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Catalytic Asymmetric Reactions Mediated by Chiral Metal Complexes

Rh2(PTPA)4


Selected Publications

  • Diastereo- and Enantioselective Intramolecular 1,6-C-H Insertion Reactions of ƒ¿-Diazo Esters Catalyzed by Chiral Dirhodium(II) Carboxylates
    M. Ito, Y. Kondo, H. Nambu, M. Anada, K. Takeda, S. Hashimoto, Tetrahedron Lett., 2015, 56, 1397-1400. [DOI]

  • Asymmetric Total Synthesis of (-)-trans-Blechnic Acid via Rhodium(II)-Catalyzed C-H Insertion and Palladium(II)-Catalyzed C-H Olefination Reactions
    M. Ito, R. Namie, J. Krishnamurti, H. Miyamae. K. Takeda, H. Nambu, S. Hashimoto, Synlett, ,2014, 25, 288-292. [DOI]

  • Enantio- and Diastereoselective Hetelo-Diels-Alder Reaction between 4-Methyl-Substituted Rawal's Diene and Aldehydes Catalyzed by Chiral Dirhodium(II) Carboxamidates: Catalytic Asymmetric Synthesis of (-)-cis-Aerangis Lactone
    Y. Watanabe, N. Shimada, M. Anada, S. Hashimoto, Tetrahedron: Asymmetry, 2014, 25, 63-73. [DOI]

  • Enantioselective Cycloaddition of Carbonyl Ylides with Arylalenes using Rh2(S-TCPTTL)4
    J. Krishnamurti, H. Nambu, K. Takeda, M. Anada, S. Hashimoto, Org. & Biomol. Chem., 2013, 11, 5374-5382. [DOI]

  • Catalytic Asymmetric Intermolecular C-H Insertion Reactions of 1,4-Cyclohexadiene with 2,4-Dimethyl-3-pentyl ƒ¿-Alkyl-ƒ¿-diazoacetates using Chiral Dirhodium(II) Carboxylates.
    T. Goto, T. Onozuka, Y. Kosaka, M. Anada, K. Takeda and S. Hashimoto, Heterocycles, 2012, 86, 1647-1659. [DOI].

  • A Polymer-Supported Chiral Fluorinated Dirhodium(II) Complex for Asymmetric Amination of Silyl Enol Ethers.
    T. Oohara, H. Nambu, M. Anada, K. Takeda and S. Hashimoto, Adv. Synth. Catal., 2012, 354(11-12), 2331-2338 [DOI].

  • Enantio- and Diastereoselective Hetero-Diels-Alder Reactions between 2-Aza-3-silyloxy-1,3-butadienes and Aldehydes Catalyzed by Chiral Dirhodium(II) Carboxamidates.
    Y. Watanabe, T. Washio, J. Krishnamurthi, M. Anada and S. Hashimoto, Chem. Commun., 2012, 48(55), 6969-6971[DOI].

  • Catalytic Enantioselective Intermolecular Cycloaddition of Diazodiketoester-Derived Carbonyl Ylides with Indoles Using Chiral Dirhodium(II) Carboxylates.
    N. Shimada, T. Oohara, J. Krishnamurthi, H. Nambu and S. Hashimoto, Org. Lett., 2011, 13, 6284-6287[DOI]. (Highlighted in Synfacts 2010, 1442)

  • Continuous Flow System with a Polymer-Supported Dirhodium(II) Catalyst: Application to Enantioselective Carbonyl Ylide Cycloaddition Reactions.
    K. Takeda, T. Oohara, N. Shimada, H. Nambu and S. Hashimoto, Chem. Eur. J, 2011, 17, 13992-13998 [DOI].

  • Highly Enantioselective Cyclopropenation Reaction of 1-Alkynes with ƒ¿-Alkyl-ƒ¿-diazoesters Catalyzed by Dirhodium(II) Carboxylates.
    T. Goto, K. Takeda, N. Shimada, H. Nambu, M. Anada, M. Shiro, K. Ando, and S. Hashimoto, Angew. Chem. Int. Ed., 2011, 50, 6803-6808 [DOI].

