メンバー・研究内容

業績リスト

2012年 （平成24年）

1 Akihiko Nishikimi, Takehito Uruno, Xuefeng Duan, Qinhong Cao, Yuji Okamura, Takashi Saitoh, Nae Saito, Shunsuke Sakaoka, Yao Du, Atsushi Suenaga, Mutsuko Kukimoto-Niino, Kei Miyano, Kazuhito Gotoh, Takayoshi Okabe, Fumiyuki Sanematsu, Yoshihiko Tanaka1, Hideki Sumimoto, Teruki Honma, Shigeyuki Yokoyama, Tetsuo Nagano, Daisuke Kohda, Motomu Kanai, and Yoshinori Fukui.
  Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2.
  Chemistry & Biology (Cell Press), 19, 488–497, (2012) [Abstract] / [Full text]
2 Yukiko Sakakibara1, Hitoshi Kimura Akira Iwamura, Takashi Saitoh, Takahisa Ikegami, Genji Kurisu and Toshiharu Hase.
  A new structural insight into differential interaction of cyanobacterial and plant ferredoxins with nitrite reductase as revealed by NMR and X-ray crystallographic studies.
  The Journal of Biochemistry, 151, 483-492, (2012) [Abstract] / [Full text]
3 Yamaguchi, S., Yamane, T., Takahashi-Niki, K., Kato, I., Niki, T., Goldberg, M. S., Shen, J., Ishimoto, K., Doi, T., Iguchi-Ariga, S. M. M. and Ariga, H.
  Transcriptional activation of low-density lipoprotein receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasis.
  PLoS ONE 7(5): e38144 (2012) [Abstract] / [Full text]
4 前仲勝実、橋口隆生、柳雄介
  麻疹ウイルスと受容体との複合体の立体構と今後の展望
  日本臨床 70, 695-703 (2012). [Abstract] / [Full text]

