研究業績

2024年

  1. Ohara M, Izumi Y, Takakura H, Enomoto S, Fujii K, Yokoya A, Ogawa M. Decomposition characteristics of a hypervalent iodine compound, 2-iodosobenzoic acid, exposed to monochromatic X-rays around the iodine L3-edge energy region. Rad Phys Chem. 2024 216 , 111394 DOI 10.1016/j.radphyschem.2023.111394
  2. Goto Y, Ando K, Takakura H, Nakajima K, Kobayashi M, Inanami O, Taketsugu T, Ogawa M. Development of a red-shifted photosensitizer for near-infrared photoimmunotherapy of cancer. J Photochem Photobiol. 2024 (in press)
  3. Ogawara K, Inanami O, Takakura H, Saita K, Nakajima K, Kumar S, Ieda N, Kobayashi M, Taketsugu T, Ogawa M. Theoretical Design and Synthesis of Caged Compounds Using X-Ray-Triggered Azo Bond Cleavage. Adv Sci. 2024 e2306586 PMID 38225711

2023年

  1. Obata H, Tsuji AB, Sudo H, Sugyo A, Hashiya K, Ikeda H, Itoh M, Minegishi K, Nagatsu K, Ogawa M, Bando T, Sugiyama H, Zhang MR. Novel Auger-Electron-Emitting [191Pt-Labeled Pyrrole-Imidazole Polyamide Targeting MYCN Increases Cytotoxicity and Cytosolic dsDNA Granules in MYCN-Amplified Neuroblastoma. Pharmaceutics. 2023 16 (11), 1526 PMID 38004392
  2. Izumi Y, Ohara M, Fujii K, Yokoya A, Ogawa M. X-ray irradiation-induced ligand cleavage of a phthalocyanine derivative, tin (IV) phthalocyanine dichloride: A potential for X-ray activation of caged compounds. Rad Phys Chem. 2023 822 , 111394 DOI 10.1016/j.cplett.2023.140508
  3. Nakajima K, Ogawa M. Near-infrared photoimmunotherapy and anti-cancer immunity. Int Immunol. 2023
  4. Obata H, Ogawa M, Zalutsky MR.. DNA Repair Inhibitors: Potential Targets and Partners for Targeted Radionuclide Therapy. Pharmaceutics. 2023 15 (7), 1926 PMID 34571072
  5. Nakajima K, Sugikawa A, Yasui H, Higashikawa K, Suzuki C, Natsume T, Suzuki M, Takakura H, Tomita M, Takahashi S, Hirata K, Magata Y, Kuge Y, Ogawa M.. In vivo imaging of acute physiological responses after treatment of cancer with near-infrared photoimmunotherapy. Mol Imaging Biol. 2023 25 (4), 648-658 PMID 34571072
  6. Kobayashi H, Choyke PL, Ogawa M.. Altered choline level in atherosclerotic lesions: Upregulation of choline transporter-like protein 1 in human coronary unstable plaque. Curr Opin Chem Biol. 2023 102289 , PMID 34571072
  7. Nakamura E, Maekawa K, Saito Y, Matsumoto T, Ogawa M, Komohara Y, Asada Y, Yamashita A.. Altered choline level in atherosclerotic lesions: Upregulation of choline transporter-like protein 1 in human coronary unstable plaque. PLoS One. 2023 18 (2), e0281730 PMID 34571072

