研究業績

2020年

  1. Kono Y, Yokoyama K, Suzuki M, Takakura H, Ogawa M. Surface modification of liposomes using IR700 enables efficient controlled contents release triggered by near-IR light. Bio Pharm Bull 2020, in press.
  2. Tomita M, Suzuki M, Kono Y, Nakajima K, Matsuda T, Kuge Y, Ogawa M. Influence on [18F]FDG uptake by cancer cells after anti PD-1 therapy in an enforced-immune activated mouse tumor. EJNMMI Res 2020, 10 (1), 24. PMID 32189078
  3. Nishimoto Y, Nagashima S, Nakajima K, Ohira T, Sato T, Izawa T, Yamate J, Higashikawa K, Kuge Y, Ogawa M, Kojima C. Carboxyl-, sulfonyl-, and phosphate-terminal dendrimers as a nanoplatform with lymph node targeting. Int J Pharm 2020, 576, 119021. PMID 31917298
  4. 中島 孝平, 杉川 晃代, 安井 博宣, 東川 桂, 高倉 栄男, 志賀 哲, 久下 裕司, 小川 美香子. 光免疫療法による腫瘍環境の変化に関する[18F]FDGと[18F]FMISOを用いた検討. JSMI Report 2020, 13 (1), 17-22.
  5. 寺田 一貴, 中島 孝平, 高倉 栄男, 小川 美香子. 小分子ペプチドを利用した光免疫療法のメカニズム解明. JSMI Report 2020, 13 (1), 23-26.

2019年

  1. Inubushi M, Shibahara M, Takahashi Y, Ogawa M, Kiyono Y. From the Respective Expert Viewpoints of the ANM Specialty Editors. Ann Nucl Med 2019, 33 (12), 877-889. PMID 31745811
  2. Narita Y, Shimizu K, Ikemoto K, Uchino R, Kosugi M, Maess MB, Magata Y, Oku N, Ogawa M. Macrophage-targeted, enzyme-triggered fluorescence switch-on system for detection of embolism-vulnerable atherosclerotic plaques. J Control Release 2019 302, 105-115. PMID 30936020
  3. Shimizu Y*, Motomura A*, Takakura H, Tamaki N, Kuge Y, Ogawa M. Accumulation of hypoxia imaging probe "[18F]FMISO" in macrophages depends on macrophage polarization in addition to hypoxic state. Ann Nucl Med 2019, 33 (5), 362-367. *equally contributed. PMID 30694443

2018年

  1. Sato K, Ando K, Okuyama S, Moriguchi S, Ogura T, Totoki S, Hanaoka H, Nagaya T, Kokawa R, Takakura H, Nishimura M, Hasegawa Y, Choyke PL, Ogawa M, Kobayashi H. Photoinduced Ligand Release from a Silicon Phthalocyanine Dye Conjugated with Monoclonal Antibodies: A Mechanism of Cancer Cell Cytotoxicity after Near-Infrared Photoimmunotherapy. ACS Cent Sci 2018, 4 (11), 1559-1569. PMID 30555909
  2. Tomita M, Yasui H, Higashikawa K, Nakajima K, Takakura H, Shiga T, Kuge Y, Ogawa M. Anti PD-1 treatment increases [18F]FDG uptake by cancer cells in a mouse B16F10 melanoma model. EJNMMI Research 2018, 8, 82. PMID 30117062
  3. Sugita T, Kondo Y, Ishino S, Mori I, Horiguchi T, Ogawa M, Magata Y. Evaluation of drug effects on cerebral blood flow and glucose uptake in un-anesthetized and un-stimulated rats: application of free-moving apparatus enabling to keep rats free during PET/SPECT tracer injection and uptake. Nucl Med Commun 2018, 39 (8), 753-760. PMID 29771718
  4. Nakajima K, Takakura H, Shimizu Y, Ogawa M. Changes in plasma membrane damage inducing cell death after treatment with near-infrared photoimmunotherapy. Cancer Sci 2018 109 (9) 2889-2896. PMID 29949672
  5. Shimizu Y, Zhao S, Yasui H, Nishijima KI, Matsumoto H, Shiga T, Tamaki N, Ogawa M, Kuge Y. A Novel PET Probe "[18F]DiFA" Accumulates in Hypoxic Region via Glutathione Conjugation Following Reductive Metabolism. Mol Imaging Biol 2018 . [Epub ahead of print] PMID 29845425
  6. Nakajima K, Kimura T, Takakura H, Yoshikawa Y, Kameda A, Shindo T, Sato K, Kobayashi H, Ogawa M. Implantable wireless powered light emitting diode (LED) for near-infrared photoimmunotherapy: device development and experimental assessment in vitro and in vivo. Oncotarget 2018, 9 (28), 20048-20057. PMID 29732002
  7. Ogawa M, Takakura H. In Vivo Molecular Imaging for Biomedical Analysis and Therapies. Anal Sci 2018, 34 (3), 273-281. PMID 29526893

