3081\u3066\u3044\u308b\u7814\u7a76\u30b7\u30fc\u30ba\u3082\u751f\u307e\u308c\u305f\u3053\u3068\u304b\u3089\u3001\u4eca\u5f8c\u306f\u7523\u5b66\u9023\u643a\u306b\u3064\u306a\u3052\u3089\u308c\u308b\u3068\u8003\u3048\u3066\u3044\u308b\u3002\u672c\u7814\u7a76\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306b\u3088\u308a\u3001\u591a\u304f\u306e\u82e5\u624b\u7814\u7a76\u8005\u304c\u305d\u306e\u7814\u7a76\u6210\u679c\u306b\u3088\u308a\u53d7\u8cde\u3057\u305f\u3002\u4eba\u6750\u80b2\u6210\u306e\u89b3\u70b9\u304b\u3089\u3082\u6210\u679c\u304c\u3042\u308a\u3001\u7279\u306b\u5973\u6027\u7814\u7a76\u8005\u306e\u80b2\u6210\u306b\u3082\u8ca2\u732e\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>2019\u5e74\u5ea6\uff5e2023\u5e74\u5ea6\u306e\u6210\u679c<\/p>\n<ol>\n<li>\u816b\u760d\u8840\u7ba1\u708e\u75c7\u5f62\u8cea\u3092\u816b\u760d\u514d\u75ab\u5fae\u5c0f\u74b0\u5883\u306e\u6b63\u5e38\u5316<\/li>\n<\/ol>\n<p>\u816b\u760d\u8840\u7ba1\u3092\u88cf\u6253\u3061\u3059\u308b\u816b\u760d\u8840\u7ba1\u5185\u76ae\u7d30\u80de\uff08Tumor endothelial cell: TEC\uff09\u306e\u7279\u7570\u6027\u306e\u3046\u3061\u3001\u7279\u306b\u305d\u306e\u708e\u75c7\u5f62\u8cea\u304c\u514d\u75ab\u5fae\u5c0f\u74b0\u5883\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u306b\u3064\u3044\u3066\u7814\u7a76\u3092\u9032\u3081\u305f\u3002<\/p>\n<p>\u6211\u3005\u306fTEC\u304cIL-6\u3092\u9ad8\u767a\u73fe\u3059\u308b\u306a\u3069\u708e\u75c7\u6027\u306b\u5909\u5316\u3057\u3066\u3044\u308b\u3053\u3068\u3001\u3055\u3089\u306b\u305d\u306e\u6a5f\u5e8f\u306e\u3072\u3068\u3064\u3068\u3057\u3066\u816b\u760d\u304b\u3089\u5206\u6ccc\u3055\u308c\u308b\u7d30\u80de\u5916\u5c0f\u80de\u306b\u5185\u5305\u3055\u308c\u308bmiRNA-1246\u306e\u5f79\u5272\u3092\u660e\u3089\u304b\u306b\u3057\u305f (Torii C, et al, Sci Rep. 2021 Jul 5;11(1):13502\u3001\u672c\u5b66\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9 https:\/\/www.hokudai.ac.jp\/news\/2021\/07\/mirnail-6mirna-1246.html)\u3002\u8fd1\u5e74\u3001\u6297\u304c\u3093\u5264\u6cbb\u7642\u306b\u3088\u308a\u708e\u75c7\u304c\u8a98\u5c0e\u3055\u308c\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u304d\u305f\u304c\u3001\u6211\u3005\u306f\u30b2\u30e0\u30b7\u30bf\u30d3\u30f3\u30fb\u30b7\u30b9\u30d7\u30e9\u30c1\u30f3\u6cbb\u7642\u5f8c\u306e\u7d44\u7e54\u306b\u304a\u3044\u3066\u8a98\u5c0e\u3055\u308c\u308b\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3IL-8\u304cTEC\u306e\u85ac\u5264\u6392\u51fa\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fcMDR1\/ABCB1\u306e\u767a\u73fe\u3092\u4ea2\u9032\u3055\u305b\u308b\u3053\u3068\u3001TEC\u306eABCB1\u6a19\u7684\u304c\u6297\u304c\u3093\u5264\u8010\u6027\u514b\u670d\u306b\u3064\u306a\u304c\u308a\u65b0\u3057\u3044\u6226\u7565\u3067\u3042\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u305f(Kikuchi