2013年 （平成25年）

5 Toshihiro Aoki, Ikumi Hyohdoh, Noriyuki Furuichi, Sawako Ozawa, Fumio Watanabe, Masayuki Matsushita, Masahiro Sakaitani, Kazutomo Ori, Kenji Takanashi, Naoki Harada, Yasushi Tomii, Mitsuyasu Tabo, Kiyoshi Yoshinari, Yuko Aoki, Nobuo Shimma, Hitoshi Iikura
  The sulfamide moiety affords higher inhibitory activity and oral bioavailability to a series of coumarin dual selective RAF/MEK inhibitors.
  Bioorganic & Medicinal Chemistry Letters 23 6223–6227 (2013) [Abstract] / [Full text]
6 Ikumi Hyohdoh, Noriyuki Furuichi, Toshihiro Aoki, Yoshiko Itezono, Haruyoshi Shirai, Sawako Ozawa, Fumio Watanabe, Masayuki Matsushita, Masahiro Sakaitani, Pil-Su Ho, Kenji Takanashi, Naoki Harada, Yasushi Tomii, Kiyoshi Yoshinari, Kazutomo Ori, Mitsuyasu Tabo, Yuko Aoki, Nobuo Shimma, and Hitoshi Iikura
  Fluorine Scanning by Nonselective Fluorination: Enhancing Raf/MEK Inhibition while Keeping Physicochemical Properties.
  ACS Medicinal Chemistry Letters, 4, 1059−1063, (2013) [Abstract] / [Full text]
7 Yasuaki Komuro, Naoyuki Miyashita, Takaharu Mori, Eiro Muneyuki, Takashi Saitoh, Daisuke Kohda, and Yuji Sugita.
  Energetics of the Presequence-Binding Poses in Mitochondrial Protein Import Through Tom20.
  The Journal of Physical Chemistry B, 14, 2864-2871 (2013) [Abstract] / [Full text]
8 James Nyirenda, Shunsuke Matsumoto, Takashi Saitoh, Nobuo Maita, Nobuo N. Noda, Fuyuhiko Inagaki, and Daisuke Kohda.
  Crystallographic and NMR evidence for flexibility in oligosaccharyltransferases and its catalytic significance.
  Structure (Cell Press), 21, 32-41, (2013) [Abstract] / [Full text]
9 Abe M, Tahara M, Sakai K, Yamaguchi H, Kanou K, Shirato K, Kawase M, Noda M, Kimura H, Matsuyama S, Fukuhara H, Mizuta K, Maenaka K, Ami Y, Esumi M, Kato A, Takeda M.
  TMPRSS2 is an activating protease for respiratory parainfluenza viruses.
  J Virol, 87, 11930-5 (2013) [Abstract] / [Full text]
10 福原秀雄、陳甦芮、武田森、前仲勝実
  モルビリウイルス属の細胞侵入機構
  薬学雑誌, 133(5), 549-59 (2013) [Abstract] / [Full text]
11 喜多俊介、前仲勝実、福原秀雄
  試料作製技術
  タンパク質結晶の最前線、シーエムシー出版、9-17（2013） [Abstract] / [Full text]
12 Kong K, Enquist JA, Jr., McCallum ME, Smith GM, Matsumaru T, Menhaji-Klotz
  An enantioselective total synthesis and stereochemical revision of (+)-citrinadin B.
  E, Wood JL. J Am Chem Soc. 135, 10890-10893 (2013) [Abstract] / [Full text]
13 Kawamura S, Unno Y, Tanaka M, Sasaki T, Yamano A, Hirokawa T, Kameda T, Asai A, Arisawa M, Shuto S.
  Investigation of the Non-Covalent Binding Mode of Covalent Proteasome Inhibitors around the Transition State by Combined Use of Cyclopropylic Strain-Based Conformational Restriction and Computational Modeling.
  J. Med. Chem. 56, 5829-5842 (2013) [Abstract] / [Full text]
14 Kawamura S, Unno Y, Asai A, Arisawa M, Shuto S.
  Design and Synthesis of the Stabilized Analogs of Belactosin A with the Unnatural cis-Cyclopropane Structure.
  Org. Biomol. Chem. 14, 6615-6622 (2013) [Abstract] / [Full text]
15 Yonezawa S, Fujiwara K, Yamamoto T, Hattori K, Yamakawa H, Muto C, Hosono M, Tanaka Y, Nakano T, Takemoto H, Arisawa M, Shuto S.
  Conformational restriction approach to b-secretase (BACE1) inhibitors III: Effective investigation of the binding mode by combinational use of X-ray analysis, isothermal titration calorimetry and theoretical calculations.
  Bioorg. Med. Chem. 21, 6506-6522 (2013) [Abstract] / [Full text]
16 Hoshiya N, Kobayashi T, Arisawa M, Shuto S.
  Palladium-Catalyzed Arylation of Cyclopropanes via Directing Group-Mediated C(sp3)-H Bond Activation to Construct Quaternary Carbon Centers: Synthesis of cis- and trans-1,1,2-Trisubstituted Chiral Cyclopropanes.
  Org. Lett. 15, 6202-6205 (2013) [Abstract] / [Full text]
17 Tanabe M, Watanabe M, Hoshiya N, Mizuno A, Fukuda H, Arisawa M, Shuto S.
  Preparation of chiral bromomethylenecyclopropane and its use in Suzuki-Miyaura coupling; synthesis of the arylmethyl-Z-cyclopropane structure core.
  J. Org. Chem. 78, 11714–11720 (2013) [Abstract] / [Full text]
18 Kato, I., Maita, H., Takahashi-Niki, Saito, Y., Noguchi, N., Iguchi-Ariga, S. M. M. and Ariga, H.
  DJ-1 inhibits p53 by sequestering p53 from promoters in a DNA-binding affinity-dependent manner.
  Molecular and Cellular Biology 33(2):340-359 (2013) [Abstract] / [Full text]
19 Ariga, H., Takahashi-Niki, K., Kato, I., Maita, H., Niki, T. and Iguchi-Ariga, S. M. M.
  Neuroprotective function of DJ-1 in Parkinson’s disease.
  Oxid. Med. Cell. Long. 2013 : 683920. (2013) [Abstract] / [Full text]
20 Yamane T, Murao S, Kato-Ose I, Kashima L, Yuguchi M, Kozuka M, Takeuchi K, Ogita H, Ohkubo I, Ariga H.
  Transcriptional regulation of the legumain gene by p53 in HCT116 cells.
  Biochem Biophys Res Commun. 6;438(4):613-618 (2013) [Abstract] / [Full text]
21 Furukawa A, Kamishikiryo J, Mori D, Toyonaga K, Okabe Y, Toji A, Kanda R, Miyake Y, Ose T, Yamasaki S, Maenaka K.
  Structural analysis for glycolipid recognition by the C-type lectins Mincle and MCL.
  Proc. Natl. Acad. Sci. USA, 110(43):17438-43. (2013) [Abstract] / [Full text]
22 Kuroki K, Hirose K, Okabe Y, Fukunaga Y, Takahashi A, Shiroishi M, Kajikawa M, Tabata S, Nakamura S, Takai T, Koyanagi S, Ohdo S, Maenaka K.
  The long-term immunosuppressive effects of disulfide-linked HLA-G dimer in mice with collagen-induced arthritis.
  Hum Immunol. Apr;74(4):433-8. (2013) [Abstract] / [Full text]
23 前仲勝実, 加藤晃一
  創薬に向けた構造生物学
  YAKUGAKU ZASSHI 133(5): 507 -507 (2013) [Abstract] / [Full text]
24 Hari Y, Osawa T, Kotobuki, Yahara A, Shrestha AR, Obika S.
  Syntheisis and properties of thymidines with six-membered amide bridge.
  Bioorg Med Chem, 21, 4405-4412 (2013) [Abstract] / [Full text]
25 Otsuki N, Sekizuka T, Seki F, Sakai K, Kubota T, Nakatsu Y, Chen S, Fukuhara H, Maenaka K, Yamaguchi R, Kuroda M, Takeda M.
  Canine distemper virus with the intact C protein has the potential to replicate in human epithelial cells by using human nectin4 as a receptor.
  Virology 20;435(2):485-92. (2013) [Abstract] / [Full text]
26 Tahara M, Ito Y, Brindley MA, Ma X, He J, Xu S, Fukuhara H, Sakai K, Komase K, Rota PA, Plemper RK, Maenaka K, Takeda M.
  Functional and structural characterization of neutralizing epitopes of measles virus hemagglutinin protein.
  J Virol. 87(1):666-75. (2013) [Abstract] / [Full text]