  • Catalytic Enantioselective C-H Functionalization of Indoles with ƒ¿-Diazopropionates Using Chiral Dirhodium(II) Carboxylates: Asymmetric Synthesis of the (+)-ƒ¿-Methyl-3-indolylacetic Acid Fragment of Acremoauxin A.
    T. Goto, Y. Natori, K. Takeda, H. Nambu and S. Hashimoto, Tetrahedron: Asymmetry, 2011, 22, 907-915 [DOI].

  • 3. Enantio- and Diastereoselective Cyclopropanation with tert-Butyl ƒ¿-Diazopropionate Catalyzed by Dirhodium(II) Tetrakis[N-tetrabromophthaloyl-(S)-tert-leucinate].
    T. Goto, K. Takeda, M. Anada, K. Ando and S. Hashimoto, Tetrahedron Lett., 2011, 52, 4200-4203 [DOI].

  • A Short Catalytic Asymmetric Synthesis of Diospongins A and B via a One-pot Sequential Hetero-Diels-Alder/Mukaiyama-Michael Reaction Process.
    M. Anada, T. Washio, Y. Watanabe, K. Takeda, and S. Hashimoto, Eur. J. Org. Chem., 2010, (35), 6850-6854 [DOI].

  • Catalytic Asymmetric Synthesis of Descurainin via 1,3-Dipolar Cycloaddition of a Carbonyl Ylide using Rh2(R-TCPTTL)4.
    N. Shimada, T. Hanari, Y. Kurosaki, M. Anada, H. Nambu, and S. Hashimoto, Tetrahedron Lett., 2010, 51(50), 6572-6575.[DOI].

  • A Polymer-Supported Chiral Dirhodium(II) Complex: Highly Durable and Recyclable Catalyst for Asymmetric Intramolecular C-H Insertion Reactions.
    K. Takeda, T. Oohara, M. Anada, H. Nambu, and S. Hashimoto, Angew. Chem. Int. Ed., 2010, 49(39), 6979-6983.[DOI].

  • Catalytic Asymmetric Synthesis of the endo-6-Aryl-8-oxabicyclo[3.2.1]oct-3-en-2-one Natural Product from Ligusticum Chuanxing via 1,3-Dipolar Cycloaddition of a Formyl-Derived Carbonyl Ylide Using Rh2(S-TCPTTL)4.
    N. Shimada, T. Hanari, Y. Kurosaki, K. Takeda, M. Anada, H. Nambu, M. Shiro, and S. Hashimoto, J. Org. Chem., 2010, 75(17), 6039-6042.[DOI]. (Highlighted in Synfacts 2010, 1329)

  • Asymmetric Intermolecular N-H Insertion Reaction of Phenyldiazoacetates with Anilines Catalyzed by Achiral Dirhodium(II) Carboxylates and Cinchona Alkaloids.
    H. Saito, T. Uchiyama, M. Miyake, M. Anada, S. Hashimoto, T. Takabatake, and S. Miyairi, Heterocycles, 2010, 81(5), 1149-1155.[Abstract].

  • Catalytic Asymmetric Construction of the 7-exo-Aryl-6,8-dioxabicyclo[3.2.1]octane Framework of Psoracorylifols B and C Using a Carbonyl Ylide Cycloaddition Strategy.
    Y. Kurosaki, N. Shimada, M. Anada, H. Nambu, and S. Hashimoto, Bull. Korean Chem. Soc., 2010, 31(3), 694-696.[DOI].

  • The Mukaiyama Aldol and Mukaiyama-Michael Reaction Promoted by Commercially Available Molecular Sieves.
    M. Anada, T. Washio, Y. Watanabe, and S. Hashimoto, Heterocycles, 2010, 80(2), 1489-1503.[Abstract].

