Rough Procedure for using the Center
Appointment
■ Research purpose briefing ■ Chemical library Selection
Screening system confirmation
■ Z’ value optimization ■ Screen Scale-down ■ Cost reduction
Pilot Study
■ Screening of a few compounds to pinpoint weaknesses/problems.
Primary screening implementation
■ Weed-out biologically inactive compounds
Reproducibility & dose-dependence data validation
■ Selection of bioactive compounds ■ Establish dose-dependence
Disclosure of the validated hit-compound
■ Disclosure is done in consultation with researchers who synthesized the hit-compounds.
