Chronic pain-induced neuronal plasticity in the bed nucleus of the stria terminalis causes maladaptive anxiety
Yamauchi N, Sato K, Sato K, Murakawa S, Hamasaki Y, Nomura H, Amano T, Minami M.
Science Advances, in press
Exposure to hot and cold environments activates neurons projecting from the paraventricular thalamic nucleus to brain regions related to approach and avoidance behaviors
Estrogen signaling modulates behavioral selection toward pups and amygdalohippocampal area in the rhomboid nucleus of the bed nucleus of the stria terminalis circuit
Fukui K, Sato K, Murakawa S, Minami M, Amano T.
Neuropharmacology. 2022 Feb 15;204:108879. doi: 10.1016/j.neuropharm.2021.108879.
Exposure to hot and cold environments activates neurons projecting from the paraventricular thalamic nucleus to brain regions related to approach and avoidance behaviors
Diverse intracellular signaling pathways mediate the effects of neurotensin on the excitability of type II neurons in the rat dorsolateral bed nucleus of the stria terminalis
Kaneko T, Hara R, Amano T, Minami M.
Journal of Pharmacological Sciences, 2021 147, 86-94
2020
Inhibitory synaptic transmissions to the bed nucleus of the stria terminalis neurons projecting to the ventral tegmental area are enhanced in rats exposed to chronic mild stress.
Hara R, Takahashi D, Takehara T, Amano T, Minami M.
Mol Brain. 2020 Oct 15;13(1):139.
Noradrenaline enhances the excitatory effects of dopamine on medial prefrontal cortex pyramidal neurons in rats.
Shinohara F, Arakaki S, Amano T, Minami M, Kaneda K.
Neuropsychopharmacol Rep. 2020 Sep 8
Amygdalohippocampal area neurons that project to the preoptic area mediate infant-directed attack in male mice.
Sato K, Hamasaki Y, Fukui K, Ito K, Miyamichi K, Minami M, Amano T.
J Neurosci. 2020 Apr 7. pii: JN-RM-0438-19
Disappearance of the inhibitory effect of neuropeptide Y within the dorsolateral bed nucleus of the stria terminalis in rats with chronic pain.
Hara R, Asaoka Y, Takahashi D, Nomura H, Amano T, Minami M.
Neurosci Lett. 2020 Apr 9:134958
Acute Restraint Stress Augments the Rewarding Memory of Cocaine Through Activation of α 1 Adrenoceptors in the Medial Prefrontal Cortex of Mice
Wada S, Yanagida J, Sasase H, Zhang T, Li X, Kamii H, Domoto M, Deyama S, Hinoi E, Yamanaka A, Nishitani N, Nagayasu K, Kaneko S, Minami M, Kaneda K
Neuropharmacology. 2020 Jan 24:107968
2019
Tonic suppression of the mesolimbic dopaminergic system by enhanced corticotropin-releasing factor signaling within the bed nucleus of the stria terminalis in chronic pain model rats.
Takahashi D, Asaoka Y, Kimura K, Hara R, Arakaki S, Sakasai K, Suzuki H, Yamauchi N, Nomura H, Amano T, Minami M.
J Neurosci. 2019 Oct 16;39(42):8376-8385
Effect of gonadal steroid hormone levels during pubertal development on social behavior of adult mice toward pups and synaptic transmission in the rhomboid nucleus of the bed nucleus of the stria terminalis
Fukui K, Uki H, Minami M, Amano T.
Neurosci Lett. 2019 Jun 28:134357
Prior observation of fear learning enhances subsequent self-experienced fear learning with an overlapping neuronal ensemble in the dorsal hippocampus
Nomura H, Teshirogi C, Nakayama D, Minami M, Ikegaya Y
Mol Brain. 2019 Mar 14;12(1):21.
Glutamatergic neurons in the medial prefrontal cortex mediate the formation and retrieval of cocaine-associated memories in mice
Zhang T, Yanagida J, Kamii H, Wada S, Domoto M, Sasase H, Deyama S, Takarada T, Hinoi E, Sakimura K, Yamanaka A, Maejima T, Mieda M, Sakurai T, Nishitani N, Nagayasu K, Kaneko S, Minami M, Kaneda K
Addict Biol. 2019 Feb 7.
