Productivity

Dentistry

 

3rd term (2019-)

Original article

 

 

Review article

 

 

Book

 

 

International symposium

 

 

International conference
  1. Morimoto M, Maishi N, Matsuda A, Kitamura T, Higashino F, Kitagawa Y, Hida Y, Hida K. “Promotion of metastasis via alteration of vascular endothelium by tumor exosome miRNA” Annual Meeting ISEV2019 (Apr 26, 2019, Kyoto, Japan)

 

 

 

2nd term (2014-2018)

Original article
  1. *Hida K§, Maishi N.§, Akiyama K., Ohmura-Kakutani H., Torii C., Ohga N., Osawa T., Kikuchi H., Morimoto H., Morimoto M., Shindoh M., Shinohara N. and Hida Y.: Tumor Endothelial Cells with High Aldehyde Dehydrogenase Activity Show drug resistance, Cancer Sci, 108(11), 2195-2203, 2017. §equally contributed.
  2. *Hida K. §, Kawamoto T. §, Maishi N., Morimoto M., Akiyama K., Ohga N., Shindoh M., Shinohara N., Hida Y.: miR-145 Promoted Anoikis Resistance in Tumor Endothelial Cells, J Biochem, 162(2), 81-84, 2017. §equally contributed.
  3. Hojo T. §, Maishi N.§, Towfik AM, Akiyama K., Ohga N., Shindoh M., Hida Y., Minowa K., Fujisawa T., *Hida K.: ROS enhance angiogenic properties via regulation of NRF2 in tumor endothelial cells, Oncotarget, 8(28):45484-45495, 2017. §equally contributed.
  4. Torii C., Hida Y., Shindoh M., Akiyama K., Ohga N., Maishi N., Ohiro Y., Ono M., Totsuka Y., Kitagawa Y., Tei K., Sato Y., *Hida K.: Vasohibin-1 as a novel prognostic factor for head and neck squamous cell carcinoma, Anticancer Res, 37(3), 1219-1225, 2017.
  5. Habiba U., Kitamura T., Yanagawa-Matsuda A., Higashino F., Hida K., Totsuka Y., *Shindoh M.: HuR and podoplanin expression is associated with a high risk of malignant transformation in patients with oral preneoplastic lesions, Oncol Lett, 12(5), 3199-3207, 2016.
  6. *Hida K., Maishi N., Dorcas Akuba-Muhyia Annan, Kondoh M., Hojo T., Habiba U, Ohga N., Ishikawa K, Sato M., Torii C., Yanagiya M., Morimoto M., Hida Y., Shindoh M. “Aneuploidy of murine immortalized endothelial cell line, MS1.” J Oral Biosci, 59 (2017), 50-54, 2017.
  7. *Hida K., Maishi N., Kawamoto T., Akiyama K., Ohga N., Hida Y., Yamada K., Hojo T., Kikuchi H., Sato M., Torii C., Shinohara N., Shindoh M. “Tumor endothelial cells express high pentraxin 3 levels.” Pathol Int 66(12), 687-694, 2016.
  8. *Hida K., Maishi N., Torii C., Yanagiya M., Annan Akuba-Muhyia Dorcas., Morimoto M., Alam Mohammad Towfik. “Comparison of characteristics of mouse immortalized normal endothelial cells, MS1 and primary cultured endothelial cells” Hokkaido Journal of Dental Science. 40-48, 2016.
  9. Maishi N., Ohba Y., Akiyama K., Ohga N., Hamada J., Nagao-Kitamoto H., Mohammad Towfik Alam, Yamamoto K., Kawamoto T., Inoue N., Taketomi A., Shindoh M., Hida Y., *Hida K. “Tumour endothelial cells in high metastatic tumours promote metastasis via epigenetic dysregulation of biglycan.” Sci Rep. (2016) 6, 28039.
  10. Habiba U, *Hida K, Kitamura T, Yanagawa Matsuda A., Higashino F, Ito M Y, Ohiro Y, Totsuka Y, Shindoh M. “Expression patterns of ALDH1 and podoplanin predict the risk of malignant transformation in oral leukoplakia.” Oncol Lett. (2016) 13, 321-328.
  11. Yamada K§, Maishi N§, Akiyama K, Alam Mohammad Towfik, Ohga N, Kawamoto T, Shindoh M, Takahashi N, Kamiyama T, Hida Y, Taketomi A, and *Hida K. “CXCL 12-CXCR7 axis is important for tumor endothelial cell angiogenic property.” Int J Cancer. (2015) 137(12), 2825-2836. (selected as a cover) §equally contributed
  12. Matsumoto R, Tsuda M, Wang Lei, Maishi N, Abe T, Kimura T, Tanino M, Nishihara H, Hida K, Ohba Y, Shinohara N, Nonomura K, Tanaka S. “Adaptor protein CRK induces epithelial?mesenchymal transition and metastasis of bladder cancer cells through HGF/c-Met CRK feedback loop.” Cancer Sci. (2015) 106(6), 709-717.
  13. Akiyama K, Maishi N, Ohga N, Hida Y, Ohba Y, Alam Mohammad Towfik, Kawamoto T, Ohmura H, Yamada K, Torii C, Shindoh M, *Hida K. “Inhibition of multidrug transporter in tumor endothelial cells enhances antiangiogenic effects of low-dose metronomic paclitaxel.” Am J Pathol. (2015) 185(2), 572-580.
  14. Ohmura-Kakutani H, Akiyama K, Maishi N, Ohga N, Hida Y, Kawamoto T, Iida J, Shindoh M, Ttsuchiya K, Shinohara N, *Hida K. “Identification of Tumor Endothelial Cells with High Aldehyde Dehydrogenase Activity and a Highly Angiogenic Phenotype.” PLoS ONE. (2014) 9(12), e113910.
  15. Alam MT, Nagao-Kitamoto H, Ohga N, Akiyama K, Maishi N, Kawamoto T, Shinohara N, Taketomi A, Shindoh M, Hida Y. and *Hida K. “Suprabasin as a novel tumor endothelial cell marker.” Cancer Sci. (2015) 105(12), 1533?1540.
  16. Otsubo T, Hida Y, Ohga N, Sato H, Kai T, Matsuki Y, Takasu H, Akiyama K, Maishi N, Kawamoto T, Shinohara N, Nonomura K, *Hida K. “Identification of Novel Targets for Antiangiogenic Therapy by Comparing the Gene Expressions of Tumor and Normal Endothelial Cells.” Cancer Sci. (2014) 105(5), 560-567.
  17. Habiba U, Kitamura T. Yanagawa-Matsuda A, Hida K, Higashino F, Ohiro Y, Totsuka Y. and *Shindoh M. “Cytoplasmic expression of HuR may be a valuable diagnostic tool for determining the potential for malignant transformation of oral verrucous borderline lesions.” Oncol Rep. (2014) 31(4), 1547-1554.
  18. Ara MN, Matsuda T, Hyodo M, Sakurai Y, Ohga N, Hida K, *Harashima H. “Construction of an aptamer modified liposomal system targeted to tumor endothelial cells.” Biol. Pharm. Bull. (2014) 37(11), 1742-1749.
  19. Akhter A, Hayashi Y, Sakurai Y, Ohga N, Hida K, *Harashima H. “Ligand density at the surface of a nanoparticle and different uptake mechanism: two important factors for successful siRNA delivery to liver endothelial cells.” Int J Pharm. (2014) 475(1-2), 227-237.
  20. Ara MN, Matsuda T, Hyodo M, Sakurai Y, Ohga N, Hida K, *Harashima H. “An aptamer ligand based liposomal nanocarrier system that targets tumor endothelial cells.” Biomaterials. (2014) 35(25), 7110-7120.
  21. Ara MN, *Hyodo M, Ohga N, Akiyama K, Hida K, Hida Y, Shinohara N, Harashima H. “Identification and expression of Troponin T, a new make on the surface of cultured tumor endothelial cells by aptamer ligand.” Cancer Med. (2014) 3(4), 825-834.
  22. Sakurai Y, Hatakeyama H, Sato Y, Hyodo M, Akita H, Ohga N, Hida K, *Harashima H. “RNAi-mediated gene knockdown and anti-angiogenic therapy of RCCs using a cyclic RGD-modified liposomal-siRNA system.” J Control Release. (2014) 173, 110-8.