2022年

  1. Nakajima K, Ogawa M. Application of Imaging for Antibody-Based Cancer Therapies: Photoimmunotherapy and Immune Checkpoint Blockade Therapy. Journal of the Imaging Society of Japan 2022. 61 (6), 643-651. DOI 10.11370/isj.61.643
  2. Obata H, Kurimasa A, Muraoka T, Tsuji AB, Kondo K, Kuwahara Y, Minegishi K, Nagatsu K, Ogawa M, Zhang MR. Dynamic imaging analysis reveals Auger electron-emitting radio-cisplatin induces DNA damage depending on the cell cycle. Biochem Biophys Res Commun 2022. 637, 286-293. PMID 36410278
  3. Obata H, Tsuji AB, Sudo H, Sugyo A, Minegishi K, Nagatsu K, Ogawa M, Zhang MR. Precise quantitative evaluation of pharmacokinetics of cisplatin using a radio-platinum tracer in tumor-bearing mice. Nucl Med Commun 2022. 43 (11), 1121-1127. PMID 36410278
  4. Nagatsu K, Ohya T, Obata H, Suzuki K, Zhang MR. Special radionuclide production activities – recent developments at QST and throughout Japan. Radiochimica Acta 2022. DOI 10.1515/ract-2021-1124
  5. Takakura H, Matsuhiro S, Inanami O, Kobayashi M, Saita K, Yamashita M, Nakajima K, Suzuki M, Miyamoto N, Taketsugu T, Ogawa M. Ligand release from silicon phthalocyanine dyes triggered by X-ray irradiation. Org Biomol Chem 2022. 20 (36) 7270-7277. PMID 35972402
  6. Suzuki M, Matsuda T, Nakajima K, Yokouchi Y, Kuge Y, Ogawa M. PD1 blockade alters cell-cycle distribution and affects 3'-deoxy-3'-[18F]fluorothymidine uptake in a mouse CT26 tumor model. Ann Nucl Med 2022. Online ahead of print. PMID 35969311
  7. Takakura H, Sato H, Nakajima K, Suzuki M, Ogawa M. Correction: Takakura et al. In Vitro and In Vivo Cell Uptake of a Cell-Penetrating Peptide Conjugated with Fluorescent Dyes Having Different Chemical Properties. Cancers 2021, 13, 2245. Cancers (Basel) 2022, 14 (8), 1880. PMID 35454954 (Correction to PMID 34067065)
  8. Nakajima K, Homma M, Suzuki M, Yokouchi Y, Matsuda T, Takakura H, Hirata K, Kuge Y, Ogawa M. Reduction of tumor hypoxia by anti-PD-1 therapy assessed using pimonidazole and [18F]FMISO. Nucl Med Biol 2022, 108-109, 85-92. PMID 35367730
  9. Obata H, Tsuji AB, Kumata K, Sudo H, Minegishi K, Nagatsu K, Takakura H, Ogawa M, Kurimasa A. Development of novel 191Pt-labeled Hoechst33258: 191Pt is more suitable than 111In for targeting DNA. J Med Chem 2022, 65 (7), 5690-5700. PMID 35358392
  10. Inanami O, Hiraoka W, Goto Y, Takakura H, Ogawa M. EPR Characterisation of Phthalocyanine Radical Anions in Near-Infrared Photocleavage of the Hydrophilic Axial Ligand of a Photoimmunotherapeutic Reagent, IR700. ChemPhotoChem 2022, 6 (1), e202100172. DOI 10.1002/cptc.202100172 (Cover Profile:DOI 10.1002/cptc.202100277)
  11. Takakura H, Matsuhiro S, Kobayashi M, Goto Y, Harada M, Taketsugu T, Ogawa M. Axial-ligand-cleavable silicon phthalocyanines triggered by near-infrared light toward design of photosensitizers for photoimmunotherapy. J Photochem Photobiol A: Chem 2022, 426 (1), 113749. DOI 10.1016/j.jphotochem.2021.113749

