{"id":18,"date":"2019-05-21T16:54:28","date_gmt":"2019-05-21T07:54:28","guid":{"rendered":"https:\/\/www.pharm.hokudai.ac.jp\/nano\/?page_id=18"},"modified":"2024-12-25T14:10:11","modified_gmt":"2024-12-25T05:10:11","slug":"engineering","status":"publish","type":"page","link":"https:\/\/www.pharm.hokudai.ac.jp\/nano\/engineering","title":{"rendered":"\u5de5\u5b66\u7814\u7a76\u9662 \u7814\u7a76\u5185\u5bb9"},"content":{"rendered":"

\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u306e\u7c92\u5f84\u3092\u4efb\u610f\u306e\u30b5\u30a4\u30ba\u3067
\n\u7cbe\u5bc6\u306b\u4f5c\u88fd\u3067\u304d\u308b\u30c7\u30d0\u30a4\u30b9\u958b\u767a<\/h3>\n

\u533b\u85ac\u54c1\u5206\u91ce\u3092\u4e2d\u5fc3\u306b\u7c92\u5f84\u3092\u7cbe\u5bc6\u306b\u5236\u5fa1\u3055\u308c\u305f\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u88fd\u5264\u306e\u9700\u8981\u304c\u9ad8\u307e\u3063\u3066\u3044\u308b\u3002\u7279\u306b\u3001\u85ac\u7269\u9001\u9054\u30b7\u30b9\u30c6\u30e0\uff08Drug Delivery System: DDS\uff09\u6280\u8853\u3092\u5229\u7528\u3057\u305f\u533b\u85ac\u54c1\u306b\u304a\u3044\u3066\u3001\u30ca\u30ce\u7c92\u5b50\u306e\u5927\u304d\u3055\u306b\u3088\u3063\u3066\u9001\u9054\u3055\u308c\u308b\u81d3\u5668\u3084\u85ac\u52b9\u304c\u7570\u306a\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n

\u3053\u306e\u8ab2\u984c\u3092\u89e3\u6c7a\u3059\u308b\u305f\u3081\u306b\u3001\u30de\u30a4\u30af\u30ed\u6d41\u4f53\u30c7\u30d0\u30a4\u30b9\u30c1\u30fc\u30e0\u3067\u306f\u3001\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u306e\u7c92\u5f84\u3092\u4efb\u610f\u306e\u30b5\u30a4\u30ba\u3067\u7cbe\u5bc6\u306b\u4f5c\u88fd\u3067\u304d\u308b\u30c7\u30d0\u30a4\u30b9\u958b\u767a\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u308b\u3002\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u306f\u3001\u8102\u8cea\/\u30a2\u30eb\u30b3\u30fc\u30eb\u6eb6\u6db2\u3068\u6838\u9178\u306a\u3069\u3092\u542b\u3080\u6838\u9178\u6c34\u6eb6\u6db2\u3092\u8fc5\u901f\u306b\u5e0c\u91c8\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3042\u308b\u3002\u3053\u308c\u307e\u3067\u306b\u3001\u5f53\u30c1\u30fc\u30e0\u3067\u306f\u3001\u30de\u30a4\u30af\u30ed\u30df\u30ad\u30b5\u30fc\u69cb\u9020\u3092\u6709\u3059\u308b\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u4f5c\u88fd\u7528\u306e\u30de\u30a4\u30af\u30ed\u6d41\u4f53\u30c7\u30d0\u30a4\u30b9\u3092\u958b\u767a\u3057\u305f\uff08iLiNP\uff08invasive Lipid Nanoparticle Production\uff09\u3002iLiNP\u30c7\u30d0\u30a4\u30b9\u306f\u3001\u4e2d\u6027\u30ea\u30f3\u8102\u8cea\u3067\u3042\u308bPOPC\uff081-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine\uff09\u306e\u30ca\u30ce\u7c92\u5b50\u306e\u7c92\u5f84\u309210 nm\u9593\u9694\u3067\u7cbe\u5bc6\u306b\u5236\u5fa1\u3059\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u3066\u3044\u308b\u3002\u307e\u305f\u3001\u6838\u9178\u642d\u8f09\u8102\u8cea\uff08siRNA\u3001mRNA\uff09\u30ca\u30ce\u7c92\u5b50\u306e\u307b\u304b\u3001\u9ad8\u5206\u5b50\u30df\u30bb\u30eb\u30ca\u30ce\u7c92\u5b50\u3092\u7cbe\u5bc6\u306b\u7c92\u5f84\u5236\u5fa1\u3057\u3066\u4f5c\u88fd\u3059\u308b\u3053\u3068\u3082\u53ef\u80fd\u3067\u3042\u308b\u3002<\/p>\n

