Publication 2019

Professor Ogawa

  1. A Novel PET Probe “[18F]DiFA” Accumulates in Hypoxic Region via Glutathione Conjugation Following Reductive Metabolism.
    Shimizu Y, Zhao S, Yasui H, Nishijima KI, Matsumoto H, Shiga T, Tamaki N, Ogawa M, Kuge Y. Mol Imaging Biol. 2019 Feb;21(1):122-129. doi: 10.1007/s11307-018-1214-y.
  2. Accumulation of hypoxia imaging probe “18F-FMISO” in macrophages depends on macrophage polarization in addition to hypoxic state.
    Shimizu Y, Motomura A, Takakura H, Tamaki N, Kuge Y, Ogawa M. Ann Nucl Med. 2019 May;33(5):362-367. doi: 10.1007/s12149-019-01332-1. Epub 2019 Jan 29.

Professor Yamaguchi

  1. Temporal regulation of Lin28a during mammalian neurulation contributes to neonatal body size control.
    Miyazawa H, Muramatsu Y, Makino H, Yamaguchi Y, Miura M.
    Dev Dyn. 2019 Oct;248(10):931-941. doi: 10.1002/dvdy.87.
  2. Loss of the small GTPase Arl8b results in abnormal development of the roof plate in mouse embryos.
    Hashimoto K, Yamaguchi Y, Kishi Y, Kikko Y, Takasaki K, Maeda Y, Matsumoto Y, Oka M, Miura M, Ohata S, Katada T, Kontani K.
    Genes Cells. 2019 Jun;24(6):436-448. doi: 10.1111/gtc.12687.
  3. A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain.
    Polykratis A, Martens A, Eren RO, Shirasaki Y, Yamagishi M, Yamaguchi Y, Uemura S, Miura M, Holzmann B, Kollias G, Armaka M, van Loo G, Pasparakis M.
    Nat Cell Biol. 2019 Jun;21(6):731-742. doi: 10.1038/s41556-019-0324-3.
  4. Caspase-1 initiates apoptosis in the absence of gasdermin D.
    Tsuchiya K, Nakajima S, Hosojima S, Thi Nguyen D, Hattori T, Manh Le T, Hori O, Mahib MR, Yamaguchi Y, Miura M, Kinoshita T, Kushiyama H, Sakurai M, Shiroishi T, Suda T.
    Nat Commun. 2019 May 7;10(1):2091. doi: 10.1038/s41467-019-09753-2.

Professor Sonoshita

  1. Ung PMU*, Sonoshita M*, Scopton AP, Dar AC, Cagan RL, Schlessinger A. Integrated computational and Drosophila cancer model platform captures previously unappreciated chemicals perturbing a kinase network. PLoS Comput Biol. 2019 15:e1006878. (*equal contribution)

Professor Ohba

  1. Localization of BCR-ABL to stress granules contributes to its oncogenic function.
    Kashiwagi S, Fujioka Y, Kondo T, Satoh AO, Yoshida A, Fujioka M, Sasajima H, Amano M, Teshima T and Ohba Y. Cell Struct. Funct. 44: 195-204, 2019
  2. Folding latency of fluorescent proteins affects the mitochondrial localization of fusion proteins.
    Kashiwagi S, Fujioka Y, Satoh AO, Yoshida A, Fujioka M, Nepal P, Tsuzuki A, Aoki O, Paudel S, Sasajima H and Ohba Y. Cell Struct. Funct. 44: 183-194, 2019

Professor Kihara

  1. Kanetake T, Sassa T, Nojiri K, Sawai M, Hattori S, Miyakawa T, Kitamura T, Kihara A. (2019) Neural symptoms in a gene knockout mouse model of Sjogren-Larsson syndrome are associated with a decrease in 2-hydroxygalactosylceramide. FASEB J, 33, 928-941.
  2. Seki N, Mori K, Kitamura T, Miyamoto M, Kihara A. (2019) Yeast Mpo1 is a novel dioxygenase that catalyzes the α-oxidation of a 2-hydroxy fatty acid in an Fe2+-dependent manner. Mol Cell Biol, 39, e00428-18.
  3. Kinugasa Y, Hirano Y, Sawai M, Ohno Y, Shindo T, Asakawa H, Chikashige Y, Shibata S, Kihara A, Haraguchi T, Hiraoka Y. (2019) The very-long-chain fatty acid elongase Elo2 rescues lethal defects associated with loss of the nuclear barrier function in fission yeast cells. J Cell Sci, 132, 229021.
  4. Isokawa M, Sassa T, Hattori S, Miyakawa T, Kihara A. (2019) Reduced chain length in myelin sphingolipids and poorer motor coordination in mice deficient in the fatty acid elongase Elovl1. FAESB BioAdv, 1, 747-759.

