北海道大学大学院 薬学研究院 創薬科学研究教育センター 有機合成医薬学部門

研究業績

発表論文 2008年

  1. Structure-Based Drug Designによる分子シャペロンHsp90阻害剤の創製研究

    村中　一大、市川　聡、松田　彰

    MEDCHEM NEWS 2008, 18 (3), 52-58.

  2. ピラノースの配座制御に基づく立体選択的グリコシル化反応．

    周東　智、市川　聡、阿部　洋、松田　彰

    有機合成化学協会誌, 2008, 66, 50-59.

  3. Design and synthesis of diketopiperazine and acyclic analogs related to the caprazamycins and liposideomycins as potential antibacterial agents.

    Hirano, S.; Ichikawa, S.; Matsuda, A.

    Bioorg. Med. Chem. 2008, 16, 428-436. DOI: 10.1016/j.bmc.2007.09.022

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  4. Synthesis of caprazamycin analogs and their structure-activity relationship for antibacterial activity.

    Hirano, S.; Ichikawa, S.; Matsuda, A.

    J. Org. Chem. 2008, 73, 569-577. DOI: 10.1021/jo702264e

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  5. Triazole-linked dumbbel oligodeoxynucleotides with NF-kB binding ability as potential decoy molecules.

    Nakane, M.; Ichikawa, S.; Matsuda, A.

    J. Org. Chem. 2008, 73, 1842-1851. DOI: 10.1021/jo702459b

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  6. Structure-activity relationship of truncated analogs of caprazamycins as potential antitumor agents.

    Hirano, S.; Ichikawa, S.; Matsuda, A.

    Bioorg. Med. Chem. 2008, 16, 5123-5133. DOI: 10.1016/j.bmc.2008.03.020

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  7. Synthesis of Hsp90 inhibitor dimers as potential antitumor agents.

    Muranaka, K.; Sano, A.; Ichikawa, S.; Matsuda, A.

    Bioorg. Med. Chem. 2008, 16, 5862-5870. DOI: 10.1016/j.bmc.2008.04.070

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  8. Highly β-selective C-allylation of a ribofuranoside controlling steric hindrancein the transition state.

    Ichikawa, S.; Hayashi, R.; Hirano, S.; Matsuda, A.

    Org. Lett. 2008, 10, 5107-5110. DOI: 10.1021/ol8018743

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  9. Synthesis of 1-arylpiperazyl-2-phenylcyclopropanes designed as antidopaminergic agents: Cyclopropane-based conformationally restricted analogs of haloperidol.

    Yamaguchi, K.; Kazuta, Y.; Hirano, K.; Yamada,S.; Matsuda, A.; Shuto, S.

    Bioorg. Med. Chem. 2008, 16, 8875-8881. DOI: 10.1016/j.bmc.2008.08.061

  10. Design and synthesis of 4´´, 6´´-unsaturated cyclic ADP-carbocyclic ribose, a Ca2+ mobilizing agent selectively active in T cells.

    Kudoh, T.; Murayama, T.; Hashii, M.; Higashida, H.; Sakurai, T.; Maechling, C.; Spiess, B.; Weber, K.; Guse, A. H.; Potter, B. V. L.; Arisawa, M.; Matsuda, A.; Shuto, S.

    Tetrahedron, 2008, 64, 9754-9765. DOI: 10.1016/j.tet.2008.07.068

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