2021年

  1. Nakajima K*, Miyazaki F*, Terada K, Takakura H, Suzuki M, Ogawa M. Comparison of low-molecular-weight ligand and whole antibody in prostate-specific membrane antigen targeted near-infrared photoimmunotherapy. Int J Pharm 2021, 609, 121135. *Contributed equally. PMID 34571072
  2. Suzuki M, Katayama T, Suzuki C, Nakajima K, Magata Y, Ogawa M. Uptake of nicotinic acetylcholine receptor imaging agent is reduced in the pro-inflammatory macrophage. Nucl Med Biol 2021, 102-103, 45-55. PMID 34619460
  3. Kato T, Okada R, Goto Y, Furusawa A, Inagaki F, Wakiyama H, Furumoto H, Daar D, Turkbey B, Choyke PL, Takakura H, Inanami O, Ogawa M, Kobayashi H. Electron Donors Rather Than Reactive Oxygen Species Needed for Therapeutic Photochemical Reaction of Near-Infrared Photoimmunotherapy. ACS Pharmacol Transl Sci 2021, 4 (5), 1689-1701. PMID 34661083
  4. Ogawa M, Takakura H. Photoimmunotherapy: A new cancer treatment using photochemical reactions. Bioorg Med Chem 2021, 43, 116274. PMID 34139484
  5. Matsuoka K, Obata H, Nagatsu K, Kojima M, Yoshino T, Ogawa M, Matsunaga S. Transition-metal-free nucleophilic 211At-astatination of spirocyclic aryliodonium ylides. Org Biomol Chem 2021, 19 (25), 5525-5528. PMID 34124736
  6. Sato Y, Yamaguchi K, Ogawa M, Takekuma Y, Sugawara M. An imaging approach for determining the mechanism of enhancement of intestinal absorption of an L-theanine supplement. PLoS One 2021, 16 (6), e0253066. PMID 34115818
  7. Obata H, Tsuji AB, Sudo H, Sugyo A, Minegishi K, Nagatsu K, Ogawa M, Zhang MR. In Vitro Evaluation of No-carrier-added Radiolabeled Cisplatin ([189, 191Pt]cisplatin) Emitting Auger Electrons. Int J Mol Sci 2021, 22, 4622. PMID 33924843
  8. Obata H, Minegishi K, Nagatsu K, Ogawa M, Zhang MR. Synthesis of no-carrier-added [188, 189, 191Pt]cisplatin from a cyclotron produced 188, 189, 191PtCl42-) complex. Sci Rep 2021, 11, 8140. PMID 33854142
  9. Takakura H, Goto Y, Kitamura A, Yoshihara T, Tobita S, Kinjo M, Ogawa M. Analysis of the triplet-state kinetics of a photosensitizer for photoimmunotherapy by fluorescence correlation spectroscopy. J Photochem Photobiol A: Chem 2021, 408, 113094.
  10. Hirata H, Kuwatani M, Nakajima K, Kodama Y, Yoshikawa Y, Ogawa M, Sakamoto N. Near-infrared photoimmunotherapy (NIR-PIT) on cholangiocarcinoma using a novel catheter device with light emitting diodes. Cancer Sci 2021. 112, 828-838. PMID 33345417

2020年

  1. Nakajima K, Ogawa M. Phototoxicity in near-infrared photoimmunotherapy is influenced by the subcellular localization of antibody-IR700. Photodiagnosis Photodyn Ther 2020, 31 , 101926. PMID 32717450
  2. Nishimoto Y, Nishio M, Nagashima S, Nakajima K, Ohira T, Nakai S, Nakase I, Higashikawa K, Kuge Y, Matsumoto A, Ogawa M, Kojima C. Association of Hydrophobic Carboxyl-Terminal Dendrimers with Lymph Node-Resident Lymphocytes. Polymers 2020, 12 (7), 1474. PMID 32630042
  3. Kobayashi M, Harada M, Takakura H, Ando K, Goto Y, Takao T, Ogawa M, Taketsugu T. Theoretical and Experimental Studies on the Near-Infrared Photoreaction Mechanism of a Silicon Phthalocyanine Photoimmunotherapy Dye: Photoinduced Hydrolysis by Radical Anion Generation. Chempluschem 2020, 85, 1-6. PMID 32449613 (Cover Profile:PMID 32830450)
  4. Sano M, Hirakawa S, Suzuki M, Sakabe J, Ogawa M, Yamamoto S, Hiraide T, Sasaki T, Yamamoto N, Inuzuka K, Tanaka H, Saito T, Sugisawa R, Katahashi K, Yata T, Kayama T, Urano T, Tokura Y, Sato K, Setou M, Takeuchi H, Konno H, Unno N. Potential Role of Transforming Growth Factor-Beta 1/Smad Signaling in Secondary Lymphedema After Cancer Surgery. Cancer Sci 2020, 111 (7), 2620-2634. PMID 32412154
  5. Kono Y, Yokoyama K, Suzuki M, Takakura H, Ogawa M. Surface modification of liposomes using IR700 enables efficient controlled contents release triggered by near-IR light. Bio Pharm Bull 2020, 43 (4), 736-741. PMID 32238716
  6. Tomita M, Suzuki M, Kono Y, Nakajima K, Matsuda T, Kuge Y, Ogawa M. Influence on [18F]FDG uptake by cancer cells after anti PD-1 therapy in an enforced-immune activated mouse tumor. EJNMMI Res 2020, 10 (1), 24. PMID 32189078
  7. Nishimoto Y, Nagashima S, Nakajima K, Ohira T, Sato T, Izawa T, Yamate J, Higashikawa K, Kuge Y, Ogawa M, Kojima C. Carboxyl-, sulfonyl-, and phosphate-terminal dendrimers as a nanoplatform with lymph node targeting. Int J Pharm 2020, 576, 119021. PMID 31917298
  8. 中島 孝平, 杉川 晃代, 安井 博宣, 東川 桂, 高倉 栄男, 志賀 哲, 久下 裕司, 小川 美香子. 光免疫療法による腫瘍環境の変化に関する[18F]FDGと[18F]FMISOを用いた検討. JSMI Report 2020, 13 (1), 17-22.
  9. 寺田 一貴, 中島 孝平, 高倉 栄男, 小川 美香子. 小分子ペプチドを利用した光免疫療法のメカニズム解明. JSMI Report 2020, 13 (1), 23-26.