 

 

Review article
  1. *Hida K., Maishi N., Dorcas A. Annan, Hida Y. “Contribution of Tumor Endothelial Cells in Cancer Progression”. Int J Mol Sci. (2018) 19(5), 1272.
  2. *Hida K., Maishi N. “Abnormalities of tumor endothelial cells and cancer progression”. Oral Sci Int. (2018) 15(1), 1-6.
  3. Maishi N., *Hida K. “Tumor endothelial cells accelerate tumor metastasis”. Cancer Sci. (2017) 108(10), 1921-1926.
  4. *Hida K., Kikuchi H., Maishi N., Hida Y. “ATP-binding cassette transporters in tumor endothelial cells and resistance to metronomic chemotherapy” Cancer Lett. (2017) 400, 305-310.
  5. *Hida K, Maishi N, Sakurai Y, Hida Y, Harashima H. “Heterogeneity of tumor endothelial cells and drug delivery”. Adv Drug Deliv Rev. (2016) 99(Pt B), 140-147.
  6. *Hida K, Maishi N, Sakurai Y, Hida Y, Harashima H. “Heterogeneity of tumor endothelial cells and drug delivery”. Adv Drug Deliv Rev. (2016) 99(Pt B), 140-147.
  7. *Hida K, Maishi N, Torii C, Hida Y. “Tumor Angiogenesis – Characteristics of Tumor Endothelial Cells”. Int J Clin Oncol. (2016) 21, 206-212.

 

 

Book
  1. Hida K., Maishi N., Dorcas Akuba-Muhyia Annan and Hida Y. “Tumor Endthelial Cells and Cancer Progression” Cancer Metastasis and Cancer Stem Cell/Niche, Bentham Science Publishers (Edit by Takanori Kawaguchi) (2017) 61-73.

 

 

International symposium
  1. Hida K. “Heterogeneity of Tumor Endothelial Cells” Keystone Symposia on Molecular and Cellular Biology April 1, 2016 (Breckenridge, Colorado)
  2. Hida K. “Tumor Endothelial Cells as Key Players in Tumor Metastasis.” 2015 Asian-Australian Vascular Biology Meeting (AAVBM), Oct 15, 2015 (Busan, Korea)
  3. Hida K. “Tumor Endothelial Cells as Key Players in Tumor Metastasis.” KAIST Vascular Biology Mini-Symposium 2015, Oct 14, 2015 (Daejeon, Korea)
  4. Hida K. “Tumor endothelial cells and cancer progression.” The 74st Annual Meeting of the Japanese Cancer Association, 10th Oct, 2015 (Nagoya)
  5. Maishi N, Hida K. “Tumor endothelial cells instigate metastasis of indolent tumors.” Spring Special Symposium of the Japanese Vascular Biology and Medicine Organization, May 13, 2015 (Osaka, Japan)
  6. Maishi N. “Characterization of tumor endothelial cells for development of new anti-angiogenic therapy.” The 17th Hokkaido University ? Seoul National University Joint Symposium, Nov 28, 2014 (Sapporo).
  7. Maishi N. “Characterization of tumor endothelial cells for development of new anticancer drugs” The 17th International Congress on Oral Pathology and Medicine, May 25, 2014. (Istanbul, Turkey)
  8. Hida K. “Tumor endothelial cells as key players in tumor microenvironment.” International Symposium on Vascular Biology and Medicine combined with the 49th IDAC Symposium & the 6th Symposium for Joint Usage/Research Center of Aging. Apr 18, 2014 (Sendai, Japan)
  9. Hida K. “Heterogeneity of tumor endothelium.” The 18th International Vascular Biology Meeting, Apr 14, 2014. (Kyoto, Japan)