2017年

  1. Takakura H*, Zhang Y*, Erdmann RS*, Thompson AD*, Lin Y, McNellis B, Rivera-Molina F, Uno S, Kamiya M, Urano Y, Rothman JE, Bewersdorf J, Schepartz A, Toomre D. Long time-lapse nanoscopy with spontaneously blinking membrane probes. Nature Biotechnol 2017, 35, 773-780. *equally contributed. PMID 28071662
  2. Ogawa M, Tomita Y, Nakamura Y, Lee M. J, Lee S, Tomita S, Nagaya T, Sato K, Yamauchi T, Iwai H, Kumar A, Haystead T, Shroff H, Choyke PL, Trepel JB, Kobayashi H. Immunogenic cancer cell death selectively induced by near infrared photoimmunotherapy initiates host tumor immunity. Oncotarget 2017, 8 (6), 10425-10436. PMID 28060726
  3. Shimizu Y, Hanzawa H, Zhao Y, Fukura S, Nishijima K. I, Sakamoto T, Zhao S, Tamaki N, Ogawa M, Kuge Y. Immunoglobulin G (IgG)-Based Imaging Probe Accumulates in M1 Macrophage-Infiltrated Atherosclerotic Plaques Independent of IgG Target Molecule Expression. Mol Imaging Biol 2017, 19 (4), 531-539. PMID 27981470
  4. 中島 孝平, 志水 陽一, 高倉 栄男, 小川 美香子. 近赤外光を用いた光線免疫療法における細胞死誘発機序の検証. JSMI Report 2017, 11 (1), 56-59.

