北海道大学大学院 薬学研究院
生体分析化学研究室
業績

研究業績

原著論文・総説

  1. Ieda N, Takakura H, Maeta H, Ohira T, Tsuchiya K, Nakajima K, Ogawa M. Investigation of the substituent effect of indocyanine green derivatives for lymph imaging. Bioorg Med Chem Lett. 2024 (in press)
  2. Kawaguchi M, Minami S, Ieda N, Nakagawa H. [1,2,4]Triazolo[1,5-a]pyrimidine derivatives: Structure-activity relationship study leading to highly selective ENPP1 inhibitors. Bioorg Med Chem Lett. 2024 110 , 129820-129826 PMID 38851358
  3. Tsuchiya K, Takakura H, Nakajima K, Ieda N, Kaneko T, Hirasawa T, Kobayashi M, Yamaoka Y, Ishihara M, Taketsugu T, Ogawa M. Piperazine based pH-responsive cyanine dyes for cancer cell photoacoustic imaging. J Photochem Photobiol A. 2024 453 , 115634-115649 DOI 10.1016/j.jphotochem.2024.115634
  4. Hotta Y, Oyama K, Yoshida T, Ieda N, Mori T, Horita Y, Kataoka T, Furukawa-Hibi Y, Ohya S, Nakagawa H, Kimura K. The effects of a red-light controllable nitric oxide donor, NORD-1, on erectile dysfunction in rats with streptozotocin induced diabetes mellitus. World J Mens Health. 2024 42 , e58 PMID 38772543
  5. Ogawara K, Inanami O, Takakura H, Saita K, Nakajima K, Kumar S, Ieda N, Kobayashi M, Taketsugu T, Ogawa M. Theoretical Design and Synthesis of Caged Compounds Using X-Ray-Triggered Azo Bond Cleavage. Adv Sci. 2024 e2306586 PMID 38225711
  6. Ieda N, Nakamura A, Tomita N, Ohkubo K, Izumi R, Hotta Y, Kawaguchi M, Kimura K, Nakagawa H. A BODIPY-picolinium-cation conjugate as a blue-light-responsive caged group. RSC Advances. 2023 13 (38) 26375-26379 PMID 37671339
  7. Ieda N, Kawaguchi M, Nakagawa H. Substituent Effects at the N-Nitrosoaminophenol Moiety of a Photoinduced-Electron-Transfer-Driven Nitric Oxide Releaser. Chem Pharm Bull. 2023 71 (6) 447-450 PMID 37258199
  8. Ieda N, Sawada M, Oguchi R, Itoh M, Hirakata S, Saitoh D, Nakao A, Kawaguchi M, Sawamoto K, Yoshihara T, Mori Y, Nakagawa H. An Optochemical Oxygen Scavenger Enabling Spatiotemporal Control of Hypoxia. Angew Chem Int Ed. 2023 62 (20) e202217585 PMID 36929683
  9. Saitoh D, Suzuki A, Ieda N, Liu Z, Osakada Y, Fujitsuka M, Kawaguchi M, Nakagawa H. Photoinduced NO-Release from Polymer Dots Doped with an Ir(III) Complex and N-Methyl-N-nitroso-4-aminophenol. Org Biomol Chem. 2023 21 (20) e202217585 PMID 36942556
  10. Liu Z, Okada Y, Ichinose Y, Saitoh D, Ieda N, Yamasaki S, Nishino K, Nakagawa H, Fujitsuka M, Osakada Y. Vanadyl Naphthalocyanine-Doped Polymer Dots for Near-Infrared Light-Induced Nitric Oxide Release and Bactericidal Effects. ACS Appl Nano Mater. 2023 6 (2) 1487-1495
  11. Mori T, Hotta Y, Ieda N, Kataoka T, Nakagawa H, Kimura K. Efficacy of a Red-Light Controllable Nitric Oxide Releaser for Neurogenic Erectile Dysfunction; a Study Using a Rat Model of Cavernous Nerve Injury. ACS Appl Nano Mater. 2023 41 (4) 909-919 PMID 36649921
  12. Kawaguchi M, Furuse Y, Ieda N, Nakagawa H. Development of Nucleoside Diphosphate-Bearing Fragile Histidine Triad-Imaging Fluorescence Probes with Well-Tuned Hydrophobicity for Intracellular Delivery. ACS Sens. 2022 7 (9) 2732-2742 PMID 35981239
