 |
 |
|
| 2020 |
|
|
|
Hata S, Hu A, Piao Y, Nakaya T, Taru H, Morishima-Kawashima M, Murayama
S, Nishimura M, Suzuki T. (2020)
Enhanced amyloid-β generation by γ-secretase complex in detergent-resistant
membrane microdomains with reduced cholesterol levels.
Hum Mol Genet 29, :382-393. |
|
|
Kakuda N, Yamaguchi H, Akazawa K, Hata S, Suzuki T, Hatsuta H, Murayama S, Funamoto S, Ihara Y. (2020)
γ-Secretase Activity Is Associated with Braak Senile Plaque Stages.
Am J Pathol. 190, 1323-1331 |
|
|
Seita Y, Morimura T, Watanabe N, Iwatani C, Tsuchiya H, Nakamura S, Suzuki T, Yanagisawa D, Tsukiyama T, Nakaya M, Okamura E, Muto M, Ema M, Nishimura M, Tooyama I. (2020)
Generation of Transgenic Cynomolgus Monkeys Overexpressing the Gene for Amyloid-β Precursor Protein.
J Alzheimers Dis. 75, 45-60. |
|
|
Goto N, Saito Y, Hata S, Saito H, Oima D, Murayama C, Shigeta M, Abe T, Konno D, Matsuzaki F, Suzuki T. and Yamamoto T.(2020)
Amyloidogenic processing of amyloid b protein precursor (APP) is enhanced in the brains of Alcadein a-deficient mice.
J. Biol. Chem . 295, 9650-9662 |
|
| 2019 |
|
|
|
Motodate R, Saito H, Sobu Y, Hata S, Saito Y, Nakaya T, Suzuki T (2019)
X11 and X11-like proteins regulate the level of extrasynaptic glutamate
receptors.
J Neurochem. 148, 480-49 |
|
|
Shiraishi T, Sakaitani M, Otsuguro S, Maenaka K, Suzuki T, Nakaya T (2019)
Novel Notch signaling inhibitor NSI‑1 suppresses nuclear translocation of the Notch intracellular domain.
Int J Mol Med. 44, 1574-1584 |
|
|
Kushibiki Y, Suzuki T, Jin Y, Taru H. (2019)
RIMB-1/RIM-binding protein and UNC-10/RIM redundantly regulate presynaptic localization of the voltage-gated calcium channel in C. elegans.
J Neurosci 39, 8617-8631 |
|
|
Hata S, Omori C, Kimura A, Saito H, Kimura N, Gupta V, Pedrini S, Hone
E, Chatterjee P, Taddei K, Kasuga K, Ikeuchi T, Waragai M, Nishimura M,
Hu A, Nakaya T, Meijer L, Maeda M, Yamamoto T, Masters CL, Rowe CC, Ames
D, Yamamoto K, Martins RN, Gandy S, Suzuki T. (2019)
Decrease in p3-Alcβ37 and p3-Alcβ40, products of Alcadein β generated by
γ-secretase cleavages, in aged monkeys and patients with Alzheimer's disease.
Alzheimer's & Dementia: TRCI 5, 740-750 |
|
|
<In Memoriam>
Gandy S, Suzuki T (2019)
Paul Greengard, Ph.D. (1925-2019)
Alzheimers Dement, 15, 1229-1235 |
|
| 2018 |
|
|
|
Cam M, Durieu E, Bodin M, Manousopoulou A, Koslowski S, Vasylieva N, Barnych
B, Hammock BD, Bohl B, Koch P, Omori C, Yamamoto K, Hata S, Suzuki T, Karg
F, Gizzi P, Haber VE, Bencetic Mihaljevic V, Tavcar B, Portelius E, Pannee
J, Blennow K, Zetterberg H, Garbis SD, Auvray P, Gerber H, Fraering J,
Fraering PC, Meijer L. (2018)
Induction of Amyloid-β42 Production by Fipronil and Other Pyrazole Insecticides.
J Alzheimers Dis. 62, 1663-1681 |
|
|
Tsukamoto M, Chiba K, Sobu Y, Shiraki Y, Okumura Y, Hata S, Kitamura A,
Nakaya T, Uchida S, Kinjo M, Taru H, Suzuki T. (2018)
The cytoplasmic region of the amyloid β-protein precursor (APP) is necessary and sufficient for the enhanced fast velocity of APP transport by kinesin-1.
