2018年

1. ・ Cyclic ADP-carbocyclic-ribose and -4-thioribose, as stable mimics of cyclic ADP-ribose, a Ca2+-mobilizing second messenger.S. Shuto, Chem. Pharm. Bull., 2018, 66, 155-161.
   


2. ・ Ribavirin-related compounds exert in vitro inhibitory effects toward rabies virus. P. D. Anindita, M. Sasaki, K. Okada, N. Ito, M. Sugiyama, N. Saito-Tarashima, N. Minakawa, S. Shuto, S. Otsuguro, S. Ichikawa, A. Matsuda, K. Maenaka, Y. Orba, Antiviral Res., 2018, 154, 1-9.
   


3. ・ Ligand-phospholipid conjugation: a versatile Strategy for developing long-acting ligands that bind to membranproteins by restricting the subcellular localization of the ligand. S. Kawamura, Y. Ito, T. Hirokawa, E. Hikiyama, S. Yamada, S. Shuto,J. Med. Chem., 2018, 61, 4020-4029.
   


4. ・ Synthesis of chiral cis-cyclopropane bearing indole and chromone as potential TNF-α inhibitors. R. Kanada, M. Tanabe, R. Muromoto, Y. Sato, T. Kuwahara, H. Fukuda, M. Arisawa, T. Matsuda, M. Watanabe,S. Shuto,J. Org. Chem., 2018, 83, 7672-7682.
   


5. ・ Resolvin E1, but not resolvins E2 and E3, promotes fMLF-induced ROS generation in human neutrophils. Y. Unno, Y. Sato, H. Fukuda, K. Ishimura, H. Ikeda, M. Watanabe, S. Tansho-Nagakawa, T. Ubagai, S. Shuto, Y. Ono, FEBBS Lett., 2018, 592, 2706-2715.
   


6. ・ Resolvin E3 attenuates lipopolysaccharide-induced depression-like behavior in mice. K. Deyama, Y. Shimoda, H. Ikeda, H. Fukuda, S. Shuto, M. Minami, J. Pharmacol. Sci., 2018, 136, 86-88.
   


7. ・ Design and synthesis of cyclopropane-based conformationally restricted GABA analogues as selective inhibitors for betaine/GABA transporter 1. A. Suemasa, M. Watanabe, T. Kobayashi, H. Suzuki, H. Fukuda, M. Minami, S. Shuto, Bioorg. Med. Chem. Lett., 2018, 28, 3395-3399.
   


8. ・ Development of dihydrodibenzooxepine PPAR gamma ligands of a novel binding mode as anticancer agents: Effective mimicry of chiral structures by olefinic E/Z-isomers. K. Yamamoto, T. Tamura, K. Henmi, T. Kuboyama, A. Yanagisawa, M. Matsubara, Y. Takahashi, M. Suzuki, J. Saito, K.Ueno, S. Shuto, J. Med. Chem. Lett., 2018, 61, in press.
   


9. ・ Design and Synthesis of Histamine H3/H4 Receptor Ligands with a Cyclopropane Scaffold. M. Watanabe, T. Kobayashi, Y. Ito, H. Fukuda, S. Yamada, M. Arisawa, S. Shuto, Bioorg. Med. Chem. Lett., 2018, 28, in press.
   

その他の総説等