 

 

International conference
  1. Morimoto M., Maishi N., Matsuda A., Kitamura T., Higashino F., Yokoyama A., Kitagawa Y., Hida K. “Promotion of metastasis via alteration of vascular endothelium by tumor exosome miRNA” The 66th Annual Meeting of Japanese Association for Dental Research, 17th Nov, 2018. (Sapporo, Japan)
  2. Hida K., Kikuchi H., Maishi N., Abe T., Maruyama S., Harabayashi T., Ameda K., Matsuno Y., Hida Y., Shinohara N. “MDR1/ABCB1 upregulation in tumor blood vessels by chemotherapy-induced IL-8,” 20th International Vascular Biology Meeting, .3-7th, June, 2018 (Helsinki, Finland)
  3. Hida Y., Morimoto H., Maishi N., Nishihara H., Hatanaka Y., Matsuno Y., Nakamura T., Hirano S., Hida K. ”Biglycan, tumor endothelial cell secreting proteoglycan, as possible biomarker for lung cancer” 20th International Vascular Biology Meeting, .3-7th, June, 2018 (Helsinki, Finland)
  4. D.A.Annan, Maishi N., Soga T. R.Dawood, Hida Y., Hida K. “Tumor endothelial cells survive under lactic acidosis” AACR ANNUAL MEETING 2018, 16th April, 2018.(Chicago, Illinois, USA)
  5. Morimoto H., Maishi N., Hida Y., Nishihara H., Hatanaka Y., Matsuo Y., Nakamura Y., Hirano S., Hida K.“Biglycan, tumor endothelial secreting proteoglycan, as possible biomarker for lung cancer” AACR ANNUAL MEETING 2018, 16th April, 2018.(Chicago, Illinois, USA)
  6. Maishi N., Hida K. “Tumor endothelial cells in high metastatic tumors promote metastasis via biglycan” Protein Island Matsuyama 2017 International Symposium (PIM 2017), 13th Sep, 2017. (Matsuyama, Japan)
  7. Kikuchi H., Maishi N., Akiyama K., Morimoto M., Yanagiya M., Miyajima N., Tsuchiya K., Maruyama S., Abe T., Hida Y., Harabayashi T., Ameda K., Matsumoto R., Kashiwagi A., Matsuno Y., Shinohara N., Hida K. “Analysis of multidrug resistant transporter expression in tumor blood vessels of urothelial carcinoma during chemotherapy” 2017 ASCO Annual Meeting, 2-6th June, 2017. (Chicago, Illinois, USA)
  8. Hida K., Torii C., Maishi N., Morimoto M., Akiyama K., Kawamoto T., Minami T., Yoshioka Y., Mohammad Towfik Alam, Shindoh M., Hida Y., Ochiya T. “Tumor endothelial cells acquire drug resistance by exosomal-miR derived from high metastatic tumor” The 19th International Vascular Biology Meeting, 2nd Nov, 2016 (Boston, Massachusetts, USA)
  9. Maishi N., Ohba Y., Akiyama K., Ohga N., Hamada J., Nagao-Kitamoto H., Mohammad Towfik Alam, Shindoh M., Hida Y. Hida K. “Tumor endothelial cells in high metastatic tumors promote metastasis via biglycan” The 19th International Vascular Biology Meeting, 2nd Nov, 2016 (Boston, Massachusetts, USA)
  10. Kikuchi H., Maishi N., Akiyama K., Morimoto M., Yanagiya M., Miyajima N., Tuchiya K., Maruyama S., Abe T., Hida Y., Harabayashi T., Ameda K., Matsumoto R., Kashiwagi A., Demura T., Tsuda M., Tanaka S., Matsuno Y., Shinohara N., Hida K. “P-glycoprotein expression dynamics in tumor blood vessels of urothelial carcinoma during chemotherapy.” The 19th International Vascular Biology Meeting, 2nd Nov, 2016 (Boston, Massachusetts, USA)
  11. Shobaki N, Sato Y, Harashima H. “Optimizing siRNA delivery using specific multifunctional envelope-type nanodevice for liver sinusoidal endothelial cells.” Asian conference on nanoscience and nanotechnology, AsiaNANO 2016: Asian Conference on Nanoscience and Nanotechnology, 10-13th Oct, 2016 (Sapporo Convention Center, Sapporo, Japan)
  12. Hida K., Maishi N., Ohga N., Hida Y. “Heterogeneity of Tumor endothelium.” The 41th Naito Conference on “Cancer Heterogeneity and Plasticity: Relevance to Therapeutic Resistance”, 7th July, 2016 (Sapporo, Japan)
  13. Maishi N, Hida K. “Tumor Endothelial Cells Promote Metastasis via Biglycan.” Keystone Symposia on Molecular and Cellular Biology, 30th March, 2016. (Breckenridge, Colorado, USA)
  14. Maishi N., Ohba Y., Akiyama K., Ohga N., Hamada J., Mohammad Towfik Alam, Shindoh M., Hida Y., Hida K “Tumor endothelial cells promote metastasis via biglycan secretion” Tenth AACR-JCA Joint Conference “Breakthroughs in Cancer Research: From Biology to Therapeutics” 17th Feb, 2016. (Maui, Hawaii, USA)
  15. Maishi N, Ohba Y, Akiyama K, Ohga N, Hamada J, Mohammad Towfik Alam, Shindoh M, Hida Y, Hida K. “Tumor endothelial cells promote metastasis via biglycan secretion” The European Cancer Congress 2015. 27th September, 2015 (Vienna, Austria)
  16. Maishi N, Ohba Y, Ohga N, Akiyama K, Hamada J, Yamamoto K, Kawamoto T, Shindoh M, Hida Y, Hida K. “Tumor endothelial cells promote metastasis” The 18th International Vascular Biology Meeting, 15th April, 2014 (Kyoto, Japan)
  17. Hojo T, Maishi N, Akiyama K, Ohga N, Kondoh M, Shindoh M, Fujisawa T, Hida Y, Hida K. “Proangiogenic phenotype of Tumor Endothelial Cells induced by ROS accumulation” The 18th International Vascular Biology Meeting, 15th April, 2014 (Kyoto, Japan)
  18. Yamada K, Maishi N, Ohga N, Akiyama K, Kawamoto T, Alam Mohammad Towfik, Shindoh M, Takahashi N, Kamiyama T, Hida Y, Taketomi A, Hida K. “CXCL12/CXCR7 axis is importanrtr for tumor endothelial cellangiogenic property” The 18th International Vascular Biology Meeting, 15th April, 2014 (Kyoto, Japan)
  19. Alam Mohammad Towfik, Nagao H, Ohga N, Akiyama K, Maishi N, Kawamoto T, Shinohara N, Taketomi A, Shindoh M, Hida Y, Hida K. “SBSN is a novel Tumor Endothelial Cell marker” The 18th International Vascular Biology Meeting, 14th April, 2014 (Kyoto, Japan)
  20. Torii C, Ohga N, Akiyama K, Maishi N, Hojo T, Ohiro Y, Ono M, Totsuka Y, Kitagawa Y, Tei K, Hida Y, Shindoh M, Sato Y, Hida K. “Vasohibin-1 as a novel proangiogenic factor in oral squamous cell carcinoma” The 18th International Vascular Biology Meeting, 14th April, 2014 (Kyoto, Japan)
  21. Akiyama K, Ohga N, Hida Y, Maishi N, Alam Mohammad Towfik, Kawamoto T, Ohmura H, Yamada K, Torii C, Shindoh M, Ohba Y, Hida K. “P-gp inhibitor enhances antiangiogenic activity in metronomic chemotherapy” The 18th International Vascular Biology Meeting, 14th April, 2014 (Kyoto, Japan)