  • Highly Enantioselective Hetero-Diels-Alder Reactions between Rawal's Diene and Aldehydes Catalyzed by Chiral Dirhodium(II) Carboxamidates.
    Y. Watanabe, T. Washio, N. Shimada, M. Anada, and S. Hashimoto, Chem. Commun., 2009, (47), 7294-7296.[DOI]. (Highlighted in Synfacts 2010, 324)

  • Asymmetric Synthesis of Neolignans (-)-epi-Conocarpan and (+)-Conocarpan via Rh(II)-Catalyzed C-H Insertion Process and Revision of the Absolute Configuration of (-)-epi-Conocarpan.
    Y. Natori, H. Tsutsui, N. Sato, S. Nakamura, H. Nambu, M. Shiro, and S. Hashimoto, J. Org. Chem., 2009, 74 (11), 4418-4421.[DOI].

  • Enantioselective Construction of 2,8-Dioxabicyclo[3.2.1]octane Ring System via [2,3]-Sigmatropic Rearrangement of Oxonium Ylide Using Chiral Dirhodium(II) Carboxylates.
    N. Shimada, S. Nakamura, M. Anada, M. Shiro, and S. Hashimoto, Chem. Lett., 2009, 38 (5), 488-489.[DOI].

  • Asymmetric Approach to the Pentacyclic Skeleton of Aspidosperma Alkaloids via Enantioselective Intramolecular 1,3-Dipolar Cycloaddition of Carbonyl Ylides Catalyzed by Chiral Dirhodium(II) Carboxylates.
    H. Nambu, M. Hikime, J. Krishnamurthi, M. Kamiya, N. Shimada, and S. Hashimoto, Tetrahedron Lett., 2009, 50 (26), 3675-3678.[DOI]

  • Asymmetric Formal Synthesis of (-)-Pancracine via Catalytic Enantioselective C-H Amination Process.
    M. Anada, M. Tanaka, N. Shimada, H. Nambu, M. Yamawaki, and S. Hashimoto, Tetrahedron, 2009, 65, 3069-3077.[DOI]

  • Catalytic Asymmetric Synthesis of (-)-Ritodrine Hydrochloride via Silyl Enol Ether Amination Using Dirhodium(II) Tetrakis[tetrafluorophthaloyl-(S)-tert-leucinate].
    M. Tanaka, S. Nakamura, M. Anada, and S. Hashimoto, Heterocycles, 2008, 76, 1633-1645.[Abstract].

  • Catalytic Enantioselective Intermolecular Cycloaddition of 2-Diazo-3,6-diketoester-Derived Carbonyl Ylides with Alkynes and Styrenes Using Chiral Dirhodium(II) Carboxylates.
    N. Shimada, M. Anada, S. Nakamura, H. Nambu, H. Tsutsui, and S. Hashimoto, Org. Lett, 2008, 10, 3603-3606.[DOI] (Highlighted in Synfacts 2008, 1069)

  • Catalytic Enantioselective Amination of Silyl Enol Ethers Using Chiral Dirhodium(II) Carboxylates: Asymmetric Formal Synthesis of (-)-Metazocine.
    M. Anada, M. Tanaka, T. Washio, M. Yamawaki, T. Abe, and S. Hashimoto, Org. Lett, 2007, 9, 4559-4562.[DOI] (Highlighted in Synfacts 2008, 63)

  • Enantioselective amination of silylketene acetals with (N-arylsulfonylimino)phenyliodinanes catalyzed by chiral dirhodium(II) carboxylates: asymmetric synthesis of phenylglycine derivatives.
    M. Tanaka, Y. Kurosaki, T. Washio, M. Anada, and S. Hashimoto, Tetrahedron Lett., 2007, 48, 8799-8802.[DOI]

  • Asymmetric syntheses of diarylheptanoid natural products (-)-centrolobine and (-)-de-O-methylcentrolobine via hetero-Diels-Alder reaction catalyzed by dirhodium(II) tetrakis[(R)-(benzene-fused-phthalimido)-2-piperidinonate].
    T. Washio, R. Yamaguchi, T. Abe, H. Nambu, M. Anada, and S. Hashimoto, Tetrahedron, 2007, 63, 12037-12046.[DOI]

  • Catalytic Asymmetric Hetero-Diels-Alder Route to a Key Intermediate for the Synthesis of Calyxin L.
    T. Washio, H. Nambu, M. Anada, and S. Hashimoto, Tetrahedron: Asymmetry, 2007, 18, 2606-2612.[DOI]