Central histamine boosts perirhinal cortex activity and restores forgotten object memories
Nomura H, Mizuta H, Norimoto H, Masuda F, Miura Y, Kubo A, Kojima H, Ashizuka A, Matsukawa N, Baraki Z, Hitora-Imamura N, Nakayama D, Ishikawa T, Okada M, Orita K, Saito R, Yamauchi N, Sano Y, Kusuhara H, Minami M, Takahashi H, Ikegaya Y
Biol Psychiatry. 2019 Aug 1;86(3):230-239
2018
Exposure to hot and cold environments increases noradrenaline release in the bed nucleus of the stria terminalis in rats.
Minami S, Nomura H, Minami M.
Neuropsychopharmacol Rep. 2018 Dec;38(4):214-218
Resolvin E3 attenuates lipopolysaccharide-induced depression-like behavior in mice.
Roles of noradrenergic transmission within the ventral part of the bed nucleus of the stria terminalis in bidirectional brain-intestine interactions.
Ide S, Yamamoto R, Suzuki H, Takeda H, Minami M.
Neuropsychopharmacol Rep. 2018 Dec;38(4):182-188
Activation of the neural pathway from the dorsolateral bed nucleus of the stria terminalis to the central amygdala induces anxiety-like behaviors.
Yamauchi N, Takahashi D, Sugimura YK, Kato F, Amano T, Minami M.
Eur J Neurosci. 2018 Nov;48(9):3052-3061
Design and synthesis of cyclopropane-based conformationally restricted GABA analogues as selective inhibitors for betaine/GABA transporter 1
Suemasa A, Watanabe M, Kobayashi T, Suzuki H, Fukuda H, Minami M, Shuto S.
Bioorg Med Chem Lett. 2018 Nov 1;28(20):3395-3399
GABAergic malfunction in the anterior cingulate cortex underlying maternal immune activation-induced social deficits
Okamoto K, Hitora-Imamura N, Hioki H, Ikegaya Y.
J Neuroimmunol. 2018 Aug 15;321:92-96
Bidirectional brain‐gut interactions: Involvement of noradrenergic transmission within the ventral part of the bed nucleus of the stria terminalis
Ide S, Yamamoto R, Takeda H, Minami M
Neuropsychopharmacology Reports. 2018 Jan 2; 38(1):37-43
Sensitization of transient receptor potential vanilloid 4 and increasing its endogenous ligand 5,6-epoxyeicosatrienoic acid in rats with monoiodoacetate-induced osteoarthritis.
Hinata M, Imai S, Sanaki T, Tsuchida J, Yoshioka T, Higashino K, Yamamoto M, Imai M, Soga M, Horita N, Fukuda I, Ikeda M, Yamane S, Morita A, Kanemasa T, Sakaguchi G, Hasegawa M, Minami M, Morioka Y.
Pain. 2018 May;159(5):939-947
Pregabalin induces conditioned place preference in the rat during the early, but not late, stage of neuropathic pain.
Asaoka Y, Kato T, Ide S, Amano T, Minami M.
Neurosci Lett. 2018 Mar 6;668:133-137.
Stress augments the rewarding memory of cocaine via the activation of brainstem-reward circuitry.
Shinohara F, Asaoka Y, Kamii H, Minami M, Kaneda K.
Addict Biol. 2019 May;24(3):509-521
Suppressive effects of morphine injected into the ventral bed nucleus of the stria terminalis on the affective, but not sensory, component of pain in rats.
Maruyama C, Deyama S, Nagano Y, Ide S, Kaneda K, Yoshioka M, Minami M.
Eur J Neurosci. 2018 Jan;47(1):40-47.
Resolvin E1/E2 ameliorate lipopolysaccharide-induced depression-like behaviors via ChemR23.
Deyama S, Shimoda K, Suzuki H, Ishikawa Y, Ishimura K, Fukuda H, Hitora-Imamura N, Ide S, Satoh M, Kaneda K, Shuto S, Minami M.