2019年

  1. Inubushi M, Shibahara M, Takahashi Y, Ogawa M, Kiyono Y. From the Respective Expert Viewpoints of the ANM Specialty Editors. Ann Nucl Med 2019, 33 (12), 877-889. PMID 31745811
  2. Narita Y, Shimizu K, Ikemoto K, Uchino R, Kosugi M, Maess MB, Magata Y, Oku N, Ogawa M. Macrophage-targeted, enzyme-triggered fluorescence switch-on system for detection of embolism-vulnerable atherosclerotic plaques. J Control Release 2019 302, 105-115. PMID 30936020
  3. Shimizu Y*, Motomura A*, Takakura H, Tamaki N, Kuge Y, Ogawa M. Accumulation of hypoxia imaging probe "[18F]FMISO" in macrophages depends on macrophage polarization in addition to hypoxic state. Ann Nucl Med 2019, 33 (5), 362-367. *equally contributed. PMID 30694443

2018年

  1. Sato K, Ando K, Okuyama S, Moriguchi S, Ogura T, Totoki S, Hanaoka H, Nagaya T, Kokawa R, Takakura H, Nishimura M, Hasegawa Y, Choyke PL, Ogawa M, Kobayashi H. Photoinduced Ligand Release from a Silicon Phthalocyanine Dye Conjugated with Monoclonal Antibodies: A Mechanism of Cancer Cell Cytotoxicity after Near-Infrared Photoimmunotherapy. ACS Cent Sci 2018, 4 (11), 1559-1569. PMID 30555909
  2. Tomita M, Yasui H, Higashikawa K, Nakajima K, Takakura H, Shiga T, Kuge Y, Ogawa M. Anti PD-1 treatment increases [18F]FDG uptake by cancer cells in a mouse B16F10 melanoma model. EJNMMI Research 2018, 8, 82. PMID 30117062
  3. Sugita T, Kondo Y, Ishino S, Mori I, Horiguchi T, Ogawa M, Magata Y. Evaluation of drug effects on cerebral blood flow and glucose uptake in un-anesthetized and un-stimulated rats: application of free-moving apparatus enabling to keep rats free during PET/SPECT tracer injection and uptake. Nucl Med Commun 2018, 39 (8), 753-760. PMID 29771718
  4. Nakajima K, Takakura H, Shimizu Y, Ogawa M. Changes in plasma membrane damage inducing cell death after treatment with near-infrared photoimmunotherapy. Cancer Sci 2018, 109 (9), 2889-2896. PMID 29949672
  5. Shimizu Y, Zhao S, Yasui H, Nishijima KI, Matsumoto H, Shiga T, Tamaki N, Ogawa M, Kuge Y. A Novel PET Probe "[18F]DiFA" Accumulates in Hypoxic Region via Glutathione Conjugation Following Reductive Metabolism. Mol Imaging Biol 2018 . [Epub ahead of print] PMID 29845425
  6. Nakajima K, Kimura T, Takakura H, Yoshikawa Y, Kameda A, Shindo T, Sato K, Kobayashi H, Ogawa M. Implantable wireless powered light emitting diode (LED) for near-infrared photoimmunotherapy: device development and experimental assessment in vitro and in vivo. Oncotarget 2018, 9 (28), 20048-20057. PMID 29732002
  7. Ogawa M, Takakura H. In Vivo Molecular Imaging for Biomedical Analysis and Therapies. Anal Sci 2018, 34 (3), 273-281. PMID 29526893

