北海道大学大学院 薬学研究院
生体分析化学研究室
業績

研究業績

原著論文・総説

  1. Ieda N, Takakura H, Maeta H, Ohira T, Tsuchiya K, Nakajima K, Ogawa M. Investigation of the substituent effect of indocyanine green derivatives for lymph imaging. Bioorg Med Chem Lett. 2024 (in press)
  2. Tsuchiya K, Takakura H, Nakajima K, Ieda N, Kaneko T, Hirasawa T, Kobayashi M, Yamaoka Y, Ishihara M, Taketsugu T, Ogawa M. Piperazine based pH-responsive cyanine dyes for cancer cell photoacoustic imaging. J Photochem Photobiol A. 2024 453 , 115634 DOI 10.1016/j.jphotochem.2024.115634
  3. Kojima C, Yao J, Nakajima K, Suzuki M, Tsujimoto A, Kuge Y, Ogawa M, Matsumoto A. Attenuated polyethylene glycol immunogenicity and overcoming accelerated blood clearance of a fully PEGylated dendrimer. Int J Pharmaceut. 2024 659 , 124193 PMID 38703934
  4. Obara T, Kawano N, Tatsumi K, Katsuyama A, Nakajima K, Ogawa M, Ichikawa S. Development of small molecule–drug conjugates based on derivatives of natural proteasome inhibitors that exhibit selectivity for PSMA-expressing cancer cells. Bioorg Med Chem. 2024 108 , 117773 PMID 38850999
  5. Goto Y, Ando K, Takakura H, Nakajima K, Kobayashi M, Inanami O, Taketsugu T, Ogawa M. Development of a red-shifted photosensitizer for near-infrared photoimmunotherapy of cancer. J Photochem Photobiol. 2024 <--20 , 100230 DOI 10.1016/j.jpap.2024.100230
  6. Ogawara K, Inanami O, Takakura H, Saita K, Nakajima K, Kumar S, Ieda N, Kobayashi M, Taketsugu T, Ogawa M. Theoretical Design and Synthesis of Caged Compounds Using X-Ray-Triggered Azo Bond Cleavage. Adv Sci. 2024 e2306586 PMID 38225711
  7. Nakajima K, Ogawa M. Near-infrared photoimmunotherapy and anti-cancer immunity. Int Immunol. (in press).
  8. Nakajima K, Sugikawa A, Yasui H, Higashikawa K, Suzuki C, Natsume T, Suzuki M, Takakura H, Tomita M, Takahashi S, Hirata K, Magata Y, Kuge Y, Ogawa M. In vivo imaging of acute physiological responses after treatment of cancer with near-infrared photoimmunotherapy. Mol Imaging Biol. 2023 25 (4), 648-658 DOI 10.1007/s11307-023-01822-9
  9. Nakajima K, Ogawa M. Application of Imaging for Antibody-Based Cancer Therapies: Photoimmunotherapy and Immune Checkpoint Blockade Therapy. Journal of the Imaging Society of Japan 2022. 61 (6), 643-651. DOI 10.11370/isj.61.643
  10. Takakura H, Matsuhiro S, Inanami O, Kobayashi M, Saita K, Yamashita M, Nakajima K, Suzuki M, Miyamoto N, Taketsugu T, Ogawa M. Ligand release from silicon phthalocyanine dyes triggered by X-ray irradiation. Org Biomol Chem 2022. 20 (36) 7270-7277. PMID 35972402
  11. Suzuki M, Matsuda T, Nakajima K, Yokouchi Y, Kuge Y, Ogawa M. PD1 blockade alters cell-cycle distribution and affects 3'-deoxy-3'-[18F]fluorothymidine uptake in a mouse CT26 tumor model. Ann Nucl Med 2022. Online ahead of print. PMID 35969311