Astrocytic γ-aminobutyric acid (GABA) transporters mediate guanidinoacetate transport in rat brain.
Tachikawa M, Yashiki A, Akanuma SI, Matsukawa H, Ide S, Minami M, Hosoya KI.
Neurochem Int. 2017 Nov 24;113:1-7.
Nitric oxide in the medial prefrontal cortex contributes to the acquisition of cocaine place preference and synaptic plasticity in the laterodorsal tegmental nucleus.
Kamii H, Taoka N, Minami M, Kaneda K.
Neurosci Lett. 2017 Nov 1;660:39-44.
Rapid and sustained antidepressant effects of resolvin D1 and D2 in a chronic unpredictable stress model.
Ishikawa Y, Deyama S, Shimoda K, Yoshikawa K, Ide S, Satoh M, Minami M.
Behav Brain Res. 2017 Aug 14;332:233-236.
Resolvin D1 and D2 Reverse Lipopolysaccharide-Induced Depression-Like Behaviors Through the mTORC1 Signaling Pathway.
Deyama S, Ishikawa Y, Yoshikawa K, Shimoda K, Ide S, Satoh M, Minami M.
Int J Neuropsychopharmacol. 2017 Jul 1;20(7):575-584.
Suppression of reward-induced dopamine release in the nucleus accumbens in animal models of depression: Differential responses to drug treatment.
Minami S, Satoyoshi H, Ide S, Inoue T, Yoshioka M, Minami M.
Neurosci Lett. 2017 May 22;650:72-76.
Development-dependent behavioral change toward pups and synaptic transmission in the rhomboid nucleus of the bed nucleus of the stria terminalis.
Amano T, Shindo S, Yoshihara C, Tsuneoka Y, Uki H, Minami M, Kuroda KO.
Behav Brain Res. 2017 May 15;325(Pt B):131-137.
Activation of the NMDA receptor-neuronal nitric oxide synthase pathway within the ventral bed nucleus of the stria terminalis mediates the negative affective component of pain.
Deyama S, Sugano Y, Mori S, Amano T, Yoshioka M, Kaneda K, Minami M.
Neuropharmacology. 2017 May 15;118:59-68.
The Role of Dopaminergic Signaling in the Medial Prefrontal Cortex for the Expression of Cocaine-Induced Conditioned Place Preference in Rats.
Shinohara F, Kamii H, Minami M, Kaneda K.
Biol Pharm Bull. 2017;40(11):1983-1989.
2016
Activation of adenylate cyclase-cyclic AMP-protein kinase A signaling by corticotropin-releasing factor within the dorsolateral bed nucleus of the stria terminalis is involved in pain-induced aversion.
Kaneko T, Kaneda K, Ohno A, Takahashi D, Hara T, Amano T, Ide S, Yoshioka M, Minami M. Eur J Neurosci. 2016 Sep 30.
Chronic cocaine exposure induces noradrenergic modulation of inhibitory synaptic transmission to cholinergic neurons of the laterodorsal tegmental nucleus.
Taoka N, Kamiizawa R, Wada S, Minami M, Kaneda K. Eur J Neurosci. 2016 Sep 20.
Pain relief induces dopamine release in the rat nucleus accumbens during the early but not late phase of neuropathic pain.
Kato T, Ide S, Minami M. Neurosci Lett. 2016 Aug 26;629:73-8.
Development-dependent behavioral change toward pups and synaptic transmission in the rhomboid nucleus of the bed nucleus of the stria terminalis
Amano T, Shindo S, Yoshihara C, Tsuneoka Y, Uki H, Minami M, Kuroda KO Behavioural Brain Research, in press
2015
Intrinsic membrane plasticity via increased persistent sodium conductance of cholinergic neurons in the rat laterodorsal tegmental nucleus contributes to cocaine-induced addictive behavior.
Kamii H, Kurosawa R, Taoka N, Shinohara F, Minami M, Kaneda K. Eur J Neurosci. 2015 May;41(9):1126-38.
Distinct preoptic-BST nuclei dissociate paternal and infanticidal behavior in mice.