  • Catalytic Enantioselective Aziridination of Alkenes Using Chiral Dirhodium(II) Carboxylates.
    M. Yamawaki, M. Tanaka, T. Abe, M. Anada, and S. Hashimoto, Heterocyles, 2007, 72, 709.[Abstract][HUSCAP(PDF)]

  • Chiral Phosphine Oxide BINAPO as a Lewis Base Catalyst for Asymmetric Allylation and Aldol Reaction of Trichlorosilyl Compounds.
    S. Kotani, S. Hashimoto, and M. Nakajima, Tetrahedron, 2007, 63, 3122.[DOI]

  • Catalytic Enantioselective Tandem Carbonyl Ylide Formation/1,3-Dipolar Cycloaddition Reactions of ƒ¿-Diazo Ketones with Aromatic Aldehydes Using Dirhodium(II) Tetrakis[N-benzene-fused-phthaloyl-(S)-valinate].
    H. Tsutsui, N. Shimada, M. Anada, M. Nakajima, S. Nakamura, H. Nambu, and S. Hashimoto, Adv. Synth. Catal., 2007, 349, 521. [DOI] (Highlighted in Synfacts 2007, 827)

  • Enantioselective Synthesis of 3-Arylindan-1-ones via Intramolecular C-H Insertion Reactions of ƒ¿-Diazo-ƒÀ-ketoesters Catalyzed by Chiral Dirhodium(II) Carboxylates.
    Y. Natori, M. Anada, S. Nakamura, H. Nambu, and S. Hashimoto, Heterocyles, 2006, 70, 635.[Abstract][HUSCAP(PDF)]

  • Enantioselective Intramolecular C-H Amidation of Sulfamate Esters Catalyzed by Chiral Dirhodium(II) Carboxylates.
    M. Yamawaki, S. Kitagaki, M. Anada, and S. Hashimoto, Heterocyles, 2006, 69, 527.[Abstract][HUSCAP(PDF)]

  • Dirhodium(II) Tetrakis(perfluorobutyrate)-catalyzed 1,4-Hydrosilylation of ƒ¿,ƒÀ-Unsaturated Carbonyl Compounds.
    M. Anada, M. Tanaka, K. Suzuki, H. Nambu, and S. Hashimoto, Chem. Pharm. Bull, 2006, 54, 1622.[PDF][HUSCAP(PDF)]

  • Enantioselective Aldol Reactions of Trichlorosilyl Enol Ethers Catalyzed by the Chiral Phosphine Oxide BINAPO.
    S. Kotani, S. Hashimoto, and M. Nakajima, Synlett, 2006, 1116.[DOI]

  • Chiral Base-Catalyzed Aldol Reaction of Trimethoxysilyl Enol Ethers: Effect of Water as an Additive on Stereoselectivities.
    Y. Orito, S. Hashimoto, T. Ishizuka, and M. Nakajima, Tetrahedron, 2006, 62, 390.[DOI]

  • Dirhodium(II) Tetrakis[N-benzene-fused Phthaloyl-(S)-piperidinonate] as Chiral Lewis Acid: Catalytic Enantioselective Aldol Reactions of Acetate-derived Silylketene Acetals and Aldehydes.
    T. Washio, S. Nakamura, M. Anada, and S. Hashimoto, Heterocycles, 2005, 66, 567.[Abstract][HUSCAP(PDF)]

  • Practical Synthesis of Dirhodium(II) Tetrakis[N-phthaloyl-(S)-tert-leucinate].
    H. Tsutsui, T. Abe, S. Nakamura, M. Anada, and S. Hashimoto, Chem. Pharm. Bull., 2005, 53, 1366. [PDF][HUSCAP(PDF)]

  • Highly Enantio- and Diastereoselective Construction of 1,2-Disubstituted Cyclopentane Compounds by Dirhodium(II) Tetrakis[N-phthaloyl-(S)-tert-leucinate]-Catalyzed C-H Insertion Reactions of ƒ¿-Diazo Esters.
    K. Minami, H. Saito, H. Tsutsui, H. Nambu, M. Anada, and S. Hashimoto, Adv. Synth. Catal., 2005, 347, 1483. [DOI][HUSCAP(PDF)](Highlighted in Synfacts 2006, 45)

