発表論文　2008年

1. 1.Kudoh, T.; Murayama, T.; Hashii, M.; Higashida, H.; Sakurai, T.; Maechling, C.; Spiess, B.; Weber, K.; Guse, A. H.; Potter, B. V. L.; Arisawa, M.; Matsuda, A.; Shuto, S.
   Design and synthesis of 4´´, 6´´-unsaturated cyclic ADP-carbocyclic ribose, a Ca2+ mobilizing agent selectively active in T cells.
   Tetrahedron, 2008, 64, 9754-9765. DOI: 10.1016/j.tet.2008.07.068       
   
   

2. 2.Yamaguchi, K.; Kazuta, Y.; Hirano, K.; Yamada,S.; Matsuda, A.; Shuto, S.
   Synthesis of 1-arylpiperazyl-2-phenylcyclopropanes designed as antidopaminergic agents: Cyclopropane-based conformationally restricted analogs of haloperidol.
   Bioorg. Med. Chem. 2008, 16, 8875-8881. DOI: 10.1016/j.bmc.2008.08.061
          
   

3. 3.Ichikawa, S.; Hayashi, R.; Hirano, S.; Matsuda, A.
   Highly β-selective C-allylation of a ribofuranoside controlling steric hindrancein the transition state.
   Org. Lett. 2008, 10, 5107-5110. DOI: 10.1021/ol8018743
          

   

   
   
   

4. 4.Yasui, H.; Ogura, A. Asanuma, T.; Matsuda, A.; Kashiwakura, I.; Kuwabara, M.; Inanami, O.
   Inhibition of HIF-1α by the anticancer drug TAS106 enhances X-ray-induced apoptosis in vitro and in vivo.
   Br. J. Cancer 2008, 99, 1442-1452. DOI: 10.1038/sj.bjc.6604720
   
   

5. 5.Minakawa, N.; Sanji, M.; Kato, Y.; Matsuda, A.
   Investigations toward the selection of fully-modified 4´-thioRNA aptamers: optimization of in vitro transcription step in the presence of 4´-thioNTPs.
   Bioorg. Med. Chem. 2008, 16, 9450-9456. DOI: 10.1016/j.bmc.2008.09.048 
          

   

   
   
   

6. 6.Yoshida, K.; Yamaguchi, K.; Sone, T.; Unno, Y.; Asai, A.; Yokosawa, H.; Matsuda, A.; Arisawa, M.; Shuto, S.
   Synthesis of 2,3- and 3,4-methanoamino acid equivalents with stereochemical diversity and their conversion into the tripeptide proteasome inhibitor belactosin A and its highly potent cis-cyclopropane stereoisomer.
   Org. Lett. 2008, 10, 3571-3574. DOI: 10.1021/ol8013304
          
   

7. 7.Sakaguchi, N.; Kudoh, T.; Tsuzuki, T.; Murayama, T.; Sakurai, T.; Matsuda, A.; Arisawa, M.; Shuto, S.
   Synthesis of 5´´-branched derivatives of cyclic ADP-carbocyclic-ribose, a potent Ca2+-mobilizing agent: The first antagonists modified at the N1-ribose moiety.
   Bioorg. Med. Chem. Lett. 2008, 18, 3814-3818. DOI: 10.1016/j.bmcl.2008.04.083
          
   

8. 8.Kudoh, T.; Weber, K.; Guse, A. H.; Potter, B. V. L.; Hashii, M.; Higashida, H.; Arisawa, M.; Matsuda, A.; Shuto, S.
   Design and aynthesis of 4´´,6´´-unsaturated cyclic ADP-carbocyclic ribose as a Ca2+-mobilizing agent.
   Tetrahedron Lett. 2008, 49, 3976-3979. DOI: 10.1016/j.tetlet.2008.04.100
          
   

9. 9.Muranaka, K.; Sano, A.; Ichikawa, S.; Matsuda, A.
   Synthesis of Hsp90 inhibitor dimers as potential antitumor agents.
   Bioorg. Med. Chem. 2008, 16, 5862-5870. DOI: 10.1016/j.bmc.2008.04.070
          

   

   
   