  13. Ieda N, Yoshikawa Y, Tomita N, Ohkubo K, Hotta Y, Kawaguchi M, Kimura K, Nakagawa H. Ascorbate-assisted nitric oxide release from photocontrollable nitrosonium ion releasers for potent ex vivo photovasodilation. Chem Commun. 2022 58 (60) 8420-8423 PMID 35796257
  14. Kawaguchi M, Sekimoto E, Ohta Y, Ieda N, Murakami T, Nakagawa H. Synthesis of fluorescence probes targeting tumor-suppressor protein FHIT and identification of apoptosis-inducing FHIT inhibitors. J Med Chem. 2021 64 (13) 9567-9576 PMID 34160227
  15. Maeda K, Hotta Y, Ieda N, Kataoka T, Nakagawa H, Kimura K. Control of rat bladder neck relaxation with NORD-1, a red light–reactive nitric oxide releaser: in vitro study. J Pharmacol Sci. 2021 146 (4) 226-232 PMID 34116736
  16. Nakajima Y, Kawaguchi M, Ieda N, Nakagawa H. A set of highly sensitive sirtuin fluorescence probes for screening small-molecular SIRT defatty-acylase inhibitors. J Pharmacol Sci. 2021 12 (4) 617-624 PMID 33859801
  17. Ieda N, Hotta Y, Yamauchi A, Nishikawa A, Sasamori T, Saitoh D, Kawaguchi M, Kimura K, Nakagawa H. Development of a red-light-controllable nitric oxide releaser to control smooth muscle relaxation in vivo. ACS Chem Biol. 2020 15 (11) 2958-2965 PMID 33166443
  18. Ohta Y, Kawaguchi M, Ieda N, Nakagawa H. Synthesis of artificial substrate based on inhibitor for detecting LSD1 activity. J Clin Biochem Nutr. 2020 67 (2) 153-158 PMID 33041512
  19. Ieda N, Nakagawa H. Development of Photoredox-reaction-driven NO-releasing Reagents and Application for Photomanipulation of Vasodilation. J Synth Org Chem Jpn. 2020 78 (11) 1048-1057
  20. Ieda N, Nakagawa H. Synthesis, evaluation, and biological applications of visible-light-controllable nitric oxide releasers. Methods Enzymol. 2020 640 37-61 PMID 32560805
  21. Ohta Y, Wakita H, Kawaguchi M, Ieda N, Osada S, Nakagawa H. Ratiometric assay of CARM1 activity using a FRET-based fluorescent probe. Bioorg Med Chem Lett. 2019 29 (22) 126728 PMID 31607607
  22. Kawaguchi M, Han X, Hisada T, Nishikawa S, Kano K, Ieda N, Aoki J, Toyama T, Nakagawa H. Development of an ENPP1 fluorescence probe for inhibitor screening, cellular imaging and prognostic assessment of malignant breast cancer. J Med Chem. 2019 62 (20) 9254-9269 PMID 31536342
  23. Kawaguchi M, Ieda N, Nakagawa H. Development of Peptide-Based Sirtuin Defatty-Acylase Inhibitors Identified by the Fluorescence Probe, SFP3, That Can Efficiently Measure Defatty-Acylase Activity of Sirtuin. J Med Chem. 2019 62 (11) 5434-5452 PMID 31117516
  24. Ieda N, Hotta Y, Kawaguchi M, Kimura K, Nakagawa H. In cellullo and ex vivo availability of a yellowish-green-light-controllable NO releaser. Chem Pharm Bull. 2019 67 (6) 576-579 PMID 31155563
  25. Kunieda K, Kawaguchi M, Ieda N, Nakagawa H. In cellullo and ex vivo availability of a yellowish-green-light-controllable NO releaser. Bioorg Med Chem Lett. 2019 29 (7) 923-928 PMID 30773431
  26. Ieda N, Oka Y, Yoshihara T, Tobita S, Sasamori T, Kawaguchi M, Nakagawa H. Structure-efficiency relationship of photoinduced electron transfer-triggered nitric oxide releasers. Sci Rep. 2019 9 (1) 1430 PMID 30723285