\u672c\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3067\u306f\u3001iLINP\u30c7\u30d0\u30a4\u30b9\u306b\u3088\u308b\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u306e\u5927\u91cf\u751f\u7523\u30d7\u30ed\u30bb\u30b9\u306e\u78ba\u7acb\u3001\u30ac\u30e9\u30b9\u88fdiLINP\u30c7\u30d0\u30a4\u30b9\u306e\u958b\u767a\u3001\u30ca\u30ce\u7c92\u5b50\u306e\u4f5c\u88fd\u30d7\u30ed\u30bb\u30b9\u3092\u9ad8\u52b9\u7387\u5316\u3057\u305f\u65b0\u898f\u30c7\u30d0\u30a4\u30b9\u306e\u958b\u767a\u306a\u3069\u306b\u53d6\u308a\u7d44\u307f\u3001\u793e\u4f1a\u5b9f\u88c5\u3092\u898b\u636e\u3048\u3066\u7814\u7a76\u3092\u5c55\u958b\u3059\u308b\u3002<\/p>\n

 <\/p>\n

\u672c\u4e8b\u696d\u306e\u6210\u679c<\/strong><\/p>\n

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 <\/p>\n

2019\u5e74\u5ea6\uff5e2023\u5e74\u5ea6\u306e\u6210\u679c<\/strong><\/p>\n

\uff11\uff0e\u30de\u30a4\u30af\u30ed\u6d41\u4f53\u30c7\u30d0\u30a4\u30b9\u306b\u3088\u308b\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u306e\u88fd\u9020\u6cd5\u306e\u78ba\u7acb<\/p>\n