FEBS Lett. 592, 2716-2724 |
|
|
Fukuyama K, Kakio S, Nakazawa Y, Kobata K, Funakoshi-Tago M, Suzuki T,
Tamura H.(2018)
Roasted Coffee Reduces β-Amyloid Production by Increasing Proteasomal β-Secretase Degradation in Human Neuroblastoma SH-SY5Y Cells.
Mol Nutr Food Res. e1800238. |
|
| 2017 |
|
|
|
Omori C, Motodate R, Shiraki Y, Chiba K, Sobu Y, Kimura A, Nakaya T, Kondo H, Kurumiya S, Tanaka T, Yamamoto K, Nakajima M, Suzuki T, Hata S. (2017)
Facilitation of brain mitochondrial activity by 5-aminolevulinic acid in a mouse model of Alzheimer's disease
Nutr. Neurosci. 20, 538-546. |
|
|
Chiba K, Chien K, Sobu Y, Hata S, Kato S, Nakaya T, Okada Y, Nairn AC,
Kinjo M, Taru H, Wang R, Suzuki T (2017)
Phosphorylation of KLC1 modifies interaction with JIP1 and abolishes the
enhanced fast velocity of APP transport by kinesin-1
Mol Biol Cell 28, 3857-3869 |
|
|
Sobu Y, Furukori K, Chiba K, Nairn AC, Kinjyo M, Hata S, Suzuki T (2017)
Phosphorylation of multiple sites within an acidic region of Alcadeinα
is required for kinesin-1 association and Golgi exit of Alcadeinα cargo
Mol Biol Cell 28, 3844-3856 |
|
| 2016 |
|
|
|
Motodate, R., Saito, Y., Hata, S., Suzuki, T. (2016)
Expression and localization of X11 family proteins in neurons
Brain Res. 1646, 227–234 |
|
|
Portlius E, Durieu E, Bodin M, Cam M, Pannee J, Leuxe C, Mabondzo A, Oumata
N, Galons H, Lee J-Y, Chang Y-T, Stuber K, Koch P, Fontanine G, Potier
M, Manouspoulou A, Garbis S, Covaci A, VanDam D, De Deyn P, Karg F, Flajolet
M, Omori C, Hata S, Suzuki T, Blennow K, Zetteberg H, and Meijer L. (2016)
Specific triazine herbicides induce amyloidβ42 production.
J. Alzheimer Dis. 54, 1593-1605 |
|
|
Connor SA, Ammendrup-Johnsen I, Chan AW, Kishimoto Y, Murayama C, Kurinhara
N, Tada A, Ge Y, Yan R, LeDue JM, Matsumoto H, Kiyonari H, Kirino Y, Matsuzaki
F, Suzuki T, Murphy TH, Wang YT, Yamamoto T, Craig AM. (2016)
Altered Cortical Dynamics and Cognitive Function upon Haploinsufficiency of the Autism Linked Excitatory Synaptic Suppressor MDGA2.
Neuron 91, 1052-1068 |
|
|
Kimura, A., Hata, S., Suzuki, T. (2016)
Alternative Selection of BACE1 Cleavage Sites in APP Harboring Protective
And Pathogenic Mutations Within the Aβ Sequence
J. Biol. Chem. 291, 24041-24053 |
|
|
<Review>
Hata,S., Kimura, A., Shiraki, Y., Suzuki, T. (2016)
How an APP gene mutation protects against Alzheimer’s disease?
Trends Cell Mol. Biol. 11, 67-75 |
|
| 2015 |
|
|
|
Takei, N., Sobu, Y., Kimura, A., Urano, S., Piao, Y., Araki, Y., Taru,
H., Yamamoto, T., Hata, S., Nakaya, T., Suzuki, T. (2015)
Cytoplasmic fragment of Alcadeinα generated by regulated intramembrane
proteolysis enhances APP transport into the late-secretory pathway and
facilitates APP cleavage.