Tsuneoka Y, Tokita K, Yoshihara C, Amano T, Esposito G, Huang AJ, Yu LM, Odaka Y, Shinozuka K, McHugh TJ, Kuroda KO. EMBO J. 015 Nov 3;34(21):2652-70.
Amelioration of the reduced antinociceptive effect of morphine in the unpredictable chronic mild stress model mice by noradrenalin but not serotonin reuptake inhibitors.
Ide S, Satoyoshi H, Minami M, Satoh M. Molecular Pain. 11:47. 2015 Aug 11.
Memory formation and retrieval of neuronal silencing in the auditory cortex.
Nomura H, Hara K, Abe R, Hitora-Imamura N, Nakayama R, Sasaki T, Matsuki N, Ikegaya Y. Proc Natl Acad Sci U S A. 112(31):9740-4. 2015 Aug 4.
Prefrontal dopamine regulates fear reinstatement through the downregulation of extinction circuits.
Hitora-Imamura N, Miura Y, Teshirogi C, Ikegaya Y, Matsuki N, Nomura H. Elife.4. 2015 Jul 30.
Corticotropin-releasing factor enhances inhibitory synaptic transmission to type III neurons in the bed nucleus of the stria terminals.
Nagano Y, Kaneda K, Maruyama C, Ide S, Kato F,Minami M. Neuroscience Letters. 600:56-61. 2015 Jul 23.
How does pain induce negative emotion? Role of the bed nucleus of the stria terminalis in pain-induced place aversion.
Minami M, Ide S. Curr Mol Med. 15:184-90.(2015)
2014
Critical role of cholinergic transmission from the laterodorsal tegmental nucleus to the ventral tegmental area in cocaine-induced place preference.
Shinohara F, Kihara Y, Ide S, Minami M, Kaneda K. Neuropharmacology. 79:573-9.(2014)
Conformationally restricted GABA with bicyclo[3.1.0]hexane backbone as the first highly selective BGT-1 inhibitor.
Kobayashi T, Suemasa A, Igawa A, Ide S, Fukuda H, Abe H, Arisawa M, Minami M, Shuto S. ACS Med Chem Lett. 5:889-893.(2014)
Synthesis of 4-arylpiperidin-4-ol derivatives of loperamide as agents with potent antiproliferative effects against HCT-116 and HL-60 cells.
Hatae N, Nagayama T, Esaki H, Kujime E, Minami M, Ishikura M, Choshi T, Hibino S, Okada C, Toyota E, Nagasawa H, Iwamura T. Heterocycles. 88:663-673.(2014)
GABAergic neurons in the ventral tegmental area receive dual GABA/enkephalin- mediated inhibitory inputs from the bed nucleus of the stria terminalis.
Kudo T, Konno K, Uchigashima M, Yanagawa Y, Sora I, Minami M, Watanabe M. Eur J Neurosci, 39:1796-1809.(2014)
Haplotypes of P2RX7 gene polymorphisms are associated with both cold pain sensitivity and analgesic effect of fentanyl.
Ide S, Nishizawa D, Fukuda K, Kasai S, Hasegawa J, Hayashida M, Minami M, Ikeda K. Mol Pain, 10:75.(2014)
2013
Serotonergic modulation of neuronal activity in the nucleus accumbens following repeated methamphetamine administration.
Ishihara K*, Takahashi N, Komoto N, Yoshikawa C, Fukumoto S, Ide S, Kimura T, OzawaK.
J Pharmacol Sci. 123(2):140-6.(2013)
Tandospirone Suppresses Impulsive Action by Possible Blockade of the 5-HT Receptor.
Ohmura Y, Kumamoto H, Tsutsui-Kimura I., Minami M, Izumi T, Yoshida T, Yoshioka M. J Pharmacol Sci.122(2):84-92.(2013)
Association between genetic polymorphisms in Cav2.3 (R-type) Ca2+ channels and fentanyl sensitivity in patients undergoing painful cosmetic surgery.
Ide S*, Nishizawa D*, Fukuda K, Kasai S, Hasegawa J, Hayashida M, Minami M, Ikeda K.(*equally contribution) PLoS One. 8: e70694.(2013)
Cocaine exposure enhances excitatory synaptic drive to cholinergic neurons in the laterodorsal tegmental nucleus.
