For the purpose of contributing toward drug discovery in academia, our laboratory conducts (1)practical and highly effective chemical synthesis based on synthetic organic chemistry, and development of methodology and synthetic strategy for them, regarding natural products having complex structures and prospective biological activities for drug discovery, and biopolymers such as nucleic acid or peptide as the interests of our research. (2)development of effective synthetic methods on sugar chain derivatives and heterocyclic derivatives, and drug development leading lead compound to clinical candidates by multi-dimensional optimization.
As the requirements for drug discovery in academia are getting more difficult year by year, now is the time for us to fulfill not only supply of compounds but also certain activity, selectivity, toxic data, elucidation of mechanism of action, and so on. To overcome these requirements, we need to fully understand the substances of these problems, to design compounds for achievement, and to
synthesize them firmly. We are heading for invention of drug discovery leading and development of drug discovery theories that surpass these functions of natural products or biopolymers by higher evaluation of activity and elucidation of mechanism of action using the probe molecules. We also strive for the construction of northern drug discovery platform dealing with intractable diseases in cooperation with organizations inside or outside of Hokkaido University, institutions, private enterprises.
2024.04.02 | 小嶋さん、百崎さんの論文がscientific reportsで公開されました。 |
---|---|
2024.02.28 | 永見さんの論文がNature Chemistryで公開されました。 |
2023.11.07 | 当研究室から中村さん、岩崎さんが参画した木原研究室との共同研究に関する論文がiScience誌で公開されました。 |
2023.07.28 | 「BINDS研究者の横顔:第3回 市川聡先生」が公開されました。 |
2023.07.20 | ナノシスチンの全合成に関する論文がJ. Org. Chem.誌で公開されました。 |
2023.01.28 | 家口さんの論文がJournal of the American Chemical Societyで公開されました。 |
2023.01.19 | 駒谷さんの論文がOrganic Lettersで公開されました。 |
2022.06.24 | 大川さんの論文がChemical Communicationsで公開されました。 |
2022.04.07 | 生物活性天然物の全合成と創薬リード創成の架け橋 |
2022.03.16 | 髙科さんの論文がOrganic Lettersで公開されました。 |