Professor Maenaka

  1. Kuroki K, Matsubara H, Kanda R, Miyashita N, Shiroishi M, Fukunaga Y, Kamishikiryo J, Fukunaga A, Fukuhara H, Hirose K, Hunt JS, Sugita Y, Kita S, Ose T, Maenaka K*. Structural and Functional Basis for LILRB Immune Checkpoint Receptor Recognition of HLA-G Isoforms. J Immunol. 2019 Dec15;203(12):3386-3394. doi: 10.4049/jimmunol.1900562.
  2. Sarwono AEY, Mitsuhashi S, Kabir MHB, Shigetomi K, Okada T, Ohsaka F, Otsuguro S, Maenaka K, Igarashi M, Kato K, Ubukata M.　 Repurposing existing drugs: identification of irreversible IMPDH inhibitors by high-throughput screening.　 J Enzyme Inhib Med Chem. 2019 Dec;34(1):171-178. doi: 10.1080/14756366.2018.1540474.
  3. Furukawa A, Meguro M, Yamazaki R, Watanabe H, Takahashi A, Kuroki K, Maenaka K*. Evaluation of the Reactivity and Receptor Competition of HLA-G Isoforms toward Available Antibodies: Implications of Structural Characteristics of HLA-G Isoforms. Int J Mol Sci. 2019 Nov 26;20(23). pii: E5947. doi: 10.3390/ijms20235947.
  4. Watanabe H, Kuroki K, Yamada C, Saburi Y, Maeda N, Maenaka K*. Therapeutic effects of soluble human leukocyte antigen G2 isoform in lupus-prone MRL/lpr mice. Hum Immunol. 2019 Nov 13. pii: S0198-8859(19)31134-6. doi: 10.1016/j.humimm.2019.11.002.
  5. Oyama H, Koga H, Tadokoro T, Maenaka K, Shiota A, Yokoyama M, Noda M, Torisu T, Uchiyama S. Relation of Colloidal and Conformational Stabilities to Aggregate Formation in a Monoclonal Antibody. J Pharm Sci. 2019 Oct 24. pii: S0022-3549(19)30675-6. doi: 10.1016/j.xphs.2019.10.038.
  6. Fukuhara H, Ito Y, Sako M, Kajikawa M, Yoshida K, Seki F, Mwaba MH, Hashiguchi T, Higashibata MA, Ose T, Kuroki K, Takeda M, Maenaka K*. Specificity of Morbillivirus Hemagglutinins to Recognize SLAM of Different Species. Viruses 2019 Aug 19;11(8). pii: E761. doi: 10.3390/v11080761.
  7. Shiraishi T, Sakaitani M, Otsuguro S, Maenaka K, Suzuki T, Nakaya T. Novel Notch signaling inhibitor NSI‑1 suppresses nuclear translocation of the Notch intracellular domain. Int J Mol Med. 2019 Oct;44(4):1574-1584. doi: 10.3892/ijmm.2019.4280.
  8. Tadokoro T, Jahan ML, Ito Y, Tahara M, Chen S, Imai A, Sugimura N, Yoshida K, Saito M, Ose T, Hashiguchi T, Takeda M, Fukuhara H, Maenaka K*. Biophysical characterization and single-chain Fv construction of a neutralizing antibody to measles virus. FEBS J. 2019 Jul 9. doi: 10.1111/febs.14991.
  9. Noda M, Ishii K, Yamauchi M, Oyama H, Tadokoro T, Maenaka K, Torisu T, Uchiyama S.　 Identification of IgG1 Aggregation Initiation Region by Hydrogen Deuterium Mass Spectrometry. J Pharm Sci. 2019 Jul;108(7):2323-2333. doi: 10.1016/j.xphs.2019.02.023. Epub 2019 Mar 6.
  10. Ajith A, Portik-Dobos V, Nguyen-Lefebvre AT, Callaway C, Horuzsko DD, Kapoor R, Zayas C, Maenaka K, Mulloy LL, Horuzsko A. HLA-G dimer targets Granzyme B pathway to prolong human renal allograft survival. FASEB J. 2019 Apr;33(4):5220-5236. doi: 10.1096/fj.201802017R. 3.