Kurosawa R, Taoka N, Shinohara F, Minami M, Kaneda K. Eur J Neurosci,38:3027-3035.(2013)
Opposing Roles of Corticotropin-Releasing Factor and Neuropeptide Y within the Dorsolateral Bed Nucleus of the Stria Terminalis in the Negative Affective Component of Pain in Rats.
Ide S, Hara T, Ohno A, Tamano R, Koseki K, Naka T, Maruyama C, Kaneda K, Yoshioka M, Minami M. J Neurosci.33(14):5881-5894.(2013)
GABAergic mechanisms for shaping transient visual responses in the mouse superior colliculus.
Kaneda K* and Isa T Neuroscience.235:129-140.(2013)
Activation of β-adrenoceptors in the bed nucleus of the stria terminalis induces food intake reduction and anxiety-like behaviors.
Naka T, Ide S, Nakako T, Hirata M, Majima Y, Deyama S, Takeda H, Yoshioka M, Minami M. Neuropharmacology.67:326-330.(2013)
Addition of Cyclic Ureas and 1-Methyl-2-oxazolidone to Pyridynes: A New Approach to Pyridodiazepines, Pyridodiazocines, and Pyridooxazepines.
Saito N, Nakamura KI, Shibano S, Ide S, Minami M, Sato Y. Org Lett.15(2):386-389.(2013)
2012
Three types of neurochemical projection from the bed nucleus of the stria terminalis to the ventral tegmental area in adult mice.
Kudo T, Uchigashima M, Miyazaki T, Konno K, Yamasaki M, Yanagawa Y, Minami M, Watanabe M. J Neurosci.32(50):18035-18046.(2012)
Transient enhancement of inhibition following visual cortical lesions in the mouse superior colliculus.
Kaneda K*, Yanagawa Y, and Isa T Eur J Neurosci, 36(8):3066-3076.(2012)
Accumulating Microglia Phagocytose Injured Neurons in Hippocampal Slice Cultures: Involvement of p38 MAP Kinase.
Katayama T, Kobayashi H, Okamura T, Yamasaki-Katayama Y, Kibayashi T, Kimura H, Ohsawa K, Kohsaka S, Minami M. PLoS One.7(7):e40813.(2012)
Neuronal injury induces microglial production of macrophage inflammatory protein-1α in rat corticostriatal slice cultures.
Okamura T, Katayama T, Obinata C, Iso Y, Chiba Y, Kobayashi H, Yamada Y, Harashima H, Minami M. J Neurosci Res.90(11):2127-2133. (2012)
Lithium, but not valproic acid or carbamazepine, suppresses impulsive-like action in rats.
Ohmura Y, Tsutsui-Kimura I, Kumamoto H, Minami M, Izumi T, Yamaguchi T, Yoshida T, Yoshioka M. Psychopharmacology (Berl).219(2):421-432. (2012)
μ-opioid Receptor-Mediated Alterations of Allergen-Induced Immune Responses of Bronchial Lymph Node Cells in a Murine Model of Stress Asthma.
#Okuyama K, #Ide S, Sakurada S, Sasaki K, Sora I, Tamura G, Ohkawara Y, Takayanagi M, Ohno I. (# equally contribution) Allergol Int.61:245-258. (2012)
Nicotine- and Tar-Free Cigarette Smoke Induces Cell Damage Through Reactive Oxygen Species Newly Generated by PKC-Dependent Activation of NADPH Oxidase.
Asano H, Horinouchi T, Mai Y, Sawada O, Fujii S, Nishiya T, Minami M, Katayama T, Iwanaga T, Terada K, Miwa S. J Pharmacol Sci.118(2):275-287. (2012)
2011
Mesenchymal stem cells transmigrate across brain microvascular endothelial cell monolayers through transiently formed inter-endothelial gaps.
#Matsushita T, #Kibayashi T, Katayama T, Yamashita Y, Suzuki S, Kawamata J, Honmou O, Minami M, Shimohama S. (# equally contribution) Neurosci Lett,502:41-45 (2011)
On-off system for PI3-kinase-Akt signaling through S-nitrosylation of phosphatase with sequence homology to tensin (PTEN).