J. Biol. Chem. 290, 987-995 |
|
|
Hosono, T., Nishitsuji, K., Nakamura, T., Jung, C.G., Kontani, M., Tokuda,H.,
Kawashima, H., Kiso, Y., Suzuki, T.,Michikawa, M. (2015)
Arachidonic Acid Diet Attenuates Aβ Deposition in Tg2576 Mice
Brain Res.1613, 92-99 |
|
|
Kimura, A., Hata, S., Suzuki, T. (2015)
Stabilization of intracellular trafficking and metabolism of amyloid β-protein precursor and Alcadein β by apolipoprotein E
FEBS Lett. 589, 2394-2400 |
|
|
Hosono, T., Mouri, A., Nishitsuji, K., Jung, CG., Kontani, M., Tokuda, H., Kawashima, H., Shibata, H., Suzuki, T., Nabehsima, T., Michikawa, M. (2015)
Arachidonic or Docosahexaenoic Acid Diet Prevents Memory Impairment in
Tg2576 Mice
J. Alzheimer Dis. 48, 149–162 |
|
|
<Book>
Suzuki T., Kimura A., Chiba K., Nakaya T., Hata S .(2015)
Brain aging as a cause of Alzheimer’s disease.
“Aging Mechanism –Longevity, Metabolism, and Brain Aging” (Edits by Nozomu
Mori and Inhee Mook-Jung)
Chapter 18 pp303-318 (ISBN 978-4-431-55762-3) Springer DOI 10.1007/978-4-431-55763-0_18 |
|
| 2014 |
|
|
|
Omori, C., Kaneko, M., Nakajima, E., Akatsu, H., Waragai, M., Maeda, M.,
Morishima-Kawashima, M., Saito, Y., Nakaya, N., Taru, H., Yamamoto, T.,
Asada, T., Hata S., Suzuki T., J-ADNI (2014)
Increased levels of plasma p3-Alcα35, a major fragment of Alcadeinα by γ-secretase cleavage, in Alzheimer's disease
J. Alzheimer Dis. 39, 861-870 |
|
|
Morihara, T., Hayashi, N., Yokokoji, M., Akatsu, H., Silverman, M., Kimura,
N., Sato, M., Saito, Y., Suzuki, T., Yanagida, K., Kodama, T., Tanaka,
T., Okochi, M., Tagami, S., Kazui, H., Kudo, T., Hashimoto, R., Itoh, N.,
Nishitomi, K, Kabata-Yamagichi, Y., Tsunoda, T., Takamura, H., Katayama,
T., Kimura, R., Kamino, K., Hashizume, Y., Takeda, M. (2014)
Transcriptome analysis of distinct mouse strains reveals kinesin light
chain-1 splicing as an amyloid beta accumulation modifier
Proc. Natl. Acad. Sci. USA. 111, 2638-2643 |
|
|
Tajes, M., Eraso-Pichot, A., Rubio-Moscardó, F., Guivernau, B., Ramos-Fernández,
E., Bosch-Morató, M., Guix, F. X., Clarimón, J., Miscione, G. P., Boada,
M., Gil-Gómez, G., Suzuki, T., Molina, H., Villà-Freixa, J., Vicente, R.,
Muñoz, F. J. (2014)
Methylglyoxal Produced by Amyloid β-Peptide-Induced Nitrotyrosination of
Triosephosphate Isomerase Triggers Neuronal Death in Alzheimer Disease
J. Alzheimer Dis. 41, 273-288 |
|
|
Waragai, M., Hata, S., Suzuki, T., Ishii, R., Fujii, C., Tokuda, T., Arai,
H., Ohrui, T., Higuchi, S., Yoshida, M., Igarashi, K., Moriya, M., Iwai,
N., Uemura, K. (2014)
Utility of SPM8 plus DARTEL (VSRAD) Combined with Magnetic Resonance Spectroscopy
as Adjunct Techniques for Screening and Predicting Dementia due to Alzheimer's
Disease in Clinical Practice.
J. Alzheimer Dis. 41, 1207-1222 |
|
|
Chiba, K.., Araseki, M., Nozawa, K.., Furukori, K., Araki, Y., Matsushima,
T., Nakaya, T., Hata, S., Saito, Y., Uchida, S., Okada, Y., Nairn, AC.,
Davis, RJ., Yamamoto, T., Kinjo, M., Taru, H., Suzuki, T. (2014)
Quantitative analysis of APP axonal transport in neurons - Role of JIP1
in APP anterograde transport-
Mol. Biol. Cell 25, 3569-3580 |
|
| 2013 |
|
|
|
Piao, Y., Kimura, A., Urano, S., Saito, Y., Taru, H., Yamamoto, T., Hata,
S., Suzuki, T. (2013)
Mechanism of intramembrane cleavage of Alcadeins by γ-secretase
PLoS ONE 8, e62431 |
|
|
Hoshino, T., Suzuki, K., Matsushima, T., Yamakawa, N., Suzuki, T., Mizushima,
T. (2013)
Suppression of Alzheimer’s disease-related phenotypes by geranylgeranylacetone
in mice.