  • Asymmetric Ring Opening of meso-Epoxides Catalyzed by the Chiral Phosphine Oxide BINAPO.
    E. Tokuda, S. Kotani, H. Matsunaga, T. Ishizuka, S. Hashimoto, and M. Nakajima, Tetrahedron: Asymmetry, 2005, 16, 2391. [DOI]

  • Chiral Phosphine Oxide BINAPO as a Catalyst for Enantioselective Allylation of Aldehydes with Allyltrichlorosilanes.
    M. Nakajima, S. Kotani, T. Ishizuka, and S. Hashimoto, Tetrahedron Lett., 2005, 46, 157. [DOI]

  • Enantioselective Aldol Reaction of Trimethoxysilyl Enol Ether Catalyzed by Lithium Binaphtholate.
    M. Nakajima, Y. Orito, T. Ishizuka, and S. Hashimoto, Org. Lett., 2004, 6, 3763.[DOI]

  • A New Dirhodium(II) Carboxamidate Complex as a Chiral Lewis Acid Catalyst for Enantioselective Hetero-Diels-Alder Reactions.
    M. Anada, and T. Washio, and N. Shimada, and S. Kitagaki, and M. Nakajima, and M. Shiro, and S. Hashimoto, Angew. Chem. Int. Ed., 2004, 43, 2665.[DOI]

  • Enantioselective Aldol Reactions of Trichlorosilyl Enol Ethers Catalyzed by Chiral N,N'-Dioxides and Monodentate N-Oxides.
    M. Nakajima, T. Yokota, M. Saito, and S. Hashimoto, Tetrahedron Lett., 2004, 45, 61.[DOI]

  • Chiral N-Oxides as Catalysts or Ligands in Enantioselective Reactions.
    M. Nakajima, J. Synth. Org. Chem. Jpn., 2003, 61, 1081.

  • Synthesis and Evaluation of Novel Dirhodium(II) Carboxylate Catalysts with Atropisomeric Biaryl Backbone.
    K. Hikichi, and S. Kitagaki, and M. Anada, and S. Nakamura, and M. Nakajima, and M. Shiro, and S. Hashimoto, Heterocycles, 2003, 61, 391.[Abstract]

  • Enantioselective Michael Additions of ƒÀ-Keto Esters to ƒ¿,ƒÀ-Unsaturated Carbonyl Compounds Catalyzed by a Chiral Biquinoline N,N'-Dioxide-scandium Trifluoromethanesulfonate Complex.
    M. Nakajima, S. Yamamoto, Y. Yamaguchi, S. Nakamura, and S. Hashimoto, Tetrahedron, 2003, 59, 7307.[DOI]

  • Dirhodium(II) Tetrakis[N-tetrafluorophthaloyl-(S)-tert-leucinate]: an Exceptionally Effective Rh(II) Catalyst for Enantiotopically Selective Aromatic C-H Insertions of Diazo Ketoesters.
    H. Tsutsui, Y Yamaguchi, S. Kitagaki, S. Nakamura, M. Anada and S. Hashimoto, Tetrahedron: Asymmetry, 2003, 14, 817.[DOI]

  • Dirhodium(II) Tetrakis[N-tetrachlorophthaloyl-(S)-tert-leucinate]: a New Chiral Rh(II) Catalyst for Enantioselective Amidation of C-H Bonds:
    M. Yamawaki, H. Tsutsui, S. Kitagaki, M. Anada, and S. Hashimoto, Tetrahedron Lett., 2002, 43, 9561.[DOI]

  • Enantioselective Ring Opening of meso-Epoxides with Tetrachlorosilane Catalyzed by Chiral Bipyridine N,N'-Dioxide Derivatives.
    M. Nakajima, M. Saito, M. Uemura, and S. Hashimoto, Tetrahedron Lett., 2002, 43, 8827.[DOI]

  • Selective Synthesis of Optically Active Allenic and Homopropargylic Alcohols from Propargyl Chloride.
    M. Nakajima, M. Saito, and S. Hashimoto, Tetrahedron: Asymmetry, 2002, 13, 2449.[DOI]