 

 

 

1st term (2009-2013)

Original article
  1. Kondoh M, Ohga N, Akiyama K, Hida Y, Maishi N, Alam Mohammad Towfik, Inoue N, Shindoh M, *Hida K. “Hypoxia-induced reactive oxygen species cause chromosomal abnormalities in endothelial cells in the tumor microenvironment”. PLoS ONE. (2013) 8(11), e80349.
  2. Osawa T, Ohga N, Akiyama K, Hida Y, Kitayama K, Kawamoto T, Yamamoto K, Maishi N, Kondoh M, Onodera Y, Fujie M, Nonomura K, Shindoh M, *Hida K. “Lysyl oxidase secreted by tumour endothelial cells promotes angiogenesis and metastasis”. Br J Cancer. (2013) 109(8), 2237-2247.
  3. Maishi N, Kawamoto T, Ohga N, Yamada K, Akiyama K, Yamamoto K, Osawa T, Hida Y, Hida K. “Application of POLARIC? fluorophores in an in vivo tumor model”. Oncol Rep. (2013) 30(4), 1695-1700.
  4. Akiyama K, Ohga N, Maishi N, Hida Y, Kitayama K, Kawamoto T, Osawa T, Suzuki Y, Shinohara N, Nonomura K, Shindoh M, *Hida K. “The F-prostaglandin receptor is a novel marker for tumor endothelial cells in renal cell carcinoma”. Pathol Int. (2013) 63(1), 37-44.
  5. Kibria G, Hatakeyma H, Ohga N, Hida K, *Harashima H. “The effect of liposomal size on the targeted delivery of doxorubicin to integrin (alpha)v(beta)3-expressing tumor endothelial cells.” Biomaterials (2013) 34(22): 5617-5627.
  6. Akhter A, Hayashi Y, Sakurai Y, Ohga N, Hida K, *Harashima H. “A liposomal delivery system that targets liver endothelial cells based on a new peptide motif present in the ApoB-100 sequence.” Int J Pharm. (2013) 456: 195-201.
  7. Yamada Y, Hashida M, Hayashi Y, Tabata M, Hyodo M, Ara MN, Ohga N, Hida K, *Harashima H. “An approach to transgene expression in liver endothelial cells using a liposome-based gene vector coated with hyaluronic acid.” J Pharm Sci. (2013) 102: 3119-3127.
  8. Osawa T, Ohga N, Hida Y, Kitayama K, Akiyama K, Onodera Y, Fujie M, Shinohara N, Nonomura K, Shindoh M, *Hida K. “Prostacyclin receptor in tumor endothelial cells promotes angiogenesis in an autocrine manner”. Cancer Sci. (2012) 103(6), 1038-1044.
  9. Yamamoto K, Ohga N, Hida Y, Maishi N, Kawamoto T, Kitayama K, Akiyama K, Osawa T, Kondoh M, Matsuda K, Onodera Y, Fujie M, Kaga K, Hirano S, Shinohara N, Shindoh M, *Hida K. “Biglycan is a specific marker and an autocrine angiogenic factor of tumour endothelial cells”. Br J Cancer. (2012) 106, 1214-1223.
  10. Maishi N, Ohga N, Hida Y,　Akiyama K, Kitayama K, Osawa T, Onodera Y, Shinohara N, Nonomura K, Shindoh M, *Hida K . “CXCR7 : A novel tumor endothelial marker in renal cell carcinoma”. Pathol Int. (2012) 62(5), 309-317.
  11. Kawamoto T, Ohga N, Akiyama K, Hirata N, Kitahara S, Maishi N, Osawa T, Yamamoto K, Kondoh M, Shindoh M, Hida Y, *Hida K. “Tumor-derived microvesicles induce proangiogenic phenotype in endothelial cells via endocytosis”. PLoS ONE. (2012) 7(3), e34045.
  12. Ohga N, Ishikawa S, Maishi N, Akiyama K, Hida Y,　Kawamoto T, Sadamoto Y, Osawa T,Yamamoto K, Kondoh M, Ohmura H, Shinohara N, Nonomura K, Shindoh M, *Hida K. “Heterogeneity of Tumor Endothelial Cells: Comparison between Tumor Endothelial Cells Isolated from Highly Metastatic and Low Metastatic Tumors”. Am J Pathol. (2012), 180(3), 1294-1307.