Numajiri N, Takasawa K, Nishiya T, Tanaka H, Ohno K, Hayakawa W, Asada M, Matsuda H, Azumi K, Kamata H, Nakamura T, Hara H, Minami M, Lipton SA, Uehara T. Proc Natl Acad Sci U S A.108(25):10349-10354. (2011)
Inhibition of noradrenaline release by clonidine in the ventral bed nucleus of the stria terminalis attenuates pain-induced aversion in rats.
Deyama S, Ide S, Kondoh N, Yamaguchi T, Yoshioka M, Minami M. Neuropharmacology61(1-2):156-160 (2011)
(-)-Pentazocine induces visceral chemical antinociception, but not thermal, mechanical, or somatic chemical antinociception, in mu-opioid receptor knockout mice.
Ide S, Minami M, Uhl GR, Satoh M, Sora I, Ikeda K. Mol Pain7:23 (2011)
Selective optical control of synaptic transmission in the subcortical visual pathway by activation of viral vector-expressed halorhodopsin.
Kaneda K, Kasahara H, Matsui R, Katoh T, Mizukami H, Ozawa K, Watanabe D, Isa T. PLoS One， 6:e18452 (2011)
2010
Roles of beta- and alpha2-adrenoceptors within the central nucleus of the amygdala in the viscereal pain-induced aversion in rats.
Deyama S, Takishita A, Tanimoto S, Ide S, Nakagawa T, Satoh S, Minami M. J Pharmacol Sci, 114:123-126 (2010)
Antidepressant-Like Effect of Venlafaxine Is Abolished in mu-Opioid Receptor-Knockout Mice.
Ide S, Fujiwara S, Fujiwara M, Sora I, Ikeda K, Minami M, Uhl GR, Ishihara K. J Pharmacol Sci, 114:107-110 (2010)
Sustained activation of ERK signaling in astrocytes is critical for neuronal injury-induced monocyte chemoattractant protein-1 production in rat corticostriatal slice cultures.
Katayama T, Sakaguchi E, Komatsu Y, Oguma T, Uehara T, Minami M. Eur J Neurosci, 31:1359-1367 (2010)
Reduced emotional and corticosterone responses to stress in mu-opioid receptor knockout mice.
Ide S, Sora I, Ikeda K, Minami M, Uhl GR, Ishihara K. Neuropharmacology, 58:241-247 (2010)
2009
Reciprocal regulation of ATPgammaS-induced monocyte chemoattractant protein-1 by ERK and p38 MAP kinases in rat cortico-striatal slice cultures.
Katayama T, Ito M, Kaneko S, Satoh M, Uehara T, Minami M. J Neurosci Res, 87:1573-1581 (2009)
Neuronal injury induces cytokine-induced neutrophil chemoattractant-1 (CINC-1) production in astrocytes.
Katayama T, Tanaka H, Yoshida T, Uehara T, Minami M. J Pharmacol Sci, 109:88-93 (2009)
Role of enhanced noradrenergic transmission within the ventral bed nucleus of the stria terminalis in visceral pain-induced aversion in rats.
Deyama S, Katayama T, Kondoh N, Nakagawa T, Kaneko S, Yamaguchi T, Yoshioka M, Minami M. Behav Brain Res, 197:279-283 (2009)
2008
Analgesic requirements after major abdominal surgery are associated with OPRM1 gene polymorphism genotype and haplotype.
Hayashida M, Nagashima M, Satoh Y, Katoh R, Tagami M, Ide S, Kasai S, Nishizawa D, Ogai Y, Hasegawa J, Komatsu H, Sora I, Fukuda K, Koga H, Hanaoka K, Ikeda K. Pharmacogenomics, 9:1605-1616 (2008)
Activation of the beta-adrenoceptor-protein kinase A signaling pathway within the ventral bed nucleus of the stria terminalis mediates the negative affective component of pain in rats.