2017年

  1. Takakura H*, Zhang Y*, Erdmann RS*, Thompson AD*, Lin Y, McNellis B, Rivera-Molina F, Uno S, Kamiya M, Urano Y, Rothman JE, Bewersdorf J, Schepartz A, Toomre D. Long time-lapse nanoscopy with spontaneously blinking membrane probes. Nature Biotechnol 2017, 35, 773-780. *equally contributed. PMID 28071662
  2. Ogawa M, Tomita Y, Nakamura Y, Lee M. J, Lee S, Tomita S, Nagaya T, Sato K, Yamauchi T, Iwai H, Kumar A, Haystead T, Shroff H, Choyke PL, Trepel JB, Kobayashi H. Immunogenic cancer cell death selectively induced by near infrared photoimmunotherapy initiates host tumor immunity. Oncotarget 2017, 8 (6), 10425-10436. PMID 28060726
  3. Shimizu Y, Hanzawa H, Zhao Y, Fukura S, Nishijima K. I, Sakamoto T, Zhao S, Tamaki N, Ogawa M, Kuge Y. Immunoglobulin G (IgG)-Based Imaging Probe Accumulates in M1 Macrophage-Infiltrated Atherosclerotic Plaques Independent of IgG Target Molecule Expression. Mol Imaging Biol 2017, 19 (4), 531-539. PMID 27981470
  4. 中島 孝平, 志水 陽一, 高倉 栄男, 小川 美香子. 近赤外光を用いた光線免疫療法における細胞死誘発機序の検証. JSMI Report 2017, 11 (1), 56-59.

