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• 研究業績
• 2018

1. Improvement of SNAr Reaction Rate by an Electron-withdrawing Group in the Cross-linking of DNA Cytosine-5 Methyltransferase by a Covalent Oligodeoxyribonucleitode Inhibitor
   

   Yukiko Kasai; Kousuke Sato; Shohei Utsumi and Satoshi Ichikawa

   ChemBioChem, 2018, 19, 1866-1872.

   DOI: org/10.1002/cbic.201800244

    

   

2. Insight into the recognition mechanism of DNA cytosine-5 methyltransferases (DNMTs) by incorporation of acyclic 5-fluorocytosine (FC) nucleosides into DNA
   

   Shohei Utsumi; Kousuke Sato; Satoshi Ichikawa

   Bioorg. Med. Chem. Lett. 2018, 28, 2189-2194.

   DOI: org/10.1016/j.bmcl.2018.05.008

    

   

    

3. Ribavirin-related compounds exert in vitro inhibitory effects toward rabies virus
   

   Anindita, Paulina D.; Sasaki, Michihito; Okada, Kazuma; Ito, Naoto; Sugiyama, Makoto; Saito-Tarashima, Noriko; Minakawa, Noriaki; Shuto, Satoshi; Otsuguro, Satoko; Ichikawa, Satoshi; Matsuda, Akira; Maenaka, Katsumi; Orba, Yasuko; Sawa, Hirofumi

   Antiviral Res. 2018, 154, 1-9.

   DOI: 10.1016/j.antiviral.2018.03.011

4. Study of the structure-activity relationship of polymyxin analogues.
   

   Kinoshita, Yuhei; Yakushiji, Fumika; Matsui, Hidehito; Hanaki, Hideaki; and Ichikawa, Satoshi.*

   Bioorg. Med. Chem. Lett. 2018, 28, 2713-2716.

   DOI: 10.1016/j.bmcl.2018.03.028

    

   

5. Total synthesis of plusbacin A3 and its dideoxy derivative using a solvent-dependent diastereodivergent Joullié–Ugi three-component reaction
   

   Akira Katsuyama, Fumika Yakushiji, and Satoshi Ichikawa

   J. Org. Chem. 2018, 83, 7085–7101.

   DOI: 10.1021/acs.joc.8b00038

    

   　　

6. GlcNAc-1-P-transferase–tunicamycin complex structure reveals basis for inhibition of N-glycosylation
   

   Jiho Yoo , Ellene H. Mashalidis , Alvin C. Y. Kuk , Kazuki Yamamoto, Benjamin Kaeser, Satoshi Ichikawa  and Seok-Yong Lee

   Nat. Struct. Mol. Biol. 2018, 25, 217-224.

   DOI: 10.1038/s41594-018-0031-y

    

   

7. Mechanism-based Inhibitor of DNA Cytosine-5 Methyltransferase (DNMT) via a SNAr Reaction with an Oligodeoxyribonucleotide Containing 2-Amino-4-Halopyridine-C-Nucleoside (dXP)
   
   Kousuke Sato, Yuma Kunitomo, Yukiko Kasai, Shohei Utsumi, Isao Suetake, Shoji Tajima, Satoshi Ichikawa and Akira Matsuda.
   ChemBioChem, 2018, 19, 865-872. (as a very important paper)
   DOI: 10.1002/cbic.201700688
   
8. Solid-phase Modular Synthesis of Park Nucleotide and LipidⅠ and Lipid Ⅱ Analogues
   

   Akira Katsuyama, Kousuke Sato, Fumika Yakushiji, Takanori Matsumaru and Satoshi Ichikawa

   Chem. Pharm. Bull. 2018, 66, 84-95. (Highlighted paper selected by Editor-in-Chief)

   DOI: 10.1248/cpb.c17-00828

    

   

9. Potent anti-tumor activity of a syringolin analog in multiple myeloma: a dual inhibitor of proteasome activity targeting β2 and β5 subunits
   

   Takahashi Yoshida, Masaki Ri, Takashi Kanamori, Sho Aoki, Reham Ashour, Shiori Kinoshita, Tomoko Narita, Haruhito Totani, Ayako Masaki, Asahi Ito, Shigeru Kusumoto, Takashi Ishida, Hirokazu Komatsu, Shun Kitahata, Takuya Chiba, Satoshi Ichikawa and Shinsuke Iida

   Oncotarget, 2018, 9, 9975-9991.

   DOI: 10.18632/oncotarget.24160

    

   

10. Synthesis and Medicinal Chemistry of Muraymycins, Nucleoside Antibiotics
    

    Akira Katsuyama and Satoshi Ichikawa

    Chem. Pharm. Bull. (Review), 2018, 66, 123-131.

    DOI: 10.1248/cpb.c17-00684

     

    

11. Total Synthesis of Tunicamycin V
    

    Kazuki Yamamoto, Fumika Yakushiji, Takanori Matsumaru, and Satoshi Ichikawa

    Org. Lett. 2018, 20, 256-259.

    DOI: 10.1021/acs.orglett.7b03623

     

    

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