PLoS ONE 8, e76306 |
|
|
Chiba, K., Shimada, Y., Kinjo, M., Suzuki, T., Uchida, S. (2013)
Simple and direct assembly of kymograph from movies using Kymomaker.
Traffic 5, 1-11
Link to KymoMaker |
|
|
<Book>
Saito, Y., Matsushima, T., Suzuki, T. (2013)
Mechanism of Alzheimer Amyloid β-Protein Precursor Localization to Membrane Lipid Rafts
Understanding Alzheimer's Disease (Edited by Inga Zerr) Chapter 2 (ISBN 978-953-51-1009-5) |
|
| 2012 |
|
|
|
Hoshino, T., Namba, T., Takehara, M., Murao, N., Matsushima, T., Sugimoto,
Y., Narumiya, S., Suzuki, T. Mizushima, T. (2012)
Improvement of cognitive function in Alzheimer's disease model mice by genetic and pharmacological inhibition of the EP4 receptor.
J. Neurochem. 120, 795-805. |
|
|
Dumanis, S., Chamberlain, K. A., Sohn, Y.J., Lee, Y. J., Guenette, S. Y., Suzuki, T., Mathews, P. W., Pak, D. T. S., Rebexk, G. W., Suh, Y-h., Park, H-S., Hoe, H-S. (2012)
FE65 as a link between VLDLR and APP to regulate their trafficking and
processing.
Mol. Neurodegen. 7, 9. |
|
|
Kawano, T., Araseki, M., Araki, Y., Kinjo, M., Yamamoto, T. and Suzuki,
T. (2012)
A small peptide sequence is sufficient for initiating kinesin-1 activation
through part of TPR region of KLC1.
Traffic 13, 834-848. |
|
|
Matsushima, T., Saito, Y., Eliott, J. E., Iijima-Ando, K., Nishimura, M.,
Kimura, N., Hata, S., Yamamoto, T., Nakaya, T., Suzuki, T. (2012)
Membrane-microdomain localization of amyloid β-precyrsor protein (APP)
C-terminal fragments is regulated by phosphorylation of cytoplasmic Thr668
residue.
J. Biol. Chem. 287, 19715-17924. |
|
|
Kamogawa, K., Kohara, K., Tabara, Y., Takita, R., Miki, T., Konno, T.,
Hata, S., Suzuki, T. (2012)
Utility of plasma levels of soluble p3-Alcadeinα as a biomarker for sporadic
Alzheimer's disease.
J. Alzheimer Dis. 31, 421-428 |
|
|
Hata, S., Taniguchi, M., Piao, Y., Ikeuchi, T., Fagan, A. M., Holzman,
D. M., Bateman, R., Gandy, S., Urakami, K., Suzuki, T., J-ADNI (2012)
Multiple γ-secretase product peptides are coordinately increased in concentration
in the CSF of a subpopulation of sporadic Alzheimer's disease subjects.
Mol. Neurodegener. 7, 16. |
|
|
Maruta, C., Saito, Y., Hata, S., Gotoh, N., Suzuki, T., Yamamoto, T. (2012)
Constitutive Cleavage of the Single-pass Transmembrane Protein Alcadeinα
Prevents Aberrant Peripheral Retention of Kinesin-1.
PLoS ONE 7, e43058 |
|
|
Nishimura, M., Nakamura, S., Kimura, N., Liu, L., Suzuki, T., Tooyama,
I. (2012)
Age-related modulation of γ-secretase activity in non-human primate brains.