H, et al, Cancer Res. 2020 Jul 15;80(14):2996-3008\u3001\u00a0\u672c\u5b66\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9 https:\/\/www.hokudai.ac.jp\/news\/2020\/06\/post-684.html)\u3002<\/p>\n<p>\u6b63\u5e38\u5185\u76ae\u7d30\u80de\uff08NEC\uff09\u306b\u6bd4\u3079TEC\u3067\u767a\u73fe\u4ea2\u9032\u3057\u3066\u3044\u305f\u907a\u4f1d\u5b50\uff08TEC\u30de\u30fc\u30ab\u30fc\uff09\u306e\u3046\u3061\u3001 DAMPs\u306e\u4e00\u3064\u3067\u3042\u308bBiglycan\u3000(Bgn\uff09\u306b\u3064\u3044\u3066\u3082\u3001\u65b0\u305f\u306a\u6a5f\u80fd\u306b\u3064\u3044\u3066\u660e\u3089\u304b\u306b\u3057\u305f\u3002\u3053\u308c\u307e\u3067\u6211\u3005\u306fBgn\u304cTEC\u306e\u8840\u7ba1\u65b0\u751f\u80fd\u4fc3\u9032\u306b\u50cd\u304f\u306e\u307f\u306a\u3089\u305a\u3001\u816b\u760d\u7d30\u80de\u306e\u6d78\u6f64\u8ee2\u79fb\u80fd\u3092\u4ea2\u9032\u3055\u305b\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u3066\u304d\u305f\u3002\u4eca\u671f\u306f\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u306e\u8a73\u7d30\u306a\u89e3\u6790\u306b\u3088\u308a\u3001Bgn\u963b\u5bb3\u304c\u816b\u760d\u306e\u7dda\u7dad\u5316\u6291\u5236\u3057\u3001CD8\u967d\u6027T\u7d30\u80de\u306e\u816b\u760d\u5185\u6d78\u6f64\u3092\u5897\u52a0\u3055\u305b\u3001\u4e73\u304c\u3093\u306e\u6297\u304c\u3093\u5264\u6cbb\u7642\u52b9\u679c\u3092\u9ad8\u3081\u308b\u3053\u3068\u3092\u793a\u3057\u305f\uff08Li C, et al, Breast Cancer Research 2021 May 10;23(1):51, \u88ab\u5f15\u7528\u6570Top10\uff05\u3001\u672c\u5b66\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9 https:\/\/www.hokudai.ac.jp\/news\/2021\/05\/biglycan.html\uff09\u3002\u91cd\u8981\u306a\u3053\u3068\u306b\u3001\u6211\u3005\u306fBgn\u304c\u80ba\u304c\u3093\u306e\u8a3a\u65ad\u30de\u30fc\u30ab\u30fc\u306a\u3089\u3073\u306b\u4e88\u5f8c\u4e88\u6e2c\u56e0\u5b50\u3068\u306a\u308b\u53ef\u80fd\u6027\u3082\u793a\u3057\u305f\uff08Morimoto H, et al, Thoracic Cancer 2021 May;12(9):1347-1357)\u3002\u3055\u3089\u306b\u3001 TEC\u306eBgn\u304c\u3001LDL\u306e\u816b\u760d\u5185\u84c4\u7a4d\u3068\u597d\u4e2d\u7403\u96c6\u7a4d\u3001\u6d3b\u6027\u5316\u306b\u3088\u308bNET\u5f62\u6210\u3092\u4fc3\u9032\u3057\u3001\u816b\u760d\u306e\u8ee2\u79fb\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u3002\u305d\u306e\u6a5f\u5e8f\u3068\u3057\u3066TEC\u306b\u767a\u73fe\u3059\u308b\u9178\u5316LDL\u306e\u53d7\u5bb9\u4f53LOX-1\u304c\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u305f\uff08Tsumita T, et al, Int J Cancer. 