2017年

1. ・ Structure-specific Effects of Lipidated Oxytocin Analogs on Intracellular Calcium Levels, Parental Behavior, Plasma and Cerebrospinal Fluid Oxytocin Concentrations in Mice.S. M. Cherepanov, S. Yokoyama, A. Mizuno, W. Ichinose, O. Lopatina, A. A. Shabalova, A. B. Salmina, Y. Yamamoto, H. Okamoto, S. Shuto, H. Higashida, Pharmacol. Res. Perspect., 2017, 5, 1-14.
   


2. ・ An Entry to Chiral 1,1,2,3-Tetrasubstituted Arylcyclopropanes by Pd(II)-Catalyzed Arylation via Directing Group-Mediated C(sp3)-H Activation. N. Hoshiya, M. Kondo, H. Fukuda, M. Arisawa, J. Uenishi, S. Shuto J. Org. Chem., 2017, 82, 2535-2544.
   


3. ・ Divergent synthesis of kinase inhibitor derivatives, leading to discovery of selective Gck inhibitors, T. Matsumaru, M. Inai, T. Iwamatsu, H. Maita, S. Otsuguro, T. Nomura, A. Matsuda, S. Ichikawa, S. Shuto, K. Maenaka, T. Kan,Bioorganic Med. Chem. Lett., 2017,27, 2144-2147.
   


4. ・ Highly Conformationally-Restricted Cyclopropane Tethers with three-Dimensional Structural Diversity Drastically Enhance the Cell-Permeability of Cyclic Peptides. K. Matsui, Y. Kido, R. Watari, Y. Kashima, Y. Yoshida, S. Shuto,Chem. Eur. J., 2017, 23, 3034-3041. DOI: 10.1002/chem.201604946
   


5. ・ Discovery of Novel Seven-Membered Prostacyclin Analogs as Potent and Selective Prostaglandin FP and EP3 Dual Agonists. I. Sugimoto, T. Kambe, T. Okino, T. Obitsu, N. Ohta, T. Nishiyama, A. Kinoshita, T. Fujimoto, H. Egashira, S.Yamane, S. Shuto, K.Tani, T. Maruyama, ACS Med. Chem. Lett., 2017, 8, 107-112. DOI:10.1021/acsmedchemlett.6b00415
   


6. ・ Cyclopropane-Based Peptidomimetics Mimicking Wide-Ranging Secondary Structures of Peptides: Conformational Analysis and Their Use in Rational Ligand Optimization. A. Mizuno, T. Kameda, T. Kuwahara, H. Endoh, Y. Ito, S. Yamada, K. Hasegawa, A. Yamano, M. Watanabe, M. Arisawa, S. Shuto, Chem. Eur. J., 2017, 23, 3159-3168. DOI: 10.1002/chem.201605312.
   


7. ・ Discovery of Novel Indazole Derivatives as Orally Available β3-Adrenergic Receptor Agonists Lacking Off-Target-Based Cardiovascular Side Effect.Y. Wada, S. Nakano, A. Morimoto, K. Kasahara, T. Hayash, Y. Takada, H. Suzuki, M. NIwa-Sakai, S. Ohashi, M. Mori, T. Hirokawa, S. Shuto, J. Med. Chem., 2017, 60, 3252-3265. DOI:10.1021/acs.jmedchem.6b01197.
   


8. ・ Chemical ligation of oligonucleotides using an electrophilic phosphorothioester. H. Maruyama, R. Oikawa, M. Hayakawa, S. Takamori, Y. Kimura, N. Abe, G. Tsuji, A. Matsuda, S. Shuto, Y. Ito, H. Abe, Nucleic Acids Res Lett. , 2017, 45, 7042.
   


9. ・ Tethered 1,2-Si-group migrations in radical-mediated ring enlargements of cyclic alkoxysilanes: an EPR spectroscopic and computational investigation. J. Walton, R. Kanada, T. Iwamoto, S. Shuto, H. Abe, J. Org. Chem., 2017, 82, 6886.
   


10. Synthesis of 8-substituted analogues of cyclic ADP-4-thioribose and their unexpected identification as Ca2+-mobilizing full agonists. S. Takano, T. Tsuzuki, T. Murayama, T. Kameda, Y. Kumaki, T. Sakurai, H. Fukuda, M. Watanabe, M. Arisawa, S. Shuto, J. Med. Chem., 2017, 60, 5868.
    


11. ・ Peptides to Peptidomimetics: A Strategy Based on the Structural Features of Cyclopropane. A. Mizuno, K. Matsui, S. Shuto, Chem. Eur. J., 2017, 23, 14394-14409. DOI:10.1002/chem.201702119
    


12. ・ Intestinal transepithelial permeability of oxytocin into the blood is dependent on the receptor for advanced glycation end products in mice. H. Higashida, K. Furuhara, A.-M. Yamauchi, K. Deguchi, A. Harashima, S. Munesue, O. Lopatina, M. Gerasimenko, A. Salmina, J.-S. Zhang, H. Kodama, H. Kuroda, C. Tsuji, S. Shuto, H. Yamamoto, Y. Yamamoto, Scientific Rep., 2017, 7, Article number: 7883.
    


13. ・ A Covalent G-site inhibitor for glutathione S-transferase Pi　(GSTP). Y. Shishido, F. Tomoike, Y. Kimura, K. Kuwata, T. Yano, K Fukui, H. Fujikawa, Y. Sekido, Y. Murakami-Tonami, T. Kameda, S. Shuto, H. Abe, Chem. Commun., 2017, 53, 11138-11141.
    


14. ・ Resolvin E1 and E2 ameliorate lipopolysaccharide-induced depression-like behaviors via ChemR23S. K. Deyama, Y. Shimoda, K. Ishikawa, H. Ishimura, H. Fukuda, S. Ide, M. Satoh, S. Shuto, M. Minami, Psychopharmacology, 2017, 235, 329-336.
    


15. ・ Effects of three lipidated oxytocin analogs on behavioral deficits in CD38 knockout mice. S. M. Cherepanov, S. Akther, T. Nishimura, A. A. Shabalova, A. Mizuno, W. Ichinose, S. Shuto, Y. Yamamoto, S. Yokoyama, H. Higashida, Brain Sci., 2017, 7, 132.
    

その他の総説等