2016年

  1. Saito K, Iioka H, Kojima C, Ogawa M, Kondo E. Peptide-based tumor inhibitor encoding mitochondrial p14(ARF) is highly efficacious to diverse tumors. Cancer Sci 2016, 107 (9), 1290-1301. PMID 27317619
  2. Kobayashi H, Choyke PL, Ogawa M. Monoclonal antibody-based optical molecular imaging probes; considerations and caveats in chemistry, biology and pharmacology. Curr Opin Chem Biol 2016, 33, 32-38. PMID 27281509
  3. Masaki Y*, Shimizu Y*, Yoshioka T, Fei Feng, Zhao S, Higashino K, NumataY, Kuge Y. Imaging Mass Spectrometry Revealed the Accumulation Characteristics of the 2-nitroimidazole-based Agent “Pimonidazole” in Hypoxia. PLoS One 2016, 11 (8), e0161639. *equally contributed. PMID 27580239
  4. Sugimoto M, Shimizu Y, Zhao S, Ukon N, Nishijima KI, Wakabayashi M, Yoshioka T, Higashino K, Numata Y, Okuda T, Tamaki N, Hanamatsu H, Igarashi Y, Kuge Y. Characterization of the role of sphingomyelin synthase 2 in glucose metabolism in whole-body and peripheral tissues in mice. Biochim Biophys Acta 2016, 1861 (8PtA), 688-702. PMID 27151272
  5. Sugimoto M, Wakabayashi M, Shimizu Y, Yoshioka T, Higashino K, Numata Y, Okuda T, Zhao S, Sakai S, Igarashi Y, Kuge Y. Imaging mass spectrometry reveals acyl-chain- and region-specific sphingolipid metabolism in the kidneys of sphingomyelin synthase 2-deficient mice. PLoS One 2016, 11 (3), e0152191. PMID 27010944
  6. Shimizu Y, Kuge Y. Recent Advances in the Development of PET/SPECT Probes for Atherosclerosis Imaging. Nucl Med Mol Imaging 2016, 50 (4), 284-291. PMID 27994683
  7. Nishijima KI, Zhao S, Feng F, Shimizu Y, Akizawa H, Ohkura K, Tamaki N, Kuge Y. Preclinical Evaluation of a Thymidine Phosphorylase Imaging Probe, [123I]IIMU, for Translational Research. Perspectives on Nuclea Medicine for Molecular Diagnosis and Integrated Therapy (Springer Open) 2016, 125-130.
  8. Sakamoto T, Hanzawa H, Manri N, Sakakibara M, Shimizu Y, Zhao Y, Zhao S, Yamada S, Kamiya K, Eki Y, Suzuki A, Higuchi H, Sugano C, Tutsui H, Tamaki N, Kuge Y. Discovery and Evaluation of Biomarkers for Atherosclerosis: Differential Proteomics of Plasma and Tissues. Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy (Springer Open) 2016, 131-140.
  9. Shimizu Y, Hanzawa H, Zhao Y, Nishijima KI, Sakamoto T, Zhao S, Tamaki N, Kuge Y. Radioimmunodetection of Atherosclerotic Lesions Focusing on the Accumulation Mechanism of Immunoglobulin G. Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy (Springer Open) 2016, 141-150.
  10. Takenouchi O, Kanno A, Takakura H, Hattori M, Ozawa T. Bioluminescent indicator for highly sensitive analysis of estrogenic activity in a cell-based format. Bioconjug Chem 2016, 27, 2689-2694. PMID 27690388

