• 2019
  • 2020
  • 2021

    • 2013年

    1. ・ Synthesis of novel 4'-C-methyl-1',3'-dioxolane pyrimidine nucleosides and evaluation of its anti-HIV-1 activity. Y. Kubota, Y. Kaneda, K. Haraguchi, M. Mizuno, H. Abe, S. Shuto, T. Hamasaki, M. Baba, H. Tanaka. Tetrahedron, 2013, 69, 10884-10892.

    2. ・ Design and synthesis of the stabilized analogs of belactosin A with the unnatural cis-cyclopropane structure. S. Kawamura, Y. Unno, A. Asai, M. Arisawa, S. Shuto. Org Biomol Chem, 2013, 11(38), 6615-6622.

    3. ・ Conformational restriction approach to beta-secretase (BACE1) inhibitors III: Effective investigation of the binding mode by combinational use of X-ray analysis, isothermal titration calorimetry and theoretical calculations. S. Yonezawa, K. Fujiwara. T. Yamamoto, K. Hattori, H. Yamakawa, C. Muto, M. Hosono, Y. Tanaka, T. Nakano, H. Takemoto, M. Arisawa, S. Shuto. Bioorg Med Chem, 2013, 21(21), 6506-6522.

    4. ・ Fluorogenic probes using 4-substituted-2-nitrobenzenesulfonyl derivatives as caging groups for the analysis of human glutathione transferase catalyzed reactions. A. Shibata, Y. Nakano, M. Ito, M. Araki, J. Zhang, Y. Yoshida, S. Shuto, B. Mannervik, R. Mogenstern, Y. Ito, H. Abe. Analyst, 2013, 138, 7326-7330.

    5. ・ Polycation-assisted DNA detection by reduction triggered fluorescence amplification probe. H. Saneyoshi, N. Shimada, A. Maruyama, Y. Ito, H. Abe. Bioorganic & Medicinal Chemistry Letters, accepted (2013)

    6. ・ An epidermal growth factor derivative with binding affinity for hydroxyapatite and titanium surfaces. J. Kang, S. Tada, M. Sakuragi, H. Abe, R. Ito, J. Ishikawa, S. Kurata, T. Kitajima, T. Il Son, T. Aigaki, Y. Ito, Biomaterials,2013, 34, 9747-9753.

    7. ・ Long-lived luminogenic probe for detection of RNA in a crude solution of living bacterial cells. H. Saneyoshi, Y. Ito, H. Abe, Journal of the American Chemical Society, 2013, 135(37), 13632-13635.

    8. ・ Very rapid DNA templated reaction for efficient signal amplification and its steady-state kinetic analysis of the turnover cycle. A. Shibata, T. Uzawa, Y. Nakashima, M. Ito, Y. Nakano, S. Shuto, Y. Ito, H. Abe, Journal of the American Chemical Society, 2013, 135(38), 14172-14178.

    9. ・ Rolling circle amplification in a prokaryotic translation system using small circular RNA. N. Abe, M. Hiroshima, H. Maruyama, Y. Nakashima, Y. Nakano, A. Matsuda, Y. Sako, Y. Ito, H. Abe, Angewandte Chemie International Edition, 2013, 52(27), 7004-7008.

    10. ・ Sustained delivery of siRNA from dopamine-coated stainless steel surface. B. Joddar, A. Albayrak, J. Kang, M. Nishihara, H. Abe, Y. Ito, Acta Biomaterialia, 2013, 9, 6753-6761.

    11. ・ Cationic cholesterol-modified gelatin as an in vitro siRNA delivery vehicle. P. Ananda Kadengodlu, T. Aigaki, H. Abe, Y. Ito, Molecular Biosystems, 2013, 9, 965-968.

    12. ・ Synthesis of a nucleoside phosphorodithioate analogue responsive to microenvironmental changes through chiral induction. H. Saneyoshi, T. Mashimo, K. Hatano, Y. Ito, H. Abe, Tetrahedron Letters 2013, 54, 1080-1083.