2016年

  1. Saito K, Iioka H, Kojima C, Ogawa M, Kondo E. Peptide-based tumor inhibitor encoding mitochondrial p14(ARF) is highly efficacious to diverse tumors. Cancer Sci 2016, 107 (9), 1290-1301. PMID 27317619
  2. Kobayashi H, Choyke PL, Ogawa M. Monoclonal antibody-based optical molecular imaging probes; considerations and caveats in chemistry, biology and pharmacology. Curr Opin Chem Biol 2016, 33, 32-38. PMID 27281509
  3. Masaki Y*, Shimizu Y*, Yoshioka T, Fei Feng, Zhao S, Higashino K, NumataY, Kuge Y. Imaging Mass Spectrometry Revealed the Accumulation Characteristics of the 2-nitroimidazole-based Agent “Pimonidazole” in Hypoxia. PLoS One 2016, 11 (8), e0161639. *equally contributed. PMID 27580239
  4. Sugimoto M, Shimizu Y, Zhao S, Ukon N, Nishijima KI, Wakabayashi M, Yoshioka T, Higashino K, Numata Y, Okuda T, Tamaki N, Hanamatsu H, Igarashi Y, Kuge Y. Characterization of the role of sphingomyelin synthase 2 in glucose metabolism in whole-body and peripheral tissues in mice. Biochim Biophys Acta 2016, 1861 (8PtA), 688-702. PMID 27151272
  5. Sugimoto M, Wakabayashi M, Shimizu Y, Yoshioka T, Higashino K, Numata Y, Okuda T, Zhao S, Sakai S, Igarashi Y, Kuge Y. Imaging mass spectrometry reveals acyl-chain- and region-specific sphingolipid metabolism in the kidneys of sphingomyelin synthase 2-deficient mice. PLoS One 2016, 11 (3), e0152191. PMID 27010944
  6. Shimizu Y, Kuge Y. Recent Advances in the Development of PET/SPECT Probes for Atherosclerosis Imaging. Nucl Med Mol Imaging 2016, 50 (4), 284-291. PMID 27994683
  7. Nishijima KI, Zhao S, Feng F, Shimizu Y, Akizawa H, Ohkura K, Tamaki N, Kuge Y. Preclinical Evaluation of a Thymidine Phosphorylase Imaging Probe, [123I]IIMU, for Translational Research. Perspectives on Nuclea Medicine for Molecular Diagnosis and Integrated Therapy (Springer Open) 2016, 125-130.
  8. Sakamoto T, Hanzawa H, Manri N, Sakakibara M, Shimizu Y, Zhao Y, Zhao S, Yamada S, Kamiya K, Eki Y, Suzuki A, Higuchi H, Sugano C, Tutsui H, Tamaki N, Kuge Y. Discovery and Evaluation of Biomarkers for Atherosclerosis: Differential Proteomics of Plasma and Tissues. Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy (Springer Open) 2016, 131-140.
  9. Shimizu Y, Hanzawa H, Zhao Y, Nishijima KI, Sakamoto T, Zhao S, Tamaki N, Kuge Y. Radioimmunodetection of Atherosclerotic Lesions Focusing on the Accumulation Mechanism of Immunoglobulin G. Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy (Springer Open) 2016, 141-150.
  10. Takenouchi O, Kanno A, Takakura H, Hattori M, Ozawa T. Bioluminescent indicator for highly sensitive analysis of estrogenic activity in a cell-based format. Bioconjug Chem 2016, 27, 2689-2694. PMID 27690388

