北海道大学大学院 薬学研究院 創薬科学部門 創薬化学分野
薬化学研究室 Laboratory of Medicinal Chemistry
 

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 発表論文 2010

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  1. 1.Tanino, T.; Ichikawa, S.; Shiro, M.; Matsuda A.
    Total Synthesis of (–)-Muraymycin D2 and Its Epimer.
    J. Org. Chem. 2010, 75, 1366-1377. DOI: 10.1021/jo9027193
           


  2. 2.市川 聡、松田 彰
    新たな切り口で結核菌と戦う!
    化学, 2010, 65 (2), 30-34.

  3. 3.Kaysser, L.; Eitel, K.; Tanino, T.; Sienberg, S.; Matsuda, A.; Ichikawa, S.; Gust, B.
    A new arylsulfate sulfotransferase involved in liponucleoside antibiotic biosynthesis in streptomycetes.
    J. Biol. Chem. 2010, 285, 12684-12694. DOI: 10.1074/jbc.M109.094490

  4. 4.Ii, K.; Ichikawa, S.; Al-Dabbagh, B.; Boushss, A.; Matsuda, A.
    Function-oriented synthesis of simplified caprazamycins: discovery of oxazolidine-containing uridine derivatives as antibacterial agents against drug-resistant bacteria.
    J. Med. Chem. 2010, 53, 3793-3813. DOI: 10.1021/jm100243n
           


  5. 5.Sekiguchi, H.; Muranaka, K.; Osada, A.; Ichikawa, S.; Matsuda, A.
    Efficient synthesis of Hsp90 inhibitor dimers as potential antitumor agents.
    Bioorg. Med. Chem. 2010, 18, 5732-5737. DOI: 10.1016/j.bmc.2010.05.075
           


  6. 6.Tanino, T.; Ichikawa, S.; Al-Dabbagh, B.; Boushss, A.; Oyama, H.; Matsuda, A.
    Synthesis and Biological Evaluation of Muraymycin Analogues Active against Anti-Drug-Resistant Bacteria.
    ACS Med. Chem. Lett. 2010, 1, 258-262. DOI: 10.1021/ml100057z
           


  7. 7.Tomaya, K.; Takahashi, M.; Minakawa, N.; Matsuda, A.
    Convenient RNA Synthesis  Using a Phosphoramidite Possessing a Biotinylated Photocleavable Group.
    Org. Lett. 2010, 12, 3836-3839. DOI: 10.1021/ol101489v
           


  8. 8.Hirama, Y.; Abe, H.; Minakawa, N.; Matsuda, A.
    Synthesis and properties of a novel nucleoside derivative possessing a 2,3,5,6-tetraazabenzo[cd]azulene skelton.
    Tetrahedron, 2010, 66, 8402-8406. DOI: 10.1016/j.tet.2010.08.063 
           


  9. 9.Sako, Y.; Ichikawa, S.; Osada, A.; Matsuda, A.
    Synthesis and evaluation of 5-substituted 9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as check point 1 kinase inhibitors.
    Bioorg. Med. Chem. 2010, 18, 7878-7889. DOI: 10.1016/j.bmc.2010.09.042
           


  10. 10.Hirose, W.; Sato, K.; Matsuda, A.
    Selective Detection of 5-Formyl-2´-deoxyuridine, an Oxidative Lesion of Thymidine, in DNA by a Fluorogenic Reagent.
    Angew. Chem., Int. Ed. 2010, 49, 8392-8394. DOI: 10.1002/anie.201004087
           


  11. 11.Tsunoda, M.; Sakaue, T.; Naito, S.; Sunami, T.; Abe, N.; Ueno, Y.; Matsuda, A.; Takenaka, A.
    Insight into the structures of DNA damaged by hydroxyl radical: crystal structures of DNA duplexes containing 5-formyluracil.
    J. Nucleic Acids 2010, 107289. DOI: 10.4061/2010/107289

  12. 12.Liu, X.; Wang, Y.; Benaissa, S.; Matsuda, A.; Kantarjian, H.; Estrov, Z.; Plunkett, W.
    Homologous recombination as a resistance mechanism to replication-induced double-strand breaks caused by the antileukemia agent CNDAC.
    Blood 2010, 116, 1737-1746. DOI: 10.1182/blood-2009-05-220376

  13. 13.Sato, A.; Naito, T.; Hiramoto, A.; Goda, K.; Omi, T.; Kitade, Y.; Sasaki, T.; Matsuda, A.; Fukushima, M.; Wataya, Y.; Kim, H.-S.
    Association of RNase L with a Ras GTPase-activating-like protein IQGAP1 in mediating the apoptosis of a human cancer cell-line.
    FEBS Journal 2010, 277, 4464-4473. DOI: 10.1111/j.1742-4658.2010.07833.x

  14. 14.Ogino, T.; Sato, K.; Matsuda, A.
    Incorporation of 2´-Deoxy-2´-Isonucleoside 5´-Triphosphates (iNTPs) into DNA by A- and B-Family DNA Polymerases with Different Recognition Mechanisms.
    ChemBioChem 2010, 11, 2597-2605. DOI: 10.1002/cbic.201000449