研究業績
原著論文・総説
- Comparison of low-molecular-weight ligand and whole antibody in prostate-specific membrane antigen targeted near-infrared photoimmunotherapy. Int J Pharm 2021, 609, 121135. *Contributed equally. PMID 34571072 .
- Electron Donors Rather Than Reactive Oxygen Species Needed for Therapeutic Photochemical Reaction of Near-Infrared Photoimmunotherapy. ACS Pharmacol Transl Sci 2021, 4 (5), 1689-1701. PMID 34661083 .
- Photoimmunotherapy: A new cancer treatment using photochemical reactions. Bioorg Med Chem 2021, 43, 116274. PMID 34139484 .
- Analysis of the triplet-state kinetics of a photosensitizer for photoimmunotherapy by fluorescence correlation spectroscopy. J Photochem Photobiol A: Chem 2021, 408, 113094. .
- Theoretical and Experimental Studies on the Near-Infrared Photoreaction Mechanism of a Silicon Phthalocyanine Photoimmunotherapy Dye: Photoinduced Hydrolysis by Radical Anion Generation. Chempluschem 2020, 85, 1-6. PMID 32449613 (Cover Profile:PMID 32830450) .
- Surface modification of liposomes using IR700 enables efficient controlled contents release triggered by near-IR light. Bio Pharm Bull 2020, 43 (4), 736-741. PMID 32238716 .
- Accumulation of hypoxia imaging probe "[18F]FMISO" in macrophages depends on macrophage polarization in addition to hypoxic state. Ann Nucl Med 2019, 33 (5), 362-367. *equally contributed. PMID 30694443 .
- Photoinduced Ligand Release from a Silicon Phthalocyanine Dye Conjugated with Monoclonal Antibodies: A Mechanism of Cancer Cell Cytotoxicity after Near-Infrared Photoimmunotherapy. ACS Cent Sci 2018, 4 (11), 1559-1569. PMID 30555909 .
- Anti PD-1 treatment increases [18F]FDG uptake by cancer cells in a mouse B16F10 melanoma model. EJNMMI Research 2018, 8, 82. .
- Changes in plasma membrane damage inducing cell death after treatment with near-infrared photoimmunotherapy. Cancer Sci 2018 109 (9) 2889-2996. .
- Implantable wireless powered light emitting diode (LED) for near-infrared photoimmunotherapy: device development and experimental assessment in vitro and in vivo. Oncotarget 2018, 9 (28), 20048-20057. .
- In Vivo Molecular Imaging for Biomedical Analysis and Therapies. Anal Sci 2018, 34 (3), 273-281. .
- Long time-lapse nanoscopy with spontaneously blinking membrane probes. Nature Biotechnol 2017, 35, 773-780. *equally contributed. .
- Bioluminescent Indicator for Highly Sensitive Analysis of Estrogenic Activity in a Cell-Based Format. Bioconjug Chem 2016, 27, 2689-2694. .
- Development of a Sensitive Bioluminogenic Probe for Imaging Highly Reactive Oxygen Species in Living Rats. Angew Chem Int Ed 2015, 54, 4768-14771. *equally contributed. .
- New class of bioluminogenic probe based on bioluminescent enzyme-induced electron transfer: BioLeT. J Am Chem Soc 2015, 137, 4010-4013. *equally contributed. .
- Cell-Based Assays and Animal Models for GPCR Drug Screening. Methods Mol Biol 2015, 1272, 257-270. .
- Super-Resolution Imaging of the Golgi in Live Cells with a Bioorthogonal Ceramide Probe. Angew Chem Int Ed 2014, 53, 10242-10246. *equally contributed, Selected as Hot Paper in Angew Chem .
- Sustained accurate recording of intracellular acidification in living tissues with a photo-controllable bioluminescent protein. Proc Natl Acad Sci USA 2013, 110, 9332-9337. .
- Analysis of temporal patterns of GPCR–β-arrestin interactions using split luciferase-fragment complementation. Mol Biosyst 2013, 9, 957-964. .
- Rational Design and Development of Near-Infrared-Emitting Firefly Luciferins Available In Vivo. Angew Chem Int Ed 2013, 52, 1175-1179. Selected as Hot Paper in Angew Chem. .
- Development of 5'- and 7'-Substituted Luciferin Analogues as Acid-Tolerant Substrates of Firefly Luciferase. ChemBioChem 2012, 13, 1424-1427. .
- Visualization and Quantitative Analysis of G Protein-Coupled Receptor-β-Arrestin Interaction in Single Cells and Specific Organs of Living Mice Using Split Luciferase Complementation. ACS Chem Biol 2012, 7, 901-910. Selected as a cover art of ACS Chem Biol in May 2012. .
- Aminoluciferins as Functional Bioluminogenic Substrates of Firefly Luciferase. Chem Asian J 2011, 6, 1800-1810. .
- Ratiometric Bioluminescence Indicators for Monitoring Cyclic AMP in Live Cells Based on Luciferase-Fragment Complementation. Anal Chem 2010, 82, 9306-9313. .
- Development of Luciferin Analogues Bearing an Amino Group and Their Application as BRET Donors. Chem Asian J 2010, 5, 2053-2061. .
邦文総説
- 高倉栄男、自発的に明滅する細胞膜局在型プローブを用いた長時間の超解像イメージング法 の開発、新着論文レビュー、 http://first.lifesciencedb.jp/archives/16830
- 高倉栄男、クリックケミストリ―を用いた長時間超解像蛍光プローブによるオルガネラ動態の観察、感染・炎症・免疫、48 (1)、26-35、2018
教育業績
担当科目
分析化学 Ⅰ、化学 Ⅰ、RI実習、薬剤学実習
執筆した教科書
なし
その他教育に関する実績
なし