J. Neurochem. 123, 21-28. |
|
|
Saito, Y., Inoue, T., Zhu, G., Kimura, N., Okada, M, Nishimura, M., Kimura,
N., Murayama, S., Kaneko, S., Shigemoto, E., Imoto, K., Toshiharu Suzuki
(2012)
Hyperpolarization-activated cyclic nucleotide gated channels: a potential
molecular link between epileptic seizures and Aβ generation in Alzheimer's
disease
Mol. Neurodegener. 7, 50. |
|
| 2011 |
|
|
|
Ishikawa, T., Gotoh, N., Murayama, C., Abe, T., Iwashita, M., Matsuzaki, F., Suzuki, T., Yamamoto T. (2011)
IgSF molecule MDGA1 is involved in radial migration and positioning of a subset of cortical upper-layer neurons
Developmental Dynamics 240, 96–107. |
|
|
Nakazawa, S., Gotoh, N., Matsumoto, H., Murayama, C., Suzuki, T., Yamamoto, T. (2011)
Expression of Sorting Nexin 18 (SNX18) Is Dynamically Regulated in Developing Spinal Motor Neurons
J. Histochem. Cytochem. 59, 202-213. |
|
|
Hoshino, T., Murao, N., Namba, T., Takehara, M., Adachi, H., Katsuno, M., Sobue, G., Matsushima, T., Suzuki, T., Mizushima, T. (2011)
Suppression of Alzheimer's disease-related phenotypes by expression of heat shock protein 70 in mice.
J. Neurosci. 31, 5225-5234. |
|
|
Cheung, A.K., Ko, J.M., Lung, H.L., Chan, K.W., Stanbridge, E.J., Zabarovsky,
E.,, Tokino, T., Kashima, L., Suzuki, T., Kwong, D.L., Chua, D., Tsao,
S.W., Lung, M.L. (2011)
Cysteine-rich intestinal protein 2 (CRIP2) acts as a repressor of NF-{kappa}B-mediated
proangiogenic cytokine transcription to suppress tumorigenesis and angiogenesis
Proc. Natl. Acad. Sci. USA. 108, 8390-8395. |
|
|
Hata, S., Fujishige, S., Araki, Y., Taniguchi, M., Urakami, K., Peskind,
E., Akatsu, H., Araseki, M., Yamamoto, K., Martins, R. N., Maeda, M., Nishimura,
M., Levey, A., Chung, K. A., Montine, T., Leverenz, J., Fagan, A., Goate,
A., Bateman, R., Holtzman, D. M., Yamamoto, T., Nakaya, T., Gandy S., Suzuki,
T. (2011)
Alternative processing of γ-secretase substrates in common forms of mild
cognitive impairment and Alzheimer's disease: Evidence for γ-secretase
dysfunction
Ann. Neurol. 69, 1026-1031 |
|
|
Saito, Y., Akiyama, M., Araki, Y., Sumioka, A., Shiono, M., Taru, H., Nakaya,
T., Yamamoto, T., Suzuki, T. (2011)
Intracellular trafficking of the amyloid β-protein precursor (APP) regulated
by novel function of X11-like
PLoS ONE 6, e22108 |
|
|
Cui, H., Hung, A. C., Klaver, D. W., Suzuki, T., Freeman, C., Narkowicz,
C., Jacobson, G., Small D. H. (2011)
Effects of heparin and enoxaparin on APP processing and Aβ production in
primary cortical neurons from Tg2576 mice.
PLoS ONE 6, e23007 |
|
|
Konnno, T., Hata, S., Hamada, Y., Horikoshi. Y., Nakaya, T., Saito, Y.,
Yamamoto, T., Yamamoto, T., Maeda, M., Gandy. S., Akatsu, H. and Suzuki,
T. (2011)
Coordinated increase of γ-secretase reaction products in the plasma of
some female Japanese sporadic Alzheimer's disease patients: quantitative
analysis of p3-Alcα with a new ELISA system
Mol. Neurodegener. 6:76. |
|
|
<Book>
Hata, S., Saito, Y. and Suzuki, T. (2011)
Alzhiemer's disease as a membrane-associated enzymopathy of β-amyloid precursor protein (APP) secretases.
"Lipids and Cellular Membranes in Amyloid Disease" (Edited by
Jelinek, R.) pp177-194. Wiley-VCH (ISBN: 978-3-527-32860-4) |
|
| 2010 |
|
|
|
Mitsuishi, Y., Hasegawa, H., Matsuo, A., Araki, W., Suzuki, T., Tagami,
S., Okochi, M., Takeda, M., Roepman, R. and Nishimura, M. (2010)
Human CRB2 inhibits γ-secretase cleavage of amyloid precursor protein by
binding to presenilin complex.