Deyama S, Katayama T, Ohno A, Nakagawa T, Kaneko S, Yamaguchi T, Yoshioka M, Minami M. J Neurosci, 28, 7728-7736 (2008)
Abolished thermal and mechanical antinociception but retained visceral chemical antinociception induced by butorphanol in mu-opioid receptor knockout mice.
Ide S, Minami M, Ishihara K, Uhl GR, Satoh M, Sora I, Ikeda K. Neuropharmacology, 54, 1182-1188 (2008)
GMEB1, a novel endogenous caspase inhibitor, prevents hypoxia- and oxidative stress-induced neuronal apoptosis.
Nakagawa T, Tsuruma K, Uehara T, Nomura Y. Neurosci Lett, 438, 34-37 (2008)
2007
Inhibition of glutamatergic transmission by morphine in the basolateral amygdaloid nucleus reduces pain-induced aversion.
A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin.
Omura T, Kaneko M, Okuma Y, Orba Y, Nagashima K, Takahashi R, Fujitani N, Matsumura S, Hata A, Kubota K, Murahashi K, Uehara T, Nomura Y. J Neurochem, 99, 1456-1469 (2006)
Mu opioid receptor-dependent and independent components in effects of tramadol.
Ide S, Minami M, Ishihara K, Uhl GR, Sora I, Ikeda K. Neuropharmacology, 51, 651-658 (2006)
Inhibitory role of supraspinal P2X3/P2X2/3 subtypes on nociception in rats.
Fukui M, Nakagawa T, Minami M, Satoh M, Kaneko S. Mol Pain, 2, 19 (2006)
S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration.
Uehara T, Nakamura T, Yao D, Shi ZQ, Gu Z, Ma Y, Masliah E, Nomura Y, Lipton SA. Nature, 441, 513-517 (2006)
Linkage disequilibrium and association with methamphetamine dependence/psychosis of mu-opioid receptor gene polymorphisms.
Ide S, Kobayashi H, Ujike H, Ozaki N, Sekine Y, Inada T, Harano M, Komiyama T, Yamada M, Iyo M, Iwata N, Tanaka K, Shen H, Iwahashi K, Itokawa M, Minami M, Satoh M, Ikeda K, Sora I. Pharmacogenomics J, 6, 179-188 (2006)
Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress.
Kubota K, Niinuma Y, Kaneko M, Okuma Y, Sugai M, Omura T, Uesugi M, Uehara T, Hosoi T, Nomura Y. J Neurochem, 97,1259-1268 (2006)
Glucocorticoid modulatory element-binding protein 1 binds to initiator procaspases and inhibits ischemia-induced apoptosis and neuronal injury.
Tsuruma K, Nakagawa T, Morimoto N, Minami M, Hara H, Uehara T, Nomura Y. J Biol Chem, 281, 11397-11404. (2006)
Relationship between SUMO-1 modification of caspase-7 and its nuclear localization in human neuronal cells.
Hayashi N, Shirakura H, Uehara T, Nomura Y. Neurosci Lett, 397, 5-9 (2006)
Gene transfer of GLT-1, a glutamate transporter, into the nucleus accumbens shell attenuates methamphetamine- and morphine-induced conditioned place preference in rats.
Fujio M, Nakagawa T, Sekiya Y, Ozawa T, Suzuki Y, Minami M, Satoh M, Kaneko S. Eur J Neurosci, 22, 2744-2754 (2005)
2005
Gene transfer of GLT-1, a glutamate transporter, into the nucleus accumbens shell attenuates methamphetamine- and morphine-induced conditioned place preference in rats.
Fujio M, Nakagawa T, Sekiya Y, Ozawa T, Suzuki Y, Minami M, Satoh M, Kaneko S. Eur J Neurosci, 22, 2744-2754 (2005)
Astrapterocarpan isolated from Astragalus membranaceus inhibits proliferation of vascular smooth muscle cells.
Ohkawara S, Okuma Y, Uehara T, Yamagishi T, Nomura Y. Eur J Pharmacol, 525, 41-47 (2005)
Involvement of the bed nucleus of the stria terminalis activated by the central nucleus of the amygdala in the negative affective component of morphine withdrawal in rats.