\u65e2\u306b\u7279\u8a31\u3068\u3057\u3066\u51fa\u9858\u6e08\u307f\u3067\u3042\u3063\u305f\u30d0\u30c3\u30d5\u30eb\u69cb\u9020\u3092\u6301\u3064\u30de\u30a4\u30af\u30ed\u6d41\u4f53\u30c7\u30d0\u30a4\u30b9\uff08iLiNP\u00ae<\/sup>\u30c7\u30d0\u30a4\u30b9\uff09\u3092\u57fa\u76e4\u3068\u3057\u3066\u3001\u305d\u308c\u305e\u308c\u306e\u76ee\u7684\u306b\u5bfe\u3057\u3066\u6700\u9069\u5316\u3057\u305f\u30c7\u30d0\u30a4\u30b9\u3092\u958b\u767a\u3057\u305f\u3002\u539f\u5cf6\u5148\u751f\u306e\u30b0\u30eb\u30fc\u30d7\u3068\u306e\u9023\u643a\u306b\u3088\u308a\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3078\u306e\u30b3\u30a8\u30f3\u30b6\u30a4\u30e0Q10\u306e\u9001\u9054\uff08Hibino M et al., J Pharm Sci<\/em> 108: 2668-2676, 2019; Hibino M et al., Sci Rep<\/em> 13: 6961, 2023\uff09\u809d\u81d3\u3078\u306emRNA\u306e\u9001\u9054\uff08Hashiba A et al., J Control Release<\/em> 327: 467-476, 2020; Sato Y et al., J Control Release<\/em> 348: 648-659, 2022\uff09\u3001HBV\u611f\u67d3\u7d30\u80de\u3078\u306e\u30b2\u30ce\u30e0\u7de8\u96c6\u56e0\u5b50CRISPR\/Cas9 ribonucleoprotein\uff08RNP\uff09\u9001\u9054\uff08Sato Y et al., J Control Release<\/em> 330: 61-71, 2021\uff09\u3078\u306e\u5fdc\u7528\u306b\u6210\u529f\u3057\u305f\u3002iLiNP\u30c7\u30d0\u30a4\u30b9\u306e\u9ad8\u6027\u80fd\u5316\u3068\u3057\u3066\u3001\u4e8c\u6b21\u5e0c\u91c8\u6a5f\u80fd\u3092\u96c6\u7a4d\u5316\u3057\u305f\u30c7\u30d0\u30a4\u30b9\u306e\u958b\u767a\uff08Kimura N et al., ACS Appl Mater Interfaces<\/em> 12: 3411-3420, 2020\uff09\u3084\u3088\u308a\u7c92\u5f84\u5206\u5e03\u306e\u72ed\u3044\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u3092\u4f5c\u88fd\u53ef\u80fd\u306a3DiLiNP\u30c7\u30d0\u30a4\u30b9\uff08Kimura N et al., RSC Adv<\/em> 11: 1430-1439\u30012021\uff09\u3092\u958b\u767a\u3057\u305f\u3002\u307e\u305f\u3001iLiNP\u30c7\u30d0\u30a4\u30b9\u306b\u3088\u308b\u758e\u6c34\u6027\u85ac\u5264\u3092\u5185\u5305\u3057\u305f\u30dd\u30ea\u30de\u30fc\u30ca\u30ce\u7c92\u5b50\u306e\u4f5c\u88fd\u6280\u8853\uff08Bao Y et al., PLOS ONE<\/em> 17: e0271050, 2022; Bao Y et al., ACS Omega<\/em> 7: 33079-33086, 2022\uff09\u3001\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u306e\u51e6\u65b9\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u6280\u8853\uff08Matsuura-Sawada Y et al., ACS Appl Eng Mater<\/em> 1: 278\u2010286, 2023\uff09\u3001\u5927\u91cf\u751f\u7523\u6280\u8853\u306e\u958b\u767a\uff08Matsuura-Sawada Y, et al., ACS Appl Nano Mater<\/em> 5: 7867-7876, 2022\uff09\u306b\u6210\u529f\u3057\u305f\u3002\u4fe1\u8d8a\u5316\u5b66\u5de5\u696d\u682a\u5f0f\u4f1a\u793e\u3068\u9023\u643a\u3059\u308b\u3053\u3068\u3067\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u306e\u5927\u91cf\u751f\u7523\u30b7\u30b9\u30c6\u30e0\u306e\u958b\u767a\uff08Maeki M et al., Appl Mater Today<\/em> 31: 101754\uff09\u306b\u3082\u6210\u529f\u3057\u3001GMP\u88fd\u9020\u88c5\u7f6e\u306e\u958b\u767a\u3092\u9032\u3081\u3066\u3044\u308b\u3002\u3055\u3089\u306b\u3001\u653e\u5c04\u5149\u306e\u5c0f\u89d2X\u7dda\u6563\u4e71\u6e2c\u5b9a\u30d3\u30fc\u30e0\u30e9\u30a4\u30f3\u3068\u30de\u30a4\u30af\u30ed\u6d41\u4f53\u30c7\u30d0\u30a4\u30b9\u3092\u7d44\u307f\u5408\u308f\u305b\u3066\u3001\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u306e\u751f\u6210\u30d7\u30ed\u30bb\u30b9\u3092\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u89b3\u6e2c\u3059\u308b\u305f\u3081\u306e\u6e2c\u5b9a\u30b7\u30b9\u30c6\u30e0\u3092\u69cb\u7bc9\u3057\u305f\uff08Maeki M et al., Nanoscale Adv<\/em> 6: 2166-2176, 2024\uff09\u3002\u305d\u306e\u4ed6\u306b\u3082\u3001\u30b5\u30a4\u30ba\u306e\u5927\u304d\u306a\u30d7\u30e9\u30b9\u30df\u30c9DNA\uff0815 kbp\uff09\uff08Maeki M et al., ACS Appl Mater Interfaces<\/em> 16: 2110-2119, 2023\uff09\u306e\u9ad8\u52b9\u7387\u306a\u9001\u9054\u3084\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u69d8\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\uff08Kimura N et al., ACS Appl Bio Mater<\/em> 4: 1783-1793, 2021\uff09\u306e\u958b\u767a\u306a\u3069\u306b\u3082\u6210\u529f\u3057\u3066\u3044\u308b\u3002DDS\u5206\u91ce\u3067\u6a29\u5a01\u306e\u3042\u308b\u96d1\u8a8cJournal of Controlled Release\u306b<\/em>\u30de\u30a4\u30af\u30ed\u6d41\u4f53\u30c7\u30d0\u30a4\u30b9\u306b\u3088\u308bmRNA\u5185\u5305\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u306e\u4f5c\u88fd\u306b\u95a2\u3059\u308b\u7dcf\u8aac\uff08Maeki et al., J Control Release<\/em> 344: 80-96, 2022 Top1%\u5f15\u7528\u8ad6\u6587\uff09\u3092\u57f7\u7b46\u3057\u305f\u3002<\/p>\n