  13. Akiyama K, Ohga N, Hida Y, Kawamoto T, Sadamoto Y, Ishikawa S, Maishi N, Akino T, Kondoh M, Matsuda A, Inoue N, Shindoh M, *Hida K . “Tumor endothelial cells acquire drug resistance by MDR1 upregulation via VEGF signaling in tumor microenvironment”. Am J Pathol. (2012) 180(3), 1283-1293.
  14. Takara K, Hatakeyama H, Kibria G, Ohga N, Hida K, *Harashima H. “Size-controlled, dual-ligand modified liposomes that target the tumor vasculature show promise foruse in drug-resistant cancer therapy.” J Controlled Release. (2012) 162: 225-232.
  15. Ara MN, *Hyodo M, Ohga N, Hida K, Harashima H. “Development of a novel DNA aptamer ligand against primary cultured tumor endothelial cells.” PLoS ONE. (2012) 7: e50174.
  16. Kurosu T, Ohga N, Hida Y, Maishi N, Akiyama K, Kakuguchi W, Kuroshima T, Kondo M, Akino T, Totsuka Y, Shindoh M, Higashino F, *Hida K. “HuR keeps an angiogenic switch on by stabilizing mRNA of VEGF and COX-2 in tumor endothelium”. Br J Cancer. (2011) 104(5), 819-82.
  17. Muraki C, Ohga N, Hida Y, Nishihara H, Kato Y, Tsuchiya K, Matsuda K, Totsuka Y, Shindoh M, *Hida K. “Cyclooxygenase-2 inhibition causes antiangiogenic effects on tumor endothelial and vascular progenitor cells”. Int J Cancer. (2011) 130, 59-70.
  18. Kibria G, Hatakeyama H, Ohga N, Hida K, *Harashima H. “Dual-ligand modification of PEGylated liposomes shows better cell selectivity and efficient gene delivery.” J Controlled Release. (2011) 153: 141-148.
  19. Tsuchiya K, *Hida K, Hida Y, Muraki C, Ohga N, Kondo T, Miseki T, Nakagawa K, Shindoh M, Harabayashi T, Shinohara N, Nonomura K, Kobayashi M. “Adrenomedullin antagonist suppresses tumor formation in renal cell carcinoma through inhibitory effects on tumor endothelial cells and endothelial progenitor mobilization”. Int J Oncol. (2010) 36(6), 1379-1386.
  20. Matsuda K, Ohga N, Hida Y, Muraki C, Kurosu T, Tsuchiya K, Akino T, Shih SC, Totsuka Y, Klagsbrun M, Shindoh M, *Hida K. “Isolated tumor endothelial cells maintain specific character during long-term culture” Biochem Biophys Res Commun. (2010) 394, 947-954.
  21. Takara K, Hatakeyama H, Ohga N, Hida K, *Harashima H. “Design of a dual-ligand system using a specific ligand and cell penetrating peptide, resulting in a synergistic effect on selectivity and cellular uptake.” Int J Pharm. (2010) 396: 143-148.
  22. *Kajimoto K, Hossen MN, Hida K, Ohga N, Akita H, Hyodo M, Hida Y, Harashima H. “Isolation and Culture of Microvascular Endothelial Cells from Murine Inguinal and Epididymal Adipose Tissue.” J Immunol Methods. (2010) 357: 43-50.
  23. Akino T, *Hida K, Hida Y, Tsuchiya K, Freedman D, Muraki C, Ohga N, Matsuda K,　 Akiyama K, Harabayashi T, Shinohara N, Nonomura K, Klagsbrun M, Shindoh M. “Cytogenetic　Abnormalities of Tumor-Associated Endothelial Cells in Human Malignant Tumor”. Am J Pathol. (2009) 175(6), 2657-2667.
  24. Ohga N, *Hida K, Hida Y, Muraki C, Tsuchiya K, Matsuda K, Ohiro Y, Totsuka Y, Shindoh M. “Inhibitory Effects of Epigallocatechin-3 Gallate, a Polyphenol in Green Tea on Tumor-Associated Endothelial Cells and Endothelial Progenitor Cells”. Cancer Sci. (2009) 100(10), 1963-1970.