Nakagawa T, Yamamoto R, Fujio M, Suzuki Y, Minami M, Satoh M, Kaneko S. Neuroscience, 134, 9-19 (2005)
Caspase recruitment domain of procaspase-2 could be a target for SUMO-1 modification through Ubc9.
Shirakura H, Hayashi N, Ogino S, Tsuruma K, Uehara T, Nomura Y. Biochem Biophys Res Commun, 331, 1007-1015 (2005)
mia-induced apoptosis and neuronal injury.
Tsuruma K, Nakagawa T, Morimoto N, Minami M, Hara H, Uehara T, Nomura Y. J Biol Chem, 281, 11397-11404. (2006)
受賞状況Awards
2021
日本薬理学会 第36回 学術奨励賞
記憶・学習を司る神経回路機構および認知機能障害に対する創薬に関する研究
野村洋（講師）
日本薬学会北海道支部第148回例会 学生優秀発表賞
慢性痛ラットにおける脳内報酬系抑制への分界条床核内CRF神経情報伝達の関与
新垣紗也（学部6年）
ヒスタミンH3 受容体逆作動薬による嗅周皮質神経活動の調節
平野匡佑（博士2年）
第30回神経行動薬理若手研究者の集い 優秀発表賞
ヒスタミンH3 受容体逆作動薬による嗅周皮質神経活動の調節作用
平野匡佑（博士1年）
ヒスタミン神経活性化による記憶想起の回復
清水目倫太郎（学部4年）
2020
第71回日本薬理学会北部会 優秀発表賞
血液脳関門バリア機能に対するIL-6ファミリーサイトカインの効果
濱田奨（学部6年）
エストラジオールによる仔マウスへの行動選択制御への影響
福井清志郎（学部6年）
第43回日本神経科学大会 ジュニア研究者ポスター賞
内側視索前野のMEK1/2阻害によりGABA作動性シナプス応答と仔への攻撃行動を促進する
濱崎友美（修士1年）
2019
第8回日本神経精神薬理学会 学術奨励賞
恐怖記憶が長期間持続する神経回路機構の解明
野村洋
日本神経精神薬理学会 鍋島賞（JSNP Excellent Presentation Award for AsCNP 2019最優秀演題賞）
Chronic pain-induced plastic change in the extended amygdala neural circuit causes maladaptive anxiety
山内直紀（博士2年）
JSNP Excellent Presentation Award for AsCNP 2019
Brain histamine re-establishes access to forgotten memories after passage of long time and neuronal degeneration
野村洋
JSNP Excellent Presentation Award for AsCNP 2019 (principal investigator)
南雅文
第49回日本神経精神薬理学会 優秀演題賞
慢性痛による拡張扁桃体神経回路の可塑的変化は不安を惹起する
山内直紀（博士2年）
第49回日本神経精神薬理学会 一般演題奨励賞
慢性痛モデルマウスにおけるレゾルビンD1およびレゾルビンD2の抗うつ効果
鈴木博惠（学部6年）
NEURO2019 国内 Travel Award
Neuronal plasticity in an extended amygdala circuit induced by chronic pain causes maladaptive anxiety
山内直紀（博士2年）
2018
第 29回日本行動神経内分泌研究会 最優秀発表賞、トラベルアワード
養育行動に関係する内側視索前野上流領域の探索と機能解析
佐藤圭一郎（修士1年）
第69回日本薬理学会北部会 優秀発表賞
慢性痛による脳内報酬系機能低下の神経機構解明
木村佳祐（修士２年）
第41回日本神経科学大会 ジュニア研究者ポスター賞
The exploration and functional analysis of brain regions projecting to the medial preoptic area related to parental behavior
2nd Congress of Asian College of Neuropsychopharmacology Young Investigator Fellowship Award
Involvement of Corticotropin-releasing Factor within the Dorsolateral Part of the Bed Nucleus of the Stria Terminalis in Pain-induced Aversion 井手聡一郎（助教）
第85回日本薬理学会年会 優秀発表賞
Mesenchymal stem cells transmigrate across the blood-brain barrier through transiently formed interendothelial gaps（骨髄間葉系幹細胞の血液脳関門通過における動態解析） 片山貴博（助教）
