北海道大学大学院 薬学研究院 創薬科学研究教育センター 有機合成医薬学部門

研究業績

発表論文 2022年

  1. Synthesis of macrocyclic nucleoside antibacterials and their interactions with MraY

    Takeshi Nakaya, Miyuki Yabe, Ellene Mashalidis, Toyotaka Sato, Kazuki Yamamoto, Yuta Hikiji, Akira Katsuyama, Motoko Shinohara, Yusuke Minato, Satoshi Takahashi, Motohiro Horiuchi, Shin-ichi Yokota, Seok-Yong Lee, Satoshi Ichikawa

    Nature Commun. 2022, 13, 7575.

    DOI: 10.1038/s41467-022-35227-z

    図1

    Selected as Featured Article. Organic chemistry and chemical biology

  2. ‘Exploration and Expansion’ in Peptide Sequence: Discovery of Structurally-Optimized Polymyxin Derivatives Facilitated by Peptide Scanning and in situ Screening Chemistry

    Rintaro Kaguchi, Akira Katsuyama, Toyotaka Sato, Satoshi Takahashi, Motohiro Horiuchi, Sin-ichi Yokota, Satoshi Ichikawa

    ChemRxiv 2022

    DOI: 10.26434/chemrxiv-2022-001zq

  3. Synthesis of capuramycin and its analogues via a Ferrier-type I reaction and their biological evaluation

    Shintaro Kusaka, Kazuki Yamamoto, Motoko Shinohara, Yusuke Minato, and Satoshi Ichikawa.

    Bioorg. Med. Chem. 2022, 117011.

    DOI: 10.1016/j.bmc.2022.117011

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  4. β-Hydroxylation of α-amino-β-hydroxylbutanoyl-glycyluridine catalyzed by a nonheme hydroxylase ensures the maturation of caprazamycin

    Zadeh, S. Malek; Chen, Mei-Hua; Wang, Zhe-Chong; Astani, K. Elahe; Lo, I-Wei; Lin, Kuan-Hung; Hsu, Ning-Shian; Adhikari, Kamal; Lyu, Syue-Yi; Tsai, Hsin-Ying; Terasawa, Yuma; Yabe, Miyuki; Yamamoto, Kazuki; Ichikawa, Satoshi; Li, Tsung-Lin.

    Commun. Chem. 2022, 5, 87.

    DOI:10.1038/s42004-022-00703-6

  5. Photoinduced Concerted Dual Single-bond Rotation of a Nitrogen-containing System Realized by Chalcogen Substitution

    Shotaro Nagami, Akira Katsuyama, Rintaro Kaguchi, Tohru Taniguchi, Kenji Monde, Satoshi, Ichikawa

    ChemRxiv, 2022

    DOI:10.26434/chemrxiv-2022-4hq5r

  6. Total Synthesis of Pseudouridimycin and Its Epimer via Ugi-type Multicomponent Reaction

    Ryotaro Okawa, Courtney C. Aldrich, Satoshi Ichikawa

    Chem. Commun. 2022, 58, 7956.

    DOI: 10.1039/D2CC02442J

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  7. Design, synthesis and conformation-activity relationship analysis of LNA/BNA-type 5′-O-aminoribosyluridine as MraY inhibitors

    Shintaro Kusaka, Kazuki Yamamoto, Motoko Shinohara, Yusuke Minato, Satoshi Ichikawa.

    Bioorg. Med. Chem. 2022, 65, 116744.

    DOI: 10.1016/j.bmc.2022.116744

    1-s2.0-S0968089622001365-ga1_lrg

  8. 生物活性天然物の全合成と創薬リード創成の架け橋

    市川 聡

    薬学雑誌, 2022, 142, 355. DOI: 10.1248/yakushi.21-00185-2

  9. Solid-Phase Total Synthesis of Plusbacin A 3

    Kazuki Takashina, Akira Katsuyama, Rintaro Kaguchi, Kazuki Yamamoto, Toyotaka Sato, Satoshi Takahashi, Motohiro Horiuchi, Shin-ichi Yokota, Satoshi Ichikawa.

    Org. Lett. 2022, 24, 2253.

    DOI: 10.1021/acs.orglett.2c00667

    ol2c00667_0006

  10. Design, synthesis and biological evaluation of simplified analogues of MraY inhibitory natural product with rigid scaffold

    Kazuhiro Okamoto, Aoi Ishikawa, Ryotaro Okawa, Kazuki Yamamoto, Toyotaka Sato, Shinichi Yokota, Kazuhiro Chiba, Satoshi, Ichikawa

    Bioorg. Med. Chem. 2022, 55, 116556.

    DOI: 10.1016/j.bmc.2021.116556

    1-s2.0-S0968089621005642-ga1_lrg

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