 

 

Review article
  1. *Hida K, Ohga N, Akiyama K, Maishi N, Hida Y. “Heterogeneity of tumor endothelial cells.” Cancer Sci. (2013) 104(11): 1391-1395. (IF=3.386) (CI=0)
  2. *Hida K, Akiyama K, Ohga N, Maishi N, Hida Y. “Tumor endothelial cells acquire drug resistance in a tumor microenvironment.” J Biochem. (2013) 153(3): 243-249. (IF=2.498) (CI=3)
  3. *Hida K, Kawamoto T, Ohga N, Akiyama K, Hida Y, Shindoh M. “Altered angiogenesis in the tumor microenvironment.” Pathol Int. (2011) 61: 630-637. (IF=1.637) (CI=7)
  4. Higashino F, *Hida K, Kitamura T, Ohga N, Shindoh M. “Aberrant control of transcription and transportation of oncogenic mRNA in carcinogenesis.” Oral Sci Int. (2010) 7: 11-18.
  5. *Hida K, Ohga N, Kurosu T, Totsuka Y, Shindoh M. “Crosstalk between blood vessels and tumor microenvironment.” Oral Sci Int. (2010) 7: 1-10.
  6. *Hida K, Ohga N, Hida Y, Shindoh M. “Significance of Antiangiogenic Therapy in Head and Neck Cancer-Heterogeneity of Tumor Endothelium.” Jpn Dent Sci Review. (2009) 46: 26-32.

 

 

Book

 

 

International symposium
  1. Hida K. “Heterogeneity of Tumor Endothelial Cells.” The 43rd International Symposium of The Princess Takamatsu Cancer Research Fund “Cancer Heterogeneity: Impact on Carcinogenesis, Cancer Stem Cell, Microenvironment, Diagnosis and Treatment” 15th Nov, 2012 (Tokyo)
  2. Hida K. “Altered phenotype in endothelial cells in tumor microenvironment.” The 2nd International Symposium by JSPS Core-to-Core Program“Cooperative International Framework in TGF-β Family Signaling”, 30th Oct, 2012. (Tokyo)
  3. Hida K. “Crosstalk between tumor endothelial cells and tumor cells.” The 71st Annual Meeting of the Japanese Cancer Association, 21th Sep, 2012. (Sapporo)
  4. Hida K. “A New Insights into Tumor endothelial cell” The 5th Meeting of Asian Society of Oral and Maxillofacial Pathology, 24th Aug, 2011.（Fukuoka）
  5. Hida K. “Crosstalk between Tumor Endothelial Cells and Microenvironment.” The 13th Hokkaido University ? Seoul National University Joint Symposium, 26th Nov, 2010 (Sapporo)

 

 