2015年

  1. Niki Y, Ogawa M, Makiura R, Magata Y, Kojima C. Optimization of dendrimer structure for sentinel lymph node imaging: Effects of generation and terminal group. Nanomedicine 2015, 11 (8), 2119-2127. PMID 26348654
  2. Asanuma D, Sakabe M, Kamiya M, Yamamoto K, Hiratake J, Ogawa M, Kosaka N, Choyke PL, Nagano T, Kobayashi H, Urano Y. Sensitive beta-galactosidase-targeting fluorescence probe for visualizing small peritoneal metastatic tumours in vivo. Nat Commun 2015, 6, 6463. PMID 25765713
  3. Ogawa M, Uchino R, Kawai A, Kosugi M, Magata Y. PEG modification on111In-labeled phosphatidyl serine liposomes for imaging of atherosclerotic plaques. Nucl Med Biol 2015, 42 (3), 299-304. PMID 25533763
  4. Sakai T, Saito Y, Takashima M, Ogawa M, Magata Y. Development of radioiodinated lipophilic cationic compounds for myocardial imaging. Nucl Med Biol 2015, 42 (5), 482-487. PMID 25735221
  5. Hatano K, Sekimata K, Yamada T, Abe J, Ito K, Ogawa M, Magata Y, Toyohara J, Ishiwata K, Biggio G, Serra M, Laquintana V, Denora N, Latrofa A, Trapani G, Liso G, Suzuki H, Sawada M, Nomura M, Toyama H. Radiosynthesis and in vivo evaluation of two imidazopyridineacetamides, [11C]CB184 and [11C]CB190, as a PET tracer for 18 kDa translocator protein: direct comparison with [11C](R)-PK11195. Ann Nucl Med 2015, 29 (4), 325-335. PMID 25616581
  6. Kojima R, Takakura H, Kamiya M, Kobayashi E, Komatsu T, Ueno T, Terai T, Hanaoka K, Nagano T, Urano Y. Development of a Sensitive Bioluminogenic Probe for Imaging Highly Reactive Oxygen Species in Living Rats. Angew Chem Int Ed Engl 2015, 54 (49), 14768-14771. PMID 26474404
  7. Takakura H, Kojima R, Kamiya M, Kobayashi E, Komatsu T, Ueno T, Terai T, Hanaoka K, Nagano T, Urano Y. New class of bioluminogenic probe based on bioluminescent enzyme-induced electron transfer: BioLeT. J Am Chem Soc 2015, 137 (12), 4010-4013. PMID 25761130
  8. Takakura H, Hattori M, Tanaka M, Ozawa T. Cell-based assays and animal models for GPCR drug screening. Methods Mol Biol 2015, 1272, 257-270. PMID 25563190
  9. Masaki Y, Shimizu Y*, Yoshioka T, Tanaka Y, Nishijima KI, Zhao S, Higashino K, Sakamoto S, NumataY, Yamaguchi Y, Tamaki N, Kuge Y. The accumulation mechanism of the hypoxia imaging probe “FMISO” by imaging mass spectrometry: possible involvement of low-molecular metabolites. Sci Rep 2015, 5, 16802. PMID 26582591
  10. Sugimoto M, Shimizu Y, Yoshioka T, Wakabayashi M, Tanaka Y, Higashino K, Numata Y, Sakai S, Kihara A, Igarashi Y, Kuge Y. Histological analyses by matrix-assisted laser desorption/ionization-imaging mass spectrometry reveal differential localization of sphingomyelin molecular species regulated by particular ceramide synthase in mouse brains. Biochim Biophys Acta 2105, 1851 (12), 1554-1565. PMID 26398595
  11. Kanazaki K, Sano K, Makino A, Shimizu Y, Yamauchi F, Ogawa S, Ding N, Yano T, Temma T, Ono M, Saji H. In vivo HER2-targeted photoacoustic tumor imaging using anti-HER2 fragment antibody conjugated to iron oxide nanoparticles. Nanomedicine 2015, 11 (8), 2051-2060.
  12. Kondo N, Temma T, Shimizu Y, Ono M, Saji H. Radioiodinated Peptidic Imaging Probes for In Vivo Detection of Membrane Type-1 Matrix Metalloproteinase in Cancers. Biol Pharm Bull 2015, 38 (9), 1375-1382. PMID 26328493
  13. Zhao S, Li H, Nishijima KI, Zhao Y, Akizawa H, Shimizu Y, Ohkura K, Tamaki N, Kuge Y. Relationship between biodistribution of a novel thymidine phosphorylase (TP) imaging probe and TP expression levels in normal mice. Ann Nucl Med 2015, 29 (7), 582-587. PMID 25976738
  14. Zhao Y, Fukao K, Zhao S, Watanabe A, Yamasaki K, Shimizu Y, Kubo N, Ukon N, Nakano T, Tamaki N, Kuge Y. Irbesartan reduces atherosclerosis in Watanabe Heritable Hyperlipidemic (WHHL) rabbits: Non-invasive imaging of inflammation with 18F-FDG PET. Mol Imaging 2015, 14 (5). PMID 25812568
  15. Yamasaki K, Zhao S, Nishimura M, Zhao Y, Yu W, Shimizu Y, Nishijima K, Tamaki N, Takeda H, Kuge Y. Radiolabeled BMIPP for imaging hepatic fatty acid metabolism: Evaluation of hepatic distribution and metabolism in mice at various metabolic status induced by fasting in comparison with palmitic acid. Mol Imaging 2015, 14 , 1-11. PMID 25744134
  16. Ueda M, Hisada H, Temma T, Shimizu Y, Kimura H, Ono M, Nakamoto Y, Togashi K, Saji H. Gallium-68-Labeled Anti-HER2 Single-Chain Fv Fragment: Development and In Vivo Monitoring of HER2 Expression. Mol Imaging Biol 2015, 17 (1), 102-110. PMID 25049073