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\u672c\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306e5\u5e74\u9593\u306e\u7279\u7b46\u3059\u3079\u304d\u6210\u679c\u3068\u3057\u3066\u3001Top10%\u88ab\u5f15\u7528\u8ad6\u6587\u309212\u5831\uff08\u5185Top1\uff05\u88ab\u5f15\u7528\u8ad6\u65872\u5831\uff09\u767a\u8868\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u305f\u3002\u672c\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3067\u5f97\u3089\u308c\u305f\u7814\u7a76\u6210\u679c\u306b\u57fa\u3065\u304d\u3001\u65b0\u305f\u306a\u63d0\u6848\u306b\u3088\u308a\u771f\u6804\u57ce\u304cJST\u30fb\u3055\u304d\u304c\u3051\uff082019\uff5e2023\u5e74\uff09\u3001\u6e21\u6176\u6b21\u304c\u79d1\u7814\u8cbb\u57fa\u76e4\u7814\u7a76\uff08S\uff09\uff082024\u5e74\uff5e\uff09\u306b\u63a1\u629e\u3055\u308c\u305f\u3002\u4eba\u6750\u80b2\u6210\u306e\u89b3\u70b9\u304b\u3089\u3082\u6210\u679c\u304c\u3042\u308a\u3001\u771f\u6804\u57ce\u306f2021\u5e744\u6708\u3088\u308a\u3001\u5317\u6d77\u9053\u5927\u5b66\u5927\u5b66\u9662\u5de5\u5b66\u7814\u7a76\u9662\u306e\u51c6\u6559\u6388\u306b\u6607\u9032\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u771f\u6804\u57ce\u304c\u4ee4\u548c6\u5e74\u5ea6\u6587\u90e8\u79d1\u5b66\u5927\u81e3\u8868\u5f70\u82e5\u624b\u79d1\u5b66\u8005\u8cde\u3092\u53d7\u8cde\u3057\u305f\u3002<\/p>\n

\"\"<\/p>\n","protected":false},"excerpt":{"rendered":"\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u306e\u7c92\u5f84\u3092\u4efb\u610f\u306e\u30b5\u30a4\u30ba\u3067 \u7cbe\u5bc6\u306b\u4f5c\u88fd\u3067\u304d\u308b\u30c7\u30d0\u30a4\u30b9\u958b\u767a \u533b\u85ac\u54c1\u5206\u91ce\u3092\u4e2d\u5fc3\u306b\u7c92\u5f84\u3092\u7cbe\u5bc6\u306b\u5236\u5fa1\u3055\u308c\u305f\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u88fd\u5264\u306e\u9700\u8981\u304c\u9ad8\u307e\u3063\u3066\u3044\u308b\u3002\u7279\u306b\u3001\u85ac\u7269\u9001\u9054\u30b7\u30b9\u30c6\u30e0\uff08Drug Delivery System: DDS\uff09… View Article<\/a>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-engineering.php","meta":{"footnotes":""},"class_list":["post-18","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.pharm.hokudai.ac.jp\/nano\/wp-json\/wp\/v2\/pages\/18","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharm.hokudai.ac.jp\/nano\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pharm.hokudai.ac.jp\/nano\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharm.hokudai.ac.jp\/nano\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharm.hokudai.ac.jp\/nano\/wp-json\/wp\/v2\/comments?post=18"}],"version-history":[{"count":17,"href":"https:\/\/www.pharm.hokudai.ac.jp\/nano\/wp-json\/wp\/v2\/pages\/18\/revisions"}],"predecessor-version":[{"id":704,"href":"https:\/\/www.pharm.hokudai.ac.jp\/nano\/wp-json\/wp\/v2\/pages\/18\/revisions\/704"}],"wp:attachment":[{"href":"https:\/\/www.pharm.hokudai.ac.jp\/nano\/wp-json\/wp\/v2\/media?parent=18"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}