2015年

  1. Niki Y, Ogawa M, Makiura R, Magata Y, Kojima C. Optimization of dendrimer structure for sentinel lymph node imaging: Effects of generation and terminal group. Nanomedicine 2015, 11 (8), 2119-2127. PMID 26348654
  2. Asanuma D, Sakabe M, Kamiya M, Yamamoto K, Hiratake J, Ogawa M, Kosaka N, Choyke PL, Nagano T, Kobayashi H, Urano Y. Sensitive beta-galactosidase-targeting fluorescence probe for visualizing small peritoneal metastatic tumours in vivo. Nat Commun 2015, 6, 6463. PMID 25765713
  3. Ogawa M, Uchino R, Kawai A, Kosugi M, Magata Y. PEG modification on111In-labeled phosphatidyl serine liposomes for imaging of atherosclerotic plaques. Nucl Med Biol 2015, 42 (3), 299-304. PMID 25533763
  4. Sakai T, Saito Y, Takashima M, Ogawa M, Magata Y. Development of radioiodinated lipophilic cationic compounds for myocardial imaging. Nucl Med Biol 2015, 42 (5), 482-487. PMID 25735221
  5. Hatano K, Sekimata K, Yamada T, Abe J, Ito K, Ogawa M, Magata Y, Toyohara J, Ishiwata K, Biggio G, Serra M, Laquintana V, Denora N, Latrofa A, Trapani G, Liso G, Suzuki H, Sawada M, Nomura M, Toyama H. Radiosynthesis and in vivo evaluation of two imidazopyridineacetamides, [11C]CB184 and [11C]CB190, as a PET tracer for 18 kDa translocator protein: direct comparison with [11C](R)-PK11195. Ann Nucl Med 2015, 29 (4), 325-335. PMID 25616581
  6. Kojima R, Takakura H, Kamiya M, Kobayashi E, Komatsu T, Ueno T, Terai T, Hanaoka K, Nagano T, Urano Y. Development of a Sensitive Bioluminogenic Probe for Imaging Highly Reactive Oxygen Species in Living Rats. Angew Chem Int Ed Engl 2015, 54 (49), 14768-14771. PMID 26474404
  7. Takakura H, Kojima R, Kamiya M, Kobayashi E, Komatsu T, Ueno T, Terai T, Hanaoka K, Nagano T, Urano Y. New class of bioluminogenic probe based on bioluminescent enzyme-induced electron transfer: BioLeT. J Am Chem Soc 2015, 137 (12), 4010-4013. PMID 25761130
  8. Takakura H, Hattori M, Tanaka M, Ozawa T. Cell-based assays and animal models for GPCR drug screening. Methods Mol Biol 2015, 1272, 257-270. PMID 25563190
  9. Masaki Y, Shimizu Y*, Yoshioka T, Tanaka Y, Nishijima KI, Zhao S, Higashino K, Sakamoto S, NumataY, Yamaguchi Y, Tamaki N, Kuge Y. The accumulation mechanism of the hypoxia imaging probe “FMISO” by imaging mass spectrometry: possible involvement of low-molecular metabolites. Sci Rep 2015, 5, 16802. PMID 26582591
  10. Sugimoto M, Shimizu Y, Yoshioka T, Wakabayashi M, Tanaka Y, Higashino K, Numata Y, Sakai S, Kihara A, Igarashi Y, Kuge Y. Histological analyses by matrix-assisted laser desorption/ionization-imaging mass spectrometry reveal differential localization of sphingomyelin molecular species regulated by particular ceramide synthase in mouse brains. Biochim Biophys Acta 2105, 1851 (12), 1554-1565. PMID 26398595
  11. Kanazaki K, Sano K, Makino A, Shimizu Y, Yamauchi F, Ogawa S, Ding N, Yano T, Temma T, Ono M, Saji H. In vivo HER2-targeted photoacoustic tumor imaging using anti-HER2 fragment antibody conjugated to iron oxide nanoparticles. Nanomedicine 2015, 11 (8), 2051-2060.
  12. Kondo N, Temma T, Shimizu Y, Ono M, Saji H. Radioiodinated Peptidic Imaging Probes for In Vivo Detection of Membrane Type-1 Matrix Metalloproteinase in Cancers. Biol Pharm Bull 2015, 38 (9), 1375-1382. PMID 26328493
  13. Zhao S, Li H, Nishijima KI, Zhao Y, Akizawa H, Shimizu Y, Ohkura K, Tamaki N, Kuge Y. Relationship between biodistribution of a novel thymidine phosphorylase (TP) imaging probe and TP expression levels in normal mice. Ann Nucl Med 2015, 29 (7), 582-587. PMID 25976738
  14. Zhao Y, Fukao K, Zhao S, Watanabe A, Yamasaki K, Shimizu Y, Kubo N, Ukon N, Nakano T, Tamaki N, Kuge Y. Irbesartan reduces atherosclerosis in Watanabe Heritable Hyperlipidemic (WHHL) rabbits: Non-invasive imaging of inflammation with 18F-FDG PET. Mol Imaging 2015, 14 (5). PMID 25812568
  15. Yamasaki K, Zhao S, Nishimura M, Zhao Y, Yu W, Shimizu Y, Nishijima K, Tamaki N, Takeda H, Kuge Y. Radiolabeled BMIPP for imaging hepatic fatty acid metabolism: Evaluation of hepatic distribution and metabolism in mice at various metabolic status induced by fasting in comparison with palmitic acid. Mol Imaging 2015, 14 , 1-11. PMID 25744134
  16. Ueda M, Hisada H, Temma T, Shimizu Y, Kimura H, Ono M, Nakamoto Y, Togashi K, Saji H. Gallium-68-Labeled Anti-HER2 Single-Chain Fv Fragment: Development and In Vivo Monitoring of HER2 Expression. Mol Imaging Biol 2015, 17 (1), 102-110. PMID 25049073