2014年

  1. Ishino S, Ogawa M, Mori I, Nishimura S, Ikeda S, Sugita T, Oikawa T, Horiguchi T, Magata Y. 18F-FDG PET and intravascular ultrasonography (IVUS) images compared with histology of atherosclerotic plaques: 18F-FDG accumulates in foamy macrophages. Eur J Nucl Med Mol Imaging 2014, 41 (4), 624-633. PMID 24258009
  2. Sano M, Sasaki T, Hirakawa S, Sakabe J, Ogawa M, Baba S, Zaima N, Tanaka H, Inuzuka K, Yamamoto N, Setou M, Sato K, Konno H, Unno N. Lymphangiogenesis and angiogenesis in abdominal aortic aneurysm. PLoS One 2014, 9 (3), e89830. PMID 24651519
  3. Iwaki S, Hokamura K, Ogawa M, Takehara Y, Muramatsu Y, Yamane T, Hirabayashi K, Morimoto Y, Hagisawa K, Nakahara K, Mineno T, Terai T, Komatsu T, Ueno T, Tamura K, Adachi Y, Hirata Y, Arita M, Arai H, Umemura K, Nagano T, Hanaoka K. A design strategy for small molecule-based targeted MRI contrast agents: their application for detection of atherosclerotic plaques. Org Biomol Chem 2014, 12 (43), 8611-8618. PMID 25186130
  4. Sano K, Iwamiya Y, Kurosaki T, Ogawa M, Magata Y, Sasaki H, Ohshima T, Maeda M, Mukai T. Radiolabeled γ-polyglutamic acid complex as a nano-platform for sentinel lymph node imaging. J Control Release 2014, 194, 310-315. PMID 25238958
  5. Kojima C, Niki Y, Ogawa M, Magata Y. Prolonged local retention of subcutaneously injected polymers monitored by noninvasive SPECT imaging. Int J Pharm 2014, 476 (1-2), 164-168. PMID 25280883
  6. Ogawa M, Umeda IO, Kosugi M, Kawai A, Hamaya Y, Takashima M, Yin H, Kudoh T, Seno M, Magata Y. Development of 111In-labeled liposomes for vulnerable atherosclerotic plaque imaging. J Nucl Med 2014, 55 (1), 115-120. PMID 24337605
  7. Ogawa M, Yamauchi T, Iwai H, Magata Y, Choyke PL, Kobayashi H. A Investigation of dynamic morphological changes of cancer cells during photoimmunotherapy (PIT) by low-coherence quantitative phase microscopy. Progress in Biomedical Optics and Imaging 2014, 8931, 893110-893113.
  8. Zhu HJ, Ogawa M, Magata Y, Hirata M, Ohmomo Y, Sakahara H. Relationship between uptake of a radioiodinated quinazoline derivative and radiosensitivity in non-small cell lung cancer. Am J Nucl Med Mol Imaging 2014, 4 (4), 293-302. PMID 24982815
  9. Erdmann RS, Takakura H, Thompson AD, Rivera-Molina F, Allgeyer ES, Bewersdorf J, Toomre D, Schepartz A. Super-resolution imaging of the Golgi in live cells with a bioorthogonal ceramide probe. Angew Chem Int Ed Engl 2014, 53 (38), 10242-10246. PMID 25081303
  10. Shimizu Y, Temma T, Hara I, Makino A, Yamahara R, Ozeki EI, Ono M, Saji H. Micelle-based Activatable Probe for in vivo Near-Infrared Optical Imaging of Cancer Biomolecules. Nanomedicine 2014, 10 (1), 187-195. PMID 23811292
  11. Onoe S, Temma T, Shimizu Y, Ono M, Saji H. Investigation of cyanine dyes for in vivo optical imaging of altered mitochondrial membrane potential in tumors. Cancer Med 2014, 3 (4), 775-786. PMID 24737784
  12. Shimizu Y, Temma T, Hara I, Makino A, Kondo N, Ozeki EI, Ono M, Saji H. In vivo Imaging of Membrane Type-1 Matrix Metalloproteinase with a Novel Activatable Near-Infrared Fluorescence Probe. Cancer Sci 2014, 105 (8), 1056-1062. PMID 24863849