{"id":719,"date":"2025-01-20T12:03:52","date_gmt":"2025-01-20T03:03:52","guid":{"rendered":"https:\/\/www.pharm.hokudai.ac.jp\/nano\/?page_id=719"},"modified":"2025-01-22T11:44:18","modified_gmt":"2025-01-22T02:44:18","slug":"result","status":"publish","type":"page","link":"https:\/\/www.pharm.hokudai.ac.jp\/nano\/pharmacy\/result","title":{"rendered":"\u85ac\u5b66\u7814\u7a76\u9662 \u696d\u7e3e\u4e00\u89a7"},"content":{"rendered":"<div class=\"area\">\n<ul>\n<li><a href=\"#001\">\u8ad6\u6587<\/a><\/li>\n<li><a href=\"#002\">\u5927\u578b\u5171\u540c\u7814\u7a76\u8cbb<\/a><\/li>\n<li><a href=\"#003\">\u7523\u696d\u5275\u51fa\u90e8\u9580\u306e\u5275\u8a2d<\/a><\/li>\n<li><a href=\"#004\">\u7279\u8a31<\/a><\/li>\n<li><a href=\"#005\">\u533b\u5e2b\u30fb\u4f01\u696d\u3068\u306e\u5171\u540c\u7814\u7a76<\/a><\/li>\n<li><a href=\"#006\">\u7af6\u4e89\u7684\u8cc7\u91d1<\/a><\/li>\n<\/ul>\n<\/div>\n<p><strong><span style=\"color: #3366ff;\">\uff15\u5e74\u9593\u5168\u4f53<\/span><\/strong><br \/>\n<strong><span style=\"color: #3366ff;\">\u539f\u8457\u8ad6\u6587\uff1a76\u5831\uff085+6+6+5+9\uff1d31\uff09Top10%\u88ab\u5f15\u7528\u8ad6\u6587\u306e\u5272\u540840.7\uff05<\/span><\/strong><br \/>\n<strong><span style=\"color: #3366ff;\">\u7dcf\u8aac\uff1a23\u5831\uff080+6+1+2+0\uff1d9\uff09Top10%\u88ab\u5f15\u7528\u8ad6\u6587\u306e\u5272\u540839.1\uff05<\/span><\/strong><br \/>\n<strong><span style=\"color: #3366ff;\">\u5408\u8a08\uff1a99\u5831\uff0831+9\uff1d40\uff09Top10%\u88ab\u5f15\u7528\u8ad6\u6587\u306e\u5272\u540840.4\uff05<\/span><\/strong><br \/>\n<strong><span style=\"color: #3366ff;\">\u3000Top10\uff05\uff1a33\u5831\uff1a\u9752<\/span><\/strong><br \/>\n<strong><span style=\"color: #ff0000;\">\u3000Top1%:\uff1a6\u5831\uff1a\u8d64<\/span><\/strong><br \/>\n<strong><span style=\"color: #339966;\">\u3000Top0.1%\uff1a1\u5831\uff1a\u7dd1<\/span><\/strong><\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<h4 id=\"001\">\u8ad6\u6587<\/h4>\n<h6>2019\u5e74\u3000\u8ad6\u6587\uff08\u539f\u8457\uff0b\u7dcf\u8aac\uff1a\u82f1\u6587\uff09\u539f\u8457\uff1a12\u3001\u7dcf\u8aac\uff1a4\u3000Top10%\u88ab\u5f15\u7528\u8ad6\u6587\uff1a5 (31.3%)<\/h6>\n<ol>\n<li><span style=\"color: #3366ff;\">Sato Y, Hashiba K, Sasaki K, Maeki M, Tokeshi M, Harashima H. <a style=\"color: #3366ff;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30610950\">Understanding structure-activity relationships of pH-sensitive cationic lipids facilitates the rational identification of promising lipid nanoparticles for delivering siRNAs in vivo.<\/a> J Control Release. 295:140-152 (2019). doi: 10.1016\/ j.jconrel.2019.01.001.<\/span><\/li>\n<li><span style=\"color: #3366ff;\">Hibino M, Yamada Y, Fujishita N, Sato Y, Maeki M, Tokeshi M, Harashima H.\u3000<a style=\"color: #3366ff;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30959057\">The Use of a Microfluidic Device to Encapsulate a Poorly Water-Soluble Drug CoQ<sub>10<\/sub> in Lipid Nanoparticles and an Attempt to Regulate Intracellular Trafficking to Reach Mitochondria.<\/a>\u3000J Pharm Sci. J Pharm Sci. 108 (8), 2668-2676 (2019) doi: 10.1016\/ j.xphs.2019.04.001.<\/span><\/li>\n<li><span style=\"color: #3366ff;\">Elwakil M. M. A, Khalil I. A, Elewa Y. H. A, Kusumoto K, Sato Y, Shobaki N, Kon Y, Harashima H. Lung-endothelium-targeted nanoparticles based on a pH-sensitive lipid and the GALA peptide enable robust gene silencing and the regression of metastatic lung cancer. Adv. Funct. Mater. 29, 1807677 (2019). DOI: 10.1002\/adfm.201807677<\/span><\/li>\n<li>Yamada Y, Daikuhara S, Tamura A, Nishida K, Yui N, Harashima H.\u3000<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31165120\">Enhanced autophagy induction via the mitochondrial delivery of methylated b-cyclodextrin-threaded polyrotaxanes using a MITO-Porter.<\/a> Chem Commun (Camb). 55(50):7203-7206 (2019). doi: 10.1039\/ c9cc03272j.<\/li>\n<li>Santiwarangkool S, Akita H, Khalil IA, Abd Elwakil MM, Sato Y, Kusumoto K, Harashima H. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31185231\">A study of the endocytosis mechanism and transendothelial activity of lung-targeted GALA-modified liposomes.<\/a> J Control Release. 307:55-63 (2019). doi: 10.1016\/j.jconrel.2019.06.009.<\/li>\n<li>Sakurai Y, Kato A, Hida Y, Hamada J, Maishi N, Hida K, Harashima H. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31229434\">Synergistic Enhancement of Cellular Uptake With CD44-Expressing Malignant Pleural Mesothelioma by Combining Cationic Liposome and Hyaluronic Acid-Lipid Conjugate.<\/a> J Pharm Sci. 108(10):3218-3224 (2019). doi: 10.1016\/j.xphs. 2019.06.012.<\/li>\n<li><span style=\"color: #3366ff;\">Endo R, Nakamura T, Kawakami K, Sato Y, Harashima H. <a style=\"color: #3366ff;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31383907\">The silencing of indoleamine 2,3-dioxygenase 1 (IDO1) in dendritic cells by siRNA-loaded lipid nanoparticles enhances cell-based cancer immunotherapy.<\/a> Sci Rep. 9(1):11335 (2019). doi: 10.1038\/s41598-019-47799-w.<\/span><\/li>\n<li><span style=\"color: #3366ff;\">Younis MA, Khalil IA, Abd Elwakil MM, Harashima H. <a style=\"color: #3366ff;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31403802\">A Multifunctional Lipid-Based Nanodevice for the Highly Specific Codelivery of Sorafenib and Midkine siRNA to Hepatic Cancer Cells.<\/a> Mol Pharm. 16(9):4031-4044 (2019). doi: 10.1021\/acs. molpharmaceut.9b00738.<\/span><\/li>\n<li>Kawamura E, Hibino M, Harashima H, Yamada Y. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31472283\">Targeted mitochondrial delivery of antisense RNA-containing nanoparticles by a MITO-Porter for safe and efficient mitochondrial gene silencing.<\/a> 49:178-188 (2019). doi: 10.1016\/ j.mito.2019.08.004.<\/li>\n<li>Kimura S, Khalil IA, Elewa YHA, Harashima H. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31526828\">Spleen selective enhancement of transfection activities of plasmid DNA driven by octaarginine and an ionizable lipid and its implications for cancer immunization.<\/a>\u3000J Control Release. 313: 70-79 (2019). doi: 10.1016\/j.jconrel.2019.09.009.<\/li>\n<li>Yamada Y, Fujishita N, Harashima H.\u3000<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31595823\">A nanocarrier for the mitochondrial delivery of nucleic acids to cardiomyocytes.<\/a>\u3000Nucleosides Nucleotides Nucleic Acids. 9:1-15 (2019). doi: 10.1080\/15257770.2019.1675167.<\/li>\n<li>Katayama T, Kinugawa S, Takada S, Furihata T, Fukushima A, Yokota T, Anzai T, Hibino M,\u00a0Harashima H, Yamada Y.\u3000<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31326598\/\">A mitochondrial delivery system using liposome-based nanocarriers that target myoblast cells.<\/a>\u3000Mitochondrion 49: 66-72 (2019).<\/li>\n<li>Nakamura T, Yamada Y, Sato Y, Khalil IA, Harashima H. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31306827\">Innovative nanotechnologies for enhancing nucleic acids\/gene therapy: Controlling intracellular trafficking to targeted biodistribution.<\/a> 218, 119329 (2019). doi: 10.1016\/j.biomaterials. 2019.119329.<\/li>\n<li>Sakurai Y, Harashima H. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31387408\">Hyaluronan-modified nanoparticles for tumor-targeting.<\/a> Expert Opin Drug Deliv. 16(9):915-936 (2019). doi: 10.1080\/17425247.2019. 1645115.<\/li>\n<li>Khalil IA, Sato Y, Harashima H.\u3000<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31432700\">Recent advances in the targeting of systemically administered non-viral gene delivery systems.<\/a> Expert Opin Drug Deliv. 16(10):1037-1050 (2019). doi: 10.1080\/17425247.2019.1656196.<\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Sakurai+Y&amp;cauthor_id=31756900\">Sakurai<\/a> Y,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Akita+H&amp;cauthor_id=31756900\">Akita<\/a> H,\u00a0Harashima H. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31756900\/?from_term=harashima+h&amp;from_format=abstract&amp;from_sort=date&amp;from_pos=3\">Targeting Tumor Endothelial Cells With Nanoparticles.