  27. Furuyama T, Ishii T, Ieda N, Maeda H, Segi M, Uchiyama M, Nakagawa H. Cationic Axial Ligands on Sulfur Substituted Silicon(IV) Phthalocyanines: Improved Hydrophilicity and Exceptionally Red-shifted Absorption into the NIR Region. Chem Commun. 2019 55 (51) 7311-7314 PMID 31144690
  28. Ieda N, Itoh K, Inoue Y, Izumiya Y, Kawaguchi M, Miyata N, Nakagawa H. An irreversible inhibitor of peptidyl-prolyl cis/trans isomerase Pin1 and evaluation of cytotoxicity. Bioorg Med Chem Lett. 2019 29 (3) 353-356 PMID 30585173
  29. Kawaguchi M, Tani T, Hombu R, Ieda N, Nakagawa H. Development and Cellular Application of Visible-Light-Controllable HNO Releasers Based on Caged Piloty’s Acid. Chem Commun. 2018 54 (73) 10371-10374 PMID 30152479
  30. Sungwienwong I, Ferrie JJ, Jun JV, Liu C, Barrett TM, Hostetler ZM, Ieda N, Hendricks A, Muthusamy AK, Kohli RM, Chenoweth DM, Petersson GA, Petersson EJ. Improving the Fluorescent Probe Acridonylalanine Through a Combination of Theory and Experiment. J Phys Org Chem. 2018 31 (8) e3813 PMID 30983696
  31. Kunieda K, Hiromasa Y, Kawaguchi M, Ieda N, Nakagawa H. Development of a fluorescent probe for detection of citrulline based on photo-induced electron transfer. Bioorg Med Chem Lett. 2018 28 (5) 969-973 PMID 29439901
  32. Ferrie JJ, Ieda N, Haney CM, Walters CR, Sungwienwong I, Yoon J, Petersson EJ. Multicolor protein FRET with tryptophan, selective coumarin-cysteine labeling, and genetic acridonylalanine encoding. Chem Commun. 2017 53 (80) 11072-11075 PMID 28948265
  33. Okuno H, Ieda N, Hotta Y, Kawaguchi M, Kimura K, Nakagawa H. A yellowish-green-light-controllable nitric oxide donor based on N-nitrosoaminophenol applicable for photocontrolled vasodilation. Org Biomol Chem. 2017 15 (13) 2791-2796 PMID 28272634
  34. Kawaguchi M, Ikegawa S, Ieda N, Nakagawa H. Fluorescence Probe for Imaging Sirtuin Activity in Living Cells, Based on One-Step Cleavage of Dabcyl Quencher. ChemBioChem. 2016 17 (20) 1961-1967 PMID 27542094
  35. Hotta Y, Ieda N, Fukumoto A, Kataoka T, Kawade Y, Maeda Y, Nakagawa H, Kimura K. Light-controlled relaxation of the rat penile corpus cavernosum using NOBL-1, a novel nitric oxide releaser. Investig Clin Urol. 2016 57 (3) 215-220 PMID 27195321
  36. Ieda N, Yamada S, Kawaguchi M, Miyata N, Nakagawa H. (7-Diethylaminocomarin-4-yl)methyl Ester of Suberoylanilide Hydroxamic Acid as a Caged Inhibitor for Photocontrol of Histone Deacetylase Activity. Bioorg Med Chem. 2016 24 (12) 2789-2793 PMID 27143132
  37. Kitamura K, Kawaguchi, Ieda N, Miyata N, Nakagawa H. Visible Light-Controlled Nitric Oxide Release from Hindered Nitrobenzene Derivatives for Specific Modulation of Mitochondrial Dynamics. ACS Chem Biol. 2016 11 (5) 1271-1278 PMID 26878937
  38. Nakagawa H, Seike S, Sugimoto M, Ieda N, Kawaguchi M, Suzuki T, Miyata N. Peptidyl prolyl isomerase Pin1-inhibitory activity of D-glutamic and D aspartic acid derivatives bearing a cyclic aliphatic amine moiety. Bioorg Med Chem Lett. 2015 25 (23) 5619-5624 PMID 26508545
  39. Ieda N, Hishikawa K, Eto K, Kitamura K, Kawaguchi M, Suzuki T, Fukuhara K, Miyata N, Furuta T, Nabekura J, Nakagawa H. A double bond-conjugated dimethylnitrobenzene-type photolabile nitric oxide donor with improved two-photon cross section. Bioorg Med Chem Lett. 2015 25 (16) 3172-3175 PMID 26073004