  • Enantio- and Diastereoselective Synthesis of cis-2-Aryl-3-methoxycarbonyl-2,3-dihydrobenzofurans via the Rh(II)-Catalyzed C-H Insertion Process.
    H. Saito, H. Oishi, S. Kitagaki, S. Nakamura, M. Anada, and S. Hashimoto, Org. Lett., 2002, 4, 3887.[DOI]

  • Enantioselective Tandem Formation and [2,3]-Sigmatropic Rearrangement of Cyclic Propargylic Oxonium Ylides Catalyzed by Dirhodium(II) Tetrakis[N-phthaloyl-(S)-tert-leucinate].
    H. Tsutsui, M. Matsuura, K. Makino, S. Nakamura, M. Nakajima, S. Kitagaki, and S. Hashimoto, Isr. J. Chem., 2001, 41, 283.

  • Catalytic Asymmetric Synthesis of 1,1'-Spirobiindan-3,3'-dione via a Double Intramolecular C-H Insertion Process.
    T. Takahashi, H. Tsutsui, M. Tamura, S. Kitagaki, M. Nakajima, and S. Hashimoto, Chem. Commun., 2001, 1604.[DOI]

  • Enantioselective Michael Addition of ƒÀ-Keto Esters to Methyl Vinyl Ketone Employing a Chiral N,N'-Dioxide-scandium Trifluoromethanesulfonate Complex as a Catalyst.
    M. Nakajima, Y. Yamaguchi, and S. Hashimoto, Chem. Commun., 2001, 1596.[DOI]

  • Enantioselective [2,3]-Sigmatropic and [1,2]-Stevens Rearrangements via Intramolecular Formation of Allylic Oxonium Ylides Catalyzed by Chiral Dirhodium(II) Carboxylates.
    S. Kitagaki, Y. Yanamoto, H. Tsutsui, M. Anada, M. Nakajima, and S. Hashimoto, Tetrahedron Lett., 2001, 42, 6361.[DOI]

  • Enantiocontrol in Tandem Allylic Sulfonium Ylide Generation and [2,3]-Sigmatropic Rearrangement Catalyzed by Chiral Dirhodium(II) Complexes.
    S. Kitagaki, Y. Yanamoto, H. Okubo, M. Nakajima, and S. Hashimoto, Heterocycles, 2001, 54, 623.[Abstract]

  • Enantioselective Si-H Insertion of Methyl Phenyldiazoacetate Catalyzed by Dirhodium(II) Carboxylates Incorporating N-Phthaloyl-(S)-amino Acids as Chiral Bridging Ligands.
    S. Kitagaki, M. Kinoshita, M. Takeba, M. Anada, and S. Hashimoto, Tetrahedron: Asymmetry, 2000, 11, 3855.[DOI]

  • Enantioselective Conjugate Addition of Thiols to Cyclic Enones and Enals Catalyzed by Chiral N,N'-Dioxide-Cadmium Iodide Complex.
    M. Saito, M. Nakajima, and S. Hashimoto, Tetrahedron, 2000, 56, 9589.[DOI]

  • Enantioselective Intermolecular 1,3-Dipolar Cycloaddition via Ester-derived Carbonyl Ylide Formation Catalyzed by Chiral Dirhodium(II) Carboxylates.
    S. Kitagaki, M. Yasugahira, M. Anada, M. Nakajima, and S. Hashimoto, Tetrahedron Lett., 2000, 41, 5931.[DOI]

  • Enantioselective Conjugate Addition of Thiols to Enones and Enals Catalyzed by Chiral N-Oxide-Cadmium Complex.
    M. Saito, M. Nakajima, and S. Hashimoto, Chem. Commun, 2000, 1851.[DOI]

  • Double Stereodifferentiation in Intramolecular C-H Insertion Reaction toward the Synthesis of 1ƒÀ-Methylcarbapenem Antibiotics.
    M. Anada, S. Kitagaki, and S. Hashimoto, Heterocycles, 2000, 52, 875.[Abstract]