    13. ・ RNA-templated molecule release induced protein expression in bacterial cells. A. Shibata, Y. Ito, H. Abe, Chemical Communication, 2013, 49, 270-272

    14. ・ One-pot ring-closing metathesis/1,3-dipolar cycloaddition through assisted tandem ruthenium catalysis: synthesis of a dye with isoindolo[2,1-a]quinoline structure. M. Arisawa, Y. Fujii , H. Kato, H. Fukuda, T. Matsumoto, M. Ito, H. Abe, Y. Ito, S. Shuto, Angew. Chem. Int. Ed. 2013, 52, 1003-1007.[Highlighted in SYNFACTS 2013, 270.]

    15. ・ Characterization of the novel Trypanosoma brucei inosine 5’-monophosphate dehydrogenase. T. Bessho, S. Morii, T. Kusumoto, T. Shinohara, M. Noda, S. Uchiyama, S. Shuto, S. Nishimura, A. Djikeng, M. Duszenko, S. K. Martin, T. Inui, B. K. Kubata, Parasitology, 2013, 1-11.

    16. ・ Three-dimensional structural diversity-oriented peptidomimetics based on the cyclopropylic strain. A. Mizuno, S. Miura, M. Watanabe, Y. Ito, S. Yamada, T. Odagami, Y. Kogami, M. Arisawa, S. Shuto, Org. Lett. 2013, 15, 1686-1689.

    17. ・ Conformational restriction approach to BACE1 inhibitors II: SAR study of the isocytosine derivatives fixed with a cis-cyclopropane ring. S. Yonezawa, H. Yamakawa, C. Muto, M. Hosono, T. Yamamoto, K. Hattori, M. Sakagami, H. Togame, K. Tanaka, T. Nakano, H. Takemoto, M. Arisawa, S. Shuto, Bioorg. Med. Chem. Lett. 2013, 23, 2912-2915.

    18. ・ Potent proteasome inhibitors derived from the unnatural cis-cyclopropane isomer of belactosin A: Synthesis, Biological Activity, and Mode of Action. S. Kawamura, Y. Unno, A. List, A. Mizuno, M. Tanaka, T. Sasaki, M. Arisawa, A. Asai, M. Groll, S. Shuto, J. Med. Chem. 2013, 56, 3689-3870.

    19. ・ Suzuki?Miyaura cross-coupling reactions using a lowleaching and highly recyclable gold-supported palladium material and two types of microwave equipments. M. Al-Amin, M. Akimoto, T. Tameno, Y. Ohki, N. Takahashi, N. Hoshiya, S. Shuto, M. Arisawa, Green Chem. 2013, 15, 1142-1145.

    20. ・ The immunosuppressive agent mizoribine monophosphate is an inhibitor of the human RNA capping enzyme. F. Picard-Jean, I. Bougie, S. Shuto, M. Bisaillon, PLoS One. 2013, 8, e54621.

    21. ・ Design and synthesis of cyclic ADP-4-thioribose as a stable equivalent of cyclic ADP-ribose, a Ca2+-mobilizing second messenger. T. Tsuzuki, N. Sakaguchi, T. Kudoh, S. Takano, M. Uehara, T. Murayama, T. Sakurai, M. Hashii, H. Higashida, K. Weber, A. H. Guse, T. Kameda, T. Hirokawa, Y. Kumaki, B. V. L. Potter, H. Fukuda, M. Arisawa, S. Shuto, Angew. Chem. Int. Ed. 2013, 57, 6633-6637.

    22. ・ Design Synthesis, and Validation of Peptidomimetics with Three-dimentional Structure Diversity. A. Mizuno, S. Miura, M. Watanabe, T. Kameda, M. Arisawa, S. Shuto, Peptide Science 2013, 49, 9-10.