   
10. 10.Hirano, S.; Ichikawa, S.; Matsuda, A.
    Structure-activity relationship of truncated analogs of caprazamycins as potential antitumor agents.
    Bioorg. Med. Chem. 2008, 16, 5123-5133. DOI: 10.1016/j.bmc.2008.03.020
           

    

    
    
    

11. 11.Wang, Y.; Liu, X.; Matsuda, A.; Plunkett, W.
    Repair of 2´-C-cyano-2´-deoxy1-β-D-arabino-pentofuranosylcytosine-induced DNA single-strand breaks by transcription-coupled nucleotide excision repair.
    Cancer Res. 2008, 68, 3881-3889. DOI: 10.1158/0008-5472.CAN-07-6885
    
    

12. 12.Takahashi, M.; Daidouji, S.; Shiro, M.; Minakawa, N.; Matsuda, A.
    Synthesis and crystal structure of 2´-deoxy-2´-fluoro-4´-thioribonucleosides: substrates for the synthesis of novel modified RNAs.
    Tetrahedron 2008, 64, 4313-4324.

    

    DOI: 10.1016/j.tet.2008.02.071
           

    

    
    
    

13. 13.Matsugami, A.; Ohmiya, T.; Inada, M.; Inoue, N.; Minakawa, N.; Matsuda, A.; Katahara, M.
    Unexpected A form formation of 4´-thioDNA in solution, as revealedby NMR, and the implication on the machanism of nuclease-resistance.
    Nucleic Acids Res. 2008, 36, 1805-1812. DOI: 10.1093/nar/gkn011
    
    

14. 14.Nakane, M.; Ichikawa, S.; Matsuda, A.
    Triazole-linked dumbbel oligodeoxynucleotides with NF-kB binding ability as potential decoy molecules.
    J. Org. Chem. 2008, 73, 1842-1851. DOI: 10.1021/jo702459b
           

    

    
    
    

15. 15.Liu, X.; Matsuda, A.; Plunkett, W.
    ATR and DNA-PK cooperate in G2 checkpoint activation by the DNA strand-breaking nucleoside analogue, CNDAC.
    Mol. Cancer Ther. 2008, 7, 133-142. DOI: 10.1158/1535-7163.MCT-07-0416
    
    

16. 16.Minakawa, N.; Kawano, Y.; Murata, S.; Inoue, N.; Matsuda, A.
    Oligonucleotides containing 3-bromo-3-deazaadenine and 7-bromo-7-deazaadenine 2´-deoxynucleosides as chemical probes to investigate DNA-protein interactions.
    ChemBioChem. 2008, 9, 464-470. DOI: 10.1002/cbic.200700580
           

    

    
    
    
17. 17.Hirano, S.; Ichikawa, S.; Matsuda, A.
    Synthesis of caprazamycin analogs and their structure-activity relationship for antibacterial activity.
    J. Org. Chem. 2008, 73, 569-577. DOI: 10.1021/jo702264e
           

    

    
    
    
18. 18.Hirano, S.; Ichikawa, S.; Matsuda, A.
    Design and synthesis of diketopiperazine and acyclic analogs related to the caprazamycins and liposideomycins as potential antibacterial agents.
    Bioorg. Med. Chem. 2008, 16, 428-436.

    

    DOI: 10.1016/j.bmc.2007.09.022
           

    

    
    
    

19. 19.周東　智、市川　聡、阿部　洋、松田　彰
    ピラノースの配座制御に基づく立体選択的グリコシル化反応．
    有機合成化学協会誌, 2008, 66, 50-59.
    
    

20. 20.松田　彰
    核酸化学から創薬へ (創薬最前線).
    MEDCHEM NEWS, 2008, 18 (1), 2-6.
    
    

21. 21.村中　一大、市川　聡、松田　彰
    Structure-Based Drug Designによる分子シャペロンHsp90阻害剤の創製研究
    MEDCHEM NEWS 2008, 18 (3), 52-58.
    
    

22. 22.Matsuda, A.
    1-(3-C-Ethynyl-β-D-ribo-pentofuranosyl)cytosine (ECyd).
    Modified Nucleosides: in Biochemistry, Biotechnology and Medicine, Ed. By P. Herdewijn, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, pp483-495.