北海道大学大学院 薬学研究院
生体分析化学研究室
業績

研究業績

原著論文・総説

  1. Goto Y, Ando K, Takakura H, Nakajima K, Kobayashi M, Inanami O, Taketsugu T, Ogawa M. Development of a red-shifted photosensitizer for near-infrared photoimmunotherapy of cancer. J Photochem Photobiol. 2024 (in press)
  2. Ogawara K, Inanami O, Takakura H, Saita K, Nakajima K, Kumar S, Ieda N, Kobayashi M, Taketsugu T, Ogawa M. Theoretical Design and Synthesis of Caged Compounds Using X-Ray-Triggered Azo Bond Cleavage. Adv Sci. 2024 e2306586 PMID 38225711
  3. Nakajima K, Ogawa M. Near-infrared photoimmunotherapy and anti-cancer immunity. Int Immunol. (in press).
  4. Nakajima K, Sugikawa A, Yasui H, Higashikawa K, Suzuki C, Natsume T, Suzuki M, Takakura H, Tomita M, Takahashi S, Hirata K, Magata Y, Kuge Y, Ogawa M. In vivo imaging of acute physiological responses after treatment of cancer with near-infrared photoimmunotherapy. Mol Imaging Biol. 2023 25 (4), 648-658 DOI 10.1007/s11307-023-01822-9
  5. Nakajima K, Ogawa M. Application of Imaging for Antibody-Based Cancer Therapies: Photoimmunotherapy and Immune Checkpoint Blockade Therapy. Journal of the Imaging Society of Japan 2022. 61 (6), 643-651. DOI 10.11370/isj.61.643
  6. Takakura H, Matsuhiro S, Inanami O, Kobayashi M, Saita K, Yamashita M, Nakajima K, Suzuki M, Miyamoto N, Taketsugu T, Ogawa M. Ligand release from silicon phthalocyanine dyes triggered by X-ray irradiation. Org Biomol Chem 2022. 20 (36) 7270-7277. PMID 35972402
  7. Suzuki M, Matsuda T, Nakajima K, Yokouchi Y, Kuge Y, Ogawa M. PD1 blockade alters cell-cycle distribution and affects 3'-deoxy-3'-[18F]fluorothymidine uptake in a mouse CT26 tumor model. Ann Nucl Med 2022. Online ahead of print. PMID 35969311
  8. Takakura H, Sato H, Nakajima K, Suzuki M, Ogawa M. Correction: Takakura et al. In Vitro and In Vivo Cell Uptake of a Cell-Penetrating Peptide Conjugated with Fluorescent Dyes Having Different Chemical Properties. Cancers 2021, 13, 2245. Cancers (Basel) 2022, 14 (8), 1880. PMID 35454954 (Correction to PMID 34067065)
  9. Nakajima K, Homma M, Suzuki M, Yokouchi Y, Matsuda T, Takakura H, Hirata K, Kuge Y, Ogawa M. Reduction of tumor hypoxia by anti-PD-1 therapy assessed using pimonidazole and [18F]FMISO. Nucl Med Biol 2022, 108-109, 85-92. PMID 35367730
  10. Nakajima K*, Miyazaki F*, Terada K, Takakura H, Suzuki M, Ogawa M. Comparison of low-molecular-weight ligand and whole antibody in prostate-specific membrane antigen targeted near-infrared photoimmunotherapy. Int J Pharm 2021, 609, 121135. *Contributed equally. PMID 34571072
  11. Suzuki M, Katayama T, Suzuki C, Nakajima K, Magata Y, Ogawa M. Uptake of nicotinic acetylcholine receptor imaging agent is reduced in the pro-inflammatory macrophage. Nucl Med Biol 2021, 102-103, 45-55. PMID 34619460
  12. Hirata H, Kuwatani M, Nakajima K, Kodama Y, Yoshikawa Y, Ogawa M, Sakamoto N. Near-infrared photoimmunotherapy (NIR-PIT) on cholangiocarcinoma using a novel catheter device with light emitting diodes. Cancer Sci 2021. 112, 828-838. PMID 33345417
  13. Nakajima K, Ogawa M. Phototoxicity in near-infrared photoimmunotherapy is influenced by the subcellular localization of antibody-IR700. Photodiagnosis Photodyn Ther 2020, 31 , 101926. PMID 32717450
  14. Nishimoto Y, Nishio M, Nagashima S, Nakajima K, Ohira T, Nakai S, Nakase I, Higashikawa K, Kuge Y, Matsumoto A, Ogawa M, Kojima C. Association of Hydrophobic Carboxyl-Terminal Dendrimers with Lymph Node-Resident Lymphocytes. Polymers 2020, 12 (7), 1474. PMID 32630042
  15. Tomita M, Suzuki M, Kono Y, Nakajima K, Matsuda T, Kuge Y, Ogawa M. Influence on [18F]FDG uptake by cancer cells after anti PD-1 therapy in an enforced-immune activated mouse tumor. EJNMMI Res 2020, 10 (1), 24. PMID 32189078
  16. Nishimoto Y, Nagashima S, Nakajima K, Ohira T, Sato T, Izawa T, Yamate J, Higashikawa K, Kuge Y, Ogawa M, Kojima C. Carboxyl-, sulfonyl-, and phosphate-terminal dendrimers as a nanoplatform with lymph node targeting. Int J Pharm 2020, 576, 119021. PMID 31917298
  17. Tomita M, Yasui H, Higashikawa K, Nakajima K, Takakura H, Shiga T, Kuge Y, Ogawa M. Anti PD-1 treatment increases [18F]FDG uptake by cancer cells in a mouse B16F10 melanoma model. EJNMMI Research 2018, 8, 82. PMID 30117062
  18. Nakajima K, Takakura H, Shimizu Y, Ogawa M. Changes in plasma membrane damage inducing cell death after treatment with near-infrared photoimmunotherapy. Cancer Sci 2018, 109 (9), 2889-2896. PMID 29949672
  19. Nakajima K, Kimura T, Takakura H, Yoshikawa Y, Kameda A, Shindo T, Sato K, Kobayashi H, Ogawa M. Implantable wireless powered light emitting diode (LED) for near-infrared photoimmunotherapy: device development and experimental assessment in vitro and in vivo. Oncotarget 2018, 9 (28), 20048-20057. PMID 29732002

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