<\/a> Int J Mol Sci , 20 (23): 5819 (2019) doi:\u00a0<a href=\"https:\/\/dx.doi.org\/10.3390%2Fijms20235819\">3390\/ijms20235819<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<h6>2020\u5e74\u3000\u8ad6\u6587\uff08\u539f\u8457\uff0b\u7dcf\u8aac\uff1a\u82f1\u6587\uff09\u539f\u8457\uff1a20\u3001\u7dcf\u8aac\uff1a8 Top10%\u88ab\u5f15\u7528\u8ad6\u6587\uff1a12 (42.9%)<\/h6>\n<ol>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Sakurai+Y&amp;cauthor_id=32091909\">Sakurai<\/a> Y,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Mizumura+W&amp;cauthor_id=32091909\">Mizumura<\/a> W,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Ito+K&amp;cauthor_id=32091909\">Ito<\/a> K,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Iwasaki+K&amp;cauthor_id=32091909\">Iwasaki<\/a> K,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Katoh+T&amp;cauthor_id=32091909\">Katoh<\/a> T,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Goto+Y&amp;cauthor_id=32091909\">Goto<\/a> Y,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Suga+H&amp;cauthor_id=32091909\">Suga<\/a> H,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Harashima+H&amp;cauthor_id=32091909\">Harashima<\/a> Improved Stability of siRNA-Loaded Lipid Nanoparticles Prepared With a PEG-Monoacyl Fatty Acid Facilitates Ligand-Mediated siRNA Delivery. Mol Pharm. 17(4):1397-1404 (2020). doi: <a href=\"https:\/\/doi.org\/10.1021\/acs.molpharmaceut.0c00087\">10.1021\/acs. molpharmaceut. 0c00087 <\/a><\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Sakurai+Y&amp;cauthor_id=32087973\">Sakurai<\/a> Y,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Kato+A&amp;cauthor_id=32087973\">Kato<\/a> A,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Harashima+H&amp;cauthor_id=32087973\">Harashima<\/a> Involvement of Caveolin-1-mediated Transcytosis in the Intratumoral Accumulation of Liposomes. Biochem Biophys Res Commun. 525(2):313-318 (2020) doi: <a href=\"https:\/\/doi.org\/10.1016\/j.bbrc.2020.02.086\">10.1016\/j.bbrc.2020.02.086 <\/a><\/li>\n<li>Hamada-Tsutsumi S, Onishi M, Matsuura K, Isogawa M, Kawashima K, Sato Y, Tanaka Y. Anti-Fibrotic Mechanisms of A Human MicroRNA miR-6133. Int J Mol Sci. 21:7251 (2020). doi: 10.3390\/ijms21197251.<\/li>\n<li>Abbasi S, Sato Y, Kajimoto K, Harashima H. New Design Strategies for Controlling the Rate of Hydrophobic Drug Release from Nanoemulsions in Blood Circulation. Mol Pharm. 17:3773-3782 (2020). doi: 10.1021\/acs.molpharmaceut.0c00542.<\/li>\n<li><span style=\"color: #3366ff;\">Hashiba A, Toyooka M, Sato Y, Maeki M, Tokeshi M, Harashima H. The use of design of experiments with multiple responses to determine optimal formulations for in vivo hepatic mRNA delivery. J Control Release. 327:467-476 (2020). doi: 10.1016\/j.jconrel.2020.08.031.<\/span><\/li>\n<li>Nakamura T, Yamada K, Sato Y, Harashima H. Lipid nanoparticles fuse with cell membranes of immune cells at low temperatures leading to the loss of transfection activity. Int J Pharm. 587:119652 (2020). doi: 10.1016\/j.ijpharm.2020.119652.<\/li>\n<li>Kimura N, Maeki M, Sato Y, Ishida A, Tani H, Harashima H, Tokeshi M. Development of a Microfluidic-Based Post-Treatment Process for Size-Controlled Lipid Nanoparticles and Application to siRNA Delivery. ACS Appl Mater Interfaces. 12:3401134020 (2020). doi: 10.1021\/acsami.0c05489.<\/li>\n<li><span style=\"color: #3366ff;\">Shobaki N, Sato Y, Suzuki Y, Okabe N, Harashima H. Manipulating the function of tumor-associated macrophages by siRNA-loaded lipid nanoparticles for cancer immunotherapy. J Control Release. 325:235-248 (2020). doi: 10.1016\/j.jconrel.2020.07.001.<\/span><\/li>\n<li><span style=\"color: #3366ff;\">Sato Y, Kinami Y, Hashiba K, Maeki M, Tokeshi M, Harahima H. Different kinetics for the hepatic uptake of lipid nanoparticles between the apolipoprotein E\/low density lipoprotein receptor and the N-acetyl-D-galactosamine\/asialoglycoprotein receptor pathway. J Control Release. 322:217-226 (2020). doi: 10.1016\/j.jconrel.2020.03.006.<\/span><\/li>\n<li><span style=\"color: #ff0000;\">Nakamura T, Kawai M, Sato Y, Maeki M, Tokeshi M, Harashima H. The effect of size and charge of lipid nanoparticles prepared by microfluidic mixing on their lymph node transitivity and distribution. Mol Pharm. 17:944-953 (2020). doi: 10.1021\/acs.molpharmaceut.9b01182.\u3000 &lt;Top1%&gt;<\/span><\/li>\n<li>Sato Y, Okabe N, Note Y, Hashiba K, Maeki M, Tokeshi M, Harashima H. Hydrophobic scaffolds of pH-sensitive cationic lipids contribute to miscibility with phospholipids and improve the efficiency of delivering short interfering RNA by small-sized lipid nanoparticles. Acta Biomaterialia. 102:341-350 (2020). doi: 10.1016\/j.actbio.2019.11.022.<\/li>\n<li>Yamada Y, Munechika R, Satrialdi, Kubota F, Sato Y, Sakurai Y, Harashima H. Mitochondrial Delivery of an Anticancer Drug Via Systemic Administration Using a Mitochondrial Delivery System that Inhibits the Growth of Drug-Resistant Cancer Engrafted on Mice. J Pharm Sci. 109:2493-2500 (2020). doi: 10.1016\/j.xphs.2020.04.020.<\/li>\n<li>Maeta M, Miura N, Tanaka H, Nakamura T, Kawanishi R, Nishikawa Y, Asano K, Tanaka M, Tamagawa S, Nakai K, Tange K, Yoshioka H, Harashima H, Akita H*. Vitamin E Scaffolds of pH-Responsive Lipid Nanoparticles as DNA Vaccines in Cancer and Protozoan Infection. Mol Pharm 17: 1237-1247 (2020).<\/li>\n<li>Masuda H, Nakamura T, Harashima H. Distribution of BCG-CWS loaded nanoparticles in the spleen after intravenous injection affects cytotoxic T lymphocyte activity. J Pharm Sci 109: 1943-1950 (2020).<\/li>\n<li><span style=\"color: #3366ff;\">Satrialdi, Munechika R, Biju V, Takano Y, Harashima H, Yamada Y., The optimization of cancer photodynamic therapy by utilization of a pi-extended porphyrin-type photosensitizer in combination with MITO-Porter. ChemCommun. 56: 1145-1148 (2020). doi: 10.1039\/d0cc90222e.<\/span><\/li>\n<li>Yamada Y, Fukuda Y, Sasaki D, Maruyama M, Harashima H, Development of a nanoparticle that releases nucleic acids in response to a mitochondrial environment. Mitochondrion. 52: 67-74 (2020). doi: 10.1016\/j.mito.2020.02.009.<\/li>\n<li><span style=\"color: #3366ff;\">Kawamura E, Maruyama M, Abe J, Sudo A, Takeda A, Takada S, Yokota T, Kinugawa S, Harashima H, Yamada Y, Validation of gene therapy for mutant mitochondria by delivering mitochondrial RNA using a MITO-Porter, a liposome-based nano device. Mol. Ther. \u2013 Nuceic Acids. 20: 687-698 (2020). doi: 10.1016\/j.omtn.2020.04.004.<\/span><\/li>\n<li>Yamada Y, Somiya K, Miyauchi A, Osaka H, Harashima H, Validation of a mitochondrial RNA therapeutic strategy using fibroblasts from a Leigh syndrome patient with a mutation in the mitochondrial ND3 gene. Sci. Rep. 10: 7511 (2020). doi: 10.1038\/s41598-020-64322-8.<\/li>\n<li>Yamada Y, Maruyama M, Kita T, Usami S, Kitajiri S, Harashima H, The use of a MITO-Porter to deliver exogenous therapeutic RNA to a mitochondrial disease\u2019s cell with a A1555G mutation in the mitochondrial 12S rRNA gene results in an increase in mitochondrial respiratory activity. Mitochondrion 55: 134-144 (2020). doi: 10.1016\/j.mito.2020.09.008.<\/li>\n<li>Yamada Y, Fujishita N, Harashima H.\u3000<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31595823\">A nanocarrier for the mitochondrial delivery of nucleic acids to cardiomyocytes.<\/a>\u3000Nucleosides Nucleotides Nucleic Acids 39: 141-155 (2020).<\/li>\n<li><span style=\"color: #3366ff;\">Kimura S,\u00a0Harashima H <a style=\"color: #3366ff;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33334049\/\">Current Status and Challenges Associated with CNS-Targeted Gene Delivery across the BBB.<\/a> 12(12):1216 (2020). doi: 10.3390\/pharmaceutics 12121216.<\/span><\/li>\n<li><span style=\"color: #3366ff;\">Khalil IA, Younis MA, Kimura S, Harashima H. <a style=\"color: #3366ff;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32238701\/\">Lipid Nanoparticles for Cell-Specific in Vivo Targeted Delivery of Nucleic Acids. <\/a>Biol Pharm Bull. 43(4):584-595 (2020). doi: 10.1248\/ bpb.b19-00743.<\/span><\/li>\n<li>Younis MA, Khalil IA, Harashima H. Gene Therapy for Hepatocellular Carcinoma; Highlighting the Journey from Theory to Clinical Applications. Adv. Therap. 3: 2000087 (2020).<\/li>\n<li><span style=\"color: #3366ff;\">Nakamura T, Harashima H. Dawn of lipid nanoparticles in lymph node targeting: potential in cancer immunotherapy. Adv Drug Deliv Rev 167: 78-88 (2020).<\/span><\/li>\n<li>Yamada Y, Sato Y, Nakamura T, Harashima H. Evolution of Drug Delivery System from Viewpoint of Controlled Intracellular Trafficking and Selective Tissue Targeting toward Future Nanomedicine. J Control Release. 327:533-545 (2020). doi: 10.1016\/j.jconrel.2020.09.007.<\/li>\n<li><span style=\"color: #3366ff;\">Yamada Y, Takano Y, Satrialdi, Abe J, Hibino M, Harashima H. Therapeutic strategies for regulating mitochondrial oxidative stress. Biomolecules 10: 83 (2020). doi: 10.3390\/ biom10010083.<\/span><\/li>\n<li><span style=\"color: #3366ff;\">Yamada Y, Ito M, Arai M, Hibino M, Tsujioka T, Harashima H. Challenges in promoting mitochondrial transplantation therapy. International Journal of Molecular Sciences 21: 6365 (2020). doi: 10.3390\/ijms21176365.