メンバー・研究内容

業績リスト

2013年 （平成25年）

  • The sulfamide moiety affords higher inhibitory activity and oral bioavailability to a series of coumarin dual selective RAF/MEK inhibitors.
    Toshihiro Aoki, Ikumi Hyohdoh, Noriyuki Furuichi, Sawako Ozawa, Fumio Watanabe, Masayuki Matsushita, Masahiro Sakaitani, Kazutomo Ori, Kenji Takanashi, Naoki Harada, Yasushi Tomii, Mitsuyasu Tabo, Kiyoshi Yoshinari, Yuko Aoki, Nobuo Shimma, Hitoshi Iikura
    Bioorganic & Medicinal Chemistry Letters 23 6223–6227 (2013)
  • Fluorine Scanning by Nonselective Fluorination: Enhancing Raf/MEK Inhibition while Keeping Physicochemical Properties.
    Ikumi Hyohdoh, Noriyuki Furuichi, Toshihiro Aoki, Yoshiko Itezono, Haruyoshi Shirai, Sawako Ozawa, Fumio Watanabe, Masayuki Matsushita, Masahiro Sakaitani, Pil-Su Ho, Kenji Takanashi, Naoki Harada, Yasushi Tomii, Kiyoshi Yoshinari, Kazutomo Ori, Mitsuyasu Tabo, Yuko Aoki, Nobuo Shimma, and Hitoshi Iikura
    ACS Medicinal Chemistry Letters, 4, 1059−1063, (2013)
  • Energetics of the Presequence-Binding Poses in Mitochondrial Protein Import Through Tom20.
    Yasuaki Komuro, Naoyuki Miyashita, Takaharu Mori, Eiro Muneyuki, Takashi Saitoh, Daisuke Kohda, and Yuji Sugita.
    The Journal of Physical Chemistry B, 14, 2864-2871 (2013)
  • Crystallographic and NMR evidence for flexibility in oligosaccharyltransferases and its catalytic significance.
    James Nyirenda, Shunsuke Matsumoto, Takashi Saitoh, Nobuo Maita, Nobuo N. Noda, Fuyuhiko Inagaki, and Daisuke Kohda.
    Structure (Cell Press), 21, 32-41, (2013)
  • TMPRSS2 is an activating protease for respiratory parainfluenza viruses.
    Abe M, Tahara M, Sakai K, Yamaguchi H, Kanou K, Shirato K, Kawase M, Noda M, Kimura H, Matsuyama S, Fukuhara H, Mizuta K, Maenaka K, Ami Y, Esumi M, Kato A, Takeda M.
    J Virol, 87, 11930-5 (2013)
  • An enantioselective total synthesis and stereochemical revision of (+)-citrinadin B.
    Kong K, Enquist JA, Jr., McCallum ME, Smith GM, Matsumaru T, Menhaji-Klotz
    E, Wood JL. J Am Chem Soc. 135, 10890-10893 (2013)
  • Investigation of the Non-Covalent Binding Mode of Covalent Proteasome Inhibitors around the Transition State by Combined Use of Cyclopropylic Strain-Based Conformational Restriction and Computational Modeling.
    Kawamura S, Unno Y, Tanaka M, Sasaki T, Yamano A, Hirokawa T, Kameda T, Asai A, Arisawa M, Shuto S.
    J. Med. Chem. 56, 5829-5842 (2013)
  • Design and Synthesis of the Stabilized Analogs of Belactosin A with the Unnatural cis-Cyclopropane Structure.
    Kawamura S, Unno Y, Asai A, Arisawa M, Shuto S.
    Org. Biomol. Chem. 14, 6615-6622 (2013)
  • Conformational restriction approach to b-secretase (BACE1) inhibitors III: Effective investigation of the binding mode by combinational use of X-ray analysis, isothermal titration calorimetry and theoretical calculations.
    Yonezawa S, Fujiwara K, Yamamoto T, Hattori K, Yamakawa H, Muto C, Hosono M, Tanaka Y, Nakano T, Takemoto H, Arisawa M, Shuto S.