J. Biol. Chem. 285, 14920-14931. |
|
|
Kawai, T., Nakaya, T., and Suzuki, T. (2010)
Role of the intramolecular regions of FE65 in its trans-accumulation and in p53 stabilization in the nuclear matrix of osmotically stressed cells
FEBS Lett. 584, 765-769. |
|
|
Minami, S. S., Sung Y. M., Dumanis, S. B., Chi, S. H., Burns, M. P., Ann, E-J., Suzuki, T., Tuner, R. S., Park, H-S., Pak, D. T. S., Rebeck, G. W. and Hoe, H-S. (2010)
The cytoplasmic adaptor protein X11α and extracellular matrix protein Reelin regulate ApoE receptor 2 trafficking and cell movement.
FASEB J. 24, 58-69. |
|
|
Kondo, M., Shiono, M., Itoh, G., Takei, N., Matsushima, T., Maeda, M., Taru, H., Hata, S., Yamamoto, T., Saito, Y., Suzuki, T. (2010)
Increased amyloidogenic processing of transgenic human APP in X11-like deficient mouse brain
Mol Neurodegener. 5, 35. |
|
|
<Book>
Nakaya, T., Iijima-Ando, K., Suzuki, T. (2010)
Cell cycle regulated phosphorylation of the Alzheimer's amyloid-β protein precursor.
"Cell Cycle Regulation in Alzheimer's Disease" (Edited by Padmanabhan,
J.) pp111-122. Transworld Research Network. |
|
| 2009 |
|
|
|
Hata, S., Fujishige, S., Araki, Y, Kato, N., Araseki, M., Nishimura, M., Hartmann, D., Saftig, P., Fahrenholz, F., Taniguchi, M., Urakami, K., Akatsu, H., Martins, R. N., Yamamoto, K., Maeda, M., Yamamoto, T., Nakaya, T., Gandy, S. and Suzuki, T. (2009)
Alcadein cleavages by amyloid beta-precursor protein(APP) α- and γ-secretases
generate small peptides, p3-Alcs, indicating Alzheimer disease-related
γ-secretase dysfunction.
J. Biol. Chem. 284 36024-36033. |
|
|
Mizumaru, C., Saito, Y., Ishikawa, T., Yoshida, T., Yamamoto, T., Nakaya, T. and Suzuki, T. (2009)
Suppression of APP-containing vesicle trafficking and production of β-amyloid by AID/DHHC-12 protein.
J. Neurochem. 111, 1213-1224. |
|
|
Nakaya, T., Kawai, T. and Suzuki, T. (2009)
Metabolic stabilization of p53 by FE65 in the nuclear matrix of osmotically stressed cells.
FEBS J. 276, 6364-6374. |
|
|
Hoshino, T., Namba, T., Takehara, M., Nakaya, T., Sugimoto, Y., Araki, W., Narumiya, S., Suzuki, T.. and Mizushima, T. (2009)
Prostaglandin E2 stimulates the production of amyloid-β peptide through internalization of EP4 receptor.
J. Biol. Chem. 284, 18493-18502. |
|
|
Sano, Y., Ornthanalai, V. G., Yamada, K., Homma, C., Suzuki, H., Suzuki, T., Murphy, N. P. and Itohara, S. (2009)
X11-like protein deficiency is associated with impaired conflict resolution
in mice.
J. Neurosci. 29, 5884-5896. |
|
|
Sakuma, M., Tanaka, E., Taru, H., Tomita, S., Gandy, S., Nairn, A. C., Nakaya, T., Yamamoto, T. and Suzuki, T. (2009)
Phosphorylation the amino-terminal region of X11L regulates its interaction with APP .
J. Neurochem. 109, 465-475. |
|
|
Guix, F. X., Ill-Raga, G., Bravo, R., Nakaya, T., de Fabritiis, G., Coma, M., Miscione, G. P., Villa-Freixa, J., Suzuki, T., Fernandez-Busquets, X., Valverde, M. A., de Strooper, B. and Munoz, F. J. (2009)
Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation
and tau fibrillation.
