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Hybrid catalyst with high enantiomer selectivity

A group of Japanese researchers, including Professor Shigeki Matsunaga and Assistant Professor Tatsuhiko Yoshino, both of Hokkaido University’s Faculty of Pharmaceutical Science, and Professor Kazuaki Ishihara and Associate Professor Manabu Hatano, both of Nagoya University’s Graduate School of Engineering, has developed a technology to create a hybrid catalyst from simple-structured, commercially available rhodium and organic catalysts, which reduces chemical waste and produces molecules with high selectivity of an enantiomer, a pair of molecular structures that are non-superimposable mirror images of each other. This technology is expected to assist in rapid and low-cost drug synthesis.

 

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Original paper in Nature Catalysis DOI: 10.1038/s41929-018-0106-5

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