2014年 （平成26年）

27 Shrestha AR, Kotobuki Y,Hari Y, Obika S.
  Guanidine bridged nucleic acid (GuNA): an effect of a cationic bridged　nucleic acid on DNA binding affinity.
  ChemComm, 50, 575-577 (2014). [Abstract] / [Full text]
28 Nomura T, Watanabe S, Kaneko K, Yamanaka K, Nukina N, Furukawa Y.
  Intranuclear Aggregation of Mutant FUS/TLS as a Molecular Pathomechanism of Amyotrophic Lateral Sclerosis.
  J Biol Chem. 289, 1192-202 (2014) [Abstract] / [Full text]
29 Minami A, Ose T, Sato K, Oikawa A, Kuroki K, Maenaka K, Oguri H, Oikawa H.
  Allosteric regulation of epoxide opening cascades by a pair of epoxide hydrolases in monensin biosynthesis.
  ACS Chem Biol. In the press. [Abstract] / [Full text]
30 Yamane, T., Sugimoto, N., Maita, H., Watanabe, K., Takahashi-Niki, K., Maita, C., Kato-Ose, I., Ishikawa, S., Gao, J., Kitaura, H., Niki, T., Iguchi-Ariga, S.M.M. and Ariga, H.
  Identification of DJ-1-associated regions on human genes from SH-SY5Y cells using chromatin immunoprecipitation sequence technique.
  Journal of Molecular Biology in Press (2014) [Abstract] / [Full text]
31 Kawamura S, Unno Y, Hirokawa T, Asai A, Arisawa M, Shuto S.
  Rational Hopping of a Peptidic Scaffold into Non-Peptidic Scaffolds: Structurally Novel Potent Proteasome Inhibitors Derived from a Natural Product, Belactosin A.
  Chem. Commun. in press. [Abstract] / [Full text]
32 Toshihiro Aoki, Ikumi Hyohdoh, Noriyuki Furuichi, Sawako Ozawa, Fumio Watanabe, Masayuki Matsushita, Masahiro Sakaitani, Kenji Morikami, Kenji Takanashi, Naoki Harada, Yasushi Tomii, Koji Shiraki, Kentaro Furumoto, Mitsuyasu Tabo, Kiyoshi Yoshinari, Kazutomo Ori, Yuko Aoki, Nobuo Shimma, and Hitoshi Iikur
  Optimizing the Physicochemical Properties of Raf /MEK Inhibitors by Nitrogen Scanning
  ACS Medicinal Chemistry Letters, in press. (2014) [Abstract] / [Full text]
33 野口昌幸、堺谷政弘、水津太
  最新がん薬物療法学―がん薬物療法の最新知見―「その他のセリン・スレオニンキナーゼ阻害薬」
  日本臨床、in press. (2014) [Abstract] / [Full text]
34 長野哲雄、堺谷政弘
  アカデミア創薬を成功させるために
  実験医学増刊号、アカデミア創薬の戦略と実例, 羊土社 (2014) [Abstract] / [Full text]
35 齊藤貴士、堺谷政弘、前仲勝実
  合理的創薬と構造解析
  実験医学増刊号、アカデミア創薬の戦略と実例, 羊土社 (2014) [Abstract] / [Full text]
36 Hideo Fukuhara, Atsushi Furukawa, Katsumi Maenaka
  New Binding Face of C-type Lectin-like Domains
  Structure (Cell Press), 22, 1694-1696, (2014) [Abstract] / [Full text]