International conference
  1. Maishi N., Hida K. “Tumor endothelial cells promote metastasis” The 18th Japan-Korea Cancer Research Workshop, 30th Nov, 2013 (Gifu, Japan)
  2. Hida K, Omura H, Akiyama K, Ohga N, Maishi N, Kawamoto T, Kondoh M, Hida Y. “Characterization of stem-like tumor endothelial cells.” The 20th annual Meeting of the Japanese Vascular Biology and Medicine Organization, The 10th Korea-Japan Joint Symposium on Vascular Biology, 5-7th Dec, 2012 (Tokushima)
  3. Ohga N, Yamamoto K, Hida Y, Maishi N, Kawamoto T, Shindoh M, Hida K. “Biglycan is an autocrine angiogenic factor of tumor endothelial cells.” The 20th annual Meeting of the Japanese Vascular Biology and Medicine Organization, The 10th Korea-Japan Joint Symposium on Vascular Biology, 5-7th Dec, 2012 (Tokushima)
  4. Akiyama K, Ohga N, Hida Y, Maishi N, Alam Mohammad Towfik, Kawamoto T, Omura H, Yamada K, Torii C, Sakamoto H. Matsuda A, Hida K. “Tumor endothelium acquires drugresistance by MDR1/P-gp upregulationand metronomic chemotherapycombined with P-gp inhibitor enhancesantiangiogenic activity in vivo.” The 20th annual Meeting of the Japanese Vascular Biology and Medicine Organization, The 10th Korea-Japan Joint Symposium on Vascular Biology, 5-7th Dec, 2012 (Tokushima)
  5. Kondoh M, Ohga N, Akiyama K, Maishi N, Kawamoto T, Hida Y, Shindoh M, Hida K. “Hypoxia induces angiogenic factors andaneuploidy in micirovascular endothelialcells.” The 20th annual Meeting of the Japanese Vascular Biology and Medicine Organization, The 10th Korea-Japan Joint Symposium on Vascular Biology, 5-7th Dec, 2012 (Tokushima)
  6. Hida K. “Crosstalk between tumor endothelial cells and tumor cells.” The 71st Annual Meeting of the Japanese Cancer Association, 21th Sep, 2012 (Sapporo, Japan)
  7. Kawamoto T, Ohga N, Akiyama K, Hirata N, Kitahara S, Maishi N, Osawa T, Yamamoto K, Kondoh M, Shindoh M, Hida Y, Hida K. “Tumor-derived microvesicles induce proangiogenic phenotype in endothelial cells via endocytosis.” The 71st Annual Meeting of the Japanese Cancer Association, 20th Sep, 2012 (Sapporo, Japan)
  8. Ohga N, Yamamoto K, Hida Y, Akiyama K, Maishi N, Kawamoto T, Kitayama K, Osawa T, Hirano S, Shinohara N, Shindoh M, Hida K. “Biglycan is a specific marker and an autocrine angiogenic factor of tumour endothelial cells.” The 71st Annual Meeting of the Japanese Cancer Association, 19th Sep, 2012 (Sapporo, Japan)
  9. Akiyama K, Osawa T, Ohga N, Hida Y, Kitayama K, Kawamoto T, Yamamoto Y, Maishi N, Kondoh M, Shinohara N, Nonomura K, Shindoh M, Hida K. “The role of Lysyl oxidase on proangiogenic phenotypes of tumor endothelial cells.” The 71st Annual Meeting of the Japanese Cancer Association, 19th Sep, 2012 (Sapporo, Japan)
  10. Maishi N, Ohba Y, Ohga N, Akiyama K, Yamamoto Y, Hamada J, Kawamoto T, Osawa T, Kondoh M, Omura H, Shindoh M, Hida Y, Hida K. “The role of tumor endothelial cells in tumor metastasis.” The 71st Annual Meeting of the Japanese Cancer Association, 19th Sep, 2012 (Sapporo, Japan)
  11. Omura H, Akiyama K, Ohga N, Maishi N, Hida Y, Kawamoto T, Kondoh M, Osawa T, Yamamoto Y, Iida J, Shindoh M, Hida K. “Characterization of Aldehyde dehydrogenase(ALDH) positive tumor endothelial cells.” The 71st Annual Meeting of the Japanese Cancer Association, 19th Sep, 2012 (Sapporo, Japan)
  12. Yamamoto K, Ohga N, Hida Y, Maishi N, Kawamoto T, Kitayama K, Akiyama K, Osawa T, Kondoh M, Kaga K, Shinohara N, Shindoh M, Hirano S, Hida K. “Biglycan is a specific marker and an autocrine angiogenic factor of tumor endothelial cells.” The 17th International Vascular Biology Meeting, 5th Jun, 2012 (Wiesbaden, Germany)
  13. Hida K, Akiyama K, Ohga N, Hida Y, Kawamoto T, Sadamoto Y, Maishi N, Akino T, Kondoh M, Shindoh M. “Tumor endothelial cell s acquire drug resistance by MDR1 upregulation.” The 17th International Vascular Biology Meeting, 5th Jun, 2012 (Wiesbaden, Germany)
  14. Kawamoto T, Ohga N, Akiyama K, Hirata N, Kitahara S, Maishi N, Osawa T, Yamamoto K, Kondoh M, Shindoh M, Hida Y, Hida K. “Tumor-derived microvesicles induce proangiogenic phenotype in endothelial cells via endocytosis.” The 17th International Vascular Biology Meeting, 5th Jun, 2012 (Wiesbaden, Germany)
  15. Maishi N, Ohba Y, Yamamoto K, Ohga N, Hamada J, Akiyama K, Kawamoto T, Osawa T, Kondoh M, Ohmura H, Shindoh M, Hida Y, Hida K. “Contribution of tumor endothelial cells to tumor metastasis.” The 17th International Vascular Biology Meeting, 5th Jun, 2012 (Wiesbaden, Germany)
  16. Yamamoto K, Ohga N, Hida Y, Maishi N, Kawamoto T, Kitayama K, Akiyama K, Osawa T, Kondoh M, Kaga K, Hirano S, Shinohara N, Shindoh M, Hida K. “Biglycan is a specific marker and an autocrine angiogenic factor of tumor endothelial cells.” AACR ANNUAL MEETING 2012, 2nd Apr, 2012 (Chicago, Illinois, USA)
  17. Osawa T, Ohga N, Hida Y, Kitayama K, Yamamoto Y, Kawamoto T, Maishi N, Kondoh M, Akiyama K, Onodera Y, Shinohara N, Nonomura K, Shindoh M, Hida K. “The role of lysyl oxidase on proangiogenic phenotypes of tumor endothelial cells.” AACR ANNUAL MEETING 2012, 2nd Apr, 2012 (Chicago, Illinois, USA)