Professor Wakimoto

  1. Matsuda, K., Kuranaga, T., Wakimoto, T., “A new cyclase family catalyzing head-to-tail macrolactamization of non-ribosomal peptides”,  J. Synth. Org. Chem. Jpn. 77, 1106-1115 (2019).
  2. Jomori, T., Shiroyama, S., Ise, Y., Kohtsuka, H., Matsuda, K., Kuranaga, T., Wakimoto, T., “Scrobiculosides A and B from the deep-sea sponge Pachastrella scrobiculosa”,  J. Nat. Med. 73, 814-819 (2019).
  3. Iwao, Y., Ishida, S., Kimura, T., Wakimoto, T., Itai, S., Noguchi, S., “Crystal structures of flavone C-glycosides from oolong tea leaves: chafuroside A dihydrate and chafuroside B monohydrate”, Chem. Pharm. Bull., 67, 935-939 (2019).
  4. Matsuda, K., Kobayashi, M., Kuranaga, T., Takada, K., Ikeda, H., Matsunaga, S., Wakimoto, T., “SurE is a trans-acting thioesterase cyclizing two distinct non-ribosomal peptides
”,  Org. Biomol. Chem., 17, 1058-1061(2019).
  5. Matsuda, K., Kuranaga, T., Sano, A., Ninomiya, A., Takada, K., Wakimoto, T., “The revised structure of surugamide A
”,  Chem. Pharm. Bull., 67, 476-480 (2019).
  6. 松田研一、倉永健史、脇本敏幸：ペニシリン結合タンパク質によるペプチド環化　ファルマシア 55, 650-654 (2019)
  7. 松田研一、脇本敏幸：バクテリアが有する新たな非リボソームペプチド環化酵素　バイオサイエンスとインダストリー 77, 306-307 (2019)

Professor Ichikawa

  1. Shigetomi, Kengo; Albertus Eka Yudistira Sarwono; Ichikawa, Satoshi; Ubukata, Makoto*. Novel adenosine-derived inhibitors of Cryptosporidium parvum inosine 5’-monophosphate dehydrogenase. J.Antibiot. 2019, 72, 934-942. DOI: https://doi.org/10.1038/s41429-019-0199-3
  2. Mashalidis, Ellene H.; Kaeser, Benjamin; Terasawa, Yuma; Katsuyama, Akira; Kwon, Do-Yeon; Lee, Kiyoun; Hong, Jiyong; Ichikawa, Satoshi; Lee, Seok-Yong.* Chemical logic of MraY inhibition by antibacterial nucleoside natural products. Nature Commun. 2019, 10, 2917. DOI: 10.1038/s41467-019-10957-9
  3. Yamamoto, Kazuki; Ichikawa, Satoshi.* Tunicamycin: Chemical synthesis and biosynthesis. J. Antibiot. 2019, 72, 924-933. DOI: 10.1038/s41429-019-0200-1
  4. Nomura, Yusaku; Thuaud, Frédéric; Sekine, Daisuke; Ito, Akihiro; Maeda, Satoko; Koshino, Hiroyuki; Hashizume, Daisuke; Muranaka, Atsuya; Cruchter, Thomas; Uchiyama, Masanobu; Ichikawa, Satoshi; Matsuda, Akira; Yoshida, Minoru; Hirai, Go*; Sodeoka, Mikiko.* Synthesis of All Stereoisomers of Monomeric Spectomycin A1/A2 and Evaluation of Their Protein SUMOylation‐Inhibitory Activity. Chem. Eur. J. 2019, 25,1–7. DOI: 10.1002/chem.201901093
  5. Yamamoto Kazuki; Katsuyama Akira; Ichikawa Satoshi. Structural requirement of tunicamycin V for MraY inhibition. Bioorg. Med. Chem. 2019, 27, 1714-1719.

Professor Sugawara

  1. Aoyama T, Shibayama Y, Furukawa T, Sugawara M, Takekuma Y. Continuous Cytostatic Effects of BCR-ABL Tyrosine Kinase Inhibitors (TKIs) after Washout in Human Leukemic K562 Cells. Biol Pharm Bull. 2019 Nov 1;42(11):1805-1813. doi: 10.1248/bpb.b19-00185. Epub 2019 Aug 20. PMID: 31434819.
  2. Sasaki M, Aoyama T, Sugawara M, Takekuma Y. Influence of gastrointestinal activity on the absorption of nilotinib. Drug Metab Pharmacokinet. 2020 Feb;35(1):102-110. doi: 10.1016/j.dmpk.2019.08.006. Epub 2019 Aug 31. PMID: 31732429.
  3. Sato Y, Yokoyama S, Yamaki Y, Nishimura Y, Miyashita M, Maruyama S, Takekuma Y, Sugawara M. Enhancement of intestinal absorption of coenzyme Q10 using emulsions containing oleyl polyethylene acetic acids. Eur J Pharm Sci. 2020 Jan 15;142:105144. doi: 10.1016/j.ejps.2019.105144. Epub 2019 Nov 13. PMID: 31730802.