Brain 132, 1335-1345. |
|
|
Taru, H. and Suzuki, T. (2009)
Regulation of the physiological function and metabolism of APP by APP binding proteins. Review
J. Alzheimer Disease 18, 253-265. |
|
|
<Book>
Gandy, S., da Cruz e Silva, O., da Cruz e Silva, E., Suzuki, T., Ehrlich, M., and Small, S. (2009)
Amyloid precursor protein sorting and processing: Transmitters, hormones, and protein phosphorylation mechanisms.
"Intracellular Traffic and Neurodegenerative Disease, Research and
perspective in Alzheimer's disease" (Edited by Hyslop, Mobley and
Christen) pp1-10. Springer-Verlag Berlin Heidelberg. |
|
| 2008 |
|
|
|
Saito, Y., Sano, Y., Vassar, R., Gandy, S., Nakaya, T., Yamamoto, T., and Suzuki, T. (2008)
X11 proteins regulate the translocation of amyloid beta-protein precursor(APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in brain.
J. Biol. Chem. 283 35763-35771. |
|
|
Arakawa, T., Iwashita, M., Matsuzaki, F., Suzuki, T. and Yamamoto, T. (2008)
Paths, elongation and projections of ascending chick embryonic commissural
neurons after crossing the floor plate.
Brain Res. 1223, 25-33. |
|
|
Nakaya, T., Kawai, T. and Suzuki, T. (2008)
Regulation of FE65 nuclear translocation and function by APP in osmotically
stressed cells.
J .Biol. Chem. 283, 19119-19131. |
|
|
Sumioka, A., Saito, Y., Sakuma, M., Araki, T., Yamamoto, T. and Suzuki, T. (2008)
The X11L/X11β/MINT2 and X11L2/X11γ/MINT3 scaffold proteins shuttle between the nucleus and cytoplasm.
Exp. Cell Res. 314, 1155-1162. |
|
|
Suzuki, T. and Nakaya, T. (2008)
Regulation of APP by phosphorylation and protein interaction. Minireview
J. Biol. Chem. 283, 29633-29637. |
|
| 2007 |
|
|
|
Ikin, A., Causevic, M., Pedrini, S., Benson, L., Buxbaum, J. D., Suzuki, T., Lovestone, S., Higashiyama, S., Mustelin, T., Burgoyne, R. D. and Gandy S. (2007)
Evidence against roles for phorbol binding protein Munc13-1, ADAM adaptor
Eve-1, or vesicle trafficking phosphoprotein Munc 18 or NSF as phospho-state-sensitive
modulators of phorbol/PKC-activated Alzheimer APP ectodomain shedding.
Mol. Neurodegen. 2:23 (Electric Journal 11 pages) |
|
|
Hoshino, T., Nakaya, T., Homan, T., Tanaka, K., Sugimoto, Y., Araki, W., Narita, M., Narumiya, S., Suzuki, T. and Mizushima, T. (2007)
Involvement of prostaglandine E2 in production of amyloid-β peptides both in vitro and in vivo.
J. Biol. Chem. 282, 32676-32688. |
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Araki, Y., Kawano, T., Taru, H., Saito, Y., Wada, S., Miyamoto, K., Kobayashi, H., Ishikawa, O. H., Ohsugi, Y., Yamamoto, T., Matsuno, K., Kinjyo, M. and Suzuki, T. (2007)
The novel cargo receptor Alcadein induces vesicle association of kinesin
-1 motor components and activates axonal transport
EMBO. J. 26, 1475-1486. |
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Hoshino, T., Nakaya, T., Araki, W., Suzuki, K., Suzuki, T. and Mizushima, T. (2007)
Endoplasmic reticulum chaperones inhibit the production of amyloid-β peptides.
Biochem. J. 402, 581-589. |
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Okuda, J., Arikawa, Y., Takeuchi, Y., Mahmound, M. M., Suzuki, E., Kataoka, K., Suzuki, T., Okinaka, Y., and Nakai, T. (2006)
Intracellular replication of Edwardiella tarda in murine macrophage is dependent on the type III secretion system and induces an up-regulation of anti-apoptotic NF-kB target genes protecting the macrophage from staurosporine-induced apoptosis.