  18. Akiyama K, Ohga N, Hida Y, Kawamoto T, Sadamoto Y, Ishikawa S, Maishi N, Tomoshige A, Kondoh M, Matsuda A, Inoue N, Shindoh M, Hida K. “Tumor endothelial cells acquire drug resistance by MDR1 upregulation via VEGF signaling in tumor microenvironment.” AACR ANNUAL MEETING 2012, 2nd Apr, 2012 (Chicago, Illinois, USA)
  19. Kawamoto T, Ohga N, Akiyama K, Hirata N, Maishi N, Osawa T, Yamamoto K, Kondoh M, Shindoh M, Hida Y, Hida K. “Tumor-derived microvesicles induce proangiogenic phenotype in endothelial cells via endocytosis.” AACR ANNUAL MEETING 2012, 2nd Apr, 2012 (Chicago, Illinois, USA)
  20. Hida K. “Finding Specific Anti-cancer Drugs Using Human Tumor Vascular Cells.” 7th Annual International Partnering Conference “BIO-Europe Spring 201” 11-13th Mar, 2012 (Barcelona, Spain)
  21. Yamamoto K, Ohga N, Hida Y, Maishi N, Kawamoto T, Kitayama K, Akiyama K, Osawa T, Kondoh M, Kaga K, Hirano S, Shinohara N, Shindoh M, Hida K. “Biglycan is an angiogenic factor stimulating cell migration of tumor endothelium.” The 19th Annual Meeting of the Japanese Vascular Biology and Medicine Organization, 8-10th Dec, 2011 (Tokyo, Japan)
  22. Ohga N, Ishikawa S, Maishi N, Akiyama K, Hida Y, Kawamoto T, Sadamoto Y, Kondoh M, Ohsawa T, Yamamoto K, Ohmura H, Shindoh M, Hida K. “Heterogeneity of Tumor Endothelial Cells:Comparison between Tumor Endothelial Cells Isolated from Highly Metastatic and Low Metastatic Tumors.” The 19th Annual Meeting of the Japanese Vascular Biology and Medicine Organization, 8-10th Dec, 2011 (Tokyo, Japan)
  23. Kawamoto T, Ohga N, Akiyama K, Maishi N, Ohsawa T, Yamamoto K, Kondoh M, Osawa T, Shindoh M, Hida Y, Hida K. “Tumor-derived Microvesicles Promote Cell Motility and Tubeformation via Endocytosis in Endothelial Cells.” The 19th Annual Meeting of the Japanese Vascular Biology and Medicine Organization, 8-10th Dec, 2011 (Tokyo, Japan)
  24. Osawa T, Ohga N, Kitayama K, Hida Y, Kawamoto T, Kondoh M, Maishi N, Yamamoto K, Akiyama K, Shinohara M, Nonomura K, Shindoh M, Hida K. “The role of Lysyl oxidase on abnormal phenotypes of tumor endothelial cells.” The 19th Annual Meeting of the Japanese Vascular Biology and Medicine Organization, 8-10th Dec, 2011 (Tokyo, Japan)
  25. Akiyama K, Ohga N, Hida Y, Kawamoto T, Sadamoto Y, Ishikawa S, Maishi N, Akino T, Kondoh M, Osawa T, Yamamoto K, Ohmura H, Matsuda A, Shindoh M, Hida K. “Tumor endothelial cells aquire drug resistance by MDR1 upregulation via VEGF signaling in tumor microenvironment.” The 19th Annual Meeting of the Japanese Vascular Biology and Medicine Organization, 8-10th Dec, 2011 (Tokyo, Japan)
  26. Ohga N, Ishikawa S, Hida Y, Akiyama K, Kitayama K, Kondoh M, Maishi N, Kawamoto T, Ohsawa T, Yamamoto K, Shindoh M, Hida K. “Comparative characterization of tumor endothelial cells isolated from highly and low metastatic tumors.” The 5th Meeting of Asian Society of Oral and Maxillofacial Pathology “A New Insights into Tumor endothelial cell”, 24th Aug, 2011 (Fukuoka, Japan) (Invited Speaker)
  27. Maishi N, Ohga N, Hida Y, Ohba Y, Kawamoto T, Akiyama K, Kitayama K, Kondoh M, Ohsawa T, Yamamoto K, Inoue N, Shindoh M, Hida K. “Analysis of interaction between tumor endothelial cells and tumor cells.” AACR 102nd ANNUAL MEETING 2011, 2nd-6th Apr, 2011 (Orlando, Florida, USA)
  28. Kondoh M, Ohga N, Kitayama K, Akiyama K, Maishi N, Kawamoto T, Ohsawa T, Yamamoto K, Shindoh M, Inoue N, Hida Y, Hida K. “Gene expression analysis of circulating endothelial cells in cancer patients.” AACR 102nd ANNUAL MEETING 2011, 2nd-6th Apr, 2011 (Orlando, Florida, USA)
  29. Hida K. “Crosstalk between blood vessels and tumor　microenvironment.” The Meeting of the 20th Anniversary Celebration of the Sister School Affiliation between Graduate School of Dental Medicine, Hokkaido University and School of Dentistry, Chonbuk National University, 14th Oct, 2010 (Sapporo, Japan)
  30. Hida K, Akino T, Hida Y, Tsuchiya K, Freedman D, Muraki C, Ohga N, Matsuda K, Akiyama K, Kurosu T, Kondo M, Maishi N, Harabayashi T, Shinohara N, Nonomura K, Klagsbrun M, Shindoh M. “Cytogenetic Abnormalities of Tumor Endothelial Cells in Human Malignant Tumors.” AACR 101st ANNUAL MEETING 2010, 17-21th Apr, 2010 (Washington DC, USA)
  31. Hida Y, Ohga N, Muraki C, Akiyama K, Kondoh M, Maishi N, Kurosu T, Ishikawa S, Hirata N, Shindoh M. and Hida K. “A Green Tea Polyphenol Epigallocatechin-3 Gallate Specifically Targets Tumor-Associated Endothelial Cells.” AACR 101st ANNUAL MEETING 2010, 17-21th Apr, 2010 (Washington DC, USA)
  32. Akiyama K, Ohga N, Hida Y, Akino T, Hirata N, Kurosu T, Ishikawa S, Kondo M, Maishi N,　Kawamoto T, Inoue N, Shindoh M. and Hida K. “Endothelial cells acquire abnormalities by factors from tumor cells.” AACR 101st ANNUAL MEETING 2010, 17-21th Apr, 2010 (Washington DC, USA)
  33. Ohga N, Hida K. “Inhibitory Effects of Epigallocatechin-3 Gallate, a Polyphenol in Green Tea, on Tumor-Associated Endothelial Cells and Endothelial Progenitor Cells.” AACR-JCA Joint conference:CANCER GENOMICS, EPIGENOMICS, AND THE DEVELOPMENT OF NOVEL THERAPEUTICS, 5-9th Feb, 2010 (Waikoloa, Hawaii, USA)