  12. Takakura H, Sato H, Nakajima K, Suzuki M, Ogawa M. Correction: Takakura et al. In Vitro and In Vivo Cell Uptake of a Cell-Penetrating Peptide Conjugated with Fluorescent Dyes Having Different Chemical Properties. Cancers 2021, 13, 2245. Cancers (Basel) 2022, 14 (8), 1880. PMID 35454954 (Correction to PMID 34067065)
  13. Nakajima K, Homma M, Suzuki M, Yokouchi Y, Matsuda T, Takakura H, Hirata K, Kuge Y, Ogawa M. Reduction of tumor hypoxia by anti-PD-1 therapy assessed using pimonidazole and [18F]FMISO. Nucl Med Biol 2022, 108-109, 85-92. PMID 35367730
  14. Nakajima K*, Miyazaki F*, Terada K, Takakura H, Suzuki M, Ogawa M. Comparison of low-molecular-weight ligand and whole antibody in prostate-specific membrane antigen targeted near-infrared photoimmunotherapy. Int J Pharm 2021, 609, 121135. *Contributed equally. PMID 34571072
  15. Suzuki M, Katayama T, Suzuki C, Nakajima K, Magata Y, Ogawa M. Uptake of nicotinic acetylcholine receptor imaging agent is reduced in the pro-inflammatory macrophage. Nucl Med Biol 2021, 102-103, 45-55. PMID 34619460
  16. Hirata H, Kuwatani M, Nakajima K, Kodama Y, Yoshikawa Y, Ogawa M, Sakamoto N. Near-infrared photoimmunotherapy (NIR-PIT) on cholangiocarcinoma using a novel catheter device with light emitting diodes. Cancer Sci 2021. 112, 828-838. PMID 33345417
  17. Nakajima K, Ogawa M. Phototoxicity in near-infrared photoimmunotherapy is influenced by the subcellular localization of antibody-IR700. Photodiagnosis Photodyn Ther 2020, 31 , 101926. PMID 32717450
  18. Nishimoto Y, Nishio M, Nagashima S, Nakajima K, Ohira T, Nakai S, Nakase I, Higashikawa K, Kuge Y, Matsumoto A, Ogawa M, Kojima C. Association of Hydrophobic Carboxyl-Terminal Dendrimers with Lymph Node-Resident Lymphocytes. Polymers 2020, 12 (7), 1474. PMID 32630042
  19. Tomita M, Suzuki M, Kono Y, Nakajima K, Matsuda T, Kuge Y, Ogawa M. Influence on [18F]FDG uptake by cancer cells after anti PD-1 therapy in an enforced-immune activated mouse tumor. EJNMMI Res 2020, 10 (1), 24. PMID 32189078
  20. Nishimoto Y, Nagashima S, Nakajima K, Ohira T, Sato T, Izawa T, Yamate J, Higashikawa K, Kuge Y, Ogawa M, Kojima C. Carboxyl-, sulfonyl-, and phosphate-terminal dendrimers as a nanoplatform with lymph node targeting. Int J Pharm 2020, 576, 119021. PMID 31917298
  21. Tomita M, Yasui H, Higashikawa K, Nakajima K, Takakura H, Shiga T, Kuge Y, Ogawa M. Anti PD-1 treatment increases [18F]FDG uptake by cancer cells in a mouse B16F10 melanoma model. EJNMMI Research 2018, 8, 82. PMID 30117062
  22. Nakajima K, Takakura H, Shimizu Y, Ogawa M. Changes in plasma membrane damage inducing cell death after treatment with near-infrared photoimmunotherapy. Cancer Sci 2018, 109 (9), 2889-2896. PMID 29949672
  23. Nakajima K, Kimura T, Takakura H, Yoshikawa Y, Kameda A, Shindo T, Sato K, Kobayashi H, Ogawa M. Implantable wireless powered light emitting diode (LED) for near-infrared photoimmunotherapy: device development and experimental assessment in vitro and in vivo. Oncotarget 2018, 9 (28), 20048-20057. PMID 29732002

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