北海道大学大学院 薬学研究院 創薬科学研究教育センター 有機合成医薬学部門

研究業績

発表論文 2023年

  1. Determining the structure of protein-bound ceramides, essential lipids for skin barrier function

    Yusuke Ohno, Tetsuya Nakamura, Takafumi Iwasaki, Akira Katsuyama, Satoshi Ichikawa, Akio Kihara

    iScience, 2023, 26, 108248.

    DOI: 10.1016/j.isci.2023.108248

     

    231107_pr_pic

     

  2. Solid-Phase Synthesis of Nannocystin Ax and Its Analogues

    Daiki Miyakita, Kohei Kawanishi, Akira Katsuyama, Kazuki Yamamoto, Fumika Yakushiji, Satoshi Ichikawa

    J. Org. Chem. 2023, 88, 11367.

    DOI: 10.1021/acs.joc.3c01189

    images_medium_jo3c01189_0007

  3. Development of a Natural Product Optimization Strategy for inhibitors against the cell wall synthesis enzyme MraY, a promising antibacterial target

    Kazuki Yamamoto, Toyotaka Sato, Aili Hao, Kenta Asao, Rintaro Kaguchi, Shintaro Kusaka, Ruddarraju Radhakrishnam Raju, Daichi Kazumori,  Kiki Seo, Satoshi Takahashi, Motohiro Horiuchi, Sin-ichi Yokota, Seol-Yong Lee, Satoshi Ichikawa

    ChemRxiv 2023

    DOI: 10.26434/chemrxiv-2023-2w41l

  4. Discovery of Biologically Optimized Polymyxin Derivatives Facilitated by Peptide Scanning and In Situ Screening Chemistry
    Rintaro Kaguchi, Akira Katsuyama, Toyotaka Sato, Satoshi Takahashi, Motohiro Horiuchi, Shin-ichi Yokota, Satoshi Ichikawa
    J. Am. Chem. Soc. 2023, 145, 3665.
  5. Solid-Phase Total Synthesis of Sandramycin and Its Analogues
    Yuya Komatani, Kyoka Momosaki, Akira Katsuyama, Kazuki Yamamoto, Rintaro Kaguchi, Satoshi Ichikawa
    Org. Lett. 2023, 25, 543.
    Figure 1

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