研究業績

原著論文・総説

  1. Kono Y, Yokoyama K, Suzuki M, Takakura H, Ogawa M. Surface modification of liposomes using IR700 enables efficient controlled contents release triggered by near-IR light. Bio Pharm Bull 2020, in press.
  2. 中島 孝平, 杉川 晃代, 安井 博宣, 東川 桂, 高倉 栄男, 志賀 哲, 久下 裕司, 小川 美香子. 光免疫療法による腫瘍環境の変化に関する[18F]FDGと[18F]FMISOを用いた検討. JSMI Report 2020, 13 (1), 17-22.
  3. 寺田 一貴, 中島 孝平, 高倉 栄男, 小川 美香子. 小分子ペプチドを利用した光免疫療法のメカニズム解明. JSMI Report 2020, 13 (1), 23-26.
  4. Shimizu Y*, Motomura A*, Takakura H, Tamaki N, Kuge Y, Ogawa M. Accumulation of hypoxia imaging probe "[18F]FMISO" in macrophages depends on macrophage polarization in addition to hypoxic state. Ann Nucl Med 2019, 33 (5), 362-367. *equally contributed. PMID 30694443
  5. Sato K, Ando K, Okuyama S, Moriguchi S, Ogura T, Totoki S, Hanaoka H, Nagaya T, Kokawa R, Takakura H, Nishimura M, Hasegawa Y, Choyke PL, Ogawa M, Kobayashi H. Photoinduced Ligand Release from a Silicon Phthalocyanine Dye Conjugated with Monoclonal Antibodies: A Mechanism of Cancer Cell Cytotoxicity after Near-Infrared Photoimmunotherapy. ACS Cent Sci 2018, 4 (11), 1559-1569. PMID 30555909
  6. Tomita M, Yasui H, Higashikawa K, Nakajima K, Takakura H, Shiga T, Kuge Y, Ogawa M. Anti PD-1 treatment increases [18F]FDG uptake by cancer cells in a mouse B16F10 melanoma model. EJNMMI Research 2018, 8, 82.
  7. Nakajima K, Takakura H, Shimizu Y, Ogawa M. Changes in plasma membrane damage inducing cell death after treatment with near-infrared photoimmunotherapy. Cancer Sci 2018 109 (9) 2889-2996.
  8. Nakajima K, Kimura T, Takakura H, Yoshikawa Y, Kameda A, Shindo T, Sato K, Kobayashi H, Ogawa M. Implantable wireless powered light emitting diode (LED) for near-infrared photoimmunotherapy: device development and experimental assessment in vitro and in vivo. Oncotarget 2018, 9 (28), 20048-20057.
  9. Ogawa M, Takakura H. In Vivo Molecular Imaging for Biomedical Analysis and Therapies. Anal Sci 2018, 34 (3), 273-281.
  10. Takakura H*, Zhang Y*, Erdmann RS*, Thompson AD*, Lin Y, McNellis B, Rivera-Molina F, Uno S, Kamiya M, Urano Y, Rothman JE, Bewersdorf J, Schepartz A, Toomre D. Long time-lapse nanoscopy with spontaneously blinking membrane probes. Nature Biotechnol 2017, 35, 773-780. *equally contributed.
  11. 中島 孝平, 志水 陽一, 高倉 栄男, 小川 美香子. 近赤外光を用いた光線免疫療法における細胞死誘発機序の検証. JSMI Report 2017, 11 (1), 56-59.
  12. Takenouchi O, Kanno A, Takakura H, Hattori M, Ozawa T. Bioluminescent Indicator for Highly Sensitive Analysis of Estrogenic Activity in a Cell-Based Format. Bioconjug Chem 2016, 27, 2689-2694.
  13. Kojima R*, Takakura H*, Kamiya M, Kobayashi E, Komatsu T, Ueno T, Terai T, Hanaoka K, Nagano T, Urano Y. Development of a Sensitive Bioluminogenic Probe for Imaging Highly Reactive Oxygen Species in Living Rats. Angew Chem Int Ed 2015, 54, 4768-14771. *equally contributed.