    23. ・ DJ-1 cooperates with PYCR1 in cell protection against oxidative stress. T. Yasuda, Y. Kaji, T. Agatsuma, T. Niki, M. Arisawa, S. Shuto, H. Ariga, S. M.M. Iguchi-Ariga, Biochem. Biophys. Res. Commun. 2013, 436, 289-294.

    24. ・ Investigation of the Non-Covalent Binding Mode of Covalent Proteasome Inhibitors around the Transition State by Combined Use of Cyclopropylic Strain-Based Conformational Restriction and Computational Modeling. S. Kawamura, Y. Unno, M. Tanaka, T. Sasaki, A. Yamano, T. Hirokawa, T. Kameda, A. Asai, M. Arisawa, S. Shuto, J. Med. Chem. 2013, 56, 5829-5842.

    25. ・ Development of Second Generation Gold-Supported Palladium Material with Low-Leaching and Recyclable Characteristics in Aromatic Amination. M. Al-Amin, S. Arai, N. Hoshiya, T. Honma, Y. Tamenori, T. Sato, M. Yokoyama, A. Ishii, M. Takeuchi, T. Maruko, S. Shuto, M. Arisawa, J. Org. Chem. 2013, 78, 7575-7581.

    26. ・ CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine-Diphosphate Ribose Template. C. Moreaul, Q. Liu, R. Graeff, G. K. Wagner, M. P. Thomas, J. M. Swarbrickl, S. Shuto, H. C. Lee, Q. Hao, Barry V. L. Potter, PLoS One. 2013, 8, e66247.

    27. ・ Cyclopropane-Based conformational restriction of GABA by a stereochemical diversity-oriented strategy: Identification of an efficient lead for potent inhibitors of GABA transports. K. Nakada, M. Yoshikawa, S. Ide, A. Suemasa, S. Kawamura, T. Kobayashi, E. Masuda, Y. Ito, W. Hayakawa, T. Katayama, S. Yamada, M. Arisawa, M. Minami, S. Shuto, Bioorg. Med. Chem. 2013, 21, 4938-4950.

    28. ・ A fluorescence-based method for evaluating inositol 1,4,5-trisphosphate receptor ligands: Determination of subtype selectivity and partial agonist effects. A. Tanimura, T. Mochizuki, T. Morita, A, Nezu, Y. Tojyo, M. Arisawa, S. Shuto, J. Biotech. 2013, 167, 248-254.

    29. ・ Palladium-Catalyzed Arylation of Cyclopropanes via Directing Group-Mediated C(sp3)-H Bond Activation to Construct Quaternary Carbon Centers: Synthesis of cis- and trans-1,1,2-Trisubstituted Chiral Cyclopropanes. N. Hoshiya, T. Kobayashi, M. Arisawa, S. Shuto, Org. Lett. 2013, 15, 6202-6205.

    30. ・ Preparation of chiral bromomethylenecyclopropane and its use in Suzuki-Miyaura coupling: synthesis of the arylmethyl-Z-cyclopropane structure core. M. Tanabe, M. Watanabe, N, Hoshiya, A. Mizuno, H. Fukuda, M. Arisawa, S. Shuto, J. Org. Chem. 2013, 78, 11714-11720.

    その他の総説等

    1. ・ 阿部洋、「ナノ構造化RNAを用いたRNA干渉法」、薬学雑誌、133巻3号, 373-378

    2. ・ Seiichi Tada, Hiroshi Abe, and Yoshihiro Ito, "PEGylated Antibodies and DNA in Organic Media and Genetic PEGylation" in "Green Polymer 2." ed. by H. N. Chen and R. A. Gross, ACS, accepted (2013)

    3. ・ 阿部洋、「有機溶媒に溶ける核酸―DNA触媒の新たな可能性」、現代化学　2013年 1月号

    All Rights Reserved Laboratory of Organic Chemistry for Drug Development