<\/span><\/li>\n<li><span style=\"color: #3366ff;\">Yamada Y, Satrialdi, Hibino M, Sasaki D, Jiro A, Harashima H. Power of mitochondrial drug delivery systems to produce innovative nanomedicines. Adv. Drug. Deliv. Rev. 154-155: 187-209 (2020). doi: 10.1016\/j.addr.2020.09.010.<\/span><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<h6>2021\u5e74\u3000\u8ad6\u6587\uff08\u539f\u8457\uff0b\u7dcf\u8aac\uff1a\u82f1\u6587\uff09\u539f\u8457\uff1a13\u3001\u7dcf\u8aac\uff1a3 Top10%\u88ab\u5f15\u7528\u8ad6\u6587\uff1a7 (43.8%)<\/h6>\n<ol>\n<li><span style=\"color: #3366ff;\">Kimura S, Khalil IA, Elewa YHA,\u00a0Harashima H. <a style=\"color: #3366ff;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33422500\/\">Novel lipid combination for delivery of plasmid DNA to immune cells in the spleen.<\/a> J Control Release. 330:753-764 (2021). doi: 10.1016\/ j.jconrel.2021.01.005.<\/span><\/li>\n<li><span style=\"color: #3366ff;\">Suzuki Y, Onuma H, Sato R, Sato Y, Hashiba A, Maeki M, Tokeshi M, Kayesh MEH, Kohara M, Tsukiyama-Kohara K, Harashima H, Lipid nanoparticles loaded with ribonucleoprotein-oligonucleotide complexes synthesized using a microfluidic device exhibit robust genome editing and hepatitis B virus inhibition, J Control Release, 330: 61-71 (2021).<\/span><\/li>\n<li>Kimura N, Maeki M, Sasaki K. Sato Y, Ishida A, Tani H, Harashima H, Tokeshi M <a href=\"https:\/\/apps.webofknowledge.com\/full_record.do?product=WOS&amp;search_mode=GeneralSearch&amp;qid=2&amp;SID=E2OUCRsxoWqW9tyfSDR&amp;page=2&amp;doc=17\">Three-dimensional, symmetrically assembled microfluidic device for lipid nanoparticle production<\/a> RSC Advances\u00a011(3): 1430-1439 (2021)<\/li>\n<li><span style=\"color: #3366ff;\">Younis MA, Khalil IA, Elewa YHA, Kon Y,\u00a0Harashima H. <a style=\"color: #3366ff;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33484779\/\">Ultra-small lipid nanoparticles encapsulating sorafenib and midkine-siRNA selectively-eradicate sorafenib-resistant hepatocellular carcinoma in vivo.<\/a> J Control Release. 331:335-349 (2021). doi: 10.1016\/ j.jconrel.2021.01.021. Online ahead of print.PMID:\u00a033484779<\/span><\/li>\n<li><span style=\"color: #3366ff;\">Hagino Y, Khalil IA, Kimura S, Kusumoto K,\u00a0Harashima H. <a style=\"color: #3366ff;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33492961\/\">GALA-Modified Lipid Nanoparticles for the Targeted Delivery of Plasmid DNA to the Lungs.<\/a> Mol Pharm. 18(3):878-888 (2021). doi: 10.1021\/acs.molpharmaceut.0c00854.<\/span><\/li>\n<li>Sanghani A, Kafetzis KN, Sato Y, Elboraie S, Fajardo-Sanchez J,\u00a0Harashima H, Tagalakis AD, Yu-Wai-Man C. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33805660\/\">Novel PEGylated Lipid Nanoparticles Have a High Encapsulation Efficiency and Effectively Deliver MRTF-B siRNA in Conjunctival Fibroblasts.<\/a> 13(3):382 (2021). doi: 10.3390\/ pharmaceutics 13030382.<\/li>\n<li>Abbasi, H. Higashino, Y. Sato, K. Minami, M. Kataoka, S. Yamashita and H. Harashima.\u3000 Maximizing the Oral Bioavailability of Poorly Watersoluble Drug Using Novel Oil-like Material in Lipid-based Formulations. Mol. Pharm. 17: 3773-3782 (2020).<\/li>\n<li>A. Elwakil, T. Gao, T. Isono, Y. Sato, Y. Elewa, T. Satoh and H. Harashima. Engineered \u0190-decalactone lipomers by-pass the liver to selectively in vivo deliver mRNA to the lungs without targeting ligands Materials Horizons 8(8):2251-2259 (2021). doi: 10.1039\/d1mh00185j.<\/li>\n<li>Baudi I, Isogawa M, Moalli F, Onishi M, Kawashima K, Ishida Y, Tateno C, Sato Y,\u00a0Harashima H, Ito H, Ishikawa T, Wakita T, Iannacone M, Tanaka Y. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33979382\/\">Interferon signaling suppresses the unfolded protein response and induces cell death in hepatocytes accumulating hepatitis B surface antigen.<\/a>\u3000PLoS Pathog. 17(5):e1009228 (2021).<\/li>\n<li><span style=\"color: #ff0000;\">Nakamura T, Sato T, Endo R, Sasaki S, Takahashi N, Sato Y, Hyodo M, Hayakawa Y,\u00a0Harashima H. <a style=\"color: #ff0000;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34215690\/\">STING agonist loaded lipid nanoparticles overcome anti-PD-1 resistance in melanoma lung metastasis via NK cell activation.<\/a> J Immunother Cancer. 9(7):e002852 (2021).\u3000 &lt;Top1%&gt;<\/span><\/li>\n<li>Satrialdi, Takano Y, Hirate E, Ushijima N, Harashima H, Yamada Y. An effective in vivo mitochondria-targeting nanocarrier combined with a pai-extended porphyrin-type photosensitizer. Nanoscale Advances 3: 5919-5927 (2021)<\/li>\n<li>Nakamura T, Nakade T, Yamada K, Sato Y,\u00a0Harashima H. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34592399\/\">The hydrophobic tail of a pH-sensitive cationic lipid influences siRNA transfection activity and toxicity in human NK cell lines.<\/a> Int J Pharm. 609:121140 (2021). doi: 10.1016\/j.ijpharm.2021.121140.<\/li>\n<li><span style=\"color: #3366ff;\">Hiradate R, Khalil IA, Matsuda A, Sasaki M, Hida K,\u00a0Harashima H. <a style=\"color: #3366ff;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33038450\/\">A novel dual-targeted rosiglitazone-loaded nanoparticle for the prevention of diet-induced obesity via the browning of white adipose tissue.<\/a> Control Release. 329:665-675 (2021).<\/span><\/li>\n<li><span style=\"color: #3366ff;\">Sato Y, Nakamura T, Yamada Y,\u00a0Harashima H. <a style=\"color: #3366ff;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33358975\/\">The nanomedicine rush: New strategies for unmet medical needs based on innovative nano DDS.<\/a> J Control Release. 330:305-316 (2021).<\/span><\/li>\n<li>Yamada Y,\u00a0Harashima H. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34118041\/\">Targeting the Mitochondrial Genome Via a MITO-Porter : Evaluation of mtDNA and mtRNA Levels and Mitochondrial Function.<\/a> Methods Mol Biol. 2275:227-245 (2021).<\/li>\n<li>Sato Y, Development of lipid nanoparticles for the delivery of macromolecules based on the molecular design of pH-sensitive cationic lipids, Chem Pharm Bull, 69: 1141-1159 (2021).<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<h6>2022\u5e74\u3000\u8ad6\u6587\uff08\u539f\u8457\uff0b\u7dcf\u8aac\uff1a\u82f1\u6587\uff09\u539f\u8457\uff1a13\u3001\u7dcf\u8aac\uff1a6 Top10%\u88ab\u5f15\u7528\u8ad6\u6587\uff1a7 (36.8%)<\/h6>\n<ol>\n<li>Khalifa AM, Nakamura T*, Sato Y, Sato T, Hyodo M, Hayakawa Y, Harashima H*. Interval- and cycle-dependent combined effect of STING agonist loaded lipid nanoparticles and a PD-1 antibody. Int J Pharm 624: 122034 (2022). doi.org\/10.1016\/j.ijpharm.2022.122034.<\/li>\n<li>Fukui T, Tateno H, Nakamura T*, Yamada Y, Sato Y, Iwasaki N, Harashima H, Kadoya K*. Retrograde axonal transport of liposomes from peripheral tissue to spinal cord and DRGs by optimized phospholipid and CTB modification. Int J Mol Sci 23: 6661 (2022). org\/10.3390\/ijms23126661.<\/li>\n<li><span style=\"color: #3366ff;\">Nakamura T*, Kawakami K, Nomura M, Sato Y, Hyodo M, Hatakeyama H, Hayakawa Y, Harashima H*. Combined nano cancer immunotherapy based on immune status in a tumor microenvironment. J Control Release 345: 200-213 (2022). doi: 10.1016\/j.jconrel.2022.03.026.<\/span><\/li>\n<li>Maishi N, Sakurai Y, Hatakeyama H, Umemiya Y, Nakamura T, Endo R, Alam M, Li C, Annan, D, Kikuchi H, Morimoto H, Morimoto M, Akiyama K, Ohga N, Hida Y, Harashima H, Hida K*. Novel antiangiogenic therapy targeting biglycan using tumor endothelial cell-specific liposomal siRNA delivery system. Cancer Sci 113: 1855-1867 (2022) doi: 10.1111\/cas.15323.<\/li>\n<li>Komuro M, Nagane M*, Endo R, Nakamura T, Miyamoto T, Niwa C, Fukuyama T, Harashima H, Akihara N, Kamiie J, Suzuki R, Yamashita T. Glucosylceramide in T cells regulates the pathology of inflammatory bowel disease. Biochem Biophys Res Commun 599: 24-30 (2022). doi: 10.1016\/j.bbrc.2022.02.004.<\/li>\n<li><span style=\"color: #3366ff;\">Nakamura T*, Haloho SEE, Harashima H*. Intravenous liposomal vaccine enhances CTL generation, but not until antigen presentation. J Control Release 343: 1-12 (2022). doi: 10.1016\/ j.jconrel.2022.01.020.