研究業績

1. Mori K, Naganuma T, Kihara A.(2023)
   Role of 2-hydroxy acyl-CoA lyase HACL2 in odd-chain fatty acid production via α-oxidation in vivo. Mol Biol Cell, in press.
2. Ota A, Morita H, Naganuma T, Miyamoto M, Jojima K, Nojiri K, Matsuda J, Kihara A. (2023)
   Bifunctional DEGS2 has higher hydroxylase activity toward substrates with very-long-chain fatty acids in the production of phytosphingosine ceramides. J Biol Chem, 299 (4), 104603
3. Iino Y, Naganuma T, Arita M. (2023)
   Dysregulated ceramide metabolism in mouse progressive dermatitis resulting from constitutive activation of Jak1. J Lipid Res,64 (2), 100329
4. Morimoto A, Fukuda K, Ito Y, Tahara U, Sasaki T, Shiohama A, Kawasaki H, Kawakami E, Naganuma T, Arita M, Sasaki H, Koseki H, Matsui T, Amagai M. (2022)
   Microbiota-Independent spontaneous dermatitis associated with increased sebaceous lipid production in Tmem79-deficient mice. J Invest Dermatol, 142 (11), 2864-2872
5. Naganuma T, Fujinami N, Arita M. (2022)
   Polyunsaturated fatty acid-derived lipid mediators that regulate epithelial homeostasis. Biol Pharm Bull, 45 (8), 998-1007
6. 永沼達郎. (2021)
   皮膚の多彩な脂質代謝を捉える包括的メタボローム解析技術. 進化する皮膚科学　〜機能研究・臨床・評価・製品開発の最前線〜 , p245-253.
7. Mori K, Obara T, Seki N, Miyamoto M, Naganuma T, Kitamura T, Kihara A. (2020)
   Catalytic residues, substrate specificity, and role in carbon starvation of the 2-hydroxy FA dioxygenase Mpo1 in yeast. J Lipid Res, 61, 1104-1114.
8. Akira Utsunomiya, Takenao Chino, Natsuko Utsunomiya, Vu Huy Luong, Atsushi Tokuriki, Tatsuro Naganuma, Makoto Arita, Kiyoshi Higashi, Koichi Saito, Noriyuki Suzuki, Ayako Ohara, Manabu Sugai, Koji Sugawara, Daisuke Tsuruta, Noritaka Oyama, Minoru Hasegawa. (2019)
   Homeostatic Function of Dermokine in the Skin Barrier and Inflammation. J Invest Dermatol, 140, 838-849.
9. Honda Y, Kitamura T, Naganuma T, Abe T, Ohno Y, Sassa T, Kihara A. (2018)
   Decreased skin barrier lipid acylceramide and differentiation-dependent gene expression in ichthyosis gene Nipal4 knockout mice. J Invest Dermatol, 138, 741-749.
10. 永沼達郎，有田誠. (2017)
    脂肪酸クオリティと炎症・アレルギーの制御. 炎症と免疫, 25 (4), p265-270.
11. Narita T, Naganuma T, Sase Y, Kihara A. (2016)
    Long-chain bases of sphingolipids are transported into cells via the acyl-CoA synthetases. Sci Rep, 6, 25469.
12. Naganuma T, Takagi S, Kanetake T, Kitamura T, Hattori S, Miyakawa T, Sassa T, Kihara A. (2016)
    Disruption of the Sjögren-Larsson syndrome gene Aldh3a2 in mice increases keratinocyte growth and retards skin barrier recovery. J Biol Chem, 291,11676-11688.
13. Kitamura T, Takagi S, Naganuma T, Kihara A (2015)
    Mouse aldehyde dehydrogenase ALDH3B2 is localized to lipid droplets via two C-terminal tryptophan residues and lipid modification. Biochem J, 465, 79-87.
    （USACO のホームページで紹介）
14. Kondo N, Ohno Y, Yamagata M, Obara T, Seki N, Kitamura T, Naganuma T, Kihara A (2014)
    Identification of the phytosphingosine metabolic pathway leading to odd-numbered fatty acids. Nat Commun, 5, 5338. Corrigendum: (2015) 6, 6815
15. Naganuma T, Kihara A (2014)
    Two modes of regulation of the fatty acid elongase ELOVL6 by the 3-ketoacyl-CoA reductase KAR in the fatty acid elongation cycle. PLos One, 9, e101823.
16. Kitamura T, Naganuma T, Abe K, Nakahara K, Ohno Y, Kihara A (2013)
    Substrate specificity, plasma membrane localization, and lipid modification of the aldehyde dehydrogenase ALDH3B1. Biochim Biophys Acta, 1831, 1395-1401.
17. Yazawa T, Naganuma T, Yamagata M, Kihara A (2013)
    Identification of residues important for the catalysis, structure maintenance, and substrate specificity of yeast 3-hydroxyacyl-CoA dehydratase Phs1. FEBS Lett, 587, 804-809.
18. Nakahara K, Ohkuni A, Kitamura T, Abe K, Naganuma T, Ohno Y, Zoeller RA, Kihara A (2012) Sjögren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway. Mol Cell, 46, 461-471.
    （日本語詳細がライフサイエンス新着論文レビューに掲載。）
19. Naganuma T, Sato Y, Sassa T, Ohno Y, Kihara A (2011) Biochemical characterization of the very long-chain fatty acid elongase ELOVL7. FEBS Lett, 585, 3337-3341.
20. Okuda A, Naganuma T, Ohno Y, Abe K, Yamagata M, Igarashi Y, Kihara A (2010) Hetero-oligomeric interactions of an ELOVL4 mutant protein: implications in the molecular mechanism of Stargardt-3 macular dystrophy. Mol Vis, 16, 2438-2445.