  • One-pot Enantioselective Synthesis of Optically Active Homoallylic Alcohols from Allyl Halides and Aldehydes.
    M. Nakajima, M. Saito, and S. Hashimoto, Chem. Pharm. Bull., 2000, 48, 306.[Abstract]

  • Catalytic Enantioselective Synthesis of the Phosphodiesterase Type IV Inhibitor (R)-(-)-Rolipram via Intramolecular C-H Insertion Process.
    M. Anada, O. Mita, H. Watanabe, S. Kitagaki, and S. Hashimoto, Synlett , 1999, 1775.[DOI]

  • Enantiocontrol in Tandem Carbonyl Ylide Formation and Intermolecular 1,3-Dipolar Cycloaddition of ƒ¿-Diazo Ketones Mediated by Chiral Dirhodium(II) Carboxylate Catalyst.
    S. Kitagaki, M. Anada, O. Kataoka, K. Matsuno, C. Umeda, N. Watanabe, and S. Hashimoto, J. Am. Chem. Soc., 1999, 121, 1417.[DOI]

  • Enantioselective Synthesis of Binaphthol Derivatives by Oxidative Coupling of Naphthol Derivatives Catalyzed by Chiral Diamine-Copper Complexes.
    M. Nakajima, I. Miyoshi, K. Kanayama, S. Hashimoto, M. Noji, and K. Koga, J. Org. Chem., 1999, 64, 2264.[DOI]

  • A Concise Synthesis of (+)-ƒ¿-Allokainic Acid via Site- and Diastereoselective Intramolecular C-H Insertion Process.
    M. Anada, T. Sugimoto, N. Watanabe, M. Nakajima, and S. Hashimoto, Heterocycles, 1999, 50, 969.[Abstract]

  • Aerobic Oxidative Coupling of 2-Naphthol Derivatives Catalyzed by a Copper-Amine Complex without Solvent.
    M. Nakajima, S. Hashimoto, M. Noji, and K. Koga, Chem. Pharm. Bull., 1998, 46, 1814. [DOI]

  • Enantioseletive Intramolecular C-H Insertion Route to a Key Intermediate for the Synthesis of Trinem Antibiotics.
    M. Anada and S. Hashimoto, Tetrahedron Lett., 1998,[DOI] 39, 9063.

  • (S)-3,3'-Dimethyl-2,2'-biquinoline N,N'-Dioxide as an Efficient Catalyst for Enantioselective Addition of Allyltrichlorosilanes to Aldehydes.
    M. Nakajima, M. Saito, M. Shiro, and S. Hashimoto, J. Am. Chem. Soc., 1998, 120, 6419. [DOI]

  • Highly Enantioselective Construction of the Key Azetidin-2-ones for the Synthesis of Carbapenem Antibiotics via Intramolecular C-H Insertion Reactions of a-Methoxycarbonyl-a-diazoacetamides Catalysed by Chiral Dirhodium(II) Carboxylates.
    M. Anada, N. Watanabe, and S. Hashimoto, Chem. Commun., 1998, 1517. [DOI]

  • Enantioselective Synthesis of 4-Substituted 2-Pyrrolidinones by Site-selective C-H Insertion of a-Methoxycarbonyl-a-diazoacetanilides Catalyzed by Dirhodium(II) Tetrakis[N-phthaloyl-(S)-tert-leucinate].
    M. Anada and S. Hashimoto, Tetrahedron Lett., 1998, 39, 79. [DOI]

  • Bipyridine N,N'-Dioxide: A Felicitous Ligand for Methyltrioxorhenium-Catalyzed Epoxidation of Olefins with Hydrogen Peroxide.
    M. Nakajima, Y. Sasaki, H. Iwamoto, and S. Hashimoto, Tetrahedron Lett., 1998, 39, 87. [DOI]

  • A Novel Axially Dissymmetric Chiral Ligand Based on Amine N-Oxide: (R)- and (S)-3,3'-Dimethyl-2,2'-biquinoline N,N'-Dioxide.
    M. Nakajima, Y. Sasaki, M. Shiro, and S. Hashimoto, Tetrahedron: Asymmetry, 1997, 8, 341. [DOI]

