北海道大学大学院 薬学研究院 創薬科学部門 創薬化学分野
薬化学研究室 Laboratory of Medicinal Chemistry
 

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 発表論文 2009

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  1. 1.Yoshida, K.; Yamaguchi, K.; Mizuno, A.; Unno, Y.; Asai, A.; Sone, T.; Yokosawa, H.; Matsuda, A.; Arisawa, M.; Shuto, S.
    Three-dimentional structure-activity relationship study of belactosin A and its stereo- and regioisomers: development of potent proteasome inhibitors by a stereochemical diversity-oriented strategy.
    Org. Biol. Chem. 2009, 7, 1868-1877. DOI: 10.1039/B900384C

  2. 2.Kazuno, H.; Fujioka, A.; Fukushima, M.; Wataya, Y.; Matsuda, A.; Sasaki, T.
    1-(3-Ethynyl-β-D-ribo-pentofuranosyl)cytosine (ECyd, TAS-106), a novel potent inhibitor of RNA polymerase, potentiates the cytotoxicity of CDDP in human cancer cells both in vitro and in vivo.
    Int. J. Oncol. 2009, 34, 1373-1380. DOI: 10.3892/ijo_00000264

  3. 3.Minakawa, N.; Ogata, S.; Takahashi, M.; Matsuda, A.
    Selective recognition of unnatural imidazopyridopyrimidine:naphthyridine base pairs consisting of four hydrogen bonds by the Klenow fragment.
    J. Am. Chem. Soc. 2009, 131, 1644-1645. DOI: 10.1021/ja807391g
           


  4. 4.Takahashi, M.; Minakawa, N.; Matsuda, A.
    Synthesis and characterization of 2´-modified-4´-thioRNA: a comprehensive comparison of nuclease stability.
    Nucleic Acids Res. 2009, 37, 1353-1362. DOI: 10.1093/nar/gkn1088

  5. 5.Naito, T.; Yokogawa, T.; Takatori, S.; Goda, K.; Hiranoto, A.; Sato, A.; Kitade, Y.; Sasaki, T.; Matsuda, A.; Fukushima, M.; Wataya, Y.; Kim, H.-S.
    Role of RNase L in apoptosis induced by 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine.
    Cancer Chemthr. Pharmacol. 63, 837-850. DOI: 10.1007/s00280-008-0810-y

  6. 6.Ogata, S.; Takahashi, M.; Minakawa, N.; Matsuda, A.
    Unnatural imidazopyridopyrimidine:naphthyridine base pairs: selective incorporation and extension reaction by Deep Vent (exo–) DNA polymerase.
    Nucleic Acids Res. 2009, 37, 5602-5609. DOI: 10.1093/nar/gkp611

  7. 7.Muranaka, K.; Ichikawa, S.; Matsuda, A.
    Design and synthesis of 3´,5´-ansa-adenosines as potential Hsp90 inhibitors.
    Tetrahedron Lett. 2009, 50, 5102-5106. DOI: 10.1016/j.tetlet.2009.06.094
           


  8. 8.Takada, A.; Kamiya, H.; Shuto, S.; Matsuda, A.; Harashima, H.
    PK-PD modeling of 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine and the enhanced antitumor effect of its phospholipid derivatives in long-circulating liposomes.
    Int. J. Pharm. 2009, 377, 52-59. DOI: 10.1016/j.ijpharm.2009.04.039

  9. 9.Sato, K.; Hirose, W.; Matsuda, A.
    Synthesis of 5-formyl-2´-deoxyuridine and its incorporation into oligonucleotides.
    Curr. Protoc. Nucleic Acid Chem. 2009, Chapter 1, Unit 1.21. John Wiley & Sons.
    DOI:  10.1002/0471142700.nc0121s35