  40. Milic I, Griesser E, Vemula V, Ieda N, Nakagawa H, Miyata N, Galano JM, Oger C, Durand T, Fedorova M. Profiling and relative quantification of multiply nitrated and oxidized fatty acids. Anal Bioanal Chem. 2015 407 (19) 5587-5602 PMID 26022093
  41. Fukushima N, Ieda N, Kawaguchi M, Sasakura K, Nagano T, Hanaoka K, Miyata N, Nakagawa H. Development of photo-controllable hydrogen sulfide donor applicable in live cells. Bioorg Med Chem Lett. 2015 25 (2) 175-178 PMID 25499432
  42. Kitamura K, Ieda N, Hishikawa K, Suzuki T, Miyata N, Kiyoshi F, Nakagawa H. Visible light-induced nitric oxide release from a novel nitrobenzene derivative cross-conjugated with a coumarin fluorophore. Bioorg Med Chem Lett. 2014 24 (24) 5660-5662 PMID 25467155
  43. Ieda N, Hotta Y, Miyata N, Kimura K, Miyata N, Nakagawa H. Photomanipulation of vasodilation with a blue-light-controllable nitric oxide releaser. J Am Chem Soc. 2014 136 (19) 7085-7091 PMID 24731151
  44. Tatum PR, Sawada H, Ota Y, Itoh Y, Zhan P, Ieda N, Nakagawa H, Miyata N, Suzuki T. Identification of novel SIRT2-selective inhibitors using a click chemistry approach. Bioorg Med Chem Lett. 2014 24 (8) 1871-1874 PMID 24675380
  45. Fukushima N, Ieda N, Sasakura K, Nagano T, Hanaoka K, Suzuki T, Miyata N, Nakagawa H. Synthesis of a photocontrollable hydrogen sulfide donor using ketoprofenate photocages. Chem Commun. 2014 50 (5) 587-589 PMID 24280741
  46. Nakagawa H, Hishikawa K, Eto K, Ieda N, Namikawa T, Kamada K, Suzuki T, Miyata N, Nabekura J. Fine spatiotemporal control of nitric oxide release by infrared pulse-laser irradiation of a photolabile donor. ACS Chem Biol. 2013 8 (11) 2493-2500 PMID 23978195
  47. Kawai K, Ieda N, Aizawa K, Suzuki T, Miyata N, Nakagawa H. A reductant-resistant and metal-free fluorescent probe for nitroxyl applicable to living cells. J Am Chem Soc. 2013 8 (11) 2493-2500 PMID 23865676
  48. Aizawa K, Nakagawa H, Matsuo K, Kawai K, Ieda N, Suzuki T, Miyata N. Piloty's acid derivative with improved nitroxyl-releasing characteristics. Bioorg Med Chem Lett. 2013 23 (8) 2340-2343 PMID 23489625
  49. Ieda N, Nakagawa H, Peng T, Yang D, Suzuki T, Miyata N. Photocontrollable peroxynitrite generator based on N-methyl-N-nitrosoaminophenol for cellular application. J Am Chem Soc. 2012 134 (5) 2563-2568 PMID 22239467
  50. Ieda N, Nakagawa H, Horinouchi T, Peng T, Yang D, Tsumoto H, Suzuki T, Fukuhara K, Miyata N. Peroxynitrite generation from a NO-releasing nitrobenzene derivative in response to photoirradiation. Chem Commun. 2011 47 (22) 6449-6451 PMID 21547304

邦文総説

  1. 家田直弥、光酸素スカベンジャーの開発と培養細胞における低酸素の時空間制御、光アライアンス、Vol.34(2023)、35-39
  2. 堀田祐志, 家田直弥、難治性勃起不全の新規治療薬を目指した光制御可能なNOドナーの開発、アグリバイオ、Vol.265(2023)、73-77
  3. 堀田祐志, 家田直弥、光制御可能なNOドナーの開発と難治性勃起不全への応用、月刊「細胞」、Vol.54(2022)、147-150
  4. 家田直弥、光誘起電子移動をトリガーとした可視光制御NOドナーの開発、ファルマシア、Vol.57(2021)、14-18
  5. 家田直弥、近赤外光でがん細胞だけを狙い撃ち -光免疫療法のメカニズム解析-、月刊化学、Vol.74(2019)、61-62
  6. 家田直弥, 中川秀彦、青色光制御型一酸化窒素発生剤とその生体応用、化学工業、Vol.66(2015)、516-520

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