<\/span><\/li>\n<li><span style=\"color: #3366ff;\">Sasaki K, Sato Y*, Okuda K, Iwakawa K, Harashima H*. mRNA-loaded lipid nanoparticles targeting dendritic cells for cancer immunotherapy. Pharmaceutics 14(8): 1572 (2022) doi: 10.3390\/pharmaceutics14081572<\/span><\/li>\n<li><span style=\"color: #3366ff;\">Okuda K, Sato Y*, Kazuki Iwakawa, Sasaki K, Nana Okabe, Maeki M, Tokeshi M, Harashima H*. On the size-regulation of RNA-loaded lipid nanoparticles synthesized by microfluidic device. J Control Release 348: 648-659 (2022) doi: 10.1016\/j.jconrel.2022.06.017<\/span><\/li>\n<li>Yamada Y, Ishimaru T, Ikeda K, Harashima H, Validation of the mitochondrial delivery of vitamin B<sub>1<\/sub> to enhance ATP production using SH-SY5Y cells, a model neuroblast. J. Pharm. Sci. 111: 432-439 (2022)<\/li>\n<li>Sasaki D, Abe J, Takeda A, Harashima H, Yamada Y, Transplantation of MITO cells, mitochondria activated cardiac progenitor cells, to the ischemic myocardium of mouse enhances the therapeutic effect. Sci. Rep. 12: 4344 (2022)<\/li>\n<li>Yamada Y, Ishimaru T, Harashima H, Validation of a therapeutic strategy involving the mitochondrial delivery of thiamine pyrophosphate using a brain damage induced mouse model. Clin. Transl. Disc. 2: e43 (2022)<\/li>\n<li>Alhasan H, Terkawi MA, Matsumae G, Ebata T, Tian Y, Shimizu T, Nishida Y, Yokota S, Garcia-Martin F, M Abd Elwakil M, Takahashi D, Younis MA,\u00a0Harashima H, Kadoya K, Iwasaki. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35798730\/\">Inhibitory role of Annexin A1 in pathological bone resorption and therapeutic implications in periprosthetic osteolysis.<\/a> Nat Commun. 7;13(1):3919 (2022).<\/li>\n<li><span style=\"color: #3366ff;\">Tsujioka T, Sasaki D, Takeda A,\u00a0Harashima H, Yamada Y. <a style=\"color: #3366ff;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35008537\/\">Resveratrol-Encapsulated Mitochondria-Targeting Liposome Enhances Mitochondrial Respiratory Capacity in Myocardial Cells.<\/a> Int J Mol Sci. 23(1):112 (2022).<\/span><\/li>\n<li>Kimura S,\u00a0Harashima H. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34472471\/\">Non-invasive gene delivery across the blood-brain barrier: present and future perspectives.<\/a> Neural Regen Res. 2022 Apr;17(4):785-787. doi: 10.4103\/1673-5374. 320981.<\/li>\n<li><span style=\"color: #339966;\">Younis MA, Tawfeek HM, Abdellatif AAH, Abdel-Aleem JA,\u00a0Harashima H. <a style=\"color: #339966;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34929251\/\">Clinical translation of nanomedicines: Challenges, opportunities, and keys.<\/a> Adv Drug Deliv Rev. 181:114083 (2022). doi: 10.1016\/j.addr.2021.114083. &lt;Top0.1%&gt;<\/span><\/li>\n<li>Yamada Y, Ishizuka S, Arai M, Maruyama M, Harashima H. Recent advances in delivering RNA-based therapeutics to mitochondria. Expert Opin. Biol. Ther. 11: 1-11 (2022).<\/li>\n<li>Nakamura T*, Isoda N*, Sakoda Y, Harashima H. Strategies for fighting pandemic virus infections: integration of virology and drug delivery. J Control Release 343: 361-378 (2022). doi: 10.1016\/j.jconrel.2022.01.046.<\/li>\n<li>Yamada Y, Sato Y, Nakamura T, Harashima H. Innovative cancer nanomedicine based on immunology, gene editing, intracellular trafficking control. J Control Release 348: 357-369 (2022). doi: 10.1016\/j.jconrel.2022.05.033.<\/li>\n<li><span style=\"color: #ff0000;\">Nakamura T, Sato Y, Yamada Y, Elwakil MMA, Kimura S, Younis MA, Harashima H*. Extrahepatic targeting of lipid nanoparticles in vivo with intracellular targeting for future nanomedicines. Adv Drug Deliv Rev 188: 114417 (2022). doi.org\/10.1016\/j.addr.2022.114417 &lt;Top1%&gt;<\/span><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<h6>2023\u5e74\u3000\u8ad6\u6587\uff08\u539f\u8457\uff0b\u7dcf\u8aac\uff1a\u82f1\u6587\uff09\u539f\u8457\uff1a18\u3001\u7dcf\u8aac\uff1a2 Top10%\u88ab\u5f15\u7528\u8ad6\u6587\uff1a9 (45.0%)<\/h6>\n<ol>\n<li>Leung J, Strong C, Badior K, Robertson M, Wu X, Meledeo MA, Kang E, Paul M, Sato Y, Harashima H, Cap AP, Devine DV, Jan E, Cullis PR, Kastrup CJ. Genetically engineered transfusable platelets using mRNA lipid nanoparticles. Sci Adv 9(48): eadi0508 (2023). doi.org\/10.1126\/sciadv.adi0508<\/li>\n<li><span style=\"color: #3366ff;\">Younis MA, Sato Y, Elewa YHA, Kon Y, Harashima H. Reprogramming activated hepatic stellate cells by siRNA-loaded nanocarriers reverses liver fibrosis in mice. J Control Release 361: 592-603 (2023). doi.org\/10.1016\/j.jconrel.2023.08.021<\/span><\/li>\n<li>Elwakil M, Suzuki R, Khalifa AM, Elshami RM, Isono T, Elewa Y, Sato Y, Nakamura T, Satoh T, Harashima H. Harnessing Topology and Stereochemistry of Glycidylamine-Derived Lipid Nanoparticles for in vivo mRNA Delivery to Immune cells and their Application for Cancer Vaccination. Adv Funct Mater 2303795 (2023). doi.org\/10.1002\/adfm.202303795<\/li>\n<li>Nakamura T, Nakade T, Sato Y, Harashima H. Delivering mRNA to a human NK cell line, NK-92 cells, by lipid Int J Pharm 636: 122810 (2023). doi.org\/10.1016\/j.ijpharm. 2023.122810<\/li>\n<li><span style=\"color: #3366ff;\">Kafetzis KN, Papalamprou N, McNulty E, Thong KX, Sato Y, Mironov A, Purohit A, Welsby P, Harashima H, Yu-Wai-Man C, Taga-lakis AD. The effect of cryoprotectants and storage conditions on the transfection efficiency, stability and safety of lipid-based nanoparticles for mRNA and DNA delivery. Adv Healthcare Mater 12: 2203022 (2023). doi.org\/10.1002\/adhm.202203022<\/span><\/li>\n<li><span style=\"color: #3366ff;\">Onuma H, Sato Y*, Harashima H*. Lipid nanoparticle-based ribonucleoprotein delivery for in vivo genome editing. J Control Release 255: 406-416 (2023). org\/10.1016\/j.jconrel. 2023.02.008<\/span><\/li>\n<li><span style=\"color: #3366ff;\">Maeki M, Okada Y, Uno S, Sugiura K, Suzuki Y, Okuda K, Sato Y, Ando M, Yamazaki H, Takeuchi M, Ishida A, Tani H, Harashima H, Tokeshi M. Mass production system for RNA-loaded lipid nanoparticles using piling up microfluidic devices. Appl Mater Today 31: 101754 (2023). org\/10.1016\/j.apmt.2023.101754<\/span><\/li>\n<li><span style=\"color: #ff0000;\">Younis MA, Sato Y, Elewa YHA, Kon Y, Harashima H. Self-homing nanocarriers for mRNA delivery to the activated hepatic stellate cells in liver fibrosis. J Control Release 353: 685-698 (2023). org\/10.1016\/j.jconrel.2022.12.020 &lt;Top1%&gt;<\/span><\/li>\n<li><span style=\"color: #3366ff;\">Luo J, Tan G, Thong KX, Kafetzis KN, Vallabh N, Sheridan CM, Sato Y, Harashima H, Tagalakis AD, and Yu-Wai-Man C. Non-Viral Gene Therapy in Trabecular Meshwork Cells to Prevent Fibrosis in Minimally Invasive Glaucoma Surgery. Pharmaceutics 14: 2472 (2022). org\/10.3390\/pharmaceutics14112472<\/span><\/li>\n<li><span style=\"color: #ff0000;\">Hashiba K*, Sato Y*, Taguchi M, Sakamoto S, Otsu A, Maeda Y, Shishido T, Murakawa M, Okazaki A, Harsshima H*. Branching ionizable lipids can enhance the stability, fusogenicity, and functional delivery of mRNA. Small Sci 3: 2200071 (2023). doi.org\/10.1002\/smsc.202200071. &lt;Top1%&gt;<\/span><\/li>\n<li>Kubota F, Satrialdi, Takano Y, Maeki M, Tokeshi M, Harashima H, Yamada Y\u2020,#, Fine-tuning the encapsulation of a photosensitizer in nanoparticles reveals the relationship between internal structure and phototherapeutic effects. J. Biophotonics. 16(3): e202200119 (2023). DOI: 10.1002\/jbio.202200119.<\/li>\n<li><span style=\"color: #3366ff;\">Hori I, Harashima H, Yamada Y*, Development of a mitochondrial targeting lipid nanoparticle encapsulating berberine. Int. J. Mol. Sci. 24(2): 903 (2023). DOI: 10.3390\/ijms24020903.<\/span><\/li>\n<li>Yamaguchi A, Mukai Y, Sakuma T, Narumi K, Furugen A, Yamada Y, Kobayashi M., Monocarboxylate transporter 4 involves in energy metabolism and drug sensitivity in hypoxia. Sci Rep. 13(1): 1501 (2023).<\/li>\n<li>Hibino M, Maeki M, Tokeshi M, Ishitsuka Y, Harashima H, Yamada Y*, A System that Delivers an Antioxidant to Mitochondria for the treatment of Drug-Induced Liver Injury. Sci. Rep. 13(1): 6961 (2023). DOI: 10.1038\/s41598-023-33893-7.<\/li>\n<li>Tsuneishi T, Kojima K, Kubota F, Harashima H, Yamada Y, Sudo Y, Development of light-induced disruptive liposomes (LiDL) as a photoswitchable carrier for intracellular substance delivery. Chem. Commun. 59(49): 7591-7594 (2023). DOI: 10.1039\/d3cc02056h.<\/li>\n<li>Yamada Y*, Daikuhara S, Tamura A, Nishida K, Yui N, Harashima H, Differences in the Intracellular Localization of Methylated \u03b2-Cyclodextrins-Threaded Polyrotaxanes Lead to Different Cellular States. Biomolecules. 13 (6): 903 (2023). DOI: 10.3390\/biom13060903.<\/li>\n<li><span style=\"color: #ff0000;\">Kimura S,\u00a0Harashima H. <a style=\"color: #ff0000;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37004796\/\">On the mechanism of tissue-selective gene delivery by lipid nanoparticles.