2022 Sep 15;151(6):944-956, \u88ab\u5f15\u7528\u6570Top10\uff05\u3001\u672c\u5b66\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9 https:\/\/www.hokudai.ac.jp\/news\/2022\/06\/ldl.html)\u3002<\/p>\n<p>\u4ee5\u4e0a\u3088\u308a\u3001 TEC\u2015Bgn\u304c\u6cbb\u7642\u6a19\u7684\u3068\u3057\u3066\u3082\u6709\u671b\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u305f\u3002\u305d\u3053\u3067\u6211\u3005\u306f\u3001\u539f\u5cf6\u30b0\u30eb\u30fc\u30d7\u3068\u306e\u5171\u540c\u7814\u7a76\u3067\u3001TEC\u7279\u7570\u7684\u30ea\u30dd\u30bd\u30fc\u30e0siRNA\u30c7\u30ea\u30d0\u30ea\u30fc\u30b7\u30b9\u30c6\u30e0\u3092\u7528\u3044\u3066\u3001Bgn siRNA\u9001\u9054\u306b\u3088\u308bin vivo\u6297\u816b\u760d\u52b9\u679c\u3001\u8840\u7ba1\u65b0\u751f\u963b\u5bb3\u52b9\u679c\u3001\u816b\u760d\u8840\u7ba1\u306e\u6b63\u5e38\u5316\u3001\u816b\u760d\u306e\u7dda\u7dad\u5316\u4f4e\u4e0b\u3092\u660e\u3089\u304b\u306b\u3057\uff08Maishi N, et al, Cancer Sci. 2022 May;113(5):1855-1867\u3001\u00a0\u672c\u5b66\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9 https:\/\/www.hokudai.ac.jp\/news\/2022\/03\/biglycan-1.html\uff09\u3001Bgn\u6a19\u7684\u3068\u3057\u305f\u65b0\u898f\u8840\u7ba1\u65b0\u751f\u963b\u5bb3\u7642\u6cd5\u3092\u78ba\u7acb\u3057\u305f\uff08\u56f3\uff11)\u3002<\/p>\n<p>\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\uff08ICI\uff09\u306e\u307f\u3067\u306f\u816b\u760d\u5897\u6b96\u6291\u5236\u306b\u306f\u4e0d\u5341\u5206\u306a\u3053\u3068\u304c\u591a\u3044\u3002\u514d\u75ab\u7d30\u80de\u306e\u6d78\u6f64\u3092\u6539\u5584\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u816b\u760d\u8840\u7ba1\u3092\u6b63\u5e38\u5316\u3059\u308b\u8840\u7ba1\u65b0\u751f\u963b\u5bb3\u5264\uff08AI\uff09\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002\u305d\u3053\u3067\u3001 \u6211\u3005\u306fAI\u3092\u524d\u6295\u4e0e\u306b\u3088\u308a\u3001\u8840\u7ba1\u6b63\u5e38\u5316\u304c\u8d77\u3053\u308b\u30bf\u30a4\u30e0\u30dd\u30a4\u30f3\u30c8\u3067ICI\u6295\u4e0e\u3092\u6295\u4e0e\u3059\u308b\u3053\u3068\u3067\u514d\u75ab\u7d30\u80de\u6d78\u6f64\u304c\u6539\u5584\u3057\u3001ICI\u306e\u6cbb\u7642\u52b9\u679c\u304c\u9ad8\u307e\u308b\u53ef\u80fd\u6027\u3092\u793a\u3057\u305f\uff08Sato M, et al, Cancer Med. 2023 Apr;12(8):9760-9773, \u88ab\u5f15\u7528\u6570Top10\uff05\u3001\u672c\u5b66\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9 https:\/\/www.hokudai.ac.jp\/news\/2023\/03\/post-1194.html)\u3002\u3053\u306e\u7d50\u679c\u3092\u3082\u3068\u306b\u3001\u611b\u5a9b\u5927\u5b66\u306e\u7af9\u7530\u6d69\u4e4b\u5148\u751f\u3068\u306e\u5171\u540c\u7814\u7a76\u306b\u3088\u308aBgn\u963b\u5bb3\u5264\u5019\u88dc\u5316\u5408\u7269\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3082\u9032\u3081\u305f\u3002In vivo \u6a5f\u80fd\u89e3\u6790\u304c\u7d42\u4e86\u3057\u3001\u539f\u5cf6\u5148\u751f\u3068\u306e\u9023\u643a\u306b\u3088\u308bDDS\u306b\u3088\u308b\u6cbb\u7642\u3078\u306e\u5fdc\u7528\u3082\u8996\u91ce\u306b\u5165\u308c\u3066in