2014年

  1. Ishino S, Ogawa M, Mori I, Nishimura S, Ikeda S, Sugita T, Oikawa T, Horiguchi T, Magata Y. 18F-FDG PET and intravascular ultrasonography (IVUS) images compared with histology of atherosclerotic plaques: 18F-FDG accumulates in foamy macrophages. Eur J Nucl Med Mol Imaging 2014, 41 (4), 624-633. PMID 24258009
  2. Sano M, Sasaki T, Hirakawa S, Sakabe J, Ogawa M, Baba S, Zaima N, Tanaka H, Inuzuka K, Yamamoto N, Setou M, Sato K, Konno H, Unno N. Lymphangiogenesis and angiogenesis in abdominal aortic aneurysm. PLoS One 2014, 9 (3), e89830. PMID 24651519
  3. Iwaki S, Hokamura K, Ogawa M, Takehara Y, Muramatsu Y, Yamane T, Hirabayashi K, Morimoto Y, Hagisawa K, Nakahara K, Mineno T, Terai T, Komatsu T, Ueno T, Tamura K, Adachi Y, Hirata Y, Arita M, Arai H, Umemura K, Nagano T, Hanaoka K. A design strategy for small molecule-based targeted MRI contrast agents: their application for detection of atherosclerotic plaques. Org Biomol Chem 2014, 12 (43), 8611-8618. PMID 25186130
  4. Sano K, Iwamiya Y, Kurosaki T, Ogawa M, Magata Y, Sasaki H, Ohshima T, Maeda M, Mukai T. Radiolabeled γ-polyglutamic acid complex as a nano-platform for sentinel lymph node imaging. J Control Release 2014, 194, 310-315. PMID 25238958
  5. Kojima C, Niki Y, Ogawa M, Magata Y. Prolonged local retention of subcutaneously injected polymers monitored by noninvasive SPECT imaging. Int J Pharm 2014, 476 (1-2), 164-168. PMID 25280883
  6. Ogawa M, Umeda IO, Kosugi M, Kawai A, Hamaya Y, Takashima M, Yin H, Kudoh T, Seno M, Magata Y. Development of 111In-labeled liposomes for vulnerable atherosclerotic plaque imaging. J Nucl Med 2014, 55 (1), 115-120. PMID 24337605
  7. Ogawa M, Yamauchi T, Iwai H, Magata Y, Choyke PL, Kobayashi H. A Investigation of dynamic morphological changes of cancer cells during photoimmunotherapy (PIT) by low-coherence quantitative phase microscopy. Progress in Biomedical Optics and Imaging 2014, 8931, 893110-893113.
  8. Zhu HJ, Ogawa M, Magata Y, Hirata M, Ohmomo Y, Sakahara H. Relationship between uptake of a radioiodinated quinazoline derivative and radiosensitivity in non-small cell lung cancer. Am J Nucl Med Mol Imaging 2014, 4 (4), 293-302. PMID 24982815
  9. Erdmann RS, Takakura H, Thompson AD, Rivera-Molina F, Allgeyer ES, Bewersdorf J, Toomre D, Schepartz A. Super-resolution imaging of the Golgi in live cells with a bioorthogonal ceramide probe. Angew Chem Int Ed Engl 2014, 53 (38), 10242-10246. PMID 25081303
  10. Shimizu Y, Temma T, Hara I, Makino A, Yamahara R, Ozeki EI, Ono M, Saji H. Micelle-based Activatable Probe for in vivo Near-Infrared Optical Imaging of Cancer Biomolecules. Nanomedicine 2014, 10 (1), 187-195. PMID 23811292
  11. Onoe S, Temma T, Shimizu Y, Ono M, Saji H. Investigation of cyanine dyes for in vivo optical imaging of altered mitochondrial membrane potential in tumors. Cancer Med 2014, 3 (4), 775-786. PMID 24737784
  12. Shimizu Y, Temma T, Hara I, Makino A, Kondo N, Ozeki EI, Ono M, Saji H. In vivo Imaging of Membrane Type-1 Matrix Metalloproteinase with a Novel Activatable Near-Infrared Fluorescence Probe. Cancer Sci 2014, 105 (8), 1056-1062. PMID 24863849