  14. Takakura H*, Kojima R*, Kamiya M, Kobayashi E, Komatsu T, Ueno T, Terai T, Hanaoka K, Nagano T, Urano Y. New class of bioluminogenic probe based on bioluminescent enzyme-induced electron transfer: BioLeT. J Am Chem Soc 2015, 137, 4010-4013. *equally contributed.
  15. Takakura H, Hattori M, Tanaka M, Ozawa T. Cell-Based Assays and Animal Models for GPCR Drug Screening. Methods Mol Biol 2015, 1272, 257-270.
  16. Erdmann RS*, Takakura H*, Thompson AD, Rivera-Molina F, Allgeyer ES, Bewersdorf J, Toomre D, Schepartz A. Super-Resolution Imaging of the Golgi in Live Cells with a Bioorthogonal Ceramide Probe. Angew Chem Int Ed 2014, 53, 10242-10246. *equally contributed, Selected as Hot Paper in Angew Chem
  17. Hattori M, Haga S, Takakura H, Ozaki M, Ozawa T. Sustained accurate recording of intracellular acidification in living tissues with a photo-controllable bioluminescent protein. Proc Natl Acad Sci USA 2013, 110, 9332-9337.
  18. Hattori M, Tanaka M, Takakura H, Aoki K, Miura K, Anzai T, Ozawa T. Analysis of temporal patterns of GPCR–β-arrestin interactions using split luciferase-fragment complementation. Mol Biosyst 2013, 9, 957-964.
  19. Kojima R, Takakura H, Ozawa T, Tada Y, Nagano T, Urano Y. Rational Design and Development of Near-Infrared-Emitting Firefly Luciferins Available In Vivo. Angew Chem Int Ed 2013, 52, 1175-1179. Selected as Hot Paper in Angew Chem.
  20. Takakura H, Kojima R, Ozawa T, Nagano T, Urano Y. Development of 5'- and 7'-Substituted Luciferin Analogues as Acid-Tolerant Substrates of Firefly Luciferase. ChemBioChem 2012, 13, 1424-1427.
  21. Takakura H, Hattori M, Takeuchi M, Ozawa T. Visualization and Quantitative Analysis of G Protein-Coupled Receptor-β-Arrestin Interaction in Single Cells and Specific Organs of Living Mice Using Split Luciferase Complementation. ACS Chem Biol 2012, 7, 901-910. Selected as a cover art of ACS Chem Biol in May 2012.
  22. Takakura H, Kojima R, Urano Y, Terai T, Hanaoka K, Nagano T. Aminoluciferins as Functional Bioluminogenic Substrates of Firefly Luciferase. Chem Asian J 2011, 6, 1800-1810.
  23. Takeuchi M, Nagaoka Y, Yamada T, Takakura H, Ozawa T. Ratiometric Bioluminescence Indicators for Monitoring Cyclic AMP in Live Cells Based on Luciferase-Fragment Complementation. Anal Chem 2010, 82, 9306-9313.
  24. Takakura H, Sasakura K, Ueno T, Urano Y, Terai T, Hanaoka K, Tsuboi T, Nagano T. Development of Luciferin Analogues Bearing an Amino Group and Their Application as BRET Donors. Chem Asian J 2010, 5, 2053-2061.

邦文総説

  1. 高倉栄男、自発的に明滅する細胞膜局在型プローブを用いた長時間の超解像イメージング法 の開発、新着論文レビュー、 http://first.lifesciencedb.jp/archives/16830
  2. 高倉栄男、クリックケミストリ―を用いた長時間超解像蛍光プローブによるオルガネラ動態の観察、感染・炎症・免疫、48 (1)、26-35、2018

教育業績

担当科目

分析化学 Ⅰ、化学 Ⅰ、RI実習、薬剤学実習

執筆した教科書

なし

その他教育に関する実績

なし