<\/a> J Control Release. (2023). doi: 10.1016\/ j.jconrel.2023.03.052. &lt;Top1%&gt;<\/span><\/li>\n<li>Zhao H, Naganawa R, Yamada Y<sup>#<\/sup>, Osakada Y, Fujitsuka M, Mitomo H, Miyatake Y, Harashima H, Biju V, Takano Y<sup>#<\/sup>, \u03c0-extended porphyrin-based near-infrared photosensitizers for mitochondria-targeted photodynamic therapy. J. Photochem. Photobiol. A Chem. 449: 115397 (2024). DOI: 10.1016\/j.jphotochem.2023.115397.<\/li>\n<li>Yamada Y, Harashima H. RNA Delivery to Mitochondria. Handb Exp Pharmacol. (2023). Springer. DOI: 10.1007\/164_2023_650<\/li>\n<li>Harashima H. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38044089\/\">Innovative System for Delivering Nucleic Acids\/Genes Based on Controlled Intracellular Trafficking as Well as Controlled Biodistribution for Nanomedicines.<\/a> Biol Pharm Bull. 46(12):1648-1660 (2023). doi: 10.1248\/bpb.b23-00634.<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<h4 id=\"002\">\u5927\u578b\u5171\u540c\u7814\u7a76\u8cbb\uff08\u5e74\u9593500\u4e07\u5186\u4ee5\u4e0a\uff09<\/h4>\n<p>5\u5e74\u9593\u5168\u4f53\u300018\u4ef6\u3001\u7dcf\u984d\uff1a209,973,660\u5186\u300011,665,203\u5186\/\u4ef6<\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<h4 id=\"003\">\u7523\u696d\u5275\u51fa\u90e8\u9580\u306e\u5275\u8a2d<\/h4>\n<p>\u4f01\u696d\u540d\uff1a\u30eb\u30ab\u30fb\u30b5\u30a4\u30a8\u30f3\u30b9\u682a\u5f0f\u4f1a\u793e<br \/>\n\u8b1b\u5ea7\u540d\uff1a\u30d0\u30a4\u30aaDDS\u5b9f\u7528\u5316\u5206\u91ce<br \/>\n\u5171\u540c\u7814\u7a76\u671f\u9593\uff1a2020\u5e74\uff5e2023\u5e74<br \/>\n\u4f01\u696d\u7814\u7a76\u8005\uff08\u7279\u4efb\u6559\u54e1\uff09\u540d\uff1a\u5ddd\u702c\u82b3\u6075\u3001\u5317\u5c3b\u771f\u4e00\u90ce\u3001\u698a\u539f\u572d\u4e00\u3001\u67f4\u7530\u8cb4\u5f18<br \/>\n\u3000\u3000\u3000\u3000\u3000\u7814\u7a76\u88dc\u52a9\u30fb\u4e8b\u52d9\u54e1\uff1a \u6797\u7d14\u5b50\u3001\u68ee\u5ddd\u5f13\u7d75\u3001\u92f8\u5c4b\u9ebb\u5b50<br \/>\n\u5927\u5b66\u6559\u54e1\u540d\uff1a\u5c71\u7530\u52c7\u78e8\u3001\u539f\u5cf6\u79c0\u5409\u3001\u6e21\u6176\u6b21\u5b66<br \/>\n\u5171\u540c\u7814\u7a76\u8cbb\uff08\u76f4\u63a5\u7d4c\u8cbb\u30fb\u9593\u63a5\u7d4c\u8cbb\uff09\uff1a<br \/>\n2020\u5e74\uff5e2023\u5e74\u306e\u9593\u6bce\u5e74<br \/>\n\u7814\u7a76\u8cbb4,583,846\u5186\u3001\u5b66\u8853\u8ca2\u732e\u8cbb1,000,000\u5186\u3001\u7523\u5b66\u9023\u643a\u63a8\u9032\u7d4c\u8cbb1,675,154\u5186\u3001\u7814\u7a76\u6599 2,058,000\u5186\u3001\u30aa\u30fc\u30d7\u30f3\u30e9\u30dc\u5229\u7528\u6599 1,230,000\u5186<br \/>\n\u5e74\u9593\u7dcf\u984d: 10,547,000\u5186<\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<h4 id=\"004\">\u7279\u8a31<\/h4>\n<p>\u975e\u516c\u958b<\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<h4 id=\"005\">\u533b\u5e2b\u30fb\u4f01\u696d\u3068\u306e\u5171\u540c\u7814\u7a76<\/h4>\n<p>\u975e\u516c\u958b<\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<h4 id=\"006\">\u7af6\u4e89\u7684\u8cc7\u91d1<\/h4>\n<h5>\u00a0<\/h5>\n<h5>\u2160. \u79d1\u7814\u8cbb\u30fb\u8ca1\u56e3<\/h5>\n<p><span style=\"color: #ff0000;\">5\u5e74\u9593\u5408\u8a08\u3000\u79d1\u7814\u8cbb\uff1a176,770,000\u5186\u3000\u8ca1\u56e3\uff1a39,600,000\u5186\u3000\u7dcf\u984d\uff1a216,370,000\u5186<\/span><\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<h6><span style=\"color: #3366ff;\">2019\u5e74\u3000\u79d1\u7814\u8cbb\uff1a40,300,000\u5186\u3000\u8ca1\u56e3\uff1a10,000,000\u5186<\/span><\/h6>\n<p>\u7814\u7a76\u7a2e\u76ee\uff1a\u57fa\u76e4\u7814\u7a76(A)\uff08\u4e00\u822c\uff09<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u539f\u5cf6\u79c0\u5409<br \/>\n\u7814\u7a76\u5206\u62c5\u8005\uff1a\u4f50\u85e4\u60a0\u4ecb\u3001\u4e2d\u6751\u5b5d\u53f8\u3001\u5c71\u7530\u52c7\u78e8<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u5f8b\u901f\u6bb5\u968e\u306b\u57fa\u3065\u3044\u305f\u30a6\u30a4\u30eb\u30b9\u3092\u51cc\u99d5\u3059\u308b\u9769\u65b0\u7684\u533b\u85ac\u5206\u5b50\u9001\u9054\u30b7\u30b9\u30c6\u30e0\u306e\u5275\u88fd<br \/>\n\u7814\u7a76\u671f\u9593\uff1a2019\u5e74\u5ea6\uff5e2022\u5e74\u5ea6<br \/>\n\u7814\u7a76\u8cbb2019\u5e74\uff08\u76f4\u63a5\uff09\uff1a1490\u4e07\u5186<br \/>\n\u7814\u7a76\u8cbb2019\u5e74\uff08\u9593\u63a5\uff09\uff1a447\u4e07\u5186<br 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\/>\n\u8ab2\u984c\u756a\u53f7\uff1a17H05052<\/p>\n<p>\u7814\u7a76\u7a2e\u76ee\uff1a\u6311\u6226\u7684\u7814\u7a76\uff08\u840c\u82bd\uff09<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u4f50\u85e4\u60a0\u4ecb<br \/>\n\u7814\u7a76\u5206\u62c5\u8005\uff1a<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u7d44\u7e54\u6d78\u900f\u529b\u306b\u512a\u308c\u305fsiRNA\u642d\u8f09\u6975\u5c0f\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u306b\u3088\u308b\u65b0\u898f\u304c\u3093\u6cbb\u7642<br \/>\n\u7814\u7a76\u671f\u9593\uff1a2018\u5e74\u5ea6\uff5e2019\u5e74\u5ea6<br \/>\n\u7814\u7a76\u8cbb2019\u5e74\uff08\u76f4\u63a5\uff09\uff1a240\u4e07\u5186<br \/>\n\u7814\u7a76\u8cbb2019\u5e74\uff08\u9593\u63a5\uff09\uff1a72\u4e07\u5186<br \/>\n\u8ab2\u984c\u756a\u53f7\uff1a18K19889<\/p>\n<p>\u7814\u7a76\u7a2e\u76ee\uff1a\u516c\u76ca\u8ca1\u56e3\u6cd5\u4eba\u6b66\u7530\u79d1\u5b66\u632f\u8208\u8ca1\u56e3\u30002019\u5e74\u5ea6\u85ac\u5b66\u7cfb\u7814\u7a76\u52a9\u6210<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u5c71\u7530\u52c7\u78e8<br \/>\n\u7814\u7a76\u5206\u62c5\u8005\uff1a\u306a\u3057<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u5fc3\u7b4b\u75c7\u6cbb\u7642\u7528\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\uff24\uff24\uff33\u306e\u958b\u767a<br \/>\n\u7814\u7a76\u671f\u9593\uff1a2019-2020\u5e74\u5ea6<br \/>\n\u7814\u7a76\u8cbb2019\u5e74\uff08\u76f4\u63a5\uff09\uff1a200\u4e07\u5186<br \/>\n\u7814\u7a76\u8cbb2019\u5e74\uff08\u9593\u63a5\uff09\uff1a\u306a\u3057<br \/>\n\u8ab2\u984c\u756a\u53f7\uff1a\u306a\u3057<\/p>\n<p>\u7814\u7a76\u7a2e\u76ee\uff1a\u516c\u76ca\u8ca1\u56e3\u6cd5\u4eba\u4e0a\u539f\u8a18\u5ff5\u751f\u547d\u79d1\u5b66\u8ca1\u56e3\u30002019\u5e74\u5ea6\u7814\u7a76\u52a9\u6210\u91d1<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u5c71\u7530\u52c7\u78e8<br \/>\n\u7814\u7a76\u5206\u62c5\u8005\uff1a\u306a\u3057<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a19\u7684\u578b\u30bf\u30a6\u30ea\u30f3\u5c01\u5165DDS\u306e\u69cb\u7bc9<br \/>\n\u7814\u7a76\u671f\u9593\uff1a2019-2020\u5e74\u5ea6<br \/>\n\u7814\u7a76\u8cbb2019\u5e74\uff08\u76f4\u63a5\uff09\uff1a500\u4e07\u5186<br \/>\n\u7814\u7a76\u8cbb2019\u5e74\uff08\u9593\u63a5\uff09\uff1a\u306a\u3057<br \/>\n\u8ab2\u984c\u756a\u53f7\uff1a\u306a\u3057<\/p>\n<p>\u7814\u7a76\u7a2e\u76ee\uff1a\u516c\u76ca\u8ca1\u56e3\u6cd5\u4eba\u6301\u7530\u8a18\u5ff5\u533b\u5b66\u85ac\u5b66\u632f\u8208\u8ca1\u56e3\u30002019\u5e74\u5ea6\u6301\u7530\u8a18\u5ff5\u7814\u7a76\u52a9\u6210\u91d1<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u4e2d\u6751\u5b5d\u53f8<br \/>\n\u7814\u7a76\u5206\u62c5\u8005\uff1a\u306a\u3057<br 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\/>\n\u7814\u7a76\u671f\u9593\uff1a2020-2021\u5e74\u5ea6<br \/>\n\u7814\u7a76\u8cbb2020\u5e74\uff08\u76f4\u63a5\uff09\uff1a200\u4e07\u5186<br \/>\n\u7814\u7a76\u8cbb2020\u5e74\uff08\u9593\u63a5\uff09\uff1a\u306a\u3057<br \/>\n\u8ab2\u984c\u756a\u53f7\uff1a\u306a\u3057<\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<h6>\u00a0<\/h6>\n<h6><span style=\"color: #3366ff;\">2021\u5e74\u3000\u79d1\u7814\u8cbb\uff1a24,570,000\u5186\u3000\u8ca1\u56e3\uff1a7,000,000\u5186<\/span><\/h6>\n<p>\u7814\u7a76\u7a2e\u76ee\uff1a\u57fa\u76e4\u7814\u7a76(A)\uff08\u4e00\u822c\uff09<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u539f\u5cf6\u79c0\u5409<br \/>\n\u7814\u7a76\u5206\u62c5\u8005\uff1a\u4f50\u85e4\u60a0\u4ecb\u3001\u4e2d\u6751\u5b5d\u53f8\u3001\u5c71\u7530\u52c7\u78e8<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u5f8b\u901f\u6bb5\u968e\u306b\u57fa\u3065\u3044\u305f\u30a6\u30a4\u30eb\u30b9\u3092\u51cc\u99d5\u3059\u308b\u9769\u65b0\u7684\u533b\u85ac\u5206\u5b50\u9001\u9054\u30b7\u30b9\u30c6\u30e0\u306e\u5275\u88fd<br 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\/>\n\u7814\u7a76\u8cbb2022\u5e74\uff08\u76f4\u63a5\uff09\uff1a450\u4e07\u5186<br \/>\n\u7814\u7a76\u8cbb2022\u5e74\uff08\u9593\u63a5\uff09\uff1a135\u4e07\u5186<br \/>\n\u8ab2\u984c\u756a\u53f7\uff1a20H 04523<\/p>\n<p>\u7814\u7a76\u7a2e\u76ee\uff1a\u6311\u6226\u7684\u7814\u7a76(\u840c\u82bd)<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u5c71\u7530\u52c7\u78e8<br \/>\n\u7814\u7a76\u5206\u62c5\u8005\uff1a\u306a\u3057<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u8133\u75be\u60a3\u6cbb\u7642\u3092\u5b9f\u73fe\u3059\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a19\u7684\u578b\u30ca\u30ce\u30ab\u30d7\u30bb\u30eb\u306e\u958b\u767a<br \/>\n\u7814\u7a76\u671f\u9593\uff1a2022-2024\u5e74\u5ea6<br \/>\n\u7814\u7a76\u8cbb2022\u5e74\uff08\u76f4\u63a5\uff09\uff1a150\u4e07\u5186<br \/>\n\u7814\u7a76\u8cbb2022\u5e74\uff08\u9593\u63a5\uff09\uff1a45\u4e07\u5186<br \/>\n\u8ab2\u984c\u756a\u53f7\uff1a22K19928<\/p>\n<p>\u7814\u7a76\u7a2e\u76ee\uff1a\u57fa\u76e4\u7814\u7a76\uff08B\uff09<br 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\/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u30ca\u30ceDDS\u3067\u6311\u3080\u816b\u760d\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u3092\u6a19\u7684\u3068\u3057\u305f\u65b0\u6a5f\u8ef8\u306e\u304c\u3093\u6cbb\u7642\u6cd5\u306e\u958b\u767a<br \/>\n\u7814\u7a76\u671f\u9593\uff1a2022\u5e74\u5ea6\uff5e2024\u5e74\u5ea6<br \/>\n\u7814\u7a76\u8cbb2022\u5e74\uff08\u76f4\u63a5\uff09\uff1a180\u4e07\u5186<br \/>\n\u7814\u7a76\u8cbb2022\u5e74\uff08\u9593\u63a5\uff09\uff1a54\u4e07\u5186<br \/>\n\u8ab2\u984c\u756a\u53f7\uff1a22K19448<\/p>\n<p>\n\u7814\u7a76\u7a2e\u76ee\uff1a\u6b66\u7530\u79d1\u5b66\u632f\u8208\u8ca1\u56e3 \u85ac\u5b66\u7cfb\u7814\u7a76\u7d99\u7d9a\u52a9\u6210<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u5c71\u7530\u52c7\u78e8<br \/>\n\u7814\u7a76\u5206\u62c5\u8005\uff1a\u306a\u3057<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u5fc3\u7b4b\u75c7\u6cbb\u7642\u7528\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\uff24\uff24\uff33\u306e\u958b\u767a<br \/>\n\u7814\u7a76\u671f\u9593\uff1a2022-2027\u5e74\u5ea6<br \/>\n\u7814\u7a76\u8cbb2022\u5e74\uff08\u76f4\u63a5\uff09\uff1a300\u4e07\u5186<br \/>\n\u7814\u7a76\u8cbb2022\u5e74\uff08\u9593\u63a5\uff09\uff1a0\u4e07\u5186<\/p>\n<p>\u7814\u7a76\u7a2e\u76ee\uff1a\u6301\u7530\u8a18\u5ff5\u533b\u5b66\u85ac\u5b66\u632f\u8208\u8ca1\u56e3 \u7814\u7a76\u52a9\u6210<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u4f50\u85e4\u60a0\u4ecb<br \/>\n\u7814\u7a76\u5206\u62c5\u8005\uff1a\u306a\u3057<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u30b2\u30ce\u30e0\u7de8\u96c6\u56e0\u5b50\u642d\u8f09\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u88fd\u5264\u306b\u3088\u308b\u8840\u53cb\u75c5\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u306e\u4f5c\u51fa\u3068\u6cbb\u7642\u306e\u5b9f\u8a3c<br \/>\n\u7814\u7a76\u671f\u9593\uff1a2022-2023\u5e74\u5ea6<br \/>\n\u7814\u7a76\u8cbb2022\u5e74\uff08\u76f4\u63a5\uff09\uff1a300\u4e07\u5186<br \/>\n\u7814\u7a76\u8cbb2022\u5e74\uff08\u9593\u63a5\uff09\uff1a0\u4e07\u5186<\/p>\n<p>\u7814\u7a76\u7a2e\u76ee\uff1a Initiation of International Collaboration Programme<br \/>\n(Deutsche Forschungsgemeinschaft [\u30c9\u30a4\u30c4\u7814\u7a76\u8ca1\u56e3])<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\uff1aMisa Hirose, Yuma Yamada (\u5171\u540c\u7533\u8acb)<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1aEstablishment of a novel mitochondrial genome editing technique<br \/>\n\u7814\u7a76\u671f\u9593\uff1a2022-2023\u5e74\u5ea6<br \/>\n\u7814\u7a76\u8cbb2022-2023\u5e74\uff08\u76f4\u63a5\uff09\uff1a \u20ac 40,180 (\u56fd\u969b\u9023\u643a\u65c5\u8cbb\u3068\u3057\u3066\u4f7f\u7528)<\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<h6><span style=\"color: #3366ff;\">2023\u5e74\u3000\u79d1\u7814\u8cbb\uff1a61,200,000\u5186\u3000\u8ca1\u56e3\uff1a6,000,000\u5186<\/span><\/h6>\n<p>\u7814\u7a76\u7a2e\u76ee\uff1a\u57fa\u76e4\u7814\u7a76(S)\uff08\u4e00\u822c\uff09<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u539f\u5cf6\u79c0\u5409<br \/>\n\u7814\u7a76\u5206\u62c5\u8005\uff1a\u897f\u5c71\u4f38\u5b8f\u3001\u5185\u7530\u667a\u58eb\u3001\u4f50\u85e4\u60a0\u4ecb\u3001\u4e2d\u6751\u5b5d\u53f8\u3001\u5c71\u7530\u52c7\u78e8<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1aLNP\u3068\u30b9\u30de\u30fc\u30c8\u30dd\u30ea\u30de\u30fc\u304c\u5275\u308b\u30b3\u30a2\u30b7\u30a7\u30eb\u69cb\u9020\u3092\u6709\u3059\u308b\u6d3b\u6027\u578bmRNA\u9001\u9054\u30b7\u30b9\u30c6\u30e0<br \/>\n\u7814\u7a76\u671f\u9593\uff1a2023\u5e74\u5ea6\uff5e2027\u5e74\u5ea6<br \/>\n\u7814\u7a76\u8cbb2023 \u5e74\uff08\u76f4\u63a5\uff09\uff1a1,680\u4e07\u5186<br \/>\n\u7814\u7a76\u8cbb2023\u5e74\uff08\u9593\u63a5\uff09\uff1a504\u4e07\u5186<br \/>\n\u8ab2\u984c\u756a\u53f7\uff1a23H05451<\/p>\n<p>\u7814\u7a76\u7a2e\u76ee\uff1a\u57fa\u76e4\u7814\u7a76\uff08A\uff09<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u5c71\u7530\u52c7\u78e8<br \/>\n\u7814\u7a76\u5206\u62c5\u8005\uff1a\u771f\u6804\u57ce \u6b63\u5bff\u3001\u6b66\u7530 \u5145\u4eba\u3001\u4f50\u3005\u6728 \u5927\u8f14\u3001\u65e5\u6bd4\u91ce \u5149\u6075<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u907a\u4f1d\u5b50\u6cbb\u7642\u3092\u5b9f\u73fe\u3059\u308b\u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853\u306e\u5275\u51fa<br \/>\n\u7814\u7a76\u671f\u9593\uff1a2023\u5e74\u5ea6\uff5e2025\u5e74\u5ea6<br \/>\n\u7814\u7a76\u8cbb2023\u5e74\uff08\u76f4\u63a5\uff09\uff1a1,555\u4e07\u5186<br \/>\n\u7814\u7a76\u8cbb2023\u5e74\uff08\u9593\u63a5\uff09\uff1a465\u4e07\u5186<br \/>\n\u8ab2\u984c\u756a\u53f7\uff1a20H 04523<\/p>\n<p>\u7814\u7a76\u7a2e\u76ee\uff1a\u6311\u6226\u7684\u7814\u7a76(\u840c\u82bd)<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u5c71\u7530\u52c7\u78e8<br \/>\n\u7814\u7a76\u5206\u62c5\u8005\uff1a\u306a\u3057<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u8133\u75be\u60a3\u6cbb\u7642\u3092\u5b9f\u73fe\u3059\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a19\u7684\u578b\u30ca\u30ce\u30ab\u30d7\u30bb\u30eb\u306e\u958b\u767a<br \/>\n\u7814\u7a76\u671f\u9593\uff1a2022-2024\u5e74\u5ea6<br \/>\n\u7814\u7a76\u8cbb2023\u5e74\uff08\u76f4\u63a5\uff09\uff1a170\u4e07\u5186<br \/>\n\u7814\u7a76\u8cbb2023\u5e74\uff08\u9593\u63a5\uff09\uff1a51\u4e07\u5186<br \/>\n\u8ab2\u984c\u756a\u53f7\uff1a22K19928<\/p>\n<p>\u7814\u7a76\u7a2e\u76ee\uff1a\u6311\u6226\u7684\u7814\u7a76\uff08\u840c\u82bd\uff09<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u4e2d\u6751\u5b5d\u53f8<br \/>\n\u7814\u7a76\u5206\u62c5\u8005\uff1a\u306a\u3057<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u30ca\u30ceDDS\u3067\u6311\u3080\u816b\u760d\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u3092\u6a19\u7684\u3068\u3057\u305f\u65b0\u6a5f\u8ef8\u306e\u304c\u3093\u6cbb\u7642\u6cd5\u306e\u958b\u767a<br \/>\n\u7814\u7a76\u671f\u9593\uff1a2022\u5e74\u5ea6\uff5e2024\u5e74\u5ea6<br \/>\n\u7814\u7a76\u8cbb2023\u5e74\uff08\u76f4\u63a5\uff09\uff1a160\u4e07\u5186<br \/>\n\u7814\u7a76\u8cbb2023\u5e74\uff08\u9593\u63a5\uff09\uff1a48\u4e07\u5186<br \/>\n\u8ab2\u984c\u756a\u53f7\uff1a22K19448<\/p>\n<p>\u7814\u7a76\u7a2e\u76ee\uff1a\u57fa\u76e4\u7814\u7a76\uff08B\uff09<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u4f50\u85e4\u60a0\u4ecb<br \/>\n\u7814\u7a76\u5206\u62c5\u8005\uff1a\u306a\u3057<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u5168\u8eab\u6295\u4e0e\u578bCas9 RNP\u642d\u8f09\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u88fd\u5264\u306b\u3088\u308b\u8133\u3067\u306e\u30b2\u30ce\u30e0\u7de8\u96c6<br \/>\n\u7814\u7a76\u671f\u9593\uff1a2023-2025\u5e74\u5ea6<br \/>\n\u7814\u7a76\u8cbb2023\u5e74\uff08\u76f4\u63a5\uff09\uff1a380\u4e07\u5186<br \/>\n\u7814\u7a76\u8cbb2023\u5e74\uff08\u9593\u63a5\uff09\uff1a114\u4e07\u5186<\/p>\n<p>\n\u7814\u7a76\u7a2e\u76ee\uff1a\u6311\u6226\u7684\u7814\u7a76(\u840c\u82bd)<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u4f50\u85e4\u60a0\u4ecb<br \/>\n\u7814\u7a76\u5206\u62c5\u8005\uff1a\u306a\u3057<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1ain vivo\u597d\u4e2d\u7403\u30a8\u30f3\u30b8\u30cb\u30a2\u30ea\u30f3\u30b0\u3092\u53ef\u80fd\u3068\u3059\u308b\u6838\u9178\u642d\u8f09\u8102\u8cea\u30ca\u30ce\u7c92\u5b50<br \/>\n\u7814\u7a76\u671f\u9593\uff1a2023-2024\u5e74\u5ea6<br \/>\n\u7814\u7a76\u8cbb2023\u5e74\uff08\u76f4\u63a5\uff09\uff1a300\u4e07\u5186<br \/>\n\u7814\u7a76\u8cbb2023\u5e74\uff08\u9593\u63a5\uff09\uff1a90\u4e07\u5186<\/p>\n<p>\u7814\u7a76\u7a2e\u76ee\uff1a\u57fa\u76e4\u7814\u7a76\uff08B\uff09<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u7530\u4e2d\u9756\u4eba<br \/>\n\u7814\u7a76\u5206\u62c5\u8005\uff1a\u4f50\u85e4\u60a0\u4ecb<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u30e9\u30a4\u30bd\u30be\u30fc\u30e0\u6804\u990a\u611f\u77e5\u6a5f\u69cb\u3092\u6a19\u7684\u3068\u3057\u305fNASH\u809d\u304c\u3093\u6291\u6b62\u3092\u76ee\u6307\u3057\u305f\u5275\u85ac\u7814\u7a76<br \/>\n\u7814\u7a76\u671f\u9593\uff1a2023-2025\u5e74\u5ea6<br \/>\n\u7814\u7a76\u8cbb2023\u5e74\uff08\u76f4\u63a5\uff09\uff1a40\u4e07\u5186<br \/>\n\u7814\u7a76\u8cbb2023\u5e74\uff08\u9593\u63a5\uff09\uff1a12\u4e07\u5186<\/p>\n<p>\u7814\u7a76\u7a2e\u76ee\uff1a\u57fa\u76e4\u7814\u7a76\uff08C\uff09<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u5c71\u4e0b\u5321<br \/>\n\u7814\u7a76\u5206\u62c5\u8005\uff1a\u6c38\u6839\u5927\u5e79\u3001\u4e2d\u6751\u5b5d\u53f8<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u708e\u75c7\u6027\u8178\u75be\u60a3\u306b\u304a\u3051\u308b\u30b9\u30d5\u30a3\u30f3\u30b4\u7cd6\u8102\u8cea\u306b\u3088\u308b\u6cbb\u7642\u3092\u76ee\u6307\u3057\u305f\u57fa\u790e\u7684\u7814\u7a76\u7814\u7a76\u671f\u9593\uff1a2023\u5e74\u5ea6\uff5e2025\u5e74\u5ea6<br \/>\n\u7814\u7a76\u8cbb2023\u5e74\uff08\u76f4\u63a5\uff09\uff1a30\u4e07\u5186<br \/>\n\u7814\u7a76\u8cbb2023\u5e74\uff08\u9593\u63a5\uff09\uff1a0\u4e07\u5186<br \/>\n\u8ab2\u984c\u756a\u53f7\uff1a23K05580<\/p>\n<p>\u7814\u7a76\u7a2e\u76ee\uff1a\u6301\u7530\u8a18\u5ff5\u533b\u5b66\u85ac\u5b66\u632f\u8208\u8ca1\u56e3<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u4e2d\u6751\u5b5d\u53f8<br \/>\n\u7814\u7a76\u5206\u62c5\u8005\uff1a\u306a\u3057<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u30ca\u30ceDDS\u3092\u7528\u3044\u305fNK\u7d30\u80de\u30b5\u30d6\u30bb\u30c3\u30c8\u306e\u6a5f\u80fd\u6539\u5909\u3068\u304c\u3093\u514d\u75ab\u7642\u6cd5\u3078\u306e\u5c55\u958b<br \/>\n\u7814\u7a76\u671f\u9593\uff1a2023\u5e74\u5ea6<br \/>\n\u7814\u7a76\u8cbb2023\u5e74\uff08\u76f4\u63a5\uff09\uff1a300\u4e07\u5186<br \/>\n\u7814\u7a76\u8cbb2023\u5e74\uff08\u9593\u63a5\uff09\uff1a0\u4e07\u5186<br \/>\n\u8ab2\u984c\u756a\u53f7\uff1a\u78145-18<\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<h5>\u00a0<\/h5>\n<h5>II\u3000AMED, JST, CREST\u4ed6<\/h5>\n<p><span style=\"color: #ff0000;\">5\u5e74\u9593\u5408\u8a08\u3000\u7dcf\u984d\uff1a273,040,000\u5186<\/span><\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<h6><span style=\"color: #3366ff;\">2019\u5e74\u30008,500,000\u5186<\/span><\/h6>\n<p>\u7814\u7a76\u7a2e\u76ee\uff1aAMED\u30fb\u30b7\u30fc\u30baA\uff08\u5317\u6d77\u9053\u5927\u5b66\uff09<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u5c71\u7530\u52c7\u78e8<br \/>\n\u7814\u7a76\u5206\u62c5\u8005\uff1a\u306a\u3057<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a19\u7684\u578bDDS\u3092\u7528\u3044\u305f\u764c\u5149\u6cbb\u7642\u7528\u30ca\u30ce\u30ab\u30d7\u30bb\u30eb\u306e\u958b\u767a<br \/>\n\u7814\u7a76\u671f\u9593\uff1a 2019\u5e74\u5ea6<br \/>\n\u7814\u7a76\u8cbb2019\u5e74\uff08\u76f4\u63a5\uff09\uff1a85\u4e07\u5186<br \/>\n\u7814\u7a76\u8cbb2019\u5e74\uff08\u9593\u63a5\uff09\uff1a0\u4e07\u5186<br \/>\n\u8ab2\u984c\u756a\u53f7\uff1aA150<\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<h6><span style=\"color: #3366ff;\">2020\u5e74\u300017,800,000\u5186<\/span><\/h6>\n<p>\u7814\u7a76\u7a2e\u76ee\uff1aAMED\u30fb\u4ee4\u548c2\u5e74\u5ea6\u30b2\u30ce\u30e0\u5275\u85ac\u57fa\u76e4\u63a8\u9032\u7814\u7a76\u4e8b\u696d\u3000C-2\uff1a\u907a\u4f1d\u6027\u75be\u60a3\u306e\u30b2\u30ce\u30e0\u89e3\u6790\u3067\u5f97\u3089\u308c\u305fVUS\u3078\u306e\u6a5f\u80fd\u7684\u30a2\u30ce\u30c6\u30fc\u30b7\u30e7\u30f3\u306b\u8cc7\u3059\u308b\u57fa\u76e4\u7814\u7a76<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u5ca1\u5d0e \u5eb7\u53f8<br \/>\n\u7814\u7a76\u5206\u62c5\u8005\uff1a\u6751\u5c71\u572d\u3001\u5927\u7af9\u660e\u3001\u5c71\u7530\u52c7\u78e8\u3001\u6728\u4e0b\u5584\u4ec1<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u65e5\u672c\u4eba\u5c0f\u5150\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u75c5\u306e\u56fa\u6709VUS\u306b\u5bfe\u3059\u308b\u7db2\u7f85\u7684\u306a\u6a5f\u80fd\u7684\u30a2\u30ce\u30c6\u30fc\u30b7\u30e7\u30f3<br \/>\n\u7814\u7a76\u671f\u9593\uff1a 2020-2022\u5e74\u5ea6<br \/>\n\u7814\u7a76\u8cbb2020\u5e74\uff08\u76f4\u63a5\uff09\uff1a300\u4e07\u5186<br \/>\n\u7814\u7a76\u8cbb2020\u5e74\uff08\u9593\u63a5\uff09\uff1a90\u4e07\u5186<br \/>\n\u8ab2\u984c\u756a\u53f7\uff1a20315344<\/p>\n<p>\u7814\u7a76\u7a2e\u76ee\uff1aAMED\u30fb\u533b\u7642\u7814\u7a76\u958b\u767a\u9769\u65b0\u57fa\u76e4\u5275\u6210\u4e8b\u696d\uff08CiCLE\uff09\u7b2c5\u56de\u516c\u52df\uff08\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u5bfe\u7b56\u306b\u95a2\u3059\u308b\u7814\u7a76\u958b\u767a\u8ab2\u984c\uff09<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u83c5\u6cbc\u6b63\u53f8<br \/>\n\u7814\u7a76\u5206\u62c5\u8005\uff1a\u30b5\u30a4\u30ea\u30c3\u30af\u3001\u5c71\u7530\u52c7\u78e8\u3001\u592a\u7530\u5584\u6d69\u3001\u5e73\u4e95\u8c4a\u535a\u3001\u4f50\u85e4\u7be4\u9756\u3001\u4e95\u4e0a\u535a\u96c5\u3001\u4e45\u4fdd\u5141\u4eba<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u88fd\u5264\u306b\u3088\u308b\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u6cbb\u7642\u85ac\u306e\u7814\u7a76\u958b\u767a<br \/>\n\u7814\u7a76\u671f\u9593\uff1a 2020-2024\u5e74\u5ea6<br \/>\n\u7814\u7a76\u8cbb2020\u5e74\uff08\u76f4\u63a5\uff09\uff1a2,248,981\u5186<br \/>\n\u7814\u7a76\u8cbb2020\u5e74\uff08\u9593\u63a5\uff09\uff1a751,019\u5186<br \/>\n\u8ab2\u984c\u756a\u53f7\uff1a 20338207<\/p>\n<p>\u7814\u7a76\u7a2e\u76ee\uff1aAMED\u30fb\u4ee4\u548c2\u5e74\u5ea6\u514d\u75ab\u30a2\u30ec\u30eb\u30ae\u30fc\u75be\u60a3\u5b9f\u7528\u5316\u7814\u7a76\u4e8b\u696d<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u6cb3\u91ce\u901a\u4ec1<br \/>\n\u7814\u7a76\u5206\u62c5\u8005\uff1a\u539f\u5cf6\u79c0\u5409\u3001\u4e2d\u6751\u5b5d\u53f8<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1aT\u7d30\u80de\u7d30\u80de\u5185\u4ee3\u8b1d\u306b\u6ce8\u76ee\u3057\u305f\u5168\u8eab\u6027\u30a8\u30ea\u30c6\u30de\u30c8\u30fc\u30c7\u30b9\u306e\u75c5\u614b\u89e3\u660e<br \/>\n\u7814\u7a76\u671f\u9593\uff1a 2020-2023\u5e74\u5ea6<br \/>\n\u7814\u7a76\u8cbb2020\u5e74\uff08\u76f4\u63a5\uff09\uff1a200\u4e07\u5186<br \/>\n\u7814\u7a76\u8cbb2020\u5e74\uff08\u9593\u63a5\uff09\uff1a0\u5186<br \/>\n\u8ab2\u984c\u756a\u53f7\uff1a 20ek0410078h0001<\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<h6><span style=\"color: #3366ff;\">2021\u5e74\u300051,810,000\u5186<\/span><\/h6>\n<p>\u7814\u7a76\u7a2e\u76ee\uff1aAMED\u30fb\u4ee4\u548c2\u5e74\u5ea6\u30b2\u30ce\u30e0\u5275\u85ac\u57fa\u76e4\u63a8\u9032\u7814\u7a76\u4e8b\u696d\u3000C-2\uff1a\u907a\u4f1d\u6027\u75be\u60a3\u306e\u30b2\u30ce\u30e0\u89e3\u6790\u3067\u5f97\u3089\u308c\u305fVUS\u3078\u306e\u6a5f\u80fd\u7684\u30a2\u30ce\u30c6\u30fc\u30b7\u30e7\u30f3\u306b\u8cc7\u3059\u308b\u57fa\u76e4\u7814\u7a76<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u5ca1\u5d0e \u5eb7\u53f8<br \/>\n\u7814\u7a76\u5206\u62c5\u8005\uff1a\u6751\u5c71\u572d\u3001\u5927\u7af9\u660e\u3001\u5c71\u7530\u52c7\u78e8\u3001\u6728\u4e0b\u5584\u4ec1<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u65e5\u672c\u4eba\u5c0f\u5150\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u75c5\u306e\u56fa\u6709VUS\u306b\u5bfe\u3059\u308b\u7db2\u7f85\u7684\u306a\u6a5f\u80fd\u7684\u30a2\u30ce\u30c6\u30fc\u30b7\u30e7\u30f3<br \/>\n\u7814\u7a76\u671f\u9593\uff1a 2020-2022\u5e74\u5ea6<br \/>\n\u7814\u7a76\u8cbb2021\u5e74\uff08\u76f4\u63a5\uff09\uff1a300\u4e07\u5186<br \/>\n\u7814\u7a76\u8cbb2021\u5e74\uff08\u9593\u63a5\uff09\uff1a90\u4e07\u5186<br \/>\n\u8ab2\u984c\u756a\u53f7\uff1a20315344<\/p>\n<p>\u7814\u7a76\u7a2e\u76ee\uff1aAMED\u30fb\u533b\u7642\u7814\u7a76\u958b\u767a\u9769\u65b0\u57fa\u76e4\u5275\u6210\u4e8b\u696d\uff08CiCLE\uff09\u7b2c5\u56de\u516c\u52df\uff08\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u5bfe\u7b56\u306b\u95a2\u3059\u308b\u7814\u7a76\u958b\u767a\u8ab2\u984c\uff09<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u83c5\u6cbc\u6b63\u53f8<br \/>\n\u7814\u7a76\u5206\u62c5\u8005\uff1a\u30b5\u30a4\u30ea\u30c3\u30af\u3001\u5c71\u7530\u52c7\u78e8\u3001\u592a\u7530\u5584\u6d69\u3001\u5e73\u4e95\u8c4a\u535a\u3001\u4f50\u85e4\u7be4\u9756\u3001\u4e95\u4e0a\u535a\u96c5\u3001\u4e45\u4fdd\u5141\u4eba<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u88fd\u5264\u306b\u3088\u308b\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u6cbb\u7642\u85ac\u306e\u7814\u7a76\u958b\u767a<br \/>\n\u7814\u7a76\u671f\u9593\uff1a 2020-2024\u5e74\u5ea6<br \/>\n\u7814\u7a76\u8cbb2021\u5e74\uff08\u76f4\u63a5\uff09\uff1a5,443,327\u5186<br \/>\n\u7814\u7a76\u8cbb2021\u5e74\uff08\u9593\u63a5\uff09\uff1a1,556,673\u5186<br \/>\n\u8ab2\u984c\u756a\u53f7\uff1a 20338207<\/p>\n<p>\u7814\u7a76\u7a2e\u76ee\uff1aAMED\u30fb\u4ee4\u548c2\u5e74\u5ea6\u514d\u75ab\u30a2\u30ec\u30eb\u30ae\u30fc\u75be\u60a3\u5b9f\u7528\u5316\u7814\u7a76\u4e8b\u696d<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u6cb3\u91ce\u901a\u4ec1<br \/>\n\u7814\u7a76\u5206\u62c5\u8005\uff1a\u539f\u5cf6\u79c0\u5409\u3001\u4e2d\u6751\u5b5d\u53f8<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1aT\u7d30\u80de\u7d30\u80de\u5185\u4ee3\u8b1d\u306b\u6ce8\u76ee\u3057\u305f\u5168\u8eab\u6027\u30a8\u30ea\u30c6\u30de\u30c8\u30fc\u30c7\u30b9\u306e\u75c5\u614b\u89e3\u660e<br \/>\n\u7814\u7a76\u671f\u9593\uff1a 2020-2023\u5e74\u5ea6<br \/>\n\u7814\u7a76\u8cbb2021\u5e74\uff08\u76f4\u63a5\uff09\uff1a100\u4e07\u5186<br \/>\n\u7814\u7a76\u8cbb2021\u5e74\uff08\u9593\u63a5\uff09\uff1a0\u5186<br \/>\n\u8ab2\u984c\u756a\u53f7\uff1a 21ek0410078h0002<\/p>\n<p>\u7814\u7a76\u7a2e\u76ee\uff1aAMED\u30fb\u4ee4\u548c3\u5e74\u5ea6\u5275\u6210\u57fa\u76e4\u63a8\u9032\u7814\u7a76\u4e8b\u696d<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u4e2d\u6751\u5b5d\u53f8<br \/>\n\u7814\u7a76\u5206\u62c5\u8005\uff1a\u4f50\u85e4\u60a0\u4ecb\u3001\u771f\u6804\u57ce\u6b63\u5bff\u3001\u6cb3\u91ce\u901a\u4ec1<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u30b5\u30d6\u30bb\u30c3\u30c8\u30ec\u30d9\u30eb\u3067\u7d30\u80de\u6a19\u7684\u5316\u3092\u53ef\u80fd\u3068\u3059\u308b\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u6280\u8853\u306e\u958b\u767a<br \/>\n\u7814\u7a76\u671f\u9593\uff1a 2021-2025\u5e74\u5ea6<br \/>\n\u7814\u7a76\u8cbb2021\u5e74\uff08\u76f4\u63a5\uff09\uff1a2300\u4e07\u5186<br \/>\n\u7814\u7a76\u8cbb2021\u5e74\uff08\u9593\u63a5\uff09\uff1a690\u5186<br \/>\n\u8ab2\u984c\u756a\u53f7\uff1a 21ak0101172h001<\/p>\n<p>\u7814\u7a76\u7a2e\u76ee\uff1aJST\u30fb\u5275\u767a\u7684\u7814\u7a76\u652f\u63f4\u4e8b\u696d\uff08\u7b2c\u4e00\u671f\uff09<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u5c71\u7530\u52c7\u78e8<br \/>\n\u7814\u7a76\u5206\u62c5\u8005\uff1a\u306a\u3057<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u4eba\u5de5\u5171\u751f\u304c\u62d3\u304f\u65b0\u3057\u3044\u7d30\u80de\u751f\u7269\u5b66<br \/>\n\u7814\u7a76\u671f\u9593\uff1a 2021-2023\u5e74\u5ea6<br \/>\n\u7814\u7a76\u8cbb2021\u5e74\uff08\u76f4\u63a5\uff09\uff1a770\u4e07\u5186<br \/>\n\u7814\u7a76\u8cbb2021\u5e74\uff08\u9593\u63a5\uff09\uff1a231\u5186<br \/>\n\u8ab2\u984c\u756a\u53f7\uff1a 20352825<\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<h6><span style=\"color: #3366ff;\">2022\u5e74\u300084,930,000\u5186<\/span><\/h6>\n<p>\u7814\u7a76\u7a2e\u76ee\uff1aJST\u30fb\u5275\u767a\u7684\u7814\u7a76\u652f\u63f4\u4e8b\u696d\uff08\u7b2c\u4e00\u671f\uff09<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u5c71\u7530\u52c7\u78e8<br \/>\n\u7814\u7a76\u5206\u62c5\u8005\uff1a\u306a\u3057<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u4eba\u5de5\u5171\u751f\u304c\u62d3\u304f\u65b0\u3057\u3044\u7d30\u80de\u751f\u7269\u5b66<br \/>\n\u7814\u7a76\u671f\u9593\uff1a 2021-2023\u5e74\u5ea6<br \/>\n\u7814\u7a76\u8cbb2022\u5e74\uff08\u76f4\u63a5\uff09\uff1a880\u4e07\u5186<br \/>\n\u7814\u7a76\u8cbb2022\u5e74\uff08\u9593\u63a5\uff09\uff1a264\u5186<br \/>\n\u8ab2\u984c\u756a\u53f7\uff1a 20352825<\/p>\n<p>\u7814\u7a76\u7a2e\u76ee\uff1aAMED\u30fb\u4ee4\u548c3\u5e74\u5ea6\u5275\u6210\u57fa\u76e4\u63a8\u9032\u7814\u7a76\u4e8b\u696d<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u4e2d\u6751\u5b5d\u53f8<br \/>\n\u7814\u7a76\u5206\u62c5\u8005\uff1a\u4f50\u85e4\u60a0\u4ecb\u3001\u771f\u6804\u57ce\u6b63\u5bff\u3001\u6cb3\u91ce\u901a\u4ec1<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u30b5\u30d6\u30bb\u30c3\u30c8\u30ec\u30d9\u30eb\u3067\u7d30\u80de\u6a19\u7684\u5316\u3092\u53ef\u80fd\u3068\u3059\u308b\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u6280\u8853\u306e\u958b\u767a<br \/>\n\u7814\u7a76\u671f\u9593\uff1a 2021-2025\u5e74\u5ea6<br \/>\n\u7814\u7a76\u8cbb2022\u5e74\uff08\u76f4\u63a5\uff09\uff1a4580\u4e07\u5186\uff08\u8abf\u6574\u8cbb\u542b\uff09<br \/>\n\u7814\u7a76\u8cbb2022\u5e74\uff08\u9593\u63a5\uff09\uff1a1374\u4e07\u5186<br \/>\n\u8ab2\u984c\u756a\u53f7\uff1a 22ak0101172h002<\/p>\n<p>\u7814\u7a76\u7a2e\u76ee\uff1aAMED\u30fb\u4ee4\u548c2\u5e74\u5ea6\u30b2\u30ce\u30e0\u5275\u85ac\u57fa\u76e4\u63a8\u9032\u7814\u7a76\u4e8b\u696d\u3000C-2\uff1a\u907a\u4f1d\u6027\u75be\u60a3\u306e\u30b2\u30ce\u30e0\u89e3\u6790\u3067\u5f97\u3089\u308c\u305fVUS\u3078\u306e\u6a5f\u80fd\u7684\u30a2\u30ce\u30c6\u30fc\u30b7\u30e7\u30f3\u306b\u8cc7\u3059\u308b\u57fa\u76e4\u7814\u7a76<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u5ca1\u5d0e \u5eb7\u53f8<br \/>\n\u7814\u7a76\u5206\u62c5\u8005\uff1a\u6751\u5c71\u572d\u3001\u5927\u7af9\u660e\u3001\u5c71\u7530\u52c7\u78e8\u3001\u6728\u4e0b\u5584\u4ec1<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u65e5\u672c\u4eba\u5c0f\u5150\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u75c5\u306e\u56fa\u6709VUS\u306b\u5bfe\u3059\u308b\u7db2\u7f85\u7684\u306a\u6a5f\u80fd\u7684\u30a2\u30ce\u30c6\u30fc\u30b7\u30e7\u30f3<br \/>\n\u7814\u7a76\u671f\u9593\uff1a 2020-2022\u5e74\u5ea6<br \/>\n\u7814\u7a76\u8cbb2022\u5e74\uff08\u76f4\u63a5\uff09\uff1a300\u4e07\u5186<br \/>\n\u7814\u7a76\u8cbb2022\u5e74\uff08\u9593\u63a5\uff09\uff1a90\u4e07\u5186<br \/>\n\u8ab2\u984c\u756a\u53f7\uff1a20315344<\/p>\n<p>\u7814\u7a76\u7a2e\u76ee\uff1aAMED\u30fb\u4ee4\u548c2\u5e74\u5ea6\u514d\u75ab\u30a2\u30ec\u30eb\u30ae\u30fc\u75be\u60a3\u5b9f\u7528\u5316\u7814\u7a76\u4e8b\u696d<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u6cb3\u91ce\u901a\u4ec1<br \/>\n\u7814\u7a76\u5206\u62c5\u8005\uff1a\u539f\u5cf6\u79c0\u5409\u3001\u4e2d\u6751\u5b5d\u53f8<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1aT\u7d30\u80de\u7d30\u80de\u5185\u4ee3\u8b1d\u306b\u6ce8\u76ee\u3057\u305f\u5168\u8eab\u6027\u30a8\u30ea\u30c6\u30de\u30c8\u30fc\u30c7\u30b9\u306e\u75c5\u614b\u89e3\u660e<br \/>\n\u7814\u7a76\u671f\u9593\uff1a 2020-2023\u5e74\u5ea6<br \/>\n\u7814\u7a76\u8cbb2022\u5e74\uff08\u76f4\u63a5\uff09\uff1a100\u4e07\u5186<br \/>\n\u7814\u7a76\u8cbb2022\u5e74\uff08\u9593\u63a5\uff09\uff1a0\u5186<br \/>\n\u8ab2\u984c\u756a\u53f7\uff1a 22ek0410078h0003<\/p>\n<p>\u7814\u7a76\u7a2e\u76ee\uff1aAMED\u30fb\u518d\u751f\u533b\u7642\u5b9f\u73fe\u62e0\u70b9\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u30d7\u30ed\u30b0\u30e9\u30e0<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u5317\u7560\u5eb7\u53f8<br \/>\n\u7814\u7a76\u5206\u62c5\u8005\uff1a\u771f\u4e0b\u77e5\u58eb\u3001\u4f50\u85e4\u60a0\u4ecb\u3001\u5c0f\u6797\u4e9c\u5e0c\u5b50<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u65b0\u898f\u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853\u3068\u30ca\u30ceDDS\u63a2\u7d22\u306b\u3088\u308b\u30c0\u30a6\u30f3\u75c7\u5019\u7fa4\u306e\u77e5\u7684\u767a\u9054\u969c\u5bb3\u306b\u5bfe\u3059\u308b\u907a\u4f1d\u5b50\u6cbb\u7642\u6cd5\u306e\u958b\u767a<br \/>\n\u7814\u7a76\u671f\u9593\uff1a 2022-2024\u5e74\u5ea6<br \/>\n\u7814\u7a76\u8cbb2022\u5e74\uff08\u76f4\u63a5\uff09\uff1a100\u4e07\u5186<br \/>\n\u7814\u7a76\u8cbb2022\u5e74\uff08\u9593\u63a5\uff09\uff1a0\u5186<br \/>\n\u8ab2\u984c\u756a\u53f7\uff1a 22bm1123004h0001<\/p>\n<p>\n\u7814\u7a76\u7a2e\u76ee\uff1aAMED\u30fb\u30ef\u30af\u30c1\u30f3\u958b\u767a\u306e\u305f\u3081\u306e\u4e16\u754c\u30c8\u30c3\u30d7\u30ec\u30d9\u30eb\u7814\u7a76\u958b\u767a\u62e0\u70b9\u306e\u5f62\u6210\u4e8b\u696d<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u6fa4\u6d0b\u6587<br \/>\n\u7814\u7a76\u5206\u62c5\u8005\uff1a\u559c\u7530\u5b8f\u3001\u6c60\u7530\u5bcc\u592b\u3001\u4f50\u85e4\u5f70\u5f66\u3001\u9ad8\u5c71\u559c\u597d\u3001\u539f\u5cf6\u79c0\u5409\u3001\u524d\u4ef2\u52dd\u5b9f\u3001\u6751\u4e0a\u6b63\u6643\u3001\u4eca\u91ce\u54f2\u3001Katarzyna Kedzierska<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u30ef\u30af\u30c1\u30f3\u958b\u767a\u306e\u305f\u3081\u306e\u4e16\u754c\u30c8\u30c3\u30d7\u30ec\u30d9\u30eb\u7814\u7a76\u958b\u767a\u62e0\u70b9\u7fa4\u3000\u5317\u6d77\u9053\u30b7\u30ca\u30b8\u30fc\u30ad\u30e3\u30f3\u30d1\u30b9\uff08\u5317\u6d77\u9053\u5927\u5b66\u30ef\u30af\u30c1\u30f3\u7814\u7a76\u958b\u767a\u62e0\u70b9\uff09<br \/>\n\u7814\u7a76\u671f\u9593\uff1a 2022-2024\u5e74\u5ea6<br \/>\n\u7814\u7a76\u8cbb2022\u5e74\uff08\u76f4\u63a5\uff09\uff1a700\u4e07\u5186<br \/>\n\u7814\u7a76\u8cbb2022\u5e74\uff08\u9593\u63a5\uff09\uff1a105\u4e07\u5186<br \/>\n\u8ab2\u984c\u756a\u53f7\uff1a223fa627005<\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<h6><span style=\"color: #3366ff;\">2023\u5e74\u3000110,000,000\u5186<\/span><\/h6>\n<p>\u7814\u7a76\u7a2e\u76ee\uff1aJST\u30fb\u5275\u767a\u7684\u7814\u7a76\u652f\u63f4\u4e8b\u696d\uff08\u7b2c\u4e00\u671f\uff09<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u5c71\u7530\u52c7\u78e8<br \/>\n\u7814\u7a76\u5206\u62c5\u8005\uff1a\u306a\u3057<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u4eba\u5de5\u5171\u751f\u304c\u62d3\u304f\u65b0\u3057\u3044\u7d30\u80de\u751f\u7269\u5b66<br \/>\n\u7814\u7a76\u671f\u9593\uff1a 2021-2023\u5e74\u5ea6<br \/>\n\u7814\u7a76\u8cbb2023\u5e74\uff08\u76f4\u63a5\uff09\uff1a650\u4e07\u5186<br 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