    Bioorg. Med. Chem. 21, 6506-6522 (2013)
  • Palladium-Catalyzed Arylation of Cyclopropanes via Directing Group-Mediated C(sp3)-H Bond Activation to Construct Quaternary Carbon Centers: Synthesis of cis- and trans-1,1,2-Trisubstituted Chiral Cyclopropanes.
    Hoshiya N, Kobayashi T, Arisawa M, Shuto S.
    Org. Lett. 15, 6202-6205 (2013)
  • Preparation of chiral bromomethylenecyclopropane and its use in Suzuki-Miyaura coupling; synthesis of the arylmethyl-Z-cyclopropane structure core.
    Tanabe M, Watanabe M, Hoshiya N, Mizuno A, Fukuda H, Arisawa M, Shuto S.
    J. Org. Chem. 78, 11714–11720 (2013)
  • DJ-1 inhibits p53 by sequestering p53 from promoters in a DNA-binding affinity-dependent manner.
    Kato, I., Maita, H., Takahashi-Niki, Saito, Y., Noguchi, N., Iguchi-Ariga, S. M. M. and Ariga, H.
    Molecular and Cellular Biology 33(2):340-359 (2013)
  • Neuroprotective function of DJ-1 in Parkinson’s disease.
    Ariga, H., Takahashi-Niki, K., Kato, I., Maita, H., Niki, T. and Iguchi-Ariga, S. M. M.
    Oxid. Med. Cell. Long. 2013 : 683920. (2013)
  • Transcriptional regulation of the legumain gene by p53 in HCT116 cells.
    Yamane T, Murao S, Kato-Ose I, Kashima L, Yuguchi M, Kozuka M, Takeuchi K, Ogita H, Ohkubo I, Ariga H.
    Biochem Biophys Res Commun. 6;438(4):613-618 (2013)
  • Structural analysis for glycolipid recognition by the C-type lectins Mincle and MCL.
    Furukawa A, Kamishikiryo J, Mori D, Toyonaga K, Okabe Y, Toji A, Kanda R, Miyake Y, Ose T, Yamasaki S, Maenaka K.
    Proc. Natl. Acad. Sci. USA, 110(43):17438-43. (2013)
  • The long-term immunosuppressive effects of disulfide-linked HLA-G dimer in mice with collagen-induced arthritis.
    Kuroki K, Hirose K, Okabe Y, Fukunaga Y, Takahashi A, Shiroishi M, Kajikawa M, Tabata S, Nakamura S, Takai T, Koyanagi S, Ohdo S, Maenaka K.
    Hum Immunol. Apr;74(4):433-8. (2013)
  • Syntheisis and properties of thymidines with six-membered amide bridge.
    Hari Y, Osawa T, Kotobuki, Yahara A, Shrestha AR, Obika S.
    Bioorg Med Chem, 21, 4405-4412 (2013)
  • Canine distemper virus with the intact C protein has the potential to replicate in human epithelial cells by using human nectin4 as a receptor.
    Otsuki N, Sekizuka T, Seki F, Sakai K, Kubota T, Nakatsu Y, Chen S, Fukuhara H, Maenaka K, Yamaguchi R, Kuroda M, Takeda M.
    Virology 20;435(2):485-92. (2013)
  • Functional and structural characterization of neutralizing epitopes of measles virus hemagglutinin protein.
    Tahara M, Ito Y, Brindley MA, Ma X, He J, Xu S, Fukuhara H, Sakai K, Komase K, Rota PA, Plemper RK, Maenaka K, Takeda M.
    J Virol. 87(1):666-75. (2013)


総説、共著など

  • モルビリウイルス属の細胞侵入機構
    福原秀雄、陳甦芮、武田森、前仲勝実
    薬学雑誌, 133(5), 549-59 (2013)
  • 試料作製技術
    喜多俊介、前仲勝実、福原秀雄
    タンパク質結晶の最前線、シーエムシー出版、9-17（2013）
  • 創薬に向けた構造生物学
    前仲勝実, 加藤晃一
    YAKUGAKU ZASSHI 133(5): 507 -507 (2013)