vivo\u6cbb\u7642\u52b9\u679c\u691c\u8a3c\u306e\u6e96\u5099\u3092\u9032\u3081\u3066\u3044\u308b\uff08\u56f3\uff11\uff09\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-708\" src=\"https:\/\/www.pharm.hokudai.ac.jp\/nano\/wp-content\/uploads\/2024\/12\/5d344a8dae129a3746c60d8c3db5ceb4.png\" alt=\"\" width=\"1026\" height=\"574\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>\u708e\u75c7\u3092\u60f9\u8d77\u3055\u305b\u308bBgn\u304cTEC\u304b\u3089\u5206\u6ccc\u3055\u308c\u3001\u5fae\u5c0f\u74b0\u5883\u306b\u4f5c\u7528\u3057\u3001\u816b\u760d\u306e\u9032\u5c55\u306b\u50cd\u3044\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3053\u3068\u304b\u3089\u3001\u6211\u3005\u306f\u539f\u767a\u5de3\u306b\u52a0\u3048\u3066\u8ee2\u79fb\u81d3\u5668\u306b\u304a\u3051\u308b\u8840\u7ba1\u708e\u75c7\u3068\u8ee2\u79fb\u306e\u95a2\u4fc2\u306b\u3064\u3044\u3066\u3082\u7814\u7a76\u3092\u9032\u3081\u305f\u3002\u53e3\u8154\u5185\u7d30\u83ccStreptococcus mutans\u304c\u6b6f\u5468\u708e\u306a\u3069\u306b\u3088\u308a\u8840\u4e2d\u306b\u4fb5\u5165\u3057\u3001\u80ba\u306e\u8840\u7ba1\u306b\u708e\u75c7\u6027\u5909\u5316\u3092\u8d77\u3053\u3057\u3066\u304c\u3093\u306e\u8ee2\u79fb\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u305f(Yu L, et al, Cancer Sci. 2022 Nov;113(11):3980-3994\u3001\u88ab\u5f15\u7528\u6570Top10\uff05\u3001Cancer Science Young Scientist Award\u3001\u5148\u7aef\u6b6f\u5b66\u30b9\u30af\u30fc\u30eb\u6700\u512a\u79c0\u8cde\u53d7\u8cde\u3001\u672c\u5b66\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9 https:\/\/www.hokudai.ac.jp\/news\/2022\/09\/post-1097.html)\u3002\u3055\u3089\u306b\u6211\u3005\u306f\u3001\u304c\u3093\u60a3\u8005\u306e\u6b7b\u4ea1\u539f\u56e0\u3068\u3057\u30662\u756a\u76ee\u306b\u591a\u3044\u8840\u6813\u75c7\u306b\u3082\u8840\u7ba1\u708e\u75c7\u304c\u5bc4\u4e0e\u3059\u308b\u3053\u3068\u3092\u5b9f\u8a3c\u3057\u305f (Yu L, et al, Cancer Sci. 2024 Feb;115(2):648-659\u3001\u672c\u5b66\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9 https:\/\/www.hokudai.ac.jp\/news\/2023\/12\/post-1368.html)\u3002<\/p>\n<p>\u4e00\u65b9\u3001\u6211\u3005\u306fTEC\u306e\u5e79\u7d30\u80de\u6027\u306e\u767a\u898b\u306b\u3088\u308a\u3001TEC\u304c\u304c\u3093\u7d30\u80de\u3068\u3068\u3082\u306b\u30af\u30e9\u30b9\u30bf\u30fc\u3092\u5f62\u6210\u3057\u8ee2\u79fb\u5f62\u6210\u306b\u6df1\u304f\u95a2\u4e0e\u3059\u308b\u3068\u3044\u3046\u65b0\u305f\u306a\u8ee2\u79fb\u6a5f\u69cb\u3092\u7740\u60f3\u3057\u3001in vivo \u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u306a\u3089\u3073\u306b\u30d2\u30c8\u81e8\u5e8a\u691c\u4f53\u306b\u3088\u308a\u5b9f\u8a3c\u3057\u305f\u3002\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u89e3\u6790\u306b\u3088\u308a\u3001TEC\u304c\u30af\u30e9\u30b9\u30bf\u30fc\u4e2d\u306e\u304c\u3093\u7d30\u80de\u306e\u751f\u5b58\u3092\u30b5\u30dd\u30fc\u30c8\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u305f\u3002\u6e21\u6176\u6b21\u5148\u751f\u30b0\u30eb\u30fc\u30d7\u304c\u958b\u767a\u3057\u305f3D\u30c7\u30d0\u30a4\u30b9\u3092\u7528\u3044\u3066\u300140\u4f8b\u4ee5\u4e0a\u306e\u304c\u3093\u60a3\u8005\u8840\u6db2\u691c\u4f53\u3092\u89e3\u6790\u3057\u3001\u304c\u3093\u60a3\u8005\u8840\u4e2d\u30af\u30e9\u30b9\u30bf\u30fc\u6355\u6349\u306b\u6210\u529f\u3057\u305f\u3002\u307e\u305f\u3001200\u4f8b\u4ee5\u4e0a\u306e\u65e9\u671f\u304c\u3093\u60a3\u8005\u306e\u75c5\u7406\u7d44\u7e54\u6a19\u672c\u3092\u89e3\u6790\u3057\u3001\u672c\u30af\u30e9\u30b9\u30bf\u30fc\u306e\u691c\u51fa\u304c\u518d\u767a\u8ee2\u79fb\u3068\u9ad8\u3044\u76f8\u95a2\u3092\u793a\u3059\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\uff08\u8ad6\u6587\u6295\u7a3f\u6e96\u5099\u4e2d\uff09\u3002\u8ee2\u79fb\u4e88\u6e2c\u3001\u3042\u308b\u3044\u306f\u8853\u5f8c\u6297\u304c\u3093\u5264\u6cbb\u7642\u306e\u5fc5\u8981\u6027\u5224\u5b9a\u306b\u5fdc\u7528\u53ef\u80fd\u306a\u65b0\u305f\u306a\u8a3a\u65ad\u65b9\u6cd5\u958b\u767a\u3092\u76ee\u6307\u3057\u3066\u3044\u308b(\u56f32)\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-714\" src=\"https:\/\/www.pharm.hokudai.ac.jp\/nano\/wp-content\/uploads\/2025\/01\/7984dcfb961f3bae8f1a1b4f97d7c562.png\" alt=\"\" width=\"723\" height=\"281\" \/><\/p>\n<p>&nbsp;<\/p>\n<ol start=\"2\">\n<li>\u611f\u67d3\u75c7\u306b\u304a\u3051\u308b\u8840\u7ba1\u75c5\u614b\u306e\u89e3\u660e\u3068\u6cbb\u7642\u85ac\u958b\u767a<\/li>\n<\/ol>\n<p>\u4eba\u7363\u5171\u901a\u611f\u67d3\u75c7\u56fd\u969b\u5171\u540c\u7814\u7a76\u6240\u306e\u6fa4\u5148\u751f\u30b0\u30eb\u30fc\u30d7\u3089\u3068\u9023\u643a\u3057\u3001\u52a0\u9f62\u30de\u30a6\u30b9\u306e\u307f\u304c\u91cd\u75c7\u5316\u3057\u3066\u6b7b\u4ea1\u3059\u308b\u30de\u30a6\u30b9\u99b4\u5316SARS-CoV-2\u30a6\u30a4\u30eb\u30b9\u3092\u7528\u3044\u3066\u3001\u611f\u67d3\u5f8c\u91cd\u75c7\u5316\u3057\u305f\u52a0\u9f62\u30de\u30a6\u30b9\u306e\u80ba\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u3092\u5206\u96e2\u3057\u3001\u91cd\u75c7\u5316\u3057\u306a\u3044\u82e5\u9f62\u30de\u30a6\u30b9\u80ba\u304b\u3089\u3082\u540c\u69d8\u306b\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u3092\u5206\u96e2\u3057\u305d\u308c\u305e\u308c\u306e\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u3092\u7db2\u7f85\u7684\u306b\u6bd4\u8f03\u3057\u305f\u3002\u52a0\u9f62\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306b\u3088\u308b\u8840\u5c0f\u677f\u3084\u514d\u75ab\u7d30\u80de\u6d3b\u6027\u5316\u4ea2\u9032\u6a5f\u69cb\u3092\u898b\u51fa\u3057\u3001\u91cd\u75c7\u5316\u306b\u306f\u8840\u7ba1\u306e\u52a0\u9f62\u5909\u5316\u304c\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u305f\uff08Tsumita