  • Highly Enantioselective Intermolecular Cyclopropanation Catalyzed by Dirhodium(II) Tetrakis[3(S)-phthalimido-2-piperidonate]: Solvent Dependency of the Enantioselection.
    S. Kitagaki, H. Matsuda, N. Watanabe, and S. Hashimoto, Synlett, 1997, 1171. [DOI]

  • Site- and Enantiocontrol in Intramolecular C-H Insersion Reactions of a-Diazo Carbonyl Compounds Catalyzed by DirhodiumC arboxylates.
    S. Hashimoto, N. Watanabe, M. Anada, and S. Ikegami, J. Synth. Org. Chem. Jpn., 1996, 54, 988. [DOI]

  • Dirhodium(II) Tetrakis[3(S)-phthalimido-2-piperidinonate]: A Novel Dirhodium(II) Carboxamidate Catalyst for Asymmetric Cyclopropanation.
    N. Watanabe, H. Matsuda, H. Kuribayashi, and S. Hashimoto, Heterocycles, 1996, 42, 537. [DOI]

  • Dirhodium(II) Tetrakis[N-phthaloyl-(S)-tert-leucinate]: A Notable Catalyst for Enantiotopically Selective Aromatic Substitution Reactions of a-Diazocarbonyl Compounds.
    N. Watanabe, T. Ogawa, Y. Ohtake, S. Ikegami, and S. Hashimoto, Synlett, 1996, 85. [DOI]

  • Asymmetric Creation of Quaternary Carbon Centers by Enantiotopically Selective Aromatic C-H Insertion Catalyzed by Chiral Dirhodium(II) Carboxylates.
    N. Watanabe, Y. Ohtake, S. Hashimoto, M. Shiro, and S. Ikegami, Tetrahedron Lett., 1995, 36, 1491. [DOI]

  • Catalytic Asymmetric Synthesis of Binaphthol Derivatives by Aerobic Oxidative Coupling of 3-Hydroxy-2-naphthoates with Chiral Diamine-Copper Complex.
    M. Nakajima, K. Kanayama, I. Miyoshi, and S. Hashimoto, Tetrahedron Lett., 1995, 36, 9519. [DOI]

  • Enantioselective Intramolecular C-H Insertion Reactions of N-Alkyl-N-tert-Butyl-a-Methoxycarbonyl-a-Diazoacetamides Catalyzed by Dirhodium(II) Carboxylates: Catalytic, Asymmetric Construction of 2-Azetidinones.
    N. Watanabe, M. Anada, S. Hashimoto, and S. Ikegami, Synlett, 1994, 1031. [DOI]

  • Double Asymmetric Induction in Intramolecular C-H Insertion Reactions of a-Diazo b-Keto Esters.
    S. Hashimoto, N. Watanabe, K. Kawano, and S. Ikegami, Synth. Commun., 1994, 24, 3277. [DOI]

  • Enantioselective Intramolecular C-H Insertion Reactions of a-Diazo b-Keto Esters Catalyzed by Dirhodium(II) Tetrakis[N-phthaloyl-(S)-phenylalaninate]: The Effect of the Substituent at the Insertion Site on Enantioselectivity.
    S. Hashimoto, N. Watanabe, and S. Ikegami, Synlett, 1994, 353. [DOI]

  • A New Catalytic System for Aerobic Oxidative Coupling of 2-Naphthol Derivatives by the Use of CuCl-Amine Complex: A Practical Synthesis of Binaphthol Derivatives.
    M. Noji, M. Nakajima, and K. Koga, Tetrahedron Lett., 1994, 35, 7983. [DOI]

  • Enhancement of Enantioselectivity in Intramolecular C-H Insertion Reactions of a-Diazo b-Keto Esters Catalyzed by Chiral Dirhodium(II) Carboxylates.
    S. Hashimoto, N. Watanabe, T. Sato, M. Shiro, and S. Ikegami, Tetrahedron Lett., 1993, 34, 5109. [DOI]


    Department of Synthetic and Industrial Chemistry
    Graduate School of Pharmaceutical Sciences
    Hokkaido University

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