Microbial Pathogenesis 41, 226-240. |
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| 2006 |
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Sano, Y., Nakaya, T., Pedrini, S., Takeda, S., Iijima-Ando, K., Iijima, K., Mathews, P. M., Itohara, S., Gandy, S. and Suzuki, T. (2006)
Physiological mouse brain Aβ levels are not related to the phosphorylation atate of threonine-668 of Alzheimer’s APP.
PLoS ONE Issue1, e51. (electric Journal) |
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Sano, Y., Syuzo-Takabatake, A., Nakaya, T., Saito, Y., Tomita, S., Itohara, S. and Suzuki, T. (2006)
Enhanced amyloidogenic metabolism of the amyloid b-protein precursor in
the X11L-deficint mouse brain.
J. Biol. Chem. 281, 37853-37860. |
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Nakaya, T. and Suzuki, T. (2006)
Role of APP phosphorylation in FE65-dependent gene transactivation mediated by AICD.
Genes Cells 11, 633-645. |
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Suzuki, T., Araki, Y., Yamamoto, T. and Nakaya, T. (2006)
Trafficking of Alzheimer’s disease-related membrane proteins and its participation in disease pathogenesis.
J. Biochem. Minireviews 139, 949-955. |
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Fujimura, Y., Iwashita, M., Matsuzaki, F., Yamamoto, T. (2006)
MDGA1, an IgSF molecule containing a MAM domain, heterophilically associates with axon- and muscle-associated binding partners through distinct structural domains.
Brain Res. 1101, 12-19. |
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| 2005 |
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Sumioka, A., Nagaishi, S., Yoshida, N., Lin, A., Miura, M., and Suzuki, T. (2005)
Role of 14-3-3γ in FE65-dependent gene transactivation mediated by the APP cytoplasmic fragment.
J. Biol. Chem. 280, 42364-42374. |
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Asaumi, M., Iijima, K., Sumioka, A., Iijima, A,.K., Kirino, Y., Nakaya, T. and Suzuki, T. (2005)
Interaction of N-terminal acetyltransferase with the cytoplasmic domain of β-amyloid precursor protein and its effect on Aβ secretion
J. Biochem. 137, 147-155. |
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von Rotz, R. C., Kohli, B. M., Bosset, J., Meier, M., Suzuki, T., Nitsch, R. M., and Konietzko, U. (2004)
The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor.
J. Cell Sci. 117, 4435-4448. |
|
| 2004 |
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Taru, H., Yoshikawa, K.,and Suzuki, T. (2004)
Suppression of the caspase cleavage of beta-amyloid precursor protein by its cytoplasmic phosphorylation.
FEBS Lett. 567, 248-252. |
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Araki, Y., Miyagi, N., Kato, N., Yoshida, T., Wada, S., Nishimura, M., Komano, H., Yamamoto, T., De Strooper, B., Yamamoto, K., and Suzuki, T. (2004)
Coordinated metabolism of Alcadein and amyloid β-protein precursor regulates FE65-dependent gene transactivation.
J. Biol. Chem. 279, 24343-24354. |
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Tabuchi, A., Ishii, A., Fukuchi, M., Kobayashi, S., Suzuki, T., and Tsuda M. (2004)
Activity-dependent increase in β-amyloid precursor protein mRNA expression
in neurons
Neuroreport 15, 1329-1333. |
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Sawamura, N., Mihee, K., Wenxin, Y., Zou, K., Handa, K., Suzuki, T., Gong, J-S., Yanagisawa, K. and Michikawa, M. (2004)
Modulation of amyloid precursor protein cleavage by cellular Sphingolipids.
J. Biol. Chem. 279, 11984-11991. |
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| 2003 |
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Araki, Y., Tomita, S., Yamaguchi, H., Miyagi, N., Sumioka, A., Kirino, Y.,and Suzuki, T. (2003)
Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein mediated stabilization of amyloid β-protein precursor metabolism.
J. Biol. Chem. 278, 49448-49458. |
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Sumioka, A., Imoto, S., Martins, R. N., Kirino, Y., and Suzuki, T. (2003)
XB51 isoforms mediate Alzheimer’s β-amyloid peptide production by X11L-dependent and –independent mechanisms.
Biochem. J. 374, 261-268. |
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Inomata, H., Nakamura, Y., Hayakawa, A., Takata, H., Suzuki, T., Miyazawa, K., and Kitamura, N. (2003)
A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1.
J. Biol. Chem. 278, 22946-22955. |
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