2012年

1. ・ Cyclopropane-based stereochemical diversity-oriented conformational restriction strategy: Histamine H3 and/or H4 receptor ligands with the 2,3-methanobutane backbone. Mizuki Watanabe, Takaaki Kobayashi, Takatsugu Hirokawa, Akira Yoshida, Yoshihiko Ito, Shizuo Yamada, Naoki Orimoto, Yasundo Yamasaki, Mitsuhiro Arisawa, Satoshi Shuto, Org. Biomol. Chem., 2012, 10, 736-745.
   


2. ・ Discovery of a Novel Class of Potent Human Deoxyuridine Triphosphatase Inhibitors Remarkably Enhancing the Antitumor Activity of Thymidylate Synthase Inhibitors. Seiji Miyahara, Hitoshi Miyakoshi, Tatsushi Yokogawa, Khoon Tee Chong, Junko Taguchi, Toshiharu Muto, Kanji Endoh, Wakako Yano, Takeshi Wakasa, Hiroyuki Ueno, Yayoi Takao, Akio Fujioka, Akihiro Hashimoto, Kenjirou Itou, Keisuke Yamamura, Makoto Nomura, Hideko Nagasawa, Satoshi Shuto, Masayoshi Fukuoka, J. Med. Chem., 2012, 55, 2970-2980.
   


3. ・ Synthesis and Discovery of N-Carbonylpyrrolidine- or N-Sulfonylpyrrolidine-Containing Uracil Derivatives as Potent Human Deoxyuridine Triphosphatase Inhibitors. Hitoshi Miyakoshi, Seiji Miyahara, Tatsushi Yokogawa, Khoon Tee Chong, Junko Taguchi, Kanji Endoh, Wakako Yano, Takeshi Wakasa, Hiroyuki Ueno, Yayoi Takao, Makoto Nomura, Satoshi Shuto, Hideko Yagasawa, Masayoshi Fukuoka, J. Med. Chem., 2012, 55, 2960-2969.
   


4. ・ Ligand-Free Buchwald-Hartwig Aromatic Aminations of Aryl Halides Catalyzed by Low-Leaching and Highly Recyclable Sulfur-Modified Gold-Supported Palladium Material. Mohammad Al-Amin, Tetsuo Honma, Naoyuki Hoshiya, Satoshi Shuto, Mitsuhiro Arisawa, Adv. Synth. Cat., 2012, 354, 1061-1068.
   


5. ・ Ruthenium-Catalyzed Cycloisomerization and Its Application to the Synthesis of (±)-Cinchonaminone. Takao Ogawa, Tomonori Nakamura, Takuya Araki, Koujirou Yamamoto, Satoshi Shuto, Mitsuhiro Arisawa, Eur. J. Org. Chem., 2012, 2012, 3084-3087.
   


6. ・ Discovery of Highly Potent Human Deoxyuridine Triphosphatase Inhibitors Based on the Conformation Restriction Strategy. Seiji Miyahara, Hitoshi Miyakoshi, Tatsushi Yokogawa, Khoon Tee Chong, Junko Taguchi, Toshiharu Muto, Kanji Endoh, Wakako Yano, Takeshi Wakasa, Hiroyuki Ueno, Yayoi Takao, Akio Fujioka, Akihiro Hashimoto, Kenjirou Itou, Keisuke Yamamura, Makoto Nomura, Hideko Nagasawa, Satoshi Shuto, Masayoshi Fukuoka, J. Med. Chem., 2012, 55, 5483-5496.
   


7. ・ Structure Formation and Catalytic Activity of DNA Dissolved in Organic Solvents. Hiroshi Abe, Naoko Abe, Aya Shibata, Keiji Ito, Yoshiyuki Tanaka, Mika Ito, Hisao Saneyoshi, Satoshi Shuto, Yoshihiro Ito, Angew. Chem. Int. Ed., 2012, 51, 6475-6479.
   


8. ・ Universal Caging Group for the in-Cell Detection of Glutathione Transferase Applied to 19F NMR and Bioluminogenic Probes. Mika Ito, Aya Shibata, Jie Zhang, MIchio Hiroshima, Yasushi Sako, Yukiko Nakano, Kyoko Kojima-Aikawa, Bengt Mannervik, Satoshi Shuto, Yoshihiko Ito, Ralf Morgenstern, Hiroshi Abe, Chem BioChem 2012, 13, 1428-1432.
   


9. ・ 1,2,3-Triazole-Containing Uracil Derivatives with Excellent Pharmacokinetics as a Novel Class of Potent Human Deoxyuridine Triphosphatase Inhibitors. H. Miyakoshi, S. Miyahara, T. Yokogawa, K. Endoh, T. Muto, W. Yano, T. Wakasa, H. Ueno, K. T. Chong, J. Taguchi, M. Nomura, Y. Takao, A. Fujioka, A. Hashimoto, K Itou, K. Yamamura, S. Shuto, H. Nagasawa, M. Fukuoka, J. Med. Chem. 2012, 55, 6427-6437.
   


10. ・ Design and synthesis of indomethacin analogues that inhibit P-glycoprotein and/or multidrug resistant protein without COX inhibitory activity. M. Arisawa, Y. Kasaya, T. Obata, T. Sasaki, T. Nakamura, K. Araki, K. Yamamoto, A. Sasaki, A. Yamano, M. Ito, H. Abe, Y. Ito, S. Shuto, J. Med. Chem. 2012, 55, 8152-8163.
    


11. ・ Conformational Restriction Approach to g-Secretase (BACE1) Inhibitors: Effect of a Cyclopropane Ring to Induce an Alternative Binding Mode. S. Yonezawa, T. Yamamoto, H. Yamakawa, C. Muto, M. Hosono, K. Hattori, K. Higashino, T. Yutsudo, H. Iwamoto, Y. Kondo, M. Sakagami, H. Togame, Y. Tanaka, T. Nakano, H. Takemoto, M. Arisawa, S. Shuto, J. Med. Chem. 2012, 55, 8838-8858.
    

その他の総説等

1. ・ 有澤光弘, 石井　晃, 周東　智, リユース可能なスモールリリース型 「硫黄修飾金に担持したパラジウム触媒」の開発, ・G媒, 2012, 54, 197-202