北海道大学大学院 薬学研究院 創薬科学研究教育センター 有機合成医薬学部門

研究業績

発表論文 2025年

  1. A selective RPL15 PROTAC degrader enhances anti-PD-1 immunotherapy in a murine melanoma tumor model

    Runa Takahashi, Kazuki Yamamoto, Hikaru Toya, Haruka Shoji, Kohei Kawanishi, Kyoka Momosaki, Miyuki Yabe, Ken Takashima, Ryuta Muromoto, Satoshi Ichikawa, Tadashi Matsuda, Yuichi Kitai

    Oncogene 2025, 44, 4846.

    DOI : 10.1038/s41388-025-03641-4

     

    スクリーンショット 2025-12-01 15.20.40

     

  2. Retrosynthetic Analysis-Aware Fragment Linking for Structure-Guided Ligand Extension

    Akira Katsuyama, Yasuaki Tokodai, Kazuki Hoshi, Satoshi Ichikawa

    ChemRxiv 2025

    DOI : 10.26434/chemrxiv-2025-6w91z

     

  3. Non-ribosomal peptide cyclase-directed chemoenzymatic synthesis of lariat lipopeptides

    Masakazu Kobayashi, Kenichi Matsuda, Yuito Yamada, Rintaro Ichihara, Naho Onozawa, Hanako Fukano, Yoshihiko Hoshino, Aki Hirabayashi, Masato Suzuki, Akira Katsuyama, Satoshi Ichikawa, Toshiyuki Wakimoto

    Nat. Chem. 2025, ASAP.

    DOI : 10.1038/s41557-025-01979-6

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  4. Ozonated olive oil inhibits melanoma proliferation by inducing ferroptosis

    Seong-Jin An, Jun-Ichi Kashiwakura, Akira Katsuyama, Sumihito Togi, Yuichi Kitai, Ryuta Muromoto, Toshiaki Miura, Satoshi Ichikawa, Tadashi Matsuda

    BioChem. BioPhys. Rep. 2025, 44, 102267.

    DOI: 10.1016/j.bbrep.2025.102267

  5. Design, Synthesis, and Biological Evaluation of Lipid-Modified Derivatives of Tunicamycins

    Kazuki Yamamoto, Toyotaka Sato, Ellene H. Mashalidis, Seok-Yong Lee, Motohiro Horiuchi, Satoshi Ichikawa

    Chem. Eur. J. 2025, 0, e02296.

    DOI: 10.1002/chem.202502296

    山本さん_論文

  6. pH-Controlled isomerization kinetics of ortho-disubstituted benzamidines: E/Z isomerism and axial chirality

    Ryota Kimura, Satoshi Ichikawa, Akira Katsuyama

    Beilstein J. Org. Chem. 2025, 21, 1568-1576.

    DOI: 10.3762/bjoc.21.120

  7. Structure–Activity Relationship of Pseudouridimycin Focusing on the Improvement of Chemical Stability

    Ryotaro Okawa, Irina Artsimovitch, Akira Katsuyama, Toyotaka Sato, Courtney C. Aldrich, Satoshi Ichikawa

    J. Med. Chem. 2025, 68, 15461-15482.

    DOI: 10.1021/acs.jmedchem.5c00052

    大川さん_article

  8. Concise Total Synthesis of Sandramycin and Its Analogues via Cyclodimerization Using Mitsunobu Reaction

    Radhakrishnam R. Ruddarraju, Yuya Komatani, Yasuaki Tokodai, Satoshi Ichikawa

    J. Org. Chem. 2025, 90, 10550−10554.

    DOI: 10.1021/acs.joc.5c01110

    Raju_article

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