et al, Aging Cell 2023, e14050, doi: 10\u30021111\/acel. 14050, \u672c\u5b66\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<a href=\"https:\/\/www.hokudai.ac.jp\/news\/2023\/12\/post-1366.html\">https:\/\/www.hokudai.ac.jp\/news\/2023\/12\/post-1366.html<\/a>\uff09\u3002\u91cd\u75c7\u80ba\u708e\u306e\u8a3a\u65ad\u30de\u30fc\u30ab\u30fc\u3068\u6cbb\u7642\u85ac\u6a19\u7684\u5206\u5b50\u306e\u540c\u5b9a\u3082\u884c\u3063\u305f\uff08\u56f3\uff13\uff09\u3002\u73fe\u5728\u3001 \u539f\u5cf6\u30b0\u30eb\u30fc\u30d7\u3068\u9023\u643a\u3057\u3001\u963b\u5bb3\u5264\u3084\u5206\u5b50\u306esiRNA\u306e\u80ba\u9001\u9054DDS\u306b\u3088\u308b\u6cbb\u7642\u5b9f\u9a13\u3092\u884c\u3063\u3066\u3044\u308b\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-709\" src=\"https:\/\/www.pharm.hokudai.ac.jp\/nano\/wp-content\/uploads\/2024\/12\/36bb8351081f141b41b8c62528b76e9a.png\" alt=\"\" width=\"1067\" height=\"511\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"\u8840\u7ba1\u5236\u5fa1\u306b\u3088\u308b\u75be\u60a3\u6cbb\u7642\u306e\u5b9f\u73fe \u672c\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306f\u30012009\u5e74\u3088\u308a\u5317\u5927\u521d\u306e\u90e8\u5c40\u6a2a\u65ad\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3068\u3057\u3066\u85ac\u5b66\u7814\u7a76\u9662\u539f\u5cf6\u79c0\u5409\u5148\u751f\u30b0\u30eb\u30fc\u30d7\u3068\u306e\u9023\u643a\u306b\u3088\u308a\u958b\u59cb\u3055\u308c\u305f\u3002\u7b2c\u4e00\u671f\u300c\u8840\u7ba1\u3092\u6a19\u7684\u3068\u3059\u308b\u9769\u65b0\u7684\u533b\u85ac\u5206\u5b50\u9001\u9054\u6cd5\u306e\u57fa\u76e4\u6280\u8853\u306e\u78ba\u7acb\u300d\uff0820&#8230; <a class=\"view-article\" href=\"https:\/\/www.pharm.hokudai.ac.jp\/nano\/dentistry\">View Article<\/a>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-dentistry.php","meta":{"footnotes":""},"class_list":["post-16","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.pharm.hokudai.ac.jp\/nano\/wp-json\/wp\/v2\/pages\/16","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharm.hokudai.ac.jp\/nano\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pharm.hokudai.ac.jp\/nano\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharm.hokudai.ac.jp\/nano\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharm.hokudai.ac.jp\/nano\/wp-json\/wp\/v2\/comments?post=16"}],"version-history":[{"count":18,"href":"https:\/\/www.pharm.hokudai.ac.jp\/nano\/wp-json\/wp\/v2\/pages\/16\/revisions"}],"predecessor-version":[{"id":717,"href":"https:\/\/www.pharm.hokudai.ac.jp\/nano\/wp-json\/wp\/v2\/pages\/16\/revisions\/717"}],"wp:attachment":[{"href":"https:\/\/www.pharm.hokudai.ac.jp\/nano\/wp-json\/wp\/v2\/media?parent=16"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}