北海道大学大学院 薬学研究院 創薬科学研究教育センター 有機合成医薬学部門

研究業績

発表論文 2024年

  1. Concise Synthesis of 11-Noriridoids via Pauson–Khand Reaction

    Ryuji Kouda, Kazuki Yamamoto, Akira Katsuyama, Satoshi Ichikawa, Fumika Yakushiji

    Chem. Pharm. Bull. 2024, 72, 547–558.

    DOI:10.1248/cpb.c24-00190

  2. Development of a natural product optimization strategy for inhibitors against MraY, a promising antibacterial target

    Kazuki Yamamoto, Toyotaka Sato, Aili Hao, Kenta Asao, Rintaro Kaguchi, Shintaro Kusaka, Radhakrishnam Raju Ruddarraju, Daichi Kazamori, Kiki Seo, Satoshi Takahashi, Motohiro Horiuchi, Shin-ichi Yokota, Seok-Yong Lee & Satoshi Ichikawa

    Nature Communications 2024, 15, 5085.

    DOI:10.1038/s41467-024-49484-7 

    スクリーンショット 2024-06-17 102107

  3. Development of small molecule–drug conjugates based on derivatives of natural proteasome inhibitors that exhibit selectivity for PSMA-expressing cancer cells

    Takahiro Obara, Nanami, Kawano, Kengo Tatsumi, Akira Katsuyama, Kohei Nakajima, Mikako Ogawa, Satoshi Ichikawa

    Bioorg. Med. Chem. 2024, 108, 117773.

    DOI:10.1016/j.bmc.2024.117773

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  4. 天然物創薬を加速化する構造最適化プロセスの開発

    市川 聡, 勝山 彬, 山本 一貴

    有機合成化学協会誌, 2024, 82, 493.

    DOI:10.5059/yukigoseikyokaishi.82.493

  5. The MraY Inhibitor Muraymycin D2 and Its Derivatives Induce Enlarged Cells in Obligate Intracellular Chlamydia and Wolbachia and Break the Persistence Phenotype in Chlamydia
    Iris Löckener, Lara Vanessa Behrmann, Jula Reuter, Andrea Schiefer, Anna Klöckner, Sebastian Krannich, Christian Otten, Katja Mölleken, Satoshi Ichikawa, Achim Hoerauf, Tanja Schneider, Kenneth M. Pfarr, Beate Henrichfreise

    Antibiotics 2024, 13, 421.

    DOI:10.3390/antibiotics13050421

    MRY

  6. Modulation of Proteasome Subunit Selectivity of Syringolins

    Kengo Tatsumi, Shun Kitahata, Yuya Komatani, Akira Katsuyama, Fumika Yakushiji, Satoshi Ichikawa

    Bioorg. Med. Chem. 2024, 106, 117733.

    DOI:10.1016/j.bmc.2024.117733

    syringoline

  7. Synthesis and biological evaluation of echinomycin analogues as potential colon cancer agent

    Keita Kojima, Hiroaki Konishi, Kyoka Momosaki, Yuya Komatani, Akira Katsuyama, Koji Nakagawa, Kayoko Kanamitsu, FumikaYakushiji, Mikihiro Fujiya & Satoshi Ichikawa

    Sci. rep. 2024, 14, 7628.

    DOI:10.1038/s41598-024-58196-3

     

    スクリーンショット 2024-05-14 200345

  8. Photoinduced dual bond rotation of a nitrogen-containing system realized by chalcogen substitution

    Shotaro Nagami, Rintaro Kaguchi, Taichi Akahane, Yu Harabuchi, Tohru Taniguchi, Kenji Monde, Satoshi Maeda, Satoshi Ichikawa, Akira Katsuyama

    Nat. Chem. 2024, 16, 959-969.

    DOI:10.1038/s41557-024-01461-9

     

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  9. あなたのラボから薬を生み出す　アカデミア創薬の実践 All JAPAN体制の先端技術支援を利用した創薬の最前線

    実験医学増刊 Vol.42 No.2　善光龍哉，辻川和丈／編

     

    第３章 １. ビルドアップライブラリー戦略による天然物創薬加速